ACR Meeting Abstracts

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Abstracts tagged "Rheumatoid arthritis (RA)"

  • Abstract Number: 1335 • 2013 ACR/ARHP Annual Meeting

    Sarcopenia Is Associated With Joint Damage In Rheumatoid Arthritis patients a Cross Sectional Study In a Peruvian Population

    Erika Noriega1, Rocio V. Gamboa-Cardenas1, Manuel F. Ugarte-Gil2,3, Mariela Medina-Chinchon2, Francisco Zevallos-Miranda2, J. Mariano Cucho-Venegas2, Risto A. Perich-Campos2,4, Jose L. Alfaro-Lozano2, Zoila Rodriguez-Bellido2,4 and Cesar A. Pastor-Asurza2,4, 1Rheumatology, Hospital Almenara, Lima, Peru, 2Rheumatology, Hospital Guillermo Almenara, EsSalud, Lima, Peru, 3Universidad Cientifica del Sur, Lima, Peru, 4Universidad Nacional Mayor de San Marcos, Lima, Peru

    Background/Purpose: Sarcopenia is a low-level, smoldering inflammatory state driven by cytokines and oxidative stress. In rheumatoid arthritis (RA) the relationship between sarcopenia and severity of…
  • Abstract Number: 224 • 2013 ACR/ARHP Annual Meeting

    Ultrasound Evaluation Of Joints, Tendons and Subcutaneous Tissue Of Hands In 74  Scleroderma Patients

    Anat Scheiman-Elazary1, Ami Ben-Artzi2, Suzanne Kafaja2, V Ranganath3, Nabeel Borazan4, Philip J. Clements5 and Daniel Furst6, 1Rheumatology, Rheumatology UCLA, Los Angeles, CA, 2David Geffen School of Medicine, UCLA, Los Angeles, CA, 3Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 4Medicine, Rheumatology UCLA, Los Angeles, CA, 5University of California, Los Angeles, Department of Medicine, Los Angeles, CA, 6Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA

    Background/Purpose: A previous ultrasound study of the hands in scleroderma (SSC) and rheumatoid arthritis (RA), found mild inflammatory changes in the tendons and joints of…
  • Abstract Number: 2644 • 2013 ACR/ARHP Annual Meeting

    Phase IB/Iia Study On Intravenous Administration Of Expanded Allogeneic Adipose-Derived Mesenchymal Stem Cells In Refractory Rheumatoid Arthritis Patients

    JM Alvaro-Gracia1, Juan A. Jover2, Rosario Garcia-Vicuña3, Luis Carreño4, Alberto Alonso5, Sara Marsal6, Francisco J. Blanco7, Víctor M. Martínez-Taboada8, Peter C. Taylor9, Federico Díaz-González10 and Lydia Dorrego11, 1Unidad de Terapias Biológicas. Servicio de Reumatología, Hospital Universitario de La Princesa, Madrid, Spain, 2Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 3Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 4Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, 5Hospital de Cruces, Bilbao, Spain, 6Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 7INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, 8Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV., Santander, Spain, 9NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 10Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, 11TiGenix, Tres Cantos, Spain

    Background/Purpose: Expanded adipose-derived stem cells (eASCs) are shown to have immune-modulatory effects both in vitro and in animal models of arthritis. eASCs are currently under…
  • Abstract Number: 1952 • 2013 ACR/ARHP Annual Meeting

    The Value Of An Automated Ultrasound System In The Detection Of Synovitis

    Ruediger Mueller1, Mathias Gruenke2, Joerg Wendler3, Florian Schuch3, Karina Hofmann-Preiss4, Ina Boettger4, Ruediger Jakobs5, Hendrik Schulze-Koops6 and Johannes von Kempis1, 1Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, 2Division of Rheumatoloy, Medizinische Klinik IV, University of Munich, Munich, Germany, 3Schwerpunktpraxis Rheumatologie, Erlangen, Germany, 4Institut für bildgebende Diagnostik und Therapie, Erlangen, Germany, 5Siemens AG, Erlangen, Germany, 6Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose: The detection of joint swelling caused by synovitis is important for the diagnosis and assessment of inflammatory arthritis. Ultrasound (US) and MRI have proven…
  • Abstract Number: 1291 • 2013 ACR/ARHP Annual Meeting

    COVA322: Overcoming Limitations Of Current Biologics In Rheumatoid Arthritis By a Novel, Bispecific Tumor-Necrosis-Factor-Alpha / Interleukin-17A (TNF/IL-17A) Inhibitor Moving Towards The Clinic

