ACR Meeting Abstracts

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Abstracts tagged "Rheumatoid arthritis (RA)"

  • Abstract Number: 953 • 2019 ACR/ARP Annual Meeting

    Treatment Patterns and Persistency Following the First Biologic DMARD in Patients with Rheumatoid Arthritis: Real-World Analysis of 2012–2016 US Medicare Data

    Robin Dore1, Lawrence Chang 2, Yuanyuan Ji 3, Suying Li 3, Jenya Antonova 2 and Mark Genovese 4, 1Private practice, Tustin, CA, 2Gilead Sciences, Foster City, CA, 3Chronic Disease Research Group, Minneapolis, MN, 4Stanford University, Stanford, CA

    Background/Purpose: In RA patients not meeting treat-to-target goals despite treatment with a biologic (b)DMARD, ACR guidelines1 recommend using other targeted immunomodulators (TIM): TNF-α inhibitor (TNFi),…
  • Abstract Number: 1156 • 2019 ACR/ARP Annual Meeting

    Differences in Clinical Outcomes According to the Healthcare Regime in Colombian Patients with Rheumatoid Arthritis

    Julian Barahona-Correa1, Jorge Florez 1, Mateo Rodriguez 2, Karen Ramirez 3, Paul Mendez-Patarroyo 1, Paola Coral-Alvarado 1 and Gerardo Quintana-López 1, 1Reumavance Group, section of Rheumatology, Fundacion Santa Fe de Bogota University Hospital, Bogota DC, Distrito Capital de Bogota, Colombia, 2School of Medicine, Universidad de Los Andes, Bogota, Distrito Capital de Bogota, Colombia, 3School of Medicine, Universidad Nacional de Colombia, Bogota DC, Distrito Capital de Bogota, Colombia

    Background/Purpose: Rheumatoid Arthritis (RA) generates high impact on patients and healthcare systems. Adequate control of disease activity depends to a large extent on the access…
  • Abstract Number: 1342 • 2019 ACR/ARP Annual Meeting

    Identification of Heterogenous Treatment Response Trajectories to anti-IL6 Receptor Treatment in Rheumatoid Arthritis

    Joseph Patrick Michele Blair1, Cecilie Bager 2, Man Hung Eric Tang 2, Morten Karsdal 3, Anne Bay-Jensen 4 and Søren Brunak 5, 1Univeristy of Copenahgen, Copenhagen, Denmark, 2Nordic Bioscience ProScion, Copenhagen, Denmark, 3Nordic Bioscience, Copenhagen, Denmark, 4Nordic Bioscience, Herlev, Denmark, 5Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark

    Background/Purpose: Rheumatoid arthritis (RA) is a complex autoimmune disease with a fluctuating course of disease activity and progression. Although treatments have improved substantially in recent…
  • Abstract Number: 1369 • 2019 ACR/ARP Annual Meeting

    Angiogenic Factors for Assessing Rheumatoid Arthritis in the Era of Sonographic Diagnosis and Biologic Therapy

    Ji-Won Kim1, Jin-Sun Kong 2, Youngjae Park 3 and Wan-Uk Kim 3, 1Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, 2Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Background/Purpose: Previously, we demonstrated the direct pro-inflammatory role of the vascular endothelial growth factor (VEGF) and the placenta growth factor (PlGF), and angiogenic factors in…
  • Abstract Number: 1396 • 2019 ACR/ARP Annual Meeting

    Persistence of Tocilizumab Therapy Among Patients with Rheumatoid Arthritis: Data from the US-Based Corrona Rheumatoid Arthritis Registry

    Dimitrios Pappas1, Taylor Blachley 2, Jennie Best 3, Steve Zlotnick 3, Kelechi Emeanuru 2 and Joel Kremer 4, 1Columbia University, New York, NY, 2Corrona, LLC, Waltham, MA, 3Genentech, Inc., South San Francisco, CA, 4Albany Medical College and The Center for Rheumatology; Corrona, LLC, Albany, NY

