Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 417 • 2012 ACR/ARHP Annual Meeting
The Potential Role of PTPRD Gene Copy Number Variation in Susceptibility to Rheumatoid Arthritis
Seung Cheol Shim¹, Donghyuk Sheen², Mi Kyoung Lim¹ and Hyo Park¹, ¹Medicine, Eulji University Hospital, Daejeon, South Korea, ²Rheumatology, Eulji University Hospital, Daejeon, South Korea
Background/Purpose: Since it is important to explore genetic variations associated with rheumatoid arthritis (RA), genome-wide association studies (GWAS) have led to the identification of RA…
Abstract Number: 105 • 2012 ACR/ARHP Annual Meeting
Combined Synovial and Structural Ultrasound Score for the Diagnosis of RA
Gary A. Kunkel¹, Grant W. Cannon² and Daniel O. Clegg³, ¹Div of Rheumatology, George Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, ²Division of Rheumatology, George E. Wahlen VA Medical Center, Salt Lake City, UT, ³Division of Rheumatology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT
Background/Purpose: Current ultrasonographic scoring systems used to assess the degree of finger joint synovitis in rheumatoid arthritis (RA) are not designed for distinguishing healthy or…
Abstract Number: 2607 • 2012 ACR/ARHP Annual Meeting
Adherence to a Treat-to-Target Strategy in Early Rheumatoid Arthritis: Results of the Dutch Rheumatoid Arthritis Monitoring Remission Induction Cohort
Marloes Vermeer¹, Ina H. Kuper², Hein J. Bernelot Moens³, Monique Hoekstra⁴, Marcel D. Posthumus⁵, Piet L.C.M. van Riel⁶ and Mart A.F.J. van de Laar⁷, ¹University of Twente & Medisch Spectrum Twente, Enschede, Netherlands, ²Medisch Spectrum Twente, Enschede, Netherlands, ³Ziekenhuisgroep Twente, Hengelo, Netherlands, ⁴Isala Klinieken, Zwolle, Netherlands, ⁵Department of Rheumatology, University of Groningen, University Medical Center, Groningen, Netherlands, ⁶Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁷Rheumatology, University of Twente & Medisch Spectrum Twente, Enschede, Netherlands
Adherence to a Treat-to-Target Strategy in Early Rheumatoid Arthritis: Results of the Dutch Rheumatoid Arthritis Monitoring Remission Induction CohortBackground/Purpose: A treat-to-target (T2T) approach has proven…
Abstract Number: 1824 • 2012 ACR/ARHP Annual Meeting
Do Statins Reduce the Incidence of Connective Tissue Disease? A Retrospective Cohort Study
Thomas W. Schmidt¹, Daniel F. Battafarano¹, Christopher R. Frei², Eric M. Mortensen³ and Ishak Mansi⁴, ¹Rheumatology, San Antonio Military Medical Center, San Antonio, TX, ²Pharmacotherapy Education and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, ³Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, ⁴Internal Medicine, San Antonio Military Medical Center, San Antonio, TX
Background/Purpose: Due to their anti-inflammatory effects, statins were proposed to lower the incidence of connective tissue diseases (CTD). The objective of this study is to…
Abstract Number: 1043 • 2012 ACR/ARHP Annual Meeting
Assessment of Rheumatoid Arthritis Disease Activity by Power Doppler Ultrasonography: Association with Routine Clinical Indices and Its Usefulness in Detecting Remission
Hiroaki Taguchi, Kazuo Nishi, Takeo Kudo and Yutaka Okano, Division of Rheumatology, Department of Medicine, Kawasaki Municipal Kawasaki Hospital, Kawasaki, Japan
Background/Purpose: Power Doppler ultrasonography (PDUS) is sensitive for detecting synovitis in patients with rheumatoid arthritis (RA). We aimed to clarify the association of PDUS findings…
Abstract Number: 426 • 2012 ACR/ARHP Annual Meeting
Dickkopf-1 Stimulates Fibroblast-Like Synoviocyte Migration Through Janus Kinase Activation
