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Abstract Number: 37

Cardiovascular Disease in Immune-Mediated Inflammatory Diseases: Cross Sectional Analysis of the Influence of Demographic and Traditional Cardiovascular Risk Factors

Luis Rodriguez-Rodriguez1,2, Pedro P Perrotti3, Adrìa Aterido3, Jesús Tornero4, Carlos Ferrandiz5, Juan D. Cañete6, Antonio Fernandez-Nebro7, Javier P Gisbert8, Eugeni Domènech9,10, María López-Lasanta3, Sara Marsal3, Benjamín Fernández-Gutiérrez1,11 and IMID Consortium, 1Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, 2Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 3Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 4Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, 5Dermatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 6Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain, 7Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, 8Gastroenterology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 9Gastroenterology & Hepatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10CIBERehd, Madrid, Spain, 11Rheumatology, Hospital Clínico San Carlos, Madrid, Spain

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Cardiovascular disease, inflammatory bowel disease (IBD), Psoriatic arthritis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)

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Session Information

Date: Sunday, November 8, 2015

Session Title: Epidemiology and Public Health Poster I: Comorbidities and Outcomes of Systemic Inflammatory Diseases

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose : Our aim was 1) to analyze the association between demographic and traditional cardiovascular risk factors (CVRF) and cardiovascular disease (CVD) in subjects affected with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis (Ps), psoriatic arthritis (PsA), Crohn’s disease (CD), or ulcerative colitis (UC), and 2) to compare the standardized prevalence of CVD among these conditions.

Methods : Subjects included in this cross-sectional study were collected as part of the Immune-Mediated Inflammatory Disease Consortium between 2007-2010. Demographic and clinical data was collected using standardized questionnaires during a clinical interview with close questions and review of medical records. Multivariate logistic regression models adjusted by demographic (gender, age, educational level, elapsed time from IMID diagnosis) and traditional CVRF [dyslidepemia (DL), type 2 diabetes (T2D), obesity (OB), ever smoking] were constructed for each IMID. Results for each variable were combined using inverse variance weighted metaanalysis. Standardized prevalence for each IMID, adjusted by demographic and traditional CVRF [per 100 patients, with 95% confidence intervals (CI)] was calculated using marginal analysis.

Results: 9951 patients were included (Table 1). Table 2 shows the association between demographic and traditional CVRF and CVD in each IMID. When results from the 6 cohorts were combined, males, lower educational level, older age and more time elapsed from disease diagnosis, and presence of DL and T2D were independently associated with a higher risk of CVD. SLE exhibited the highest standardized prevalence, followed by RA, Ps, CD, PsA and UC (Figure 1).

Conclusion : The contribution to CV risk of demographic and traditional CVRF is different for each IMID. SLE showed the higher standardize prevalence of CVD when compared to other IMIDs.

 

 

Table 1: Demographic characteristics and prevalence of CVD disease and traditional CV risk factors of the patients included in this study.

 

RA (n = 2152)

PsA (n = 1147)

Ps (n = 2497)

SLE (n = 760)

CD (n = 1938)

UC (n = 1457)

Age, (n)  X (IQR)

(1996) 61

(52 to 70)

(1113) 52

(41.09 to 63)

(2430) 47

(36 to 59)

(702) 44

(35 to 55)

(1913) 39

(32 to 49)

(1436) 47

(37 to 58.12)

Women, n (%)

1.567 (77.69)

522 (47.28)

1.057 (43.46)

671 (93.19)

956 (49.84)

663 (46.01)

 Calendar year at IMID

diagnosis, (n)  X (IQR)

(2144) 1998

(1991 to 2004)

(1137) 2003

(1996 to 2007)

(2482) 1992

(1980 to 2001)

(678) 1999

(1993 to 2004)

(1314) 1998

(1993 to 2002)

(975) 1998

(1993 to 2002)

Elapsed time from IMID diagnosis

to study§, in years , (n)  X (IQR)

(2132) 10

(5 to 17)

(1076) 7

(3 to 13)

(2480) 17

(8 to 29)

(675) 10

(6 to 17)

(1313) 10

(6 to 15)

(975) 10

(7 to 16)

Secondary or higher education, n (%)

655 (33.73)

449 (44.46)

1278 (54.20)

378 (54.00)

1187 (62.77)

785 (55.48)

CVD, n (%)

91 (4.23)

24 (2.09)

94 (3.76)

24 (3.16)

14 (0.72)

22 (1.51)

Current/past smoker, n (%)

828 (49.49)

533 (59.55)

1.411 (69.68)

369 (62.02)

1.282 (74.62)

727 (62.08)

Arterial hypertension, n (%)

638 (29.65)

–

476 (19.06)

178 (23.42)

123 (6.35)

148 (10.16)

Dyslipidemia, n (%)

433 (20.12)

157 (13.69)

436 (17.46)

125 (16.45)

68 (3.51)

127 (8.72)

Type 2 diabetes, n (%)

172 (7.99)

92 (8.02)

203 (8.13)

24 (3.16)

28 (1.44)

55 (3.77)

Obesity, n (%)

366 (19.02)

250 (24.56)

612 (25.82)

102 (15.36)

184 (9.97)

198 (14.25)

Number of DMARDs, X [IQR]

2 (1-3)

1 (0-2)

0 (0-0)

2 (1-2)

1 (0-1)

0 (0-1)

Patients with biological drugs, n (%)

914 (42.47)

299 (26.07)

493 (19.74)

47 (6.18)

282 (14.55)

70 (4.80)

 

Table 2: Multivariate logistic regression models to analyze the influence of demographic and traditional cardiovascular (CV) risk factors in the prevalence of CV disease in each of our 6 cohorts.

Figure 1: Standardized prevalence of cardiovascular disease, with 95% confidence intervals, for each IMID.

 

 


Disclosure: L. Rodriguez-Rodriguez, None; P. P. Perrotti, None; A. Aterido, None; J. Tornero, None; C. Ferrandiz, None; J. D. Cañete, None; A. Fernandez-Nebro, None; J. P. Gisbert, None; E. Domènech, None; M. López-Lasanta, None; S. Marsal, None; B. Fernández-Gutiérrez, None.

To cite this abstract in AMA style:

Rodriguez-Rodriguez L, Perrotti PP, Aterido A, Tornero J, Ferrandiz C, Cañete JD, Fernandez-Nebro A, Gisbert JP, Domènech E, López-Lasanta M, Marsal S, Fernández-Gutiérrez B. Cardiovascular Disease in Immune-Mediated Inflammatory Diseases: Cross Sectional Analysis of the Influence of Demographic and Traditional Cardiovascular Risk Factors [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/cardiovascular-disease-in-immune-mediated-inflammatory-diseases-cross-sectional-analysis-of-the-influence-of-demographic-and-traditional-cardiovascular-risk-factors/. Accessed July 2, 2022.
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