ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)"

  • Abstract Number: 2450 • 2016 ACR/ARHP Annual Meeting

    Do Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis Have Reduced Fertility and Parity? a Systematic Review

    Claire-Louise Murphy1, Harriet Sharp2, Hanh Nguyen3, Anisur Rahman1 and Ian Giles4, 1Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 2Rheumatology, University College London, London, United Kingdom, 3Rheumatology, University College London Hospital, London, United Kingdom, 4Department of Rheumatology, University College London Hospital NHS Foundation Trust, London, United Kingdom

    Background/Purpose: Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA) often affect women of reproductive age. It remains unclear as to whether these inflammatory rheumatic conditions…
  • Abstract Number: 1212 • 2016 ACR/ARHP Annual Meeting

    A Combined Large Scale Meta-Analysis Identifies COG6 As a Novel Shared Risk Locus for Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Ana Márquez1, Laura Vidal-Bralo2, Luis Rodriguez-Rodriguez3, Miguel Angel González-Gay4, Alejandro Balsa5, Isidoro Gonzalez-Alvaro6, Patricia Carreira7, Norberto Ortego Centeno8, Maria del Mar Ayala Gutierrez9, Francisco José García-Hernández10, Francisca González Escribano11, José Mario Sabio12, Carles Tolosa13, Ana Suárez14, Antonio Gonzalez15, Leonid Padyukov16, Jane Worthington17, Timothy J. Vyse18,19, Marta E. Alarcon Riquelme20,21 and Javier Martín1, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, 2Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 3Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, 5Department of Rheumatology and Institute for Health Research (IdiPAZ), University Hospital La Paz, Madrid, Spain, 6Rheumatology, Rheumatology Service, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 7Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 8Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 9Department of Internal Medicine, Hospital Carlos Haya, Málaga, Spain, 10Department of Internal Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 11Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), Sevilla, Spain, 12Department of Internal Medicine, Hospital Virgen de las Nieves, Granada, Spain, 13Department of Internal Medicine, Hospital Parc Taulí, Sabadell, Spain, 14Department of Functional Biology, Immunology Area, Faculty of Medicine, University of Oviedo, Oviedo, Spain, 15Laboratorio de Investigación 10 and Rheumatology Unit, Instituto de Investigación Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 16Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 17Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 18Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, 19Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, 20Centro de Genómica e Investigación Oncológica (GENYO), Pfizer-Universidad de Granada-Junta de Andalucía, Granada, Spain, 21Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: One of the main limitations of the association studies in autoimmunity is the difficulty in identifying genetic risk variants with modest effects, given the…
  • Abstract Number: 1579 • 2016 ACR/ARHP Annual Meeting

    Small Rnaseq Reveals Different Plasma miRNA Signature in Patients with RA and SLE: A Pilot Study

    Michelle J. Ormseth1, Joseph F. Solus2, Yan Guo3, Quanhu Sheng3, Ryan Allen3, Kasey C. Vickers3 and C Michael Stein3, 1Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, 3Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: MicroRNAs (miRNAs) are ~22-nt RNAs that post-transcriptionally regulate gene expression and serve as biomarkers of many disease states. Most previous plasma miRNA studies in…
  • Abstract Number: 1758 • 2016 ACR/ARHP Annual Meeting

    Physical Activity and Sedentary Behaviour in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Alexandra Legge1, John Hanly2 and Chris Blanchard1, 1Department of Medicine, Dalhousie University, Halifax, NS, Canada, 2Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are at increased risk for premature cardiovascular disease. As sedentary behaviour and lack of…
  • Abstract Number: 1791 • 2016 ACR/ARHP Annual Meeting

    Loss of Elbow Hyperextension in Females with Early Rheumatologic Disease Was Common in Systemic Lupus Erythematosus and Rheumatoid Arthritis but Rare in Fibromyalgia

    John P. Case1, Heidi Tucker2 and Congbin Wang3, 1Internal Medicine/Rheumatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, 2Rush Medical College, Chicago, IL, 3Internal medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL

    Background/Purpose:   The elbow extension angle (ELB) is commonly given as 180o although most healthy females exhibit hyperextension(1).  The loss of hyperextension (LOH) in a…
  • Abstract Number: 2112 • 2016 ACR/ARHP Annual Meeting