Yubin Luo¹, Bryan Dieffenbach², Jung-Soo Song³, Jinseok Kim⁴, David L. Boyle⁵, Michael Karin⁶, Gary S. Firestein⁷ and Maripat Corr⁸, ¹Medicine, UCSD School of Medicine, La Jolla, CA, ²Medicine, UCSD School of Medicine, la Jolla, CA, ³Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Internal Medicine, Jeju National University Hospital, Jeju, Korea, South Korea, ⁵Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁶Departments of Pharmacology, UCSD School of Medicine, La Jolla, CA, ⁷Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁸Medicine, Univ of California-San Diego, La Jolla, CA
Background/Purpose: Wnt (wingless) pathway signaling has been implicated in patterning in embryogenesis and in adult wound healing and homeostasis. A canonical Wnt antagonist, Dickkopf-1 (DKK-1),…
Abstract Number: 73 • 2012 ACR/ARHP Annual Meeting
Trends in 21^stcentury Health Care Utilization in a Rheumatoid Arthritis Cohort Compared to the General Population
Sofia Hagel¹, Ingemar F. Petersson², Ann B. I. Bremander³, Elisabet Lindqvist⁴, Charlotte Bergknut⁵ and Martin Englund⁶, ¹Department of Clinical Sciences Lund, Section for Rheumatology, Lund, Lund University and Skåne University Hospital, Lund, Sweden, ²Lund University, Lund, Sweden, ³Department of Exercise Physiology, Biomechanics and Health, Halmstad University School of Business and Engineering,, Halmstad, Sweden, ⁴Department of Clinical Sciences, Lund, Section for Rheumatology, Lund, Lund University and Skåne University Hospital, Lund, Sweden, ⁵Department of Orthopedics, Lund University, Lund, Sweden, ⁶Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: To study twenty-first century trends in health care utilization by rheumatoid arthritis (RA) patients compared to the general population. Methods: Observational cohort study; using Swedish…
Abstract Number: 2549 • 2012 ACR/ARHP Annual Meeting
Induction of Remission in Patients with up to 12 Months of Moderate-to-Severe Rheumatoid Arthritis Symptoms Treated with Etanercept Plus Methotrexate Over 52 Weeks
Paul Emery¹, Mohammed Hamoudeh², Oliver FitzGerald³, Bernard Combe⁴, Stefanie Gaylord⁵, Theresa Williams⁵, Jack Bukowski⁶, Ronald Pedersen⁵, Andrew S. Koenig⁷ and Bonnie Vlahos⁵, ¹Department of Rheumatology, Leeds General Infirmary, Leeds, United Kingdom, ²Department of Medicine - Rheumatology, Hamad Medical Corporation, Doha, Qatar, ³Department of Rheumatology, St.Vincent's University Hospital, Dublin, Ireland, ⁴Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ⁵Department of Specialty Care, Pfizer Inc., Collegeville, PA, ⁶Department of Specialty Care, Pfizer Inc, Collegeville, PA, ⁷Pfizer, Inc., Collegeville, PA
Background/Purpose: In the COMET study, etanercept (ETN) plus methotrexate (MTX) therapy in patients with early rheumatoid arthritis (RA) yielded high clinical remission rates,1 but whether…
Abstract Number: 1834 • 2012 ACR/ARHP Annual Meeting
Utilization and Expected Cost of Rheumatoid Arthritis Patients Treated with Golimumab: A Specialty Pharmacy Perspective
Lorie Ellis¹, Susan Bolge², Heidi Hanna³, Christina White³ and Patricia Rice⁴, ¹Health Economics & Outcomes Research, Janssen Scientific Affairs, LLC, Horsham, PA, ²Janssen Scientific Affairs, LLC, Horsham, PA, ³Diplomat Specialty Pharmacy, Flint, MI, ⁴Statistics, CliniRx Research, Naperville, IL
Background/Purpose: Golimumab is a 50 mg, once-monthly, patient-administered anti-tumor necrosis factor alpha (anti-TNF) therapy indicated for moderate to severe rheumatoid arthritis (RA), active psoriatic arthritis,…
Abstract Number: 1046 • 2012 ACR/ARHP Annual Meeting
Automated Breast Volume Scanner (ABVS), a New Automated Ultrasonic Device, Is Useful to Examine Joint Injury in Patients with Rheumatoid Arthritis
