Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 2327 • 2019 ACR/ARP Annual Meeting
Cardiovascular Disease in Rheumatoid Arthritis: Risk Factors and the Role of Auto-antibodies
Leticia Ferri¹, Grace Crocket ², Yuting Kuang ³, Boris Breznen ⁴ and Mir Sohail Fazeli ⁴, ¹Bristol-Myers Squibb Company, Princeton, NJ, ²Bristol-Myers Squibb; Rutgers University, New York City, NY, ³Doctor Evidence, Doctor Evidence, CA, ⁴Doctor Evidence, Santa Monica, CA
Background/Purpose: Shorter life expectancy in RA patients has in part been associated with an increased incidence of cardiovascular disease (CVD). This literature review summarizes the…
Abstract Number: 2346 • 2019 ACR/ARP Annual Meeting
Interstitial Lung Abnormalities in Rheumatoid Arthritis Patients: Identifying Associated Risk Factors
Karina Bonfiglioli¹, Márcio Sawamura ², Renato Nakagawa ³, Fábio Arimura ³, Diana Rangel ³, Cleonice Bueno ⁴, Ana Cristina de Medeiros Ribeiro ¹, Carlos Carvalho ³, Eloisa Bonfa ⁵, Ronaldo Kairalla ³ and Leticia Kawano-Dourado ⁶, ¹Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ²Division of Radiology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Br, Sao Paulo, Sao Paulo, Brazil, ³Pulmonary Division, Heart Institute (InCor)- Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ⁴Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Sao Paulo, Brazil, ⁶University of Sao Paulo, Sao Paulo, Brazil
Background/Purpose: A wide spectrum of interstitial lung abnormalities (ILA) occurs in patients with rheumatoid arthritis (RA). This study characterized ILA in large single-center cohort, including…
Abstract Number: 2373 • 2019 ACR/ARP Annual Meeting
Two Decades of Changes in RA Treatment and Disease Outcomes from the United States
Sofia Pedro¹, Alyssa Dominique ², Rebecca Schumacher ¹, Yomei Shaw ¹, Kristin Wipfler ¹, Teresa Simon ³ and Kaleb Michaud ⁴, ¹FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS, ²Bristol-Myers Squibb, Princeton, NJ, ³Bristol-Myers Squibb*, Princeton, NJ, ⁴FORWARD, The National Databank for Rheumatic Diseases and University of Nebraska Medical Center, Wichita, KS
Background/Purpose: RA causes significant morbidity and mortality. Over the last two decades, several new medications and strategies for treating RA earlier and more aggressively have…
Abstract Number: 2402 • 2019 ACR/ARP Annual Meeting
Which Factors Influence Achievement of Treatment Satisfaction in Rheumatoid Arthritis?
Martin Schaefer¹, Jörn Kekow ², Karin Rockwitz ³, Anke Liebhaber ⁴, Angela Zink ⁵ and Anja Strangfeld ⁶, ¹German Rheumatism Research Center, Berlin, Germany, ²Otto von Guericke University Magdeburg and Helios Clinic Vogelsang-Gommern, Vogelsang-Gommern, Germany, ³Rheumatologist, Goslar, Germany, ⁴Rheumatologist, Halle/ Salle, Germany, ⁵German Rheumatism Research Centre and Charité University medicine, Berlin, Germany, ⁶German Rheumatism Research Center (DRFZ), Berlin, Germany
Background/Purpose: The satisfaction of rheumatoid arthritis (RA) patients with their pharmacological therapy is a relevant patient reported outcome which influences treatment adherence and continuation. However,…
Abstract Number: 2817 • 2019 ACR/ARP Annual Meeting
Lysosomal Placement of the Energy Sensors AMPK and mTORC1 Controls Tissue Inflammation in Rheumatoid Arthritis
Zhenke Wen ¹, Ke Jin ¹, Yinyin Li ¹, Bowen Wu ¹, Jorg Goronzy ¹ and Cornelia Weyand¹, ¹Stanford University, Stanford, CA
