Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 447 • 2019 ACR/ARP Annual Meeting
Nail Abnormalities in a Cohort of Rheumatoid Arthritis Patients: Repetitive Trauma-Related Findings in Toenails Are Associated with Radiographic Damage
Virginia Pascual-Ramos¹, Silvia Méndez-Flores ¹, Judith Domínguez-Cherit ¹, Ana Gabriela Sánchez-Cárdenas ¹, Ana Barrera-Vargas ², Javier Merayo-Chalico ¹ and Irazú Contreras-Yáñez ¹, ¹Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Distrito Federal, Mexico, ²Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico
Background/Purpose: Different dermatological changes and nail abnormalities have been reported in rheumatoid arthritis (RA) patients, some of which are specifically associated with the disease, while…
Abstract Number: 473 • 2019 ACR/ARP Annual Meeting
RA Presents in Disease Patterns Impacting Treatment Response
Kathryne Marks¹, Dana Symons ², Cynthia Crowson ³, Pamela Sinicrope ⁴ and Kelly O'Neill ⁵, ¹Rosalind Franklin University of Medicine and Science, Gurnee, IL, ²Rheumatoid Patient Foundation, Inc., Rockford, MI, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic, Rochester, MN, ⁵Rheumatoid Patient Foundation, Inc., Winter Springs, FL
Background/Purpose: Despite significant research on rheumatoid arthritis (RA), disease courses have not been clearly described. Like systemic lupus erythematosus and multiple sclerosis, RA displays a…
Abstract Number: 523 • 2019 ACR/ARP Annual Meeting
The Impact of Upadacitinib versus Methotrexate or Adalimumab on Individual and Composite Disease Measures in Patients with Rheumatoid Arthritis
Ronald van Vollenhoven¹, Andrew Östör ², Eduardo Mysler ³, Nemanja Damjanov ⁴, In-Ho Song ⁵, Yanna Song ⁶, Jessica Suboticki ⁵ and Vibeke Strand ⁷, ¹Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, the Netherlands, Amsterdam, Netherlands, ²Cabrini Medical Centre, Monash University, Malvern, Australia, Malvern, Australia, ³Organización Medica de Investigación, Buenos Aires, Argentina, Buenos Aires, Argentina, ⁴Institute of Rheumatology, Belgrade University School of Medicine, Belgrade, Serbia, Belgrade, Serbia, ⁵AbbVie Inc., North Chicago, IL, USA, North Chicago, IL, ⁶AbbVie Inc., North Chicago, IL, USA, North Chicago, ⁷Division of Immunology/Rheumatology, Stanford University, Stanford, CA
Background/Purpose: In Phase 3 trials, upadacitinib (UPA), an oral JAK1-selective inhibitor, has been assessed as monotherapy vs MTX (SELECT-EARLY1) and in combination with MTX vs…
Abstract Number: 819 • 2019 ACR/ARP Annual Meeting
The Long Noncoding RNA HOTTIP Regulates Cell Cycle and Inflammatory Response in Hand Synovial Fibroblasts
Mojca Frank-Bertoncelj ¹, Tadeja Kuret², Ana Županič ³, Snezna Sodin-Semrl ⁴, Oliver Distler ⁵ and Caroline Ospelt ¹, ¹University Hospital Zürich, Zürich, Switzerland, ²University Hospital Zürich, Zurich, Tajikistan, ³University Hospital Zürich, Zurich, Switzerland, ⁴University Medical Center Ljubljana, Ljubljana, Slovenia, ⁵Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Previously we showed that the long noncoding RNA (lncRNA) HOTTIP is exclusively expressed in synovial fibroblasts (SF) from distal joints, such as small joints…
Abstract Number: 926 • 2019 ACR/ARP Annual Meeting
Methotrexate Is Associated with Reduced Cardiovascular Risk in Rheumatoid Arthritis Independent of Disease Activity Modification
Tate Johnson¹, Joshua Baker ², Punyasha Roul ¹, Harlan Sayles ¹, Grant Cannon ³, Brian Sauer ³, Ted Mikuls ⁴ and Bryant England ⁵, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pennsylvania, Philadelphia, PA, ³Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, ⁴VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁵VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha
