ACR Meeting Abstracts

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Abstracts tagged "Response Criteria"

  • Abstract Number: 0520 • ACR Convergence 2023

    How Do Early Disease Activity and Early Clinical Response Associate with Long-Term Outcomes with Ixekizumab in Radiographic Axial Spondyloarthritis?

    Sofia Ramiro1, Cedric Lukas2, Louis Bessette3, Pendleton Wickersham4, Soyi Liu-Leage5, Tommaso Panni5, Rebecca Bolce5, Boris Janos5, Michael Nissen6 and James Cheng-Chung Wei7, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2CHU Montpellier, Montpellier, France, 3Centre de l'Ostéoporose et de Rhumatologie de Québec, Quebec City, QC, Canada, 4Arthritis Associates PA, San Antonio, TX, 5Eli Lilly and Company, Indianapolis, IN, 6Geneva University Hospitals, Geneva, Switzerland, 7Chung Shan Medical University Hospital, Department of Rheumatology, Taichung, Taiwan

    Background/Purpose: The ASAS-EULAR recommendations for the management of axial spondyloarthritis (axSpA) advise that a patient be assessed for biological disease-modifying anti-rheumatic drug (bDMARD) treatment response…
  • Abstract Number: 0746 • ACR Convergence 2023

    The Association Between Sonographic Imaging Phenotype and Response to Treatment in Patients with Psoriatic Arthritis

    Jessica Gutierrez Manjarrez1, Sydney Thib2, Richard J. Cook3 and Lihi Eder4, 1Women’s College Research Institute / Department of Medicine, University of Toronto, Toronto, ON, Canada, 2Women’s College Research Institute, Toronto, ON, Canada, 3Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, 4Women’s College Research Institute, Division of Rheumatology, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Ultrasound (US) may improve characterization of psoriatic arthritis (PsA) phenotypes and help predict disease outcomes. We aimed to assess whether US phenotypes are associated…
  • Abstract Number: 0840 • ACR Convergence 2023

    Head-to-Head Comparison of TLL-018 and Tofacitinib in Patients with Active Rheumatoid Arthritis: Final Results from a Phase IIa Study

    Xiaofeng Zeng1, chanyuan wu2, Jiankang Hu3, SHENGYUN LIU4, Zhenyu Jiang5, Jingyang Li6, Xiaoxia Wang7, Ju Liu8, Chaofan Yuan9, Guang Yang10 and Chris Liang10, 1Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 3Pingxiang People’s Hospital, PingXiang, China, 4The First Affiliated Hospital Of Zhengzhou University, Zhengzhou, China, 5The First Hospital of Jilin University, Changchun, China, 6Zhuzhou Central Hospital, Zhuzhou, China, 7Second Hospital of Shanxi Medical University, Taiyuan, China, 8Jiujiang No. 1 People’s Hospital, JiuJiang, China, 9Hangzhou Highlightll Pharmaceutical Co., Ltd, Beijing, China, 10Hangzhou Highlightll Pharmaceutical Co., Ltd, HangZhou, China

    Background/Purpose: None of the currently approved treatments for rheumatoid arthritis (RA) can achieve ACR50 in >50% of the patients, and 5 – 20% of the…
  • Abstract Number: 0974 • ACR Convergence 2023

    Validation of Boolean 2.0 Criteria for Assessing Remission and Predicting Quality of Life in Korean Patients with Rheumatoid Arthritis Undergoing Targeted Therapy

    Soo-Kyung Cho1, Yeo-Jin Song1, Jungyong Han2, Hye Won Kim3, Eunwoo Nam3 and Yoon-Kyoung Sung1, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 3Hanyang University Institute for Rheumatology Research, Seoul, South Korea

    Background/Purpose: The management of rheumatoid arthritis (RA) focuses on achieving remission as a treatment goal. The updated ACR/EULAR remission definition (Boolean criteria 2.0) has raised…
  • Abstract Number: 1172 • ACR Convergence 2023

    Relapse Rate After Glucocorticoid-free Remission in Idiopathic Inflammatory Myopathies with Validation of the International Myositis Assessment & Clinical Studies Group (IMACS) Criteria for Remission and Relapse

    Hideaki Tsuji1, Fabricio Espinosa-Ortega2, Maryam Dastmalchi2, Ingrid Lundberg2 and Karin Lodin3, 1Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Stockholm, Sweden, 3Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Huddinge, Sweden

    Background/Purpose: Our aim was to explore whether maintenance of remission in patients with idiopathic inflammatory myopathy (IIM) depends on glucocorticoids (GCs) after achieving remission. Therefor…
  • Abstract Number: 1423 • ACR Convergence 2023

    Impact of Upadacitinib on Enthesitis and Dactylitis by Location in Patients with Psoriatic Arthritis and an Inadequate Response to Biologic DMARDs from the SELECT-PsA 2 Trial

    Laura Coates1, Catherine Bakewell2, Majed Khraishi3, Shirley Chen4, Tianming Gao4, Arathi Setty4, Heather Jones5, Sandra Ciecinski4 and Eduardo Mysler6, 1University of Oxford, Oxford, United Kingdom, 2Intermountain Healthcare Medical Group, Salt Lake City, UT, 3Memorial University of Newfoundland, St. John's, NL, Canada, 4AbbVie, Inc., North Chicago, IL, 5AbbVie, Inc., Mettawa, IL, 6Organización Medica de Investigación, Buenos Aires, Argentina

