Abstracts tagged "Rheumatoid arthritis (RA)"

Abstract Number: 1390 • 2019 ACR/ARP Annual Meeting
Prediction of Clinical Response to Abatacept in Rheumatoid Arthritis Patients Through the Determination of Anti-Carbamylated Proteins Antibodies Levels
Silvia Piantoni¹, Michele Boldini ¹, Rajesh Kumar ¹, Emirena Garrafa ¹, Chiara Bazzani ², Micaela Fredi ³, Ilaria Cavazzana ¹, Angela Tincani ³ and Franco Franceschini ³, ¹ASST Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy, Brescia, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Brescia, Italy
Background/Purpose: Carbamylation is a non-enzymatic irreversible post-translational modification of proteins. The presence of anti-carbamylated protein antibodies (anti-CarP) has been observed in rheumatoid arthritis (RA). In…
Abstract Number: 1427 • 2019 ACR/ARP Annual Meeting
Comparison of Real-World Persistence of Subcutaneously Administered Biologic Disease-Modifying Antirheumatic Drug Therapies Among Patients with Rheumatoid Arthritis Switching from Another Biologic
Jennie Best¹, Lenore Tominna ¹ and Ibrahim Abbass ¹, ¹Genentech, Inc., South San Francisco, CA
Background/Purpose: The EULAR and ACR clinical guidelines recommend switching to a different disease-modifying antirheumatic drug (DMARD) when biologic-treated patients experience treatment failure or toxicity. Lack…
Abstract Number: 1858 • 2019 ACR/ARP Annual Meeting
Beta-2-Glycoprotein-I IgA Antibodies Predict Coronary Plaque Burden, Progression and Moderate the Effect of Inflammation on Atherosclerosis in Rheumatoid Arthritis
George Karpouzas¹, Sarah Ormseth ¹, Elizabeth Hernandez ¹, Viet Bui ¹ and Matthew Budoff ¹, ¹Harbor-UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, CA
Background/Purpose: Beta-2-glycoprotein-I(b2GPI), an apolipoprotein abundant in plasma, is readily expressed in human atherosclerotic plaque. Anti-b2GPI-IgA antibodies (Ab) have been previously reported in both rheumatoid arthritis…
Abstract Number: 1940 • 2019 ACR/ARP Annual Meeting
Investigating the Post-Partum Flare in Rheumatoid Arthritis Using Transcriptome Analysis
Matthew Wright¹, Dana Goin ², Mette Smed ³, Lior Pachter ⁴, J. Lee Nelson ⁵, Nicholas Jewell ⁶, Jørn Olsen ⁷, Merete Lund Hetland ⁸, Vibeke Zoffmann ⁹ and Damini Jawaheer ¹⁰, ¹UCSF Benioff Children's Hopsital Oakland, Oakland, ²UCSF Benioff Children's Hospital Oakland, Oakland, ³Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, ⁴Caltech, Pasadena, ⁵Fred Hutchinson Cancer Research Center, Seattle, ⁶University of California Berkeley, Berkeley, ⁷Aarhus University Hospital, Aarhus, Denmark, ⁸DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, ⁹Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, ¹⁰UCSF Benioff Children's Hospital Oakland, Oakland, CA
Background/Purpose: Women with Rheumatoid arthritis (RA) tend to have a predictable flare of disease activity in the months after childbirth. The mechanism(s) underlying this post-partum…
Abstract Number: 2094 • 2019 ACR/ARP Annual Meeting
Evaluation of Influenza and Pneumococcal Vaccination Rate in Patients with Rheumatoid Arthritis and Spondyloarthritis, and the Attitudes of Rheumatologists About Vaccination
İdil Kurut Aysin ¹, Murat Aysin ², Dilek Solmaz ³, Nazmiye Baş Tomas ⁴, Filiz Koç ⁴, Elif Durak Ediboğlu ⁴, Gokhan Kabadayi ⁵, Onay Gercik ³, Sercan Gücenmez ⁴ and Servet Akar⁶, ¹Izmir Katip Celebi University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ²University of Izmir Katip Celebi Faculty of Medicine, Public Health, İzmir, Turkey, ³Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ⁴University of Izmir Katip Celebi Faculty of Medicine, Rheumatology, İzmir, Turkey, ⁵Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İzmir, Turkey, ⁶Izmir Katip Celebi University, Faculty of Medicine, Division of Rheumatology, İzmir, Turkey
Background/Purpose: Patients with inflammatory arthritis have increased risk of infections which may lead to morbidity and mortality. Some of those infections could be prevented by…
Abstract Number: 2259 • 2019 ACR/ARP Annual Meeting