Background/Purpose: CD4 T cells from patients with rheumatoid arthritis (RA) are metabolically reprogrammed, diverting glucose away from glycolysis towards the production of biosynthetic precursors. Several…
Abstract Number: 2911 • 2019 ACR/ARP Annual Meeting
A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response – Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy
Frances humby ¹, Maya H. Buch ², Patrick Durez ³, Myles Lewis ¹, Michele Bombardieri ¹, Hasan Rizvi ⁴, Stephen Kelly ⁴, Liliane Fosatti ¹, Rebecca Hands ¹, Giovanni Giorli ¹, Arti Mahto ¹, Carlomaurizio Montecucco ⁵, Bernard Lauwerys ⁶, Vasco Romao ⁷, Arthur Pratt ⁸, Serena Bugatti ⁹, Nora Ng ¹⁰, Felice Rivellese ¹, Pauline Ho ¹¹, Mattia Bellan ¹², Mattia Congia ¹³, Patrick Verschueren ¹⁴, Pier Paolo Sainaghi ¹², Nagui Gendi ¹⁵, Bhaskar Dasgupta ¹⁶, Alberto Cauli ¹⁷, Piero Reynolds ¹⁸, Juan Cañete ¹⁹, Robert J. Moots ²⁰, Peter Taylor ²¹, Christopher Edwards ²², John Isaacs ⁸, Peter Sasieni ²³, João Eurico Fonseca ²⁴, Ernest Choy ²⁵ and Costantino Pitzalis²⁶, ¹Queen Mary University of London, London, United Kingdom, ²University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ³Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, UCL Saint-Luc, Brussels, Belgium, ⁴Barts Health NHS Trust, London, United Kingdom, ⁵Department of Rheumatology, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy, Pavia, Italy, ⁶University of Louvain, Louvain, Belgium, ⁷University of Lisbon, Lisbon, Portugal, ⁸University of Newcastle, Newcastle, United Kingdom, ⁹University of Pavia, Pavia, Italy, ¹⁰Guys and St Thomas NHS Trust, London, United Kingdom, ¹¹University of Manchester, Manchester, United Kingdom, ¹²University of Novara, Novara, Italy, ¹³University of Cagliari, Cagliari, Italy, ¹⁴University of Leuven, Leuven, Belgium, ¹⁵Basildon Hospital NHS Trust, Basildon, United Kingdom, ¹⁶Southend University Hospital, NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, ¹⁷Rheumatology Unit, University Clinic AOU and University of Cagliari, Cagliari, Italy, ¹⁸Homerton University NHS Trust, London, United Kingdom, ¹⁹Rheumatology Department, Hospital Clínic and IDIBAPS,, Barcelona, Spain, ²⁰Institute of Ageing and Chronic Disease, Liverpool, United Kingdom, ²¹University of Oxford, Oxford, United Kingdom, ²²University of Southampton, Southampton, United Kingdom, ²³Kings College London, London, United Kingdom, ²⁴Rheumatology and Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte; Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa; Centro Académico de Medicina de Lisboa; Lisbon, Portugal., Lisbon, Portugal, ²⁵Cardiff University School of Medicine, Cardiff, United Kingdom, ²⁶Centre for Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom
Background/Purpose: Although biologic therapies have transformed the outlook for rheumatoid arthritis (RA), the lack of a major treatment response in over 50% of patients, the…
Abstract Number: 49 • 2019 ACR/ARP Annual Meeting
Towards a Single Cell Portrait of Rheumatoid Arthritis – Development of a Single Cell Multiomics Pipeline for Phase 2 of the Accelerating Medicine Partnership (AMP) – RA Network
