Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 1053 • 2012 ACR/ARHP Annual Meeting
Severe Joint Injury Assessed by Musculoskeletal Ultrasonography (MSKUS) Predicts the Presence of MRI-Proven Osteitis in Patients with Rheumatoid Arthritis
Shin-ya Kawashiri¹, Takahisa Suzuki², Yoshikazu Nakashima¹, Yoshiro Horai³, Naoki Iwamoto³, Kunihiro Ichinose⁴, Kazuhiko Arima³, Mami Tamai², Hideki Nakamura⁵, Tomoki Origuchi⁶, Kiyoshi Aoyagi⁷ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: MRI-proven osteitis is known as the prognostic factor toward radiographic progression in patients with rheumatoid arthritis (RA). Musculoskeletal ultrasonography (MSKUS) is another high sensitive…
Abstract Number: 401 • 2012 ACR/ARHP Annual Meeting
Can We Improve Outcomes in Early Rheumatoid Arthritis by Determining Best Practices? An Analysis of the Canadian Early Rheumatoid Arthritis Cohort (CATCH)
Jamie Harris¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Gilles Boire⁶, Boulos Haraoui⁷, Glen S. Hazlewood⁸, Ashley Bonner⁹, Janet E. Pope¹⁰ and CATCH Investigators¹¹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁸Medicine, University of Toronto, Toronto, ON, Canada, ⁹McMaster University, Hamilton, ON, Canada, ¹⁰Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ¹¹Toronto, ON, Canada
Background/Purpose: The goal of ERA treatment is remission but many patients do not achieve this state due to patient factors and perhaps differences in treating…
Abstract Number: 54 • 2012 ACR/ARHP Annual Meeting
Use of Health Plan Data to Assess Feasibility of Large Pragmatic Clinical Trials in Rheumatoid Arthritis
Jeffrey R. Curtis¹, Lang Chen², Fenglong Xie³, Jie Zhang¹, Kenneth G. Saag⁴, Stacey Cofield⁵, Kevin L. Winthrop⁶, Nicole C. Wright⁷ and Elizabeth S. Delzell⁸, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁴Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ⁵School of Public Health, Department of Biostatistics, Univ of Alabama at Birmingham,, Birmingham, AL, ⁶Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, ⁷Epidemiology, The University of Alabama at Birmingham, Birmingham, AL, ⁸Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Large pragmatic clinical trials (PCTs) are increasingly used to conduct comparative effectiveness research (CER). PCTs typically have simple inclusion/exclusion criteria and hard outcomes (e.g.…
Abstract Number: 2342 • 2012 ACR/ARHP Annual Meeting
Synovial Tissue Analysis in the Pre-Clinical Phase of Arthritis: T-Cell Infiltration Preceding the Development of Arthritis
Maria J. H. de Hair¹, Marleen G. H. van de Sande¹, Tamara H. Ramwadhdoebe², Robert B. M. Landewé³, Christiaan van der Leij⁴, Mario Maas⁵, Dirkjan van Schaardenburg⁶, Danielle Marie Gerlag¹, Lisa G.M. van Baarsen² and Paul P. Tak⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology , Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁴Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Radiology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: We have previously shown in a pilot study that there is no evident synovial inflammation in autoantibody-positive individuals who are at risk of developing…
Abstract Number: 1718 • 2012 ACR/ARHP Annual Meeting
Cost Effectiveness of Nurse-Led Care for People with Rheumatoid Arthritis: A Multicentre RCT
Mwidimi Ndosi¹, Martyn Lewis², Claire Hale³, Howard Bird⁴, Sarah Ryan², Helen Quinn⁴, Elizabeth McIvor⁵, Julia Taylor⁶, Gail Burbage⁷, Deborah Bond⁸, Jo White⁹, Debbie Chagadama¹⁰, Sandra Green¹¹, Lesley Kay¹², Adrian V. Pace¹³, Victoria Bejarano¹⁴, Paul Emery¹⁵ and Jackie Hill¹⁶, ¹Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ²Keele University, Staffordshire, United Kingdom, ³School of Healthcare, University of Leeds, Leeds, United Kingdom, ⁴University of Leeds, Leeds, United Kingdom, ⁵Stobhill Hospital, Glasgow, UK, Glasgow, United Kingdom, ⁶Rheumatology Centre, Poole Hospital NHS Trust, Poole, United Kingdom, ⁷King's Mill Hospital, Mansfield, United Kingdom, ⁸Queen Elizabeth Hospital King's Lynn, King's Lynn, United Kingdom, ⁹Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ¹⁰Rheumatology, Royal London Hospital, London, United Kingdom, ¹¹Rheumatology, Weston General Hospital, Weston-Super-Mare, United Kingdom, ¹²Department of Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ¹³Rheumatology, Russells Hall Hospital, Dudley, United Kingdom, ¹⁴Rheumatology, Barnsley Hospital, Barnsley, United Kingdom, ¹⁵Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ¹⁶Acumen, University of Leeds, Leeds, United Kingdom
