Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 110 • 2012 ACR/ARHP Annual Meeting
Comparing Palmar and Dorsal Ultrasound Assessment of Small Joint Synovitis in Rheumatoid Arthritis: Dorsal Greyscale Mode Yields Significantly Better Concordance with Power Doppler
Matthias Witt¹, Felix Mueller¹, Hendrik Schulze-Koops² and Mathias Grunke³, ¹Division of Rheumatology, Medizinische Klinik und Poliklinik IV, University of Munich, Munich, Germany, ²Division of Rheumatology, University of Munich, Munich, Germany, ³Division for Rheumatology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
Background/Purpose: MCP and PIP joints are frequently involved in rheumatoid arthritis. Complete ultrasound assessment of these joints requires the palmar and the dorsal approach for…
Abstract Number: 2098 • 2012 ACR/ARHP Annual Meeting
Patient Report Outcomes Variance Between Centers Is Much Lower Than Physician and Laboratory Assessed Measures of Rheumatoid Arthritis Activity: Results From a Multinational Study
Nasim A. Khan¹, Horace Spencer², Tuulikki Sokka³ and QUEST-RA⁴, ¹Rheumatology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, ²University of Arkansas for Medical Sciences, Little Rock, AR, ³Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland, ⁴Jyväskylä
Background/Purpose: Clinical trials and epidemiological rheumatoid arthritis (RA) studies often recruit patients from multiple centers. We studied the proportion of variance in the American…
Abstract Number: 1288 • 2012 ACR/ARHP Annual Meeting
A Significant Number of Patients with Chronic Arthritis Received a Reduced Dosage of Biological Drugs: an Observational Study in Clinical Practice
Jose Inciarte-Mundo¹, Maria Victoria Hernández², Violeta Rosario¹, Sonia Cabrera¹, Virginia Ruiz-Esquide³, Maria Eugenia Gomez-Caballero¹, Jose A. Gómez-Puerta¹, Julio Ramirez¹, Juan D. Cañete² and Raimon Sanmarti¹, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, ³Rheumatology, Hospital Clinic, Barcelona, Spain
Background/Purpose: Biological agents are used to treat chronic arthritis according to the standard dosages from phase III clinical trials. However, in some patients, a good…
Abstract Number: 479 • 2012 ACR/ARHP Annual Meeting
Active Immunization with TNF-Kinoid in Rheumatoid Arthritis Patients with Secondary Resistance to Tumor Necrosis Factor-Alpha Antagonists Is Safe and Immunogenic
Patrick Durez¹, Pedro Miranda², Antoaneta Toncheva³, Alberto Berman Sr.⁴, Oscar L. Rillo⁵, Yves Boutsen⁶, Tatjana Kehler⁷, Eugenia Mociran⁸, LiAn Soto Saez⁹, Bruno Fautrel¹⁰, Xavier Mariette¹¹, Panayot Solakov¹², Eleonora Lucero¹³, Tonko Vlak¹⁴, Simeon Grazio¹⁵, Ksenija Mastrovic¹⁶, Rodica Chiriac¹⁷, Géraldine Grouard-Vogel¹⁸, Olivier Dhellin¹⁸, Stéphane Ouary¹⁸, Pierre Vandepapeliere¹⁸ and Marie-Christophe Boissier¹⁹, ¹Department of Rheumatology, Université Catholique de Louvain, Brussels, Belgium, ²Universidad de Chile and Centro de Estudios Reumatologicos, Santiago de Chile, Chile, ³National Multiprofile Transport Hospital, Sofia, Bulgaria, ⁴Internal Medicine, Hospital Padilla, Tucuman, Argentina, ⁵Rheumatology, Hospital General de Agudos "Dr. E. Tornú", Buenos Aires, Argentina, ⁶UCL Mont-Godinne, Godinne, Belgium, ⁷Thalassotherapia Opatija, Opatija, Croatia, ⁸Emergency County Hospital Dr Constantin Opis, Maramures, Romania, ⁹Sociedad Medica del Aparato Locomotor SA, Santiago de Chile, Chile, ¹⁰Rheumatology / GRC08-EEMOIS, APHP-Pitie Salpetriere Hospital / UPMC, Paris, France, ¹¹Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France, ¹²Plovdiv, Diagnostic and Consulting Center, Plovdiv, Bulgaria, ¹³Rheumatology Unit, Padilla Hospital, Tucumán, Argentina, ¹⁴University Hospital Split, Split, Croatia, ¹⁵Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia, ¹⁶Clinical Hospital Sveti Duh, Zagreb, Croatia, ¹⁷Rehabilitation clinical Hospital Iasi, Iasi, Romania, ¹⁸NEOVACS SA, Paris, France, ¹⁹Dept of Rheumatology, Hopital Avicenne, Bobigny, France