Background/Purpose: Rheumatoid arthritis (RA) patients are at increased risk of cardiovascular disease (CVD). Methotrexate (MTX), a mainstay in the treatment of RA, appears to mitigate…
Abstract Number: 1133 • 2019 ACR/ARP Annual Meeting
Medicare Spending (2012-2017) on Disease Modifying Agents Commonly Used in Rheumatoid Arthritis
Deepan Dalal¹, Tingting Zhang ² and Theresa Shireman ², ¹Brown University, Riverside, RI, ²Brown University, Providence, RI
Background/Purpose: Biologic disease modifying agents (DMARDs) have become an integral part of rheumatoid arthritis (RA) treatment guidelines, but they are associated with a substantial increase…
Abstract Number: 1335 • 2019 ACR/ARP Annual Meeting
Tumor Necrosis Factor Alpha Inhibitor (TNF-α Inhibitor) Exposure and Risk of Hip Fracture in Veterans with Rheumatoid Arthritis: A Nested Case Control Study
Sarah Homann¹, Carlos Grijalva ¹, S. Bobo Tanner ¹ and James Morrow ¹, ¹Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with rheumatoid arthritis (RA) have a much greater risk of sustaining a hip fracture than those without RA. Hip fractures cause significant morbidity…
Abstract Number: 1362 • 2019 ACR/ARP Annual Meeting
Relationship Between Waking Functions and Disease Activity in Rheumatoid Arthritis Patients Analyzed by Wearable Device
Masahiro Tada¹, Yutaro Yamada ², Koji Mandai ² and Noriaki Hidaka ¹, ¹Osaka City General Hospital, Osaka, Japan, ²Osaka City University Graduate School of Medicine, Osaka, Japan
Background/Purpose: We reported that the prevalence of sarcopenia was 28% and locomotive syndrome was 52% in patients with rheumatoid arthritis (RA)1. It is unknown that…
Abstract Number: 1390 • 2019 ACR/ARP Annual Meeting
Prediction of Clinical Response to Abatacept in Rheumatoid Arthritis Patients Through the Determination of Anti-Carbamylated Proteins Antibodies Levels
Silvia Piantoni¹, Michele Boldini ¹, Rajesh Kumar ¹, Emirena Garrafa ¹, Chiara Bazzani ², Micaela Fredi ³, Ilaria Cavazzana ¹, Angela Tincani ³ and Franco Franceschini ³, ¹ASST Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy, Brescia, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Brescia, Italy
Background/Purpose: Carbamylation is a non-enzymatic irreversible post-translational modification of proteins. The presence of anti-carbamylated protein antibodies (anti-CarP) has been observed in rheumatoid arthritis (RA). In…
Abstract Number: 1427 • 2019 ACR/ARP Annual Meeting
Comparison of Real-World Persistence of Subcutaneously Administered Biologic Disease-Modifying Antirheumatic Drug Therapies Among Patients with Rheumatoid Arthritis Switching from Another Biologic
Jennie Best¹, Lenore Tominna ¹ and Ibrahim Abbass ¹, ¹Genentech, Inc., South San Francisco, CA
Background/Purpose: The EULAR and ACR clinical guidelines recommend switching to a different disease-modifying antirheumatic drug (DMARD) when biologic-treated patients experience treatment failure or toxicity. Lack…
Abstract Number: 1858 • 2019 ACR/ARP Annual Meeting
Beta-2-Glycoprotein-I IgA Antibodies Predict Coronary Plaque Burden, Progression and Moderate the Effect of Inflammation on Atherosclerosis in Rheumatoid Arthritis
George Karpouzas¹, Sarah Ormseth ¹, Elizabeth Hernandez ¹, Viet Bui ¹ and Matthew Budoff ¹, ¹Harbor-UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, CA
