Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 53 • 2012 ACR/ARHP Annual Meeting
Comparison of Decision Rules for Identifying Patients with Rheumatoid Arthritis (RA) in Administrative Healthcare Databases
John G. Hanly, Kara Thompson and Chris Skedgel, Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada
Background/Purpose: Identification of RA cases in administrative healthcare databases is used to estimate disease frequency, healthcare utilization and cost for RA. However, the optimal methodology…
Abstract Number: 2441 • 2012 ACR/ARHP Annual Meeting
Readability and Suitability Assessment of Patient Education Materials in Rheumatic Diseases
Rennie L. Rhee¹, Joan Marie Von Feldt², H. Ralph Schumacher³ and Peter A. Merkel⁴, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Univ of Pennsylvania/Philadelphia VAMC, Philadelphia, PA, ³Department of Medicine, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Comprehension of health resources may be challenging for patients particularly those with limited health literacy. The objective of this study was to examine the…
Abstract Number: 1765 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Is Associated with Signaling Alterations in Naturally Occurring Autoreactive B-Lymphocytes
Taras Lyubchenko¹, Ganna Liubchenko², Holly C. Appleberry², Christopher C. Striebich², Karen E. Franklin², Lezlie A. Derber³ and V. Michael Holers⁴, ¹Medicine, University of Colorado Denver, Aurora, CO, ²University of Colorado Denver, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Rheumatology Division, University of Colorado Denver, Aurora, CO
Background/Purpose: Alterations in B cell immune tolerance are important in the development of autoimmune rheumatoid arthritis (RA). Recent studies in healthy human subjects have identified…
Abstract Number: 1053 • 2012 ACR/ARHP Annual Meeting
Severe Joint Injury Assessed by Musculoskeletal Ultrasonography (MSKUS) Predicts the Presence of MRI-Proven Osteitis in Patients with Rheumatoid Arthritis
Shin-ya Kawashiri¹, Takahisa Suzuki², Yoshikazu Nakashima¹, Yoshiro Horai³, Naoki Iwamoto³, Kunihiro Ichinose⁴, Kazuhiko Arima³, Mami Tamai², Hideki Nakamura⁵, Tomoki Origuchi⁶, Kiyoshi Aoyagi⁷ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: MRI-proven osteitis is known as the prognostic factor toward radiographic progression in patients with rheumatoid arthritis (RA). Musculoskeletal ultrasonography (MSKUS) is another high sensitive…
Abstract Number: 401 • 2012 ACR/ARHP Annual Meeting
Can We Improve Outcomes in Early Rheumatoid Arthritis by Determining Best Practices? An Analysis of the Canadian Early Rheumatoid Arthritis Cohort (CATCH)
Jamie Harris¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Gilles Boire⁶, Boulos Haraoui⁷, Glen S. Hazlewood⁸, Ashley Bonner⁹, Janet E. Pope¹⁰ and CATCH Investigators¹¹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁸Medicine, University of Toronto, Toronto, ON, Canada, ⁹McMaster University, Hamilton, ON, Canada, ¹⁰Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ¹¹Toronto, ON, Canada
Background/Purpose: The goal of ERA treatment is remission but many patients do not achieve this state due to patient factors and perhaps differences in treating…
Abstract Number: 54 • 2012 ACR/ARHP Annual Meeting
Use of Health Plan Data to Assess Feasibility of Large Pragmatic Clinical Trials in Rheumatoid Arthritis
Jeffrey R. Curtis¹, Lang Chen², Fenglong Xie³, Jie Zhang¹, Kenneth G. Saag⁴, Stacey Cofield⁵, Kevin L. Winthrop⁶, Nicole C. Wright⁷ and Elizabeth S. Delzell⁸, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁴Div Clinical Immun & Rheum, Univ of Alabama-Birmingham, Birmingham, AL, ⁵School of Public Health, Department of Biostatistics, Univ of Alabama at Birmingham,, Birmingham, AL, ⁶Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, ⁷Epidemiology, The University of Alabama at Birmingham, Birmingham, AL, ⁸Epidemiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Large pragmatic clinical trials (PCTs) are increasingly used to conduct comparative effectiveness research (CER). PCTs typically have simple inclusion/exclusion criteria and hard outcomes (e.g.…