Background/Purpose: Blocking TNF alpha (TNFα) with monoclonal antibodies (mAbs) has been successful in the treatment of rheumatoid arthritis. However secondary resistances are frequent and impose…
Abstract Number: 112 • 2012 ACR/ARHP Annual Meeting
Time-Integrated Synovitis Activity Assessed by Power Doppler Ultrasound Significantly Correlates with Radiographic Progression in Rheumatoid Arthritis Patients Treated with Methotrexate Alone but Not in Those Treated with TNF Antagonists
Kei Ikeda, Daiki Nakagomi, Yoshie Sanayama, Mieko Yamagata, Ayako Okubo, Taro Iwamoto, Hirotoshi Kawashima, Kentaro Takahashi and Hiroshi Nakajima, Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
Background/Purpose: Although a number of studies have shown a higher sensitivity of ultrasound than clinical joint examination in detecting synovitis in patients with rheumatoid arthritis…
Abstract Number: 2099 • 2012 ACR/ARHP Annual Meeting
Patient Self-Assessments and Selected Patient Reported Outcomes May Reliably Identify Rheumatoid Disease Flare in Early Rheumatoid Arthritis Patients
Vivian P. Bykerk¹, Clifton O. Bingham III², Ernest Choy³, Juan Xiong⁴, Gilles Boire⁵, Carol A. Hitchon⁶, Janet E. Pope⁷, J. Carter Thorne⁸, Boulos Haraoui⁹, Edward Keystone¹⁰ and Susan J. Bartlett¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, ⁴Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ¹⁰University of Toronto, Toronto, ON, Canada, ¹¹Clinical Epidemiology, McGill University, Montreal, QC, Canada
Background/Purpose: Significant RA worsening or flare may predict poorer outcomes and signal a need for treatment reassessment. However, there is little agreement about how to…
Abstract Number: 1293 • 2012 ACR/ARHP Annual Meeting
Importance of Steady-State Trough Concentrations After Intravenous Golimumab with Concomitant Methotrexate in Subjects with Active Rheumatoid Arthritis
J. H. Leu¹, Z. Xu¹, C. Hu¹, Alan Mendelsohn¹, J. Ford¹, Hugh M. Davis² and H. Zhou¹, ¹Janssen Research and Development, LLC, Spring House, PA, ²Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: To determine an optimized dosing regimen for IV golimumab in subjects with active RA using population pharmacokinetic (PK) modeling and simulation. Methods: Two Phase…
Abstract Number: 489 • 2012 ACR/ARHP Annual Meeting
The Comparative Effectiveness of Anti-TNF Medications Among Older and Disabled Rheumatoid Arthritis Patients in the U.S. Medicare Population
Huifeng Yun¹, Fenglong Xie², Elizabeth S. Delzell³, Lang Chen⁴, Shuo Yang⁵, Kenneth G. Saag⁶ and Jeffrey R. Curtis⁷, ¹Health Care Organization & Policy, University of Alabama-Birmingham, Birmingham, AL, ²Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ³Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ⁴Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Evaluating the real world effectiveness of biologic DMARDs in rheumatoid arthritis (RA) patients using administrative claims data has previously not been feasible due to…
Abstract Number: 114 • 2012 ACR/ARHP Annual Meeting
US Examination of Wrists and Hands: A Comparison Between Rheumatoid Arthritis and Psoriatic Arthritis
Andrea Delle Sedie¹, Elisa Cioffi¹, Linda Carli², Elena Sardano³, Stefano Bombardieri¹ and Lucrezia Riente¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Immunology Unit, University of Pisa, Immunology Unit, University of Pisa, Italy
Background/Purpose: very little is known about the differences in joint and periarticular structure involvement in rheumatoid or psoriatic arthritis (PsA). The main pathological features detected…
Abstract Number: 2074 • 2012 ACR/ARHP Annual Meeting
Combined Effects of a c-Fos/AP-1 Inhibitor T-5224 and Methotrexate On Collagen-Induced Arthritis in Mice