    Dragan Grabulovski, Michela Silacci, Nadja Baenziger-Tobler, Wibke Lembke, Wenjuan Zha, Richard Woods, Isabella Attinger-Toller, Roger Santimaria, Susann Koenig-Friedrich, Ulrike von der Bey, Mathias Locher and Julian Bertschinger, Covagen AG, Schlieren, Switzerland

    Background/Purpose: Biologic treatment options such as TNF inhibitors have revolutionized the treatment of inflammatory diseases, such as rheumatoid arthritis (RA), psoriasis and psoriatic arthritis. However, there…
  • Abstract Number: 190 • 2013 ACR/ARHP Annual Meeting

    A Meta-Analysis and  Systematic Literature Review: Effect Of The Method Used To Measure Adherence In Rheumatoid Arthritis On Its Rate, and Evaluation Of Associated Factors

    Anat Scheiman-Elazary1, Cortney Shourt2, M. Cameron Hay3 and Daniel Furst4, 1Rheumatology, Rheumatology UCLA, Los Angeles, CA, 2Rheumatology UCLA, Los Angeles, CA, 3Anthropology Miami University, Oxford, OH, 4Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles, CA

    Background/Purpose: Adherence reported in the literature for RA varies widely (49.5-98%)1. This variability may result in part from different methods used to measure adherence. Our…
  • Abstract Number: 2486 • 2013 ACR/ARHP Annual Meeting

    Clinical Performance Of 4 Methods For Detecting Latent Tuberculosis Infection (LTbI) In Patients With Active Chronic Inflammatory Arthritis Taking TNFα Blockers

    Carina M F Gomes1, Maria Teresa Terreri2, Maria Isabel Pinto3, Karen Oseki3, Fernanda Spina4 and Marcelo M. Pinheiro5, 1Rheumatology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, 2Pediatrics, Universidade Federal de São Paulo / UNIFESP, Sao Paulo, Brazil, 3Pediatrics, Universidade Federal de São Paulo, Sao Paulo, Brazil, 4Rheumatology Division, Universidade Federal de São Paulo Unifesp/EPM, Brazil, Universidade Federal de São Paulo, Sao Paulo, Brazil, 5Brazilian Registry of Spondyloarthritis, São Paulo, Brazil

    Background/Purpose: About 5% of the Brazilian population has some chronic inflammatory arthropathy (CIA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PA) and juvenile…
  • Abstract Number: 1942 • 2013 ACR/ARHP Annual Meeting

    Ultrasound Shows Tenosynovitis to be Frequently Present  as Well As Sensitive to Change in RA Patients On Biologic Medication

    Hilde B. Hammer, Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Ultrasound (US) (grey scale (GS) and power Doppler (PD)) is a sensitive tool for examination of tenosynovitis in patients with rheumatoid arthritis (RA). The…
  • Abstract Number: 1226 • 2013 ACR/ARHP Annual Meeting

    Adherence With Current Osteoporosis Treatment Guidelines Among Rheumatologists Caring For Patients With Rheumatoid Arthritis Using Items From The Fracture Risk Assessment Tool Score

    Jennifer Watt1, Andrew E. Thompson2, Nicole G. H. Le Riche3 and Janet E. Pope4, 1Medicine, University of Western Ontario, London, ON, Canada, 2Rheumatology, St. Josephs Health Ctr, London, ON, Canada, 3Department of Medicine, St. Joseph's Hospital, London, ON, Canada, 4Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Background/Purpose: To assess whether the Fracture Risk Assessment Tool (FRAX) score in patients with RA correlates with likelihood of osteoporosis (OP) prescription including drug treatment,…
  • Abstract Number: L12 • 2013 ACR/ARHP Annual Meeting

    Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Demonstrates Efficacy and Significantly Reduces Proinflammatory Cytokines in Patients with Active Longstanding Rheumatoid Arthritis with High Gonadotropin Levels: A Proof-of-Concept, Double-Blind, Randomized Trial

    Anita Kåss1,2, Ivana Hollan3, Peter Torjesen4, Hans Christian Gulseth5 and Øystein T. Førre6, 1Faculty of Medicine, University of Oslo, Oslo, Norway, 2Dept. of Rheumatology, Betanien Hospital, Skien, Norway, 3Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 4Department of Endocrinology, Oslo University Hospital, Oslo, Norway, 5Rheumatology, Betanien Hospital, Skien, Norway, 6Oslo University Hospital, Oslo, Norway

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is unclear, and treatment options can be improved. Gonadotropin-releasing hormone (GnRH) stimulates immune responses (1). Inhibiting GnRH, by…
  • Abstract Number: 2413 • 2013 ACR/ARHP Annual Meeting

    Expression and Function Of a YAP, a Novel Pathway In Fibroblast-Like Synoviocyte In Rheumatoid Arthritis