Shin-ya Kawashiri¹, Takahisa Suzuki², Yoshikazu Nakashima¹, Akitomo Okada², Naoki Iwamoto³, Kunihiro Ichinose⁴, Mami Tamai², Kazuhiko Arima², Hideki Nakamura⁵, Tomoki Origuchi⁶, Masataka Uetani⁷, Kiyoshi Aoyagi⁸ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁶Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Radiology and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁸Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Automated Breast Volume Scanner (ABVS) is an ultrasonic device to be developed for the automated scanning for mammary glands. We have tried to explore…
Abstract Number: 428 • 2012 ACR/ARHP Annual Meeting
TNFα Modulates the Expression of Circadian Clock Gene, Per2, Via D-Box Motif in the Promoter Region in Rheumatoid Synovial Cells
Kohsuke Yoshida¹, Akira Hashiramoto², Takaichi Okano³, Nao Shibanuma⁴ and Shunichi Shiozawa⁵, ¹Hyogo Prefectural Rehabilitation Center at Nishi-harima, Tatsuno, Japan, ²Department of Internal Medicine, Kobe University Graduate School of Medicine / The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan, ³The Center for Rheumatic Diseases,, Kobe University Hospital, Kobe, Japan, ⁴The Center for Rheumatic Diseases, Kobe University Hospital / Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, ⁵Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: The mammalian clock genes including Clock (circadian locomotor output cycles kaput), Bmal1 (brain and muscle Arnt-like protein 1), Per (Period) and Cry (Cryptochrome) regulate…
Abstract Number: 81 • 2012 ACR/ARHP Annual Meeting
Transitions Among Disease Activity States: Estimates and Models of Covariate Associations
George W. Reed¹, David H. Collier², Andrew S. Koenig³, Katherine C. Saunders⁴, Joel M. Kremer⁵ and Sameer Kotak⁶, ¹University of Massachusetts Medical School, Worcester, MA, ²Amgen Inc., Thousand Oaks, CA, ³Specialty Care, Pfizer Inc, Collegeville, PA, ⁴Corrona, LLC., Southborough, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶Specialty Care, Pfizer Inc., New York, NY
Background/Purpose: Many RA patients have variable disease activity over time due to disease variability, reduction in efficacy of current medications, environmental factors and other…
Abstract Number: 2426 • 2012 ACR/ARHP Annual Meeting
Prevalence and Characteristics of Sleep Problems in Rheumatoid Arthritis: A Systematic Review of the Literature
Cassandra Coleman¹ and Yvonne C. Lee², ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) patients commonly complain of sleep problems. Difficulties with sleep may be associated with increased fatigue, greater pain and worse quality of…
Abstract Number: 1792 • 2012 ACR/ARHP Annual Meeting
Identification of the Antimicrobial Peptide LL-37 As a Potential Mediator of Synovial Inflammation in Rheumatoid Arthritis
Petra Neregård¹, Marianne Engström¹, Erik Af Klint¹, Birgitta Agerberth² and Anca Catrina³, ¹Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Department of Medical Biochemistry and Biophysics, Chemistry I, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: LL-37, a member of the cathelicidin family of host defense peptides, has a broad range of antimicrobial and immunomodulatory effects that potentially can have…
Abstract Number: 1049 • 2012 ACR/ARHP Annual Meeting
The Prevalence of the Ultrasonographic Positive Power Doppler Synovitis Is High and Predicts the Risk of Relapse and Structural Progression in Rheumatoid Arthritis in Clinical Remission: A Systematic Literature Review and Meta Analysis
Huong Nguyen¹, Adeline Ruyssen-Witrand¹, Arnaud L. Constantin¹, Violaine Foltz², Frédérique Gandjbakhch³ and Alain G. Cantagrel¹, ¹Rheumatology, Purpan University Hospital, Toulouse, France, ²APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France, ³Department of Rheumatology, APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France
Background/Purpose: Ultrasonography (US) can detect synovitis in patients with rheumatoid arthritis (RA) more sensitively than clinical examination either in active disease or in remission.1, 2…

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