Kevin Wei¹, Anna Helena Jonsson ¹, Fan Zhang ², Aparna Nathan ³, Joseph Mears ², Gerald Watts ², Zhu Zhu ², ilya Korsunsky ², Laura Donlin ⁴, Deepak Rao ², Andrew Filer ⁵, Accelerating Medicine Partnership (AMP) ⁶, Brendan Boyce ⁷, Ellen Gravallese ⁸, V. Michael Holers ⁹, Larry Moreland ¹⁰, Peter Gregersen ¹¹, Vivian Bykerk ¹², Jennifer Anolik ⁷, Soumya Raychaudhuri ² and Michael Brenner ¹³, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA, ⁴Hospital For Special Surgery, New York, NY, ⁵Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom, ⁶Brigham and Women's Hospital, Boston, ⁷University of Rochester Medical Center, Rochester, NY, ⁸University of Massachusetts Medical School, Worcester, MA, ⁹University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ¹⁰University of Pittsburgh, PITTSBURGH, PA, ¹¹Feinstein Institutes for Medical Research, Manhasset, NY, ¹²Hospital for Special Surgery, New York City, NY, ¹³Brigham and Women’s Hospital:, Boston
Background/Purpose: The goal of the Accelerating Medicines Partnership (AMP) program is to study synovial tissue from individuals with rheumatoid arthritis (RA) using high-dimensional analyses. During…
Abstract Number: 181 • 2019 ACR/ARP Annual Meeting
Prevalence of Renal Impairment in a US Rheumatoid Arthritis Population
Jon Giles¹, Lee Simon ², Janet Pope ³, Jim Paik ⁴, Michael Grabner ⁵, Amanda Quebe ⁶, Carol Gaich ⁶, Claudia Salinas ⁶ and Jeffrey Curtis ⁷, ¹Division of Rheumatology, Columbia University, New York, NY, ²SDG LLC, Cambridge, ³Western University, London, ON, Canada, ⁴Eli Lilly & Company, Indianapolis, IN, ⁵HealthCore, Inc., Wilmington, DE, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Clinical management of rheumatoid arthritis (RA) must consider patient renal function, particularly for medications that rely on renal clearance and require dose adjustment or…
Abstract Number: 252 • 2019 ACR/ARP Annual Meeting
Treatment Sequences, Effectiveness, and Costs of Tumor Necrosis Factor Inhibitor Cycling Compared with Swapping to a Novel Disease-modifying Anti-rheumatic Drug in Rheumatoid Arthritis Patients
Aliza Karpes ¹, Zhigang Duan ², Hui Zhao ², Lincy Lal ³, Wenyaw Chan ³, Maria E. Suárez-Almazor ⁴, Sharon Giordano ², John Swint ³ and Maria Lopez-Olivo², ¹School of Public Health, The University of Texas Health Science Center at Houston, Dallas, TX, ²The University of Texas, MD Anderson Cancer Center, Houston, TX, ³School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, ⁴Department of Rheumatology/Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX , USA., Houston, TX
Background/Purpose: To evaluate the sequences of therapeutic drugs used by rheumatoid arthritis (RA) patients whose initial tumor necrosis factor inhibitor (TNFi) therapy failed, as well…
Abstract Number: 439 • 2019 ACR/ARP Annual Meeting
Improved Patient-Reported Outcomes in Patients with Persistently Active Rheumatoid Arthritis Following Treatment with Repository Corticotropin Injection
Daniel Furst¹, George Wan ², Jingyu Liu ³, Julie Zhu ³, Laura Bartels-Peculis ³, Mary Panaccio ³ and Roy Fleischmann ⁴, ¹University of California, Los Angeles, CA, ²Mallinckrodt Pharmaceuticals, Bedminster, NJ, ³Mallinckrodt Pharmaceuticals, ARD, LLC, Bedminster, NJ, ⁴Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by progressive inflammation and irreversible joint damage. Treatment of active disease includes disease-modifying anti-rheumatic drugs (DMARDs)…
Abstract Number: 464 • 2019 ACR/ARP Annual Meeting
Continuous Decrease in Serum RF Titer During Anti-TNF Therapy Was Associated with Suppression in Progression of RA Joint Damage
Takayoshi Owada¹, Kazuhiro Kurasawa ¹, Yuta Takamura ¹, Toshiyuki Miyao ¹, Ayae Tanaka ¹, Ryutaro Yamazaki ¹, Satoko Arai ¹, Reika Maezawa ¹ and Masafumi Arima ¹, ¹Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi, Japan
Background/Purpose: A number of studies have investigated the association between serum RF and joint damage in early and established RA patients, and positive and high-titer…