Abstract Number: 2342 • 2012 ACR/ARHP Annual Meeting
Synovial Tissue Analysis in the Pre-Clinical Phase of Arthritis: T-Cell Infiltration Preceding the Development of Arthritis
Maria J. H. de Hair¹, Marleen G. H. van de Sande¹, Tamara H. Ramwadhdoebe², Robert B. M. Landewé³, Christiaan van der Leij⁴, Mario Maas⁵, Dirkjan van Schaardenburg⁶, Danielle Marie Gerlag¹, Lisa G.M. van Baarsen² and Paul P. Tak⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology , Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁴Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Radiology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: We have previously shown in a pilot study that there is no evident synovial inflammation in autoantibody-positive individuals who are at risk of developing…
Abstract Number: 1718 • 2012 ACR/ARHP Annual Meeting
Cost Effectiveness of Nurse-Led Care for People with Rheumatoid Arthritis: A Multicentre RCT
Mwidimi Ndosi¹, Martyn Lewis², Claire Hale³, Howard Bird⁴, Sarah Ryan², Helen Quinn⁴, Elizabeth McIvor⁵, Julia Taylor⁶, Gail Burbage⁷, Deborah Bond⁸, Jo White⁹, Debbie Chagadama¹⁰, Sandra Green¹¹, Lesley Kay¹², Adrian V. Pace¹³, Victoria Bejarano¹⁴, Paul Emery¹⁵ and Jackie Hill¹⁶, ¹Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ²Keele University, Staffordshire, United Kingdom, ³School of Healthcare, University of Leeds, Leeds, United Kingdom, ⁴University of Leeds, Leeds, United Kingdom, ⁵Stobhill Hospital, Glasgow, UK, Glasgow, United Kingdom, ⁶Rheumatology Centre, Poole Hospital NHS Trust, Poole, United Kingdom, ⁷King's Mill Hospital, Mansfield, United Kingdom, ⁸Queen Elizabeth Hospital King's Lynn, King's Lynn, United Kingdom, ⁹Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ¹⁰Rheumatology, Royal London Hospital, London, United Kingdom, ¹¹Rheumatology, Weston General Hospital, Weston-Super-Mare, United Kingdom, ¹²Department of Rheumatology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ¹³Rheumatology, Russells Hall Hospital, Dudley, United Kingdom, ¹⁴Rheumatology, Barnsley Hospital, Barnsley, United Kingdom, ¹⁵Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ¹⁶Acumen, University of Leeds, Leeds, United Kingdom
Background/Purpose: Despite the establishment of the innovative rheumatology nurse-led clinics (NLC) in the UK, the evidence of their cost-effectiveness is unknown. This study aimed at…
Abstract Number: 975 • 2012 ACR/ARHP Annual Meeting
Dense Genotyping of Risk Loci in Black South Africans with Rheumatoid Arthritis: An Association Study
Nimmisha Govind¹, Ananyo Choudhury², Bridget Hodkinson¹, Claudia Ickinger¹, Jacqueline Frost³, Annette T. Lee⁴, Peter K. Gregersen⁵, Richard J. Reynolds⁶, S. Louis Bridges Jr.⁷, Scott Hazelhurst², Michèle Ramsay³ and Mohammed Tikly¹, ¹Rheumatology, Division of Rheumatology, University of the Witwatersrand, Johannesburg, South Africa, ²Wits Bioinformatics Department, Wits Bioinformatics Department, University of the Witwatersrand, Johannesburg, South Africa, ³Division of Human Genetics, National Health Laboratory Service, Division of Human Genetics, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa, ⁴Genomics & Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁵Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁶Clinical Immunology and Rheumatology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Genome wide association studies (GWAS) have identified numerous rheumatoid arthritis (RA) risk loci in patients of European and Asian ancestry but the causal variants…
Abstract Number: 381 • 2012 ACR/ARHP Annual Meeting
DAS Does Not Predict Increasing Treatment in Early Rheumatoid Arthritis: Results From the CATCH Study