Background/Purpose: Beta-2-glycoprotein-I(b2GPI), an apolipoprotein abundant in plasma, is readily expressed in human atherosclerotic plaque. Anti-b2GPI-IgA antibodies (Ab) have been previously reported in both rheumatoid arthritis…
Abstract Number: 1940 • 2019 ACR/ARP Annual Meeting
Investigating the Post-Partum Flare in Rheumatoid Arthritis Using Transcriptome Analysis
Matthew Wright¹, Dana Goin ², Mette Smed ³, Lior Pachter ⁴, J. Lee Nelson ⁵, Nicholas Jewell ⁶, Jørn Olsen ⁷, Merete Lund Hetland ⁸, Vibeke Zoffmann ⁹ and Damini Jawaheer ¹⁰, ¹UCSF Benioff Children's Hopsital Oakland, Oakland, ²UCSF Benioff Children's Hospital Oakland, Oakland, ³Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, ⁴Caltech, Pasadena, ⁵Fred Hutchinson Cancer Research Center, Seattle, ⁶University of California Berkeley, Berkeley, ⁷Aarhus University Hospital, Aarhus, Denmark, ⁸DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, ⁹Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, ¹⁰UCSF Benioff Children's Hospital Oakland, Oakland, CA
Background/Purpose: Women with Rheumatoid arthritis (RA) tend to have a predictable flare of disease activity in the months after childbirth. The mechanism(s) underlying this post-partum…
Abstract Number: 2094 • 2019 ACR/ARP Annual Meeting
Evaluation of Influenza and Pneumococcal Vaccination Rate in Patients with Rheumatoid Arthritis and Spondyloarthritis, and the Attitudes of Rheumatologists About Vaccination
İdil Kurut Aysin ¹, Murat Aysin ², Dilek Solmaz ³, Nazmiye Baş Tomas ⁴, Filiz Koç ⁴, Elif Durak Ediboğlu ⁴, Gokhan Kabadayi ⁵, Onay Gercik ³, Sercan Gücenmez ⁴ and Servet Akar⁶, ¹Izmir Katip Celebi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ²University of Izmir Katip Celebi Faculty of Medicine, Public Health, İzmir, Turkey, ³Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ⁴University of Izmir Katip Celebi Faculty of Medicine, Rheumatology, İzmir, Turkey, ⁵Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ⁶Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey
Background/Purpose: Patients with inflammatory arthritis have increased risk of infections which may lead to morbidity and mortality. Some of those infections could be prevented by…
Abstract Number: 2259 • 2019 ACR/ARP Annual Meeting
Physical Challenges in RA: A Qualitative Study of an Online Patient Support Group
Jude des Bordes ¹, Jessica Foreman ¹, Maria Lopez-Olivo¹, Susan K Peterson ¹, Tiffany Westrich-Robertson ², Catherine Hofstetter ³, Anne Lyddiatt ⁴, Amye Leong ⁵ and Maria E. Suárez-Almazor ⁶, ¹The University of Texas, MD Anderson Cancer Center, Houston, TX, ²International Foundation for Autoimmune and Autoinflammatory Arthritis, Saint Louis, MO, ³Patient advocate, Toronto, ON, Canada, ⁴Musculoskeletal Group, Cochrane Collaboration, Toronto, ON, Canada, ⁵7. Healthy Motivation and the Global Alliance for Musculoskeletal Health of the Bone and Joint Decade, Santa Barbara, CA, ⁶Department of Rheumatology/Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX , USA., Houston, TX
Background/Purpose: Patients with rheumatoid arthritis (RA) face a number of challenges which adversely affect their quality of life. The objective was to qualitatively evaluate content…
Abstract Number: 2315 • 2019 ACR/ARP Annual Meeting
Association of Rheumatic Autoimmune Disease, Including Rheumatoid Arthritis, with Post-Traumatic Stress Disorder but Not Traumatic Brain Injury in Veterans
Biji Kurien ¹, Calin Prodan ² and Robert Scofield¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus, are 2- to 3-fold more common among those with post-traumatic stress disorder (PTSD) than…

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