    Background/Purpose: Understanding persistence of biologic therapies and factors associated with discontinuation can help inform treatment decisions for patients with rheumatoid arthritis (RA). We sought to…
  • Abstract Number: 1434 • 2019 ACR/ARP Annual Meeting

    Improvement in Matrix metalloproteinase-3 Levels at 12 Weeks Independently Predicts Achievement of Low Disease Activity at 52 Weeks in Bio-switch Patients with Rheumatoid Arthritis Treated with Abatacept

    Nobunori Takahashi1, Toshihisa Kojima 1, Kenya Terabe 1, Shuji Asai 1 and Naoki Ishiguro 1, 1Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Background/Purpose: Japanese post-marketing surveillance (PMS) data demonstrated that effectiveness of abatacept in rheumatoid arthritis (RA) patients with previous biologics treatment (bio-switch) was significantly lower than…
  • Abstract Number: 1886 • 2019 ACR/ARP Annual Meeting

    Antibody Systems Targeting Citrullinated, Carbamylated, and Peptidyl Arginine Deaminase Autoantigens Distinguish Rheumatoid Arthritis in Combination with Rheumatoid Factors

    Thierry Dervieux1, Joel Kremer 2, John Conklin 1, Kelley Brady 1, Roberta Alexander 1, Tyler O'Malley 3, Jing Shi 1, Claudia Ibarra 1, Michael Mahler 4, Michael Weinblatt 5 and Arthur Weinstein 1, 1Exagen, Vista, CA, 2Albany Medical College and The Center for Rheumatology; Corrona, LLC, Albany, NY, 3Exagen, Oceanside, CA, 4Inova Diagnostics, San Diego, CA, 5Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Novel antibody systems including anti-carbamylated protein antibody (anti-CarP IgG) and anti-peptidyl arginine deiminase antibody (anti-PAD4 IgG) are emerging as independent diagnostic and prognostic biomarkers…
  • Abstract Number: 1998 • 2019 ACR/ARP Annual Meeting

    Major Histocompatibility Antigen HLA-DQB1*0601 Is Associated with Rheumatoid Arthritis Among Indians in a Replication Study: Evidence of Gene-Environment Interaction with LPG Stove Use

    Able Lawrence1, Anshul Dhar 2, Swayam Prakash 3, Suvrat Arya 4, Amita Aggarwal 5 and Suraksha Agrawal 6, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, 2SGPGIMS, Lucknow, India, 3Cellular and Molecular Immunology Laboratory University of California Irvine, School of Medicine USA, Irvine, CA, 4Sanjay Gandhi Postgraduate Institute, Lucknow, India, Lucknow, India, 5Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, 6SGPGIMS, Lucknow, Uttar Pradesh, India

    Background/Purpose: Shared epitope smoking interaction does not fully explain MHC association in Rheumatoid Arthritis (RA). We have previously shown HLA-DQB1*0601 (DQ6.1) to be a susceptibility…
  • Abstract Number: 2133 • 2019 ACR/ARP Annual Meeting

    Acute Myocardial Infarction in Rheumatoid Arthritis, Gout, and Osteoarthritis: A Retrospective Study Using the National Inpatient Sample from 2002-2016

    Rouhin Sen1, Sarah Aurit 2, Luay Sarsam 3, Osman Bhatty 4, Mukund Kumar 1 and Joseph Nahas 1, 1Creighton University Medical Center, Omaha, NE, 2Creighton University Medical Center, Omaha, 3Arnot Health, Elmira, NY, 4Montefiore Medical Center Wakefield Campus, Bronx, NY

    Background/Purpose: Inflammation is a risk factor in the development of cardiovascular disease. The proposed etiology centers around accelerated atherosclerosis involving various cytokines in the TNF…
  • Abstract Number: 2288 • 2019 ACR/ARP Annual Meeting