Lonnie Pyne¹, Vivian P. Bykerk², Carol A. Hitchon³, Edward Keystone⁴, J. Carter Thorne⁵, Boulos Haraoui⁶, Ashley Bonner⁷, Janet E. Pope⁸ and CATCH Investigators⁹, ¹Western University, London, ON, Canada, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Southlake Regional Health Centre, Newmarket, ON, Canada, ⁶Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁷McMaster University, Hamilton, ON, Canada, ⁸Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ⁹Toronto, ON, Canada
Background/Purpose: The disease activity score (DAS) was developed in RA to guide therapy. Its utility in practice for early rheumatoid arthritis (ERA) has not been…
Abstract Number: 56 • 2012 ACR/ARHP Annual Meeting
A Validated Mathematical Model Using Electronic Health Records to Identify Rheumatoid Arthritis Patients for Observational Studies
Aarat M. Patel¹, Ilinca D. Metes², Larry W. Moreland³, Melissa Saul⁴, Stephen R. Wisniewski⁵ and Marc C. Levesque⁶, ¹Rheumatology & Clinical Immun / Pediatric Rheumatology, Univ of Pittsburgh Med Ctr / Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Biomedical Informatics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, ⁵Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: To develop and validate a search algorithm with a high specificity and sensitivity to identify rheumatoid arthritis (RA) patients in a large health care…
Abstract Number: 2165 • 2012 ACR/ARHP Annual Meeting
Utility of Vectra-DA™ On Assessment of Rheumatoid Arthritis Disease Activity and Golimumab Response: Results of a Pilot Study From a Phase 3 Trial in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy
Sarah Lamberth, Yauheniya Cherkas, Carrie Brodmerkel and Mark Curran, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose: Currently, disease activity in Rheumatoid Arthritis (RA) is measured using scoring systems that rely primarily on a collection of subjective measures from patients and…
Abstract Number: 1693 • 2012 ACR/ARHP Annual Meeting
Oncogenic Activation of MAPK in Rheumatoid Arthritis Synovial Fibroblasts
Niloofar L. Farmani¹, Keith K. Colburn², Grace Chan³, Erica Li³, Emil Heinze⁴, Antonia Rubell³, Robert Nishimura⁵ and Richard H. Weisbart³, ¹Medicine, Olive View-UCLA Medical Center, Sylmar, CA, ²Dept Med - Rheum Sect, Loma Linda Univ Medical Center, Loma Linda, CA, ³Research, VAGLAHS, Sepulveda, CA, ⁴Rheumatology, Olive View-UCLA Medical Center, Sylmar, CA, ⁵Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA
Background/Purpose: Transformed synovial fibroblasts (SF) mediate joint-specific damage in rheumatoid arthritis (RA) by expressing integrins and metalloproteinase that promote adhesion to and invasion of cartilage.…
Abstract Number: 865 • 2012 ACR/ARHP Annual Meeting
A Methodology for Estimating Disease State Transitions: Repeated Measures Markov Models with Covariate Dependence
George W. Reed¹, Andrew S. Koenig², Katherine C. Saunders³, David H. Collier⁴, Joel M. Kremer⁵ and Sameer Kotak⁶, ¹University of Massachusetts Medical School, Worcester, MA, ²Specialty Care, Pfizer Inc, Collegeville, PA, ³Corrona, LLC., Southborough, MA, ⁴Amgen Inc., Thousand Oaks, CA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶Specialty Care, Pfizer Inc., New York, NY
Background/Purpose: Many RA patients have variable disease activity over time due to disease flare, reduction in efficacy of current medications and other disease mediating…
Abstract Number: 385 • 2012 ACR/ARHP Annual Meeting
The Wide Variation in Corticosteroid Use in Early Rheumatoid Arthritis – There Is Need for Guidelines
A. Bharadwaj¹ and Carol Alves², ¹Rheumatology, Basildon & Thurrock University Hospital NHS Trust, Basildon, United Kingdom, ²Research & Development, Basildon & Thurrock University Hospital NHS Trust, Basildon, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease which causes significant pain and swelling in the joints. The early treatment of the disease mainly…

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