    Beatrix Bartok, Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Modulating molecular pathways that regulate pathogenic behavior fibroblast-like synoviocytes (FLS) could lead to new therapies for rheumatoid arthritis (RA). Targeting transcription factors are especially…
  • Abstract Number: 1944 • 2013 ACR/ARHP Annual Meeting

    Ultrasound Characteristics Of Extensor Tendon Abnormalities and Peritendinous Fluid In Rheumatoid Arthritis

    Laurie Ann Ramrattan1 and Gurjit S. Kaeley2, 1Internal Medicine, University of Florida, Jacksonville, FL, 2College of Medicine, University of Florida, Jacksonville, FL

    Background/Purpose: Rheumatoid arthritis (RA) is synonymous for involving synovial lined structures such as joints and tendon sheaths. Alterations in the extensor tendons overlying the metacarpophalangeal…
  • Abstract Number: 1051 • 2013 ACR/ARHP Annual Meeting

    Sociodemographic, Health System, and Community Characteristics Associated With Initiation Of Biological Dmards In RA

    Edward H. Yelin1, Chris Tonner2, Seoyoung C. Kim3, Jeffrey N. Katz4, John Z. Ayanian5 and Daniel H. Solomon6, 1Medicine, UC San Francisco, San Francisco, CA, 2Medicine, University of California, San Francisco, San Francisco, CA, 3Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 4Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, 5Brigham and Women's Hospital, Boston, MA, 6Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA

    Background/Purpose: The use of biologic DMARDs for RA has improved outcomes, but it is unknown whether there are disparities in initiation of these agents by…
  • Abstract Number: 2429 • 2013 ACR/ARHP Annual Meeting

    Enhanced Responsiveness To Stimulation and Increased Extrusion Of Extracellular Traps By Rheumatoid Arthritis Neutrophil Granulocytes and of Healthy Control Neutrophils to Serum and Synovial Fluid From Rheumatoid Arthritis Patients

    Stavros Giaglis1,2, Chanchal Sur Chowdhury3, Ulrich A. Walker4, Andreas Buser5, Sinuhe Hahn6 and Paul Hasler1, 1Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 2Dept. of Biomedicine, Laboratory of Prenatal Madicine, University Hospital Basel, Basel, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Diagnostics, University Hospital Basel, Basel, Switzerland, 4Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, 5Division of Hematology; Swiss Red Cross Blood Transfusion Centre, University Hospital Basel, Basel, Switzerland, 6Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland

    Background/Purpose: Polymorphonuclear granulocytes (PMNs) are the most abundant immune cell population in the synovial fluid in the joints of patients with rheumatoid arthritis (RA) and…
  • Abstract Number: 1943 • 2013 ACR/ARHP Annual Meeting

    Results of a Reliability Exercise for the Grading of Tendon Rupture in Patients With Rheumatoid Arthritis, using  a Consensus-Based Ultrasound Score

    George A. W. Bruyn1, Petra Hanova2, Annamaria Iagnocco3, Maria-Antonietta d'Agostino4, Lene Terslev5, I. Moller6, Peter V. Balint7, E. Filippucci8, Carlos Pineda9, Marina Backhaus10, Richard van Vugt11, Richard J. Wakefield12, Paul Baudoin13, Kei Ikeda14, Artur Bachta15, Helen I. Keen16, Levent Oczakar17, Sibel Z. Aydin18, Marwin Gutierrez19, Peter Mandl20 and Esperanza Naredo21, 1Dept of Rheumatology, MC Groep hospitals, Lelystad, Netherlands, 2Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 3Sapienza University of Rome, Rome, Italy, 4Rheumatology, Versailles-Saint Quentin en Yvelines University- APHP, Ambroise-Paré Hospital, Boulogne-Billancourt, France, 5The Parker Institute, Copenhagen, Denmark, 6Instituto Poal, Barcelona, Spain, 7Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, 8University Politecnica delle Marche, Ancona, Italy, 9Biomedical Research, Instituto Nacional de Rehabilitacion, Mexico City, Mexico, 10Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, 11VU Medisch Centrum, Amsterdam, Netherlands, 12Division of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 13MC Groep hospitals, Lelystad, Netherlands, 14Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, 15Military Medical Institute, Warsaw, Poland, 16School of Medicine and Pharmacology, The University of Western Australia, Crawley, Australia, 17Hacettepe University Medical School, Ankara, Turkey, 18Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, 19Università Politecnica delle Marche, Jesi, Italy, 20Medical University of Vienna, Vienna, Austria, 21Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Background/Purpose:  To develop the first ultrasound (US) scoring system of tendon rupture in rheumatoid arthritis (RA) and assess its intra- and inter-observer reliability. Methods: We…
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