    Disease-Activity Associated Autoantibodies to Malondialdehyde-Modified Proteins Can be Isolated from Synovial B Cells in RA

    Caroline Grönwall1, Khaled Amara1, Uta Hardt1, Lelise Getu2, Jeffrey D. Greenberg3, Robert M Clancy3, Vivianne Malmström4 and Gregg J. Silverman3, 1Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 2Department of Medicine, New York University School of Medicine, New York, NY, 3Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 4Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Malondialdehyde (MDA) is a naturally occurring reactive aldehyde that arises during apoptosis or as a consequence of elevated reactive oxygen species and lipid peroxidation.…
  • Abstract Number: 2236 • 2016 ACR/ARHP Annual Meeting

    Effects of Repository Corticotropin Injection on Medication Use in Patients with Rheumatologic Conditions: A Claims Data Study

    Gihyun Myung1, Winnie Nelson2 and Maureen A. McMahon3, 1Division of Rheumatology/Department of Internal Medicine, University of California-Los Angeles, Los Angeles, CA, 2Health Economics and Outcomes Research, Mallinckrodt Pharmaceuticals, Hampton, NJ, 3University of California-Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA

    Background/Purpose: Repository corticotropin injection (RCI) may produce anti-inflammatory and immune-modulatory effects. This study examined the demographics of those who used RCI and the trends in…
  • Abstract Number: 37 • 2015 ACR/ARHP Annual Meeting

    Cardiovascular Disease in Immune-Mediated Inflammatory Diseases: Cross Sectional Analysis of the Influence of Demographic and Traditional Cardiovascular Risk Factors

    Luis Rodriguez-Rodriguez1,2, Pedro P Perrotti3, Adrìa Aterido3, Jesús Tornero4, Carlos Ferrandiz5, Juan D. Cañete6, Antonio Fernandez-Nebro7, Javier P Gisbert8, Eugeni Domènech9,10, María López-Lasanta3, Sara Marsal3, Benjamín Fernández-Gutiérrez1,11 and IMID Consortium, 1Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, 2Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 3Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 4Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, 5Dermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 6Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, 7Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, 8Gastroenterology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 9Gastroenterology & Hepatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10CIBERehd, Madrid, Spain, 11Rheumatology, Hospital Clínico San Carlos, Madrid, Spain

    Background/Purpose : Our aim was 1) to analyze the association between demographic and traditional cardiovascular risk factors (CVRF) and cardiovascular disease (CVD) in subjects affected…
  • Abstract Number: 621 • 2015 ACR/ARHP Annual Meeting

    Previous Diagnosis of Sjögren’s Syndrome As Rheumatoid Arthritis or Systemic Lupus Erythematosus

    Astrid Rasmussen1, Lida Radfar2, Kiely Grundahl3, David M. Lewis4, Donald U Stone5,6, C. Erick Kaufman7, Daniel J Wallace8, Michael H. Weisman9, Swamy Venuturupalli10, Christopher J Lessard11, Biji Kurien12, Juan-Manuel Anaya13, Michael D. Rohrer14, Raj Gopalakrishnan15, Glen D Houston16, James Chodosh17, Pamela J Hughes18, Nelson L. Rhodus19, John Ice1, Kimberly Hefner20, Jennifer A. Kelly21, Kathy L. Sivils1 and R. Hal Scofield1,22,23, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, 3Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 4College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Department of Ophthalmology, Johns Hopkins University, Riyadh, Saudi Arabia, 6Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, 7College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 8Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 9Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 10Cedars-Sinai Medical Center, West Hollywood, CA, 11Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 13Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, 14Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, 15Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota, Minneapolis, MN, 16Heartland Pathology, Oklahoma City, OK, 17Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 18Division of Oral and Maxillofacial Surgery, University of Minnesota, Minneapolis, MN, 19Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, 20Hefner Eye Care and Optical Center, Oklahoma City, OK, 21Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 22Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 23US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose: The diagnosis of Sjögren′s Syndrome (SS) is often difficult and many patients are symptomatic for years with other diagnoses before confirmation of SS. Overlapping…
  • Abstract Number: 1251 • 2015 ACR/ARHP Annual Meeting

    Physiological Evidence for Diversification of the IFNα- or IFNβ-Mediated Response Programs in Different Autoimmune Diseases