Tomomi Date¹, Yukihiko Aikawa¹, Tetsuya Yamamoto¹, Hirokazu Narita¹, Shuichi Hirono² and Shunichi Shiozawa³, ¹Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan, ²Department of Pharmaceutical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan, ³Department of Medicine & Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: Activator protein-1 (AP-1) is an important transcription factor for cytokine production and joint destruction in rheumatoid arthritis (RA), and a potential target for the…
Abstract Number: 1219 • 2012 ACR/ARHP Annual Meeting
Periodontal Disease Is Associated with Rheumatoid Arthritis but Its Severity Is Not Correlated with Rheumatoid Arthritis Disease Activity
In Ah Choi¹, Jin-Hee Kim², Kyung Hwa Kim², Hye Won Kim³, Myeong Jae Yoon¹, Bon Seung Ku⁴, Hyejin Oh³, Joo Youn Lee⁵, Eun Young Lee¹, Eun Bong Lee⁶, Yong-Moo Lee² and Young Wook Song⁷, ¹Department of Internal Medicine, School of Medicine, Seoul National University, Seoul, South Korea, ²Department of Periodontology, School of Dentistry, Seoul National University, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Central Hospital, Ulsan, South Korea, ⁵Department of molecular medicine and biophamaceutical sciences,Seoul National University, Seoul, South Korea, ⁶Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁷Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea
Background/Purpose: The prevalence of periodontal disease is known to be increased in patients with rheumatoid arthritis (RA) compared to the general population. We investigated whether…
Abstract Number: 455 • 2012 ACR/ARHP Annual Meeting
Lack of Additive Benefits of Concomitant Methotrexate Use to Tocilizumab Monotherapy for Rheumatoid Arthritis in Daily Clinical Practice
Keisuke Izumi¹, Yuko Kaneko², Hidekata Yasuoka³, Noriyuki Seta⁴, Hideto Kameda⁵, Masataka Kuwana⁵ and Tsutomu Takeuchi⁶, ¹Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ²Dept of Internal Medicine, Keio Univ School of Medicine, Shinjuku-ku, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio Univ School of Medicine, Tokyo, Japan, ⁴Department of Internal Medicine, Keio university, Tokyo, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁶Keio University School of Medicine, Tokyo, Japan
Background/Purpose: To explore the benefit of concomitant use of methotrexate (MTX) for the effectiveness of TCZ in rheumatoid arthritis (RA) patients in daily clinical practice.…
Abstract Number: 88 • 2012 ACR/ARHP Annual Meeting
The Effect of Weather On Patient Symptoms in Rheumatoid Arthritis: A Systematic Review of the Literature and Exploration of “weather sensitivity”
Annika Cutinha¹, Frederick Wolfe² and Kaleb Michaud³, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Rheumatology, National Data Bank for Rheumatic Diseases & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with rheumatoid arthritis (RA) often attribute an exacerbation of their symptoms to changes in the weather. There are several studies examining this relationship.…
Abstract Number: 1990 • 2012 ACR/ARHP Annual Meeting
Risk of Falling Is Equivalent Between Patients with Rheumatoid Arthritis and Healthy Individuals – the Tomorrow Study-
Kenji Mamoto¹, Tatsuya Koike², Tadashi Okano¹, Atsuko Kamiyama², Yuko Sugioka¹, Masahiro Tada¹ and Hiroaki Nakamura¹, ¹Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, ²Rheumatosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) who have muscle weakness and stiff or painful joints might be at increased risk of falling. The present study…
Abstract Number: 1223 • 2012 ACR/ARHP Annual Meeting
Frequency of Deep Vein Thromboses and Pulmonary Emboli in Rheumatoid Arthritis
Christian A. Pineau¹, Evelyne Vinet² and Sasha Bernatsky³, ¹Rheumatology, McGill University Health Center, Montreal, QC, Canada, ²McGill University Health Center, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada
Background/Purpose: There are few data regarding the frequency of deep vein thromboses (DVTs) and pulmonary emboli (PE’s) in patients with rheumatoid arthritis (RA). To determine…

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