Abstract Number: 502 • 2019 ACR/ARP Annual Meeting
Disease Activity Measures at Baseline and 3 Months as Predictors of Rapid Radiographic Progression in Methotrexate Naïve Patients with Early Rheumatoid Arthritis
Mohammad Movahedi ¹, Deborah Weber ¹, Pooneh Akhavan ² and Edward Keystone³, ¹Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ²Division of Rheumatology, Mount Sinai Hospital, Toronto, Canada, ³Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Progressive rheumatoid arthritis (RA) is responsible for disabilities in this patient population, characterized by radiographic joint damage. Achieving low disease activity (LDA) in RA…
Abstract Number: 551 • 2019 ACR/ARP Annual Meeting
Upadacitinib Treatment and the Routine Assessment of Patient Index Data 3 (RAPID3) Among Patients with Rheumatoid Arthritis
Martin Bergman¹, Yoshiya Tanaka ², Gustavo Citera ³, Sami Bahlas ⁴, Mira Ali ⁵, Sebastian Meerwein ⁶, Yanna Song ⁷ and Vibeke Strand ⁸, ¹Drexel University College of Medicine, Stockholm, Sweden, ²University of Occupational and Environmental Health Japan, Kitakyushu, Japan, ³Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ⁴Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, Jeddah, Saudi Arabia, ⁵AbbVie Inc., North Chicago, IL, USA, North Chiacgo, ⁶AbbVie GmbH Co. KG, Ludwigshafen, Germany, Wiesbaden, Germany, ⁷AbbVie Inc., North Chicago, IL, USA, North Chicago, ⁸Division of Immunology/Rheumatology, Stanford University, Stanford, CA
Background/Purpose: Upadacitinib (UPA) is an oral reversible JAK inhibitor engineered for greater selectivity for JAK1 vs JAK2, JAK3, and TYK2, and is currently being assessed…
Abstract Number: 850 • 2019 ACR/ARP Annual Meeting
Safety of Synthetic and Biological DMARDs: A Systematic Literature Review Informing the 2019 Update of the EULAR Recommendations for Management of Rheumatoid Arthritis
Alexandre Sepriano¹, Andreas Kerschbaumer ², Josef Smolen ², Désirée van der Heijde ¹, Maxime Dougados ³, Ronald F Van Vollenhoven ⁴, Iain McInnes ⁵, Johannes Bijlsma ⁶, Gerd Burmester ⁷, Maarten de Wit ⁸, Louise Falzon ⁹ and Robert B.M. Landewé ¹⁰, ¹Leiden University Medical Center, Leiden, Netherlands, ²Medical University of Vienna, Vienna, Austria, ³Cochin Hospital, Paris, France, ⁴Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ⁵College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ⁶UMC Utrecht, Department of Rheumatology & Clinical Immunology, Utrecht, The Netherlands, Utrecht, Netherlands, ⁷Charité—University Medicine Berlin, Berlin, Germany, ⁸Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam University Medical Centre, Amsterdam, Netherlands, ⁹Northwell Health, New York, ¹⁰Amsterdam University Medical Center, Amsterdam, Netherlands
Background/Purpose: To assess the most recent safety-data of synthetic (s) and biological (b)DMARDs to inform the 2019 update of the EULAR recommendations for the management…
Abstract Number: 992 • 2019 ACR/ARP Annual Meeting
Identification of CJ-15314, a Novel Highly Selective JAK1 Inhibitor, for the Treatment of Rheumatoid Arthritis
So Young Ki¹, Dongkyu Kim ¹, Juhyun Lee ¹, Byoung Seok Moon ¹ and Shin-Young Ryu ¹, ¹CJ Healthcare, Icheon-si, Republic of Korea
Background/Purpose: Janus kinases (JAKs) play critical roles in mediating various cytokine signaling. First-generation non-selective JAK inhibitors such as tofacitinib and baricitinib are widely used for…

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