Background/Purpose: Despite the establishment of the innovative rheumatology nurse-led clinics (NLC) in the UK, the evidence of their cost-effectiveness is unknown. This study aimed at…
Abstract Number: 975 • 2012 ACR/ARHP Annual Meeting
Dense Genotyping of Risk Loci in Black South Africans with Rheumatoid Arthritis: An Association Study
Nimmisha Govind¹, Ananyo Choudhury², Bridget Hodkinson¹, Claudia Ickinger¹, Jacqueline Frost³, Annette T. Lee⁴, Peter K. Gregersen⁵, Richard J. Reynolds⁶, S. Louis Bridges Jr.⁷, Scott Hazelhurst², Michèle Ramsay³ and Mohammed Tikly¹, ¹Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ²Wits Bioinformatics Department, Wits Bioinformatics Department, University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, National Health Laboratory Service, Division of Human Genetics, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa, ⁴Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Genome wide association studies (GWAS) have identified numerous rheumatoid arthritis (RA) risk loci in patients of European and Asian ancestry but the causal variants…
Abstract Number: 381 • 2012 ACR/ARHP Annual Meeting
DAS Does Not Predict Increasing Treatment in Early Rheumatoid Arthritis: Results From the CATCH Study
Lonnie Pyne¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Boulos Haraoui⁶, Ashley Bonner⁷, Janet E. Pope⁸ and CATCH Investigators⁹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁷McMaster University, Hamilton, ON, Canada, ⁸Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁹Toronto, ON, Canada
Background/Purpose: The disease activity score (DAS) was developed in RA to guide therapy. Its utility in practice for early rheumatoid arthritis (ERA) has not been…
Abstract Number: 56 • 2012 ACR/ARHP Annual Meeting
A Validated Mathematical Model Using Electronic Health Records to Identify Rheumatoid Arthritis Patients for Observational Studies
Aarat M. Patel¹, Ilinca D. Metes², Larry W. Moreland³, Melissa Saul⁴, Stephen R. Wisniewski⁵ and Marc C. Levesque⁶, ¹Rheumatology & Clinical Immun / Pediatric Rheumatology, Univ of Pittsburgh Med Ctr / Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Biomedical Informatics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, ⁵Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: To develop and validate a search algorithm with a high specificity and sensitivity to identify rheumatoid arthritis (RA) patients in a large health care…
Abstract Number: 2165 • 2012 ACR/ARHP Annual Meeting
Utility of Vectra-DA™ On Assessment of Rheumatoid Arthritis Disease Activity and Golimumab Response: Results of a Pilot Study From a Phase 3 Trial in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy
Sarah Lamberth, Yauheniya Cherkas, Carrie Brodmerkel and Mark Curran, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: Currently, disease activity in Rheumatoid Arthritis (RA) is measured using scoring systems that rely primarily on a collection of subjective measures from patients and…
Abstract Number: 1693 • 2012 ACR/ARHP Annual Meeting
Oncogenic Activation of MAPK in Rheumatoid Arthritis Synovial Fibroblasts
Niloofar L. Farmani¹, Keith K. Colburn², Grace Chan³, Erica Li³, Emil Heinze⁴, Antonia Rubell³, Robert Nishimura⁵ and Richard H. Weisbart³, ¹Medicine, Olive View-UCLA Medical Center, Sylmar, CA, ²Dept Med - Rheum Sect, Loma Linda Univ Medical Center, Loma Linda, CA, ³Research, VAGLAHS, Sepulveda, CA, ⁴Rheumatology, Olive View-UCLA Medical Center, Sylmar, CA, ⁵Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Transformed synovial fibroblasts (SF) mediate joint-specific damage in rheumatoid arthritis (RA) by expressing integrins and metalloproteinase that promote adhesion to and invasion of cartilage.…