Physical Challenges in RA: A Qualitative Study of an Online Patient Support Group
Jude des Bordes ¹, Jessica Foreman ¹, Maria Lopez-Olivo¹, Susan K Peterson ¹, Tiffany Westrich-Robertson ², Catherine Hofstetter ³, Anne Lyddiatt ⁴, Amye Leong ⁵ and Maria E. Suárez-Almazor ⁶, ¹The University of Texas, MD Anderson Cancer Center, Houston, TX, ²International Foundation for Autoimmune and Autoinflammatory Arthritis, Saint Louis, MO, ³Patient advocate, Toronto, ON, Canada, ⁴Musculoskeletal Group, Cochrane Collaboration, Toronto, ON, Canada, ⁵7. Healthy Motivation and the Global Alliance for Musculoskeletal Health of the Bone and Joint Decade, Santa Barbara, CA, ⁶Department of Rheumatology/Clinical Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX , USA., Houston, TX
Background/Purpose: Patients with rheumatoid arthritis (RA) face a number of challenges which adversely affect their quality of life. The objective was to qualitatively evaluate content…
Abstract Number: 2315 • 2019 ACR/ARP Annual Meeting
Association of Rheumatic Autoimmune Disease, Including Rheumatoid Arthritis, with Post-Traumatic Stress Disorder but Not Traumatic Brain Injury in Veterans
Biji Kurien ¹, Calin Prodan ² and Robert Scofield¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus, are 2- to 3-fold more common among those with post-traumatic stress disorder (PTSD) than…
Abstract Number: 2333 • 2019 ACR/ARP Annual Meeting
Risk of Incident Myocardial Infarction Among Disabled Patients with Rheumatoid Arthritis Who Were Beneficiaries of the Social Security Disability Insurance
Iris Navarro-Millan¹, Mangala Rajan ¹, Geyanne Lui ¹, Lisa Kern ¹, Laura Pinheiro ¹, Sebastian E. Sattui ², Lisa Mandl ³, Fenglong Xie ⁴, Jeffrey Curtis ⁵ and Monika Safford ¹, ¹Weill Cornell Medicine, New York, ²Hospital for Special Surgery, New York, ³Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, ⁴University of Alabama at Birmingham, Birmingham, ⁵University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Patients with RA have high risk for myocardial infarction (MI). A meta-analysis showed that the age and sex adjusted pooled relative risk of MI…
Abstract Number: 2358 • 2019 ACR/ARP Annual Meeting
Short-term Risk of Major Adverse Cardiovascular Events or Venous Thrombo-embolic Events in Patients with Rheumatoid Arthritis Initiating a Janus Kinase Inhibitor: A Meta-analysis of Randomised Controlled Trials
Margaux MALAURIE¹, Arnaud Constantin ², Yannick Degboé ¹, Adeline Ruyssen-Witrand ³ and Thomas Barnetche ⁴, ¹CHU TOULOUSE, TOULOUSE, France, ²CHU TOUOUSE, TOULOUSE, France, ³Rheumatology Unit, Toulouse university Hospital, UMR 1027, Inserm, Université Paul Sabatier Toulouse III, Toulouse, France, ⁴FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France
Background/Purpose: The objective was to investigate the short-term risk of major adverse cardiovascular events (MACEs) or venous thromboembolic events (VTEs) in patients with rheumatoid arhthritis…
Abstract Number: 2384 • 2019 ACR/ARP Annual Meeting
Yoga Improves Fatigue and Mental Health in Rheumatoid Arthritis: Preliminary Results of a Randomized Controlled Trial
Silva Pukšić¹, Joško Mitrović ², Melanie-Ivana Čulo ², Marcela Živković ³, Biserka Orehovec ⁴, Dubravka Bobek ⁵, Marko Lucijanić ⁶ and Jadranka Morović-Vergles ⁷, ¹Department of Clinical Immunology, Rheumatology and Allergology, University Hospital Dubrava, Zagreb, Croatia, Zagreb, Croatia, ²Department of Clinical Immunology, Rheumatology and Allergology, University Hospital Dubrava, Zagreb, Croatia, ³Department of Laboratory Diagnostics, University Hospital Dubrava, Zagreb, Croatia, Zagreb, Croatia, ⁴Department of Laboratory Diagnostics, University Hospital Dubrava, Zagreb, Croatia, ⁵Department of Physical Medicine and Rehabilitation with Rheumatology, University Hospital Dubrava, Zagreb, Croatia, Zagreb, Croatia, ⁶Department of Hematology, University Hospital Dubrava, Zagreb, Croatia, Zagreb, Croatia, ⁷Department of Clinical Immunology, Rheumatology and Allergology, University Hospital Dubrava, School of Medicine,Zagreb, Croatia, Zagreb, Croatia