    Pregnancy Outcomes in Women Exposed to Golimumab

    Suzan Esslinger1, Susan Gabriel 2, Marijo Otero-Lobato 3, Michael Clark 4, Pamela Sheridan 4 and Anja Geldhof 5, 1Janssen Biologics BV, Leiden, Netherlands, 2Janssen Rearch & Development, LLC, Horsham, PA, 3Janssen Biologics BV, Leiden, Zuid-Holland, Netherlands, 4Janssen Research & Development, LLC, Horsham, PA, 5Janssen Research & Development, LLC, Leiden, Netherlands

    Background/Purpose: Rheumatologic disorders and inflammatory bowel disease can affect women of childbearing potential. Golimumab (GLM) is approved for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic…
  • Abstract Number: 2320 • 2019 ACR/ARP Annual Meeting

    Knowledge of Cardiovascular Disease Risk Among Patients with Rheumatoid Arthritis

    Juan Bande1, María Medina 1, Julia Sosa 1, María Kohan 1, Silvia Papasidero 1, José Caracciolo 1, Diana Klajn 1, Julio Wacker 1, Analía Alvarez 2, Romina Lim 2, Eduardo Kerzberg 3, Damaris Alvarez 3, Alejandra Trampuz 3, Gustavo Citera 4, Maria Correa 5, Analia Dellepiane 6, Adriana Perez Davila 7, Analía Verónica Bohr 7, Dora Pereira 8, Federico Giordano 8, Mónica Sacnun 9, Claudia Hartvig, 9, Maria Noelia Bersano 9, Mónica Díaz 10, Vanesa Cecilia Cruzat 11, Laura Raiti 12, Julia Demarchi 13, Iván Dario Remolina Rincón 13, Carolina Segura Escobar 13, Mariana Benegas 14, Etel Saturansky 14, Emma Civit 15, Federica Garignani 15, Gustavo Casado 16, Andrea M. Smichowski 16, Noel Agustin Callahuara Goiburu 17, Juan Arguello 17, Maria Paula Girard Bosch 18, Rosana Quintana 19, Bernardo A. Pons-Estel 19, Carla Gobbi 20, Darío Scublinsky 21, Mariana Salcedo 22, Maria de la Vega 23, Eliana Blanco 24, Hernán Maldonado Ficco 25, Lucía Degioanni 25, Nicolás Perez 26, Alejandro Martinez Muñoz 27 Silvina Mariana Rodriguez 28, Karin Kirmayr 29 and Sandra Petruzzelli30, 1Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 2Hospital General de Agudos José M. Penna, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 3Hospital Ramos Mejía, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 4Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 5Consultorios Reumatológicos Pampa, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 6CEMEC, Casilda, Santa Fe, Argentina, 7Hospital de Rehabilitación M. Rocca, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 8Hospital Zonal de Agudos Dr. Ricardo Gutiérrez, La Plata, Buenos Aires, Argentina, 9Hospital Provincial de Rosario, Rosario, Santa Fe, Argentina, 10Centro Traumatológico Bariloche, San Carlos de Bariloche, Rio Negro, Argentina, 11Clínica Bessone, Buenos Aires, Argentina, 12Clinica Bessone, Buenos Aires, Argentina, 13Hospital Británico, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 14Sanatorio Mendez, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 15OSEP. Universidad de Mendoza. F.C. Médicas, Ciudad de Mendoza, Argentina, 16Hospital Militar Central, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 17Hospital General de Agudos B. Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 18Instituto Médico Platense, La Plata, Argentina, 19Centro Regional de Enfermedades Autoinmunes y Reumáticas (CREAR), Grupo Oroño, Rosario, Argentina, 20CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Argentina, 21Centros Médicos Ambulatorios SMG, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 22Instituto de Cardiología, San Nicolás, Santa Fe, Argentina, 23CEIM Investigaciones Medicas, Buenos Aires, Argentina, 24Hospital General de Agudos Dr. Cosme Argerich, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 25Hospital San Antonio de Padua, Río Cuarto, Cordoba, Argentina, 26Instituto de Investigaciones Médicas Alfredo Lanari, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 27Hospital Municipal Dr. R. Larcade, San Miguel, Buenos Aires, Argentina, 28Hospital Municipal de Trauma y Emergencias Dr. Federico Abete, Malvinas Argentinas, Buenos Aires, Argentina, 29Hospital Zonal Bariloche, Bariloche, Argentina, 30Casa Hospital San Juan de Dios, La Plata, Buenos Aires, Argentina