    Tamarah D. de Jong1, Saskia Vosslamber1, Elise Mantel1, Sander de Ridder1, John G. Wesseling1, Tineke C.T.M. van der Pouw Kraan2, Joep Killestein3, Ingrid E. Lundberg4, Jiri Vencovsky5,6, Irene E.M. Bultink7, Alexandre E. Voskuyl8, Michiel Pegtel1, Conny J. van der Laken9, Johannes W. Bijlsma8 and Cornelis L. Verweij1, 1Pathology, VU University medical center, Amsterdam, Netherlands, 2Molecular Cell Biology and Immunology, VU University medical center, Amsterdam, Netherlands, 3Neurology, VU University medical center, Amsterdam, Netherlands, 4Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 5Rheumatology, Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 7Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, 8Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, 9Rheumatology, VU University medical center, Amsterdam, Netherlands

    Background/Purpose: Presence of a type I interferon (IFN) signature is described for several autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis (MS), myositis (IIM)…
  • Abstract Number: 1819 • 2015 ACR/ARHP Annual Meeting

    Comparison of Electrocardiographic ST-T Changes and QTc Duration in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Laura Geraldino-Pardilla1, Yevgeniya Gartshteyn2, Jon T. Giles3, Thania Perez4, Anca D. Askanase5 and Joan M. Bathon6, 1Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 2Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, 3Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 4Columbia University, College of Physicians & Surgeons, New York, NY, 5Department of Medicine Rhemuatology, Colombia University, New York, NY, 6Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY

    Background/Purpose: Cardiovascular disease (CVD) is a leading cause of death in systemic lupus erythematosus (SLE) and in rheumatoid arthritis (RA). Longer corrected QT segments (QTc)…
  • Abstract Number: 2679 • 2014 ACR/ARHP Annual Meeting

    Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus

    Jeong-Hwa Kang1, Young-Nan Cho1, Hye Mi Jin1, Hyun-Ju Jung1, Sung-Ji Lee1, Seung-Jung Kee2 and Yong-Wook Park1, 1Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 2Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea

    Background/Purpose Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of…
  • Abstract Number: 1401 • 2014 ACR/ARHP Annual Meeting

    Higher-Order Neuropsychological Deficits Are Frequent and Occur Early in RA and SLE: The Impact of Basic Processing Abilities on Psychological Well-Being

    Giorgia Dimitraki1, Georgia Ktistaki1, Emmanouil Papastefanakis1, Antonis Fanouriakis2, Irini Gergiannaki2, George Bertsias3, Nikolaos Kougkas2, Argyro Repa3, Evangelos Karademas1, Prodromos Sidiropoulos3 and Panagiotis Simos1, 1Department of Psychology, University of Crete, Rethymnon, Greece, 2Rheumatology, Clinical Immunology and Allergy, University of Crete, Heraklion, Greece, 3Rheumatology, Clinical Immunology, and Allergy, University of Crete, Heraklion, Greece

    Background/Purpose Deficits in higher-order cognitive abilities (episodic memory, executive functions) have been reported in patients with chronic inflammatory disorders, albeit inconsistently. We investigated whether such…
  • Abstract Number: 1072 • 2014 ACR/ARHP Annual Meeting

    Sex Ratio of Offspring Born to Women with Lupus and Rheumatoid Arthritis

    Elizabeth V. Arkema1, Johan Askling1, Jane Salmon2 and Julia F Simard3, 1Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Division of Epidemiology, Health Research and Policy Department, and Division of Immunology & Rheumatology, Department of Medicine, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Women with SLE are at increased risk for pregnancy complications and specific autoantibodies may result in preferential loss of female offspring. Studies on the…
  • Abstract Number: 387 • 2014 ACR/ARHP Annual Meeting

    Levels of IgG Autoantibodies to Oxidation-Associated MDA Neo-Determinants Are a Biomarker for Systemic Inflammation and Disease Activity in SLE and RA

    Caroline Grönwall1, Lelise Getu2, Jeffrey D. Greenberg3, Robert M. Clancy4 and Gregg J. Silverman1, 1Medicine, New York University School of Medicine, New York, NY, 2New York University School of Medicine, New York, NY, 3Rheumatology, New York University School of Medicine, New York, NY, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose Monitoring disease activity in patients with autoimmune rheumatic disease is an essential part of clinical care. Highly reactive malondialdehyde (MDA) arise from reactive oxygen…
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