Abstract Number: 865 • 2012 ACR/ARHP Annual Meeting
A Methodology for Estimating Disease State Transitions: Repeated Measures Markov Models with Covariate Dependence
George W. Reed¹, Andrew S. Koenig², Katherine C. Saunders³, David H. Collier⁴, Joel M. Kremer⁵ and Sameer Kotak⁶, ¹University of Massachusetts Medical School, Worcester, MA, ²Specialty Care, Pfizer Inc, Collegeville, PA, ³Corrona, LLC., Southborough, MA, ⁴Amgen Inc., Thousand Oaks, CA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶Specialty Care, Pfizer Inc., New York, NY
Background/Purpose: Many RA patients have variable disease activity over time due to disease flare, reduction in efficacy of current medications and other disease mediating…
Abstract Number: 385 • 2012 ACR/ARHP Annual Meeting
The Wide Variation in Corticosteroid Use in Early Rheumatoid Arthritis – There Is Need for Guidelines
A. Bharadwaj¹ and Carol Alves², ¹Rheumatology, Basildon & Thurrock University Hospital NHS Trust, Basildon, United Kingdom, ²Research & Development, Basildon & Thurrock University Hospital NHS Trust, Basildon, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease which causes significant pain and swelling in the joints. The early treatment of the disease mainly…
Abstract Number: 58 • 2012 ACR/ARHP Annual Meeting
5 Million Patients and Not 0.34% Is Worrisome: Burden of Rheumatoid Arthritis in India Based On a Bone and Joint Decade India Community Oriented Program for Control of Rheumatic Disease
Arvind Chopra¹, R. Ghorpade², S. Sarmukkadam³, VL Joshi¹, AJ. Mathews⁴, L. Gauri⁵, A. Rahim⁶, K. Datta⁷, S. Chaturvedi⁸, B. Thakuria⁹, A. Mahajan¹⁰, R. Singh¹¹, A. Ghosh¹², R. Handa¹³, Manjit Saluja¹⁴, A. Venugopalan¹, V. Kunjeer¹, B. Paul⁶, S. Pal⁷, K. Wangjam¹¹, T. Kumar¹⁵ and K. Mahendranath¹⁶, ¹Rheumatology, Center for Rheumatic Diseases, Pune, India, ²Center for Rheumatic Diseases, Pune, India, ³BJMC, Pune, India, ⁴Government Medical College Hospital, Trivandrum, India, ⁵SP Medical College, Bikaner, India, ⁶Calicut Medical College, Calicut, India, ⁷Advance Rheumatology Clinic, Hyderabad, India, ⁸FRCH, Pune, India, ⁹Guwahati Medical College & Hospital, Guwahati, India, ¹⁰Government Medical College, Jammu, India, ¹¹Regional Institute of Medical Sciences, Imphal, Manipur, India, ¹²Rheumatology, Institute of Post Graduate Medical Education and Research, Kolkata, India, ¹³Department of Rheumatology, AIIMS, New Delhi, India, ¹⁴Clinical care, Center for Rheumatic Diseases, Pune, India, ¹⁵Institute of Post Graduate Medical Education and Research, Kolkata, India, ¹⁶Rheumatology Clinic, Bangalore, India
Background/Purpose : The 1 % prevalence of RA Worldwide is a deep rooted ancient dogma. None of the recent WHO ILAR COPCORD (Community Oriented Program…
Abstract Number: 2147 • 2012 ACR/ARHP Annual Meeting
Risks to Visit Emergency Room in Patients with Rheumatoid Arthritis: A Two-Year Retrospective Study
Yoshiki Nagai, Naoto Yokogawa, Kota Shimada and Shoji Sugii, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Background/Purpose: Patients with rheumatoid arthritis (RA) suffer from both physical disabilities and medical comorbidities and tend to use emergency room for many reasons. However, the…
Abstract Number: 1626 • 2012 ACR/ARHP Annual Meeting
Frequent Conversion of Tuberculosis Screening Tests During Anti-Tumor Necrosis Factor Therapy in Patients with Rheumatic Diseases
Chrisoula Hatzara¹, Emilia Hadziyannis², Anna Kandili¹, Stamatoula Tsikrika¹, Martha Minopetrou¹, Georgios Georgiopoulos¹ and Dimitrios Vassilopoulos¹, ¹2nd Department of Medicine, Athens University School of Medicine, Athens, Greece, ²2nd Department of Medicine and Laboratory of Clinical Immunology-Rheumatology, Hippokration General Hospital, University of Athens Medical School, Athens, Greece
Background/Purpose: The most recent ACR Recommendations suggest annual screening for latent tuberculosis (TB) with standard tuberculin skin test (TST) or the newer interferon-gamma release assays…

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