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a significantly higher risk of cardiovascular disease (CVD) than general population. The Heart Disease Fact Questionnaire (HDFQ-RA 1…
  • Abstract Number: 2339 • 2019 ACR/ARP Annual Meeting

    Exposure to Avian and Fungal Antigens in Patients with Rheumatoid Arthritis-AssociatedInterstitial Lung Disease: Something to Keep in Mind

    Sebastian Rodriguez-Garcia1, Raul Castellanos-Moreira 2, Fernanda Hernández-González 3, Albert Perez 4, Joel Francesqui 5, Sandra Cuerpo-Cardeñosa 5, Virginia Ruiz-Esquide 6, Mariana Benegas 7, José Ramírez 8, Carmen Lucena-Pozo 3, Carlos Agustí 3, Marc Boada 9, Estíbaliz Ruiz 4, Odette Viñas 4, Sergio Prieto-González 10, Raimon Sanmarti 11, Gerard Espinosa 12, Mariona Pascal 13, Jose Gomez-Puerta 11, Marcelo Sánchez 7 and Jacobo Sellares 3, 1Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Spain, 2Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, 3Department of Pneumology, Hospital Clínic, Barcelona, Barcelona, Spain, 4Department of Immunology, Hospital Clínic, Barcelona, Barcelona, Spain, 5Pneumology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, 6Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, 7Department of Radiodiagnosis, Hospital Clínic, Barcelona, Barcelona, Spain, 8Department of Pathological Anatomy, Hospital Clínic, Barcelona, Barcelona, Spain, 9Department of Thoracic Surgery, Hospital Clínic, Barcelona, Barcelona, Spain, 10Department of Systemic Autoimmune Diseases Hospital Clínic, Barcelona, Barcelona, Spain, 11Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain, 12Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Barcelona, Catalonia, Spain, 13Immunology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain

    Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is an extra-articular manifestation with a poor prognosis. In clinical practice, to establish such a diagnosis requires…
  • Abstract Number: 2364 • 2019 ACR/ARP Annual Meeting

    Multi-center Analyses on 518 Cases with Rheumatoid Arthritis Developing Lymphoproliferative Disorders (RA-LPD): The Prognostic Factors and the Influence of Anti-rheumatic Drugs on LPD Development

