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Abstract Number: 2399

Changes in the Initial Usage Pattern of Biologic Disease-modifying Antirheumatic Drugs in Rheumatic Diseases During the past Twelve Years: A Real-world Setting Analysis

Carlos Sánchez-Piedra1, María Colazo 2, Rosa Roselló 3, Cristina Campos 4, P. Vela 5, Cristina Bohorquez 6, Carolina Pérez-García 7, Manuel Pombo-Suarez 8, Carlos Fernández-López 9, Dolores Ruiz-Montesinos 10, Fernando Alonso 11, Federico Diaz-Gonzalez 12 and Juan Jesús Gómez-Reino 13, 1Research Unit, Spanish Society of Rheumatology, Madrid, Spain, 2Hospital de Burgos, Burgos, 3Hospital San Jorge, Huesca, 4Hospital General de Valencia, Valencia, 5Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana, Spain, 6Universitary Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcala de Henares, Spain, 7Rheumatology, Hospital del Mar, Barcelona, Catalonia, Spain, 8Unit Research, Spanish Society of Rheumatology, Madrid, Spain, 9Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 10Hospital Virgen Macarena, Sevilla, 11Unidad Investigación SER, Madrid, Spain, 12Hospital de Canarias, Tenerife, 13Hospital de Santiago, Santiago de Compostela

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: ankylosing spondylitis (AS) and psoriatic arthritis, Biologics, pharmacotherapy, Rheumatoid arthritis (RA)

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Session Information

Date: Tuesday, November 12, 2019

Session Title: RA – Treatments Poster III: Safety and Outcomes

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: During the past 15 years, advancements in the understanding of the safety and effectiveness, as well as the expanding access and availability of biologic disease-modifying anti-rheumatic drugs (bDMARDs), have likely influenced the pattern of use of such compounds in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS). This analysis is aimed at assesing changes in the baseline characteristics of RA, PsA and AS patients who underwent biological therapy from 2007 to 2019 in a real world setting. 

Methods: Data were obtained from BIOBADASER, the Spanish registry of biologics which compiles data from routine clinical practice. Patients diagnosed with RA, PsA and AS who started biological treatment from 2007 to 2019 were included. Sociodemographic and clinical variables, as well as first bDMARD use, were stratified by the starting year period (2007-2009; 2010-2012; 2013-2015; 2016-2019) and then compared using Anova. The therapeutic target chosen by physicians to manage these patients was also analyzed. Parametric values were compared using a general linear model for repeated measures with simple contrast considering the initial value (2007-2009) as the reference. 

Results: 6197 patients (3266 RA patients, 1517 PsA and 1414 AS) were included in this analysis (Table 1). Patient age at the beginning of the first biologic was significantly higher during the period 2016-2019 than in 2007-2009 (50.1 vs 50.6). Disease duration until the use of biologics decreased significantly (8.6 vs 6.5).  In RA patients, disease activity, as assessed by DAS28 at the start of the biological treatment, was significantly higher during the 2007-2009 period than in the last period analyzed (5.2 vs 4.7). The use of a TNF inhibitor as a first option also changed significantly (96.6% vs 59.8%). Regarding comorbidities, the number of rheumatic patients treated with biologics and who had a history of cancer (1.7% vs 3.9%), hypercholesterolemia (14.7% vs 26.8%), or hypertension (23.1% vs 25.1%) increased significantly. The Charlson index also increased (1.9 vs 2.2).

Conclusion: Our data show that during the last 12 years the usage pattern of biologics in patients with RA, PsA and EA has changed. Nowadays these compounds are used in patients with shorter disease evolution times, with less disease activity and with more comorbidities. The availability of greater pharmacological resources, as well as an increased knowledge of the safety and effectiveness of biologics could explain these findings. 


Disclosure: C. Sánchez-Piedra, None; M. Colazo, None; R. Roselló, None; C. Campos, None; P. Vela, None; C. Bohorquez, None; C. Pérez-García, None; M. Pombo-Suarez, None; C. Fernández-López, None; D. Ruiz-Montesinos, None; F. Alonso, None; F. Diaz-Gonzalez, None; J. Gómez-Reino, None.

To cite this abstract in AMA style:

Sánchez-Piedra C, Colazo M, Roselló R, Campos C, Vela P, Bohorquez C, Pérez-García C, Pombo-Suarez M, Fernández-López C, Ruiz-Montesinos D, Alonso F, Diaz-Gonzalez F, Gómez-Reino J. Changes in the Initial Usage Pattern of Biologic Disease-modifying Antirheumatic Drugs in Rheumatic Diseases During the past Twelve Years: A Real-world Setting Analysis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/changes-in-the-initial-usage-pattern-of-biologic-disease-modifying-antirheumatic-drugs-in-rheumatic-diseases-during-the-past-twelve-years-a-real-world-setting-analysis/. Accessed January 31, 2023.
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