Background/Purpose: Rheumatoid arthritis (RA) patients perceive reduced health-related quality of life (HRQOL) through functional disability, pain, increased fatigue and impaired psychological functioning. Previous trials demonstrated…
Abstract Number: 2716 • 2019 ACR/ARP Annual Meeting
Long Term Outcomes of Childhood Onset Rheumatoid Arthritis
Rebecca Overbury¹, Aimee Hersh ², CJ Inman ², Sara Stern ², Karen James ² and John Bohnsack ³, ¹Assisstant Professor, University of Utah, Salt Lake City, UT, ²University of Utah, Salt Lake City, UT, ³University of Utah School of Medicine, Salt Lake City, UT
Background/Purpose: Childhood onset rheumatoid arthritis (CORA) describes patients with juvenile idiopathic arthritis (JIA) who are rheumatoid factor (RF) or anti-cyclic citrullinated antibody (ACPA) positive. Phenotypically,…
Abstract Number: 2852 • 2019 ACR/ARP Annual Meeting
Shared and Differing Risk Factors for PsA, Psoriasis, AS, and RA: A Series of Case-control Studies
Alexis Ogdie¹, Xingmei Wang ¹, Thorvardur J Love ², Telma Thrastardottir ³, Maureen Dubreuil ⁴ and Joel Gelfand ⁵, ¹Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Faculty of Medicine, University of Iceland, Reykjavik, Iceland, ³University of Iceland, Reykjavik, Iceland, ⁴Boston University School of Medicine, Boston, ⁵University of Pennsylvania, Philadelphia, PA
Background/Purpose: While a handful of clinical risk factors for the development of inflammatory diseases have been identified, to date, no studies have compared risk factors…
Abstract Number: 11 • 2019 ACR/ARP Annual Meeting
Biomarker Changes for Patients with Rheumatoid Arthritis Receiving Tofacitinib with Methotrexate or Glucocorticoids vs Tofacitinib Monotherapy
Julie Lee¹, Xing Chen ¹, Weidong Zhang ¹, David Martin ¹, Craig Hyde ¹, Tomohiro Hirose ², Shweta Shah ³ and Lori Fitz ¹, ¹Pfizer Inc, Cambridge, MA, ²Pfizer Japan Inc, Toyko, Japan, ³Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. Herpes zoster (HZ) is more common in patients (pts) with RA vs…
Abstract Number: 97 • 2019 ACR/ARP Annual Meeting
Low Frequency of Circulating T Follicular Helper 1 Cells Is Associated to Adequate Response to Adalimumab Therapy in Rheumatoid Arthritis
Charlotte Lucas¹, Roussine Codo ², Jean-David Albert ³, Rachel Jean ², Stéphane Rodriguez ⁴, Patricia Amé-Thomas ⁵ and Aleth Perdriger ⁶, ¹Rheumatology department, Rennes University Hospital, France, Rennes, Bretagne, France, ²SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, ³Rheumatology department, Rennes University Hospital and Institut NUMECAN, INSERM U 1241, Rennes, Bretagne, France, ⁴PhD, SITI Laboratory, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, ⁵SITI Laboratory, Univ Rennes, Rennes University Hospital, EFS, INSERM1236, France, Rennes, Bretagne, France, ⁶Rheumatology department, Rennes University Hospital, France, Rennes, France
Background/Purpose: T follicular helper cells (Tfh) constitute a distinct CD4+ helper T-cell subset, promoting B-cell maturation and activation. Circulating Tfh (cTfh) seem to play a…
Abstract Number: 190 • 2019 ACR/ARP Annual Meeting
Accuracy of Administrative Algorithms for Identifying Interstitial Lung Disease in Rheumatoid Arthritis
Bryant England¹, Punyasha Roul ², Tina Mahajan ³, Namrata Singh ⁴, Fang Yu ², Harlan Sayles ², Grant Cannon ⁵, Brian Sauer ⁵, Joshua Baker ⁶, Jeffrey Curtis ⁷ and Ted Mikuls ⁸, ¹VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, ²University of Nebraska Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, ⁴University of Iowa, Iowa City, ⁵Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, ⁶University of Pennsylvania, Philadelphia, PA, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Interstitial lung disease (ILD) affects 10-15% of RA patients leading to significant disability and premature mortality. While large administrative datasets have been widely leveraged…

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