    Yoshihiko Hoshida1, Shiro Ohshima 2, Yukihiko Saeki 3, Masao Katayama 4, Tomoya Miyamura 5, Atsuahi Hashimoto 6, Shinji Higa 7, Hisaji Oshima 8, Masato Yagita 9, Yasushi Hiramatsu 10, Norie Yoshikawa 11, Akiko Mitsuo 12, Akira Okamoto 13, Noriyuki Chiba 14, Takao Sugiyama 15, Shouhei Nagaoka 16, Shoji Sugii 17, Keigo Setoguchi 18, Asami Abe 19, Toshiaki Sugaya 20, Masahiro Koseto 21, Yasuo Kunugiza 22, Ryousuke Yoshihara 23, Shinichiro Tsunoda 24, Tomoaki Fujisaki 25, Hiroshi Furukawa 26, Kazuyoshi Saito 27, Kiyoshi Matsui 28, Yasuhiko Tomita 29 and Shigeto Tohma 30, 1National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Osaka, Japan, 2NHO Osaka Minami Medical Canter, Kawachinagano, Osaka, Japan, 3NHO Osaka Minami Medical Center, Kawachinagano, Osaka, Japan, 4National Hospital Organization Nagoya Medical Center, Nagoya, Japan, 5NHO Kyusyu Medical Center, Fukuoka, Japan, 6NHO Sagamihara Hospital, Sagamihara, Japan, 7Osaka Second Police Hospital, Osaka, Japan, 8NHO Tokyo Medical Hospital, Tokyo, Japan, 9Kitano Hospital, Osaka, Japan, 10Japanese Red Cross Society Himeji Hospital, Himeji, Hyogo, Japan, 11NHO Miyakonojo Medical Center, Miyakonojo, Miyazaki, Japan, 12NHO Disaster Medical Center, Tokyo, Tokyo, Japan, 13National Hospital Organization HImeji Medical Center, Himeji, Hyogo, Japan, 14National Hospital Organization Morioka Medical Center, Morioka, Iwate, Japan, 15NHO Shimoshizu Hospital, Chiba, Chiba, Japan, 16Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan, 17Department of Rheumatic Diseases, Tokyo Metropoitan Tama Medica Center, Fuchu, Japan, 18Tokyo Metropolitan Cancer and Infectious Dease Center Komagome Hospital, Tokyo, Tokyo, Japan, 19Niigata Rheumatic Center, Shibata, Niigata, Japan, 20Fuchu Hospital, Izumi, Osaka, Japan, 21Nippon Life Hospital, Osaka, Osaka, Japan, 22JCHO Hoshigaoka Medical Center, Katano, Osaka, Japan, 23Hyogo Prefecture Kakogawa Hospital, Kakogawa, Hyogo, Japan, 24Sumitomo Hospital, osaka, Osaka, Japan, 25Matsuyama Red Cross Hospital, Matsuyama, Ehime, Japan, 26Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 27University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan, 28Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, 29International University of health and welfare, Narita, Chiba, Japan, 30National Hospital Organization Tokyo National Hospital, Tokyo, Japan

    Background/Purpose: Lymphoproliferative disorders (LPD) remains as a major problem to resolve among the patients with rheumatoid arthritis (RA). During few decades, rheumatic therapy has dramatically…
  • Abstract Number: 2390 • 2019 ACR/ARP Annual Meeting

    Prediction of Disease Relapses by Multi-biomarker Disease Activity Score and Autoantibody Status in RA Patients Tapering DMARD Treatment in Stable Remission

    Melanie Hagen1, Koray Tascilar 2, Michaela Reiser 3, Judith Haschka 4, Arnd Kleyer 5, Larissa Valor 6, Bernhard Manger 7, Georg Schett 8 and Jürgen Rech 9, 1Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 2Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Bayern, Germany, 3Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, 4Karl Landsteiner Institute for Gastroenterology and Rheumatology, St. Vincent Hospital Vienna, II Medical Department, Vienna, Austria, 5Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 6Friedrich-Alexander-University Erlangen-Nürnberg. Department of Internal Medicine 3 - Rheumatology and Immunology. Erlangen., Erlangen, Germany, 7Friedrich-Alexander-University Erlangen-Nürnberg. Department of Internal Medicine 3 - Rheumatology and Immunology. Erlangen. Germany., Erlangen, Germany, 8Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, 9Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Achieving remission is the ultimate treatment goal in patients with rheumatoid arthritis (RA). With the development and wider use of highly effective disease modifying…
  • Abstract Number: 2772 • 2019 ACR/ARP Annual Meeting

    Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet

    francesca cedola1, Roxana Coras 2, Marta Fernandez-Bustamante 3, Meritxell Agusti-Perez 3, Maram Al-Harthi 3, Susan Lee 3, Abha Singh 3, Choi Soo 3, Kathy Nguyen 3, Oswald Quehenberger 3, Tatyana Shekhtman 3, Shahrokh Golshan 3 and Monica Guma 4, 1University of California San Diego, Rome, Italy, 2. Department of Medicine, School of Medicine. University of California, San Diego, 3University of California San Diego, san diego, 4Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States

    Background/Purpose: RA patients often inquire about dietary interventions to improve disease control, as they perceive quick changes in pain and/or swelling after consumption of certain…
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