    Background/Purpose: Enthesitis and dactylitis are associated with reduced quality of life and greater impairment in daily activities. In the SELECT-PsA 2 phase 3 trial, the…
  • Abstract Number: 2143 • ACR Convergence 2023

    Efficacy of Filgotinib in Patients with Rheumatoid Arthritis: Week 156 Results from a Long-term Extension Study

    Maya Buch1, Daniel Aletaha2, Roberto F. Caporali3, Bernard G. Combe4, Hendrik Schulze-Koops5, Jacques-Eric Gottenberg6, Yoshiya Tanaka7, Ricardo Blanco8, Tsutomu Takeuchi9, Edmund V. Ekoka Omoruyi10, Katrien Van Beneden11, Vijay Rajendran12, Chris Watson13, Francesco De Leonardis14 and Paul Emery15, 1University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom, 2Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria, Wien, Austria, 3Department of Clinical Sciences and Community Health, University of Milan, and Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTO, Milano, Italy, 4Department of Rheumatology, Montpellier University, Montpellier, France, 5Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, Ludwig-Maximilians–University Munich, Munich, Germany, 6Rheumatology Department, Strasbourg University Hospital, Strasbourg, France, 7University of Occupational and Environmental Health, Kitakyushu, Japan, 8Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 9Keio University School of Medicine and Saitama Medical University, Tokyo, Japan, 10Biostatistics, Galapagos NV, Mechelen, Belgium, 11Medical Safety, Galapagos NV, Mechelen, Belgium, 12Clinical Research, Galapagos NV, Mechelen, Belgium, 13Medical Affairs, Galapagos Biotech Ltd., Cambridge, United Kingdom, 14Medical Affairs, Galapagos GmbH, Basel, Switzerland, 15Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: In the treatment of RA, JAK inhibitors are a valuable option to meet remission or low disease activity (LDA) treatment targets following an inadequate…
  • Abstract Number: 2334 • ACR Convergence 2023

    Remission Attainment in Patients with Systemic Lupus Erythematosus Treated with Anifrolumab Compared with Placebo over a 4-Year Period

    Ronald van Vollenhoven1, Eric Morand2, Richard A. Furie3, Kenneth Kalunian4, Raj Tummala5, Gabriel Abreu6, Hussein Al-Mossawi7 and Catharina Lindholm6, 1Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Monash University, Centre for Inflammatory Diseases, Melbourne, Australia, 3Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 4University of California San Diego, La Jolla, CA, 5BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 6BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 7BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

    Background/Purpose: In patients with SLE, remission is an established therapeutic goal associated with reduced damage accrual and flares, and improved health-related quality of life.1 Here,…
  • Abstract Number: 1414 • ACR Convergence 2022

    2022 Revision of the ACR/EULAR Remission Criteria for Rheumatoid Arthritis

    Paul Studenic1, Daniel Aletaha2, Maarten de Wit3, Tanja Stamm4, Farideh Alasti5, Diane Lacaille6, Josef Smolen1 and David Felson7, 1Medical University of Vienna, Vienna, Austria, 2Medical University Vienna, Wien, Austria, 3Patient research partner, Amsterdam, Netherlands, 4Medical University of Vienna, CeMSIIS - Center for Medical Statistics, Informatics, and Intelligent Systems, Section for Outcomes Research, Wien, Austria, 5Medical University of Vienna, Department of Internal Medicine 3, Division of Rheumatology, Vienna, Austria, 6Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, 7Boston University, Boston, MA

    Background/Purpose: More than 10 years ago ACR and EULAR endorsed provisional criteria to define remission in RA, both Boolean and index-based. However, the agreement between…
  • Abstract Number: 1628 • ACR Convergence 2022

    The Sjogren Tool for Assessing Response (STAR): Assessment of Response Rates Overall, According to Baseline Activity and by Domain: Reanalysis of 9 Clinical Trials in Primary Sjogren Syndrome

    Raphaèle Seror1, Gabriel Baron2, Divi CORNEC3, Elodie Perrodeau2, Marine Camus4, Professor Simon Bowman5, Michele Bombardieri6, Hendrika Bootsma7, Suzanne Arends7, jacques-eric gottenberg8, Benjamin A. Fisher9, Wolfgang Hueber10, Joel Van Roon11, Valerie Devauchelle12, Liseth de Wolff13, Peter Gergely14, Xavier Mariette15 and Raphaël Porcher16, 1University Hospital Paris-Saclay, Le Kremlin Bicêtre, France, 2AP-HP Hôtel Dieu Hospital, Université Paris Descartes, Paris, France, 3CHRU Brest, Brest, France, 4Department of Rheumatology, Université Paris-Saclay, APHP Hôpital Bicêtre, Le Kremlin Bicêtre, France, 5University Hospitals Birmingham, Birmingham, United Kingdom, 6Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University, London, United Kingdom, 7University Medical Center Groningen, Groningen, Netherlands, 8Strasbourg University Hospital, Strasbourg, France, 9University of Birmingham, Birmingham, United Kingdom, 10Novartis Pharmaceuticals, Basel, Switzerland, 11Rheumatology & Clinical Immunology, University of Utrecht, Utrecht, Netherlands, 12Université de Bretagne Occidentale, Brest, France, 13UMCG, Zwolle, Netherlands, 14Novartis Pharma, Basel, Switzerland, 15Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 16Université Paris Cité, Hôtel-Dieu, Paris, France

    Background/Purpose: The ESSDAI and ESSPRI, used alone, are not able to capture all features of primary Sjögren's syndrome (pSS). The NECESSITY consortium developed the Sjögren's…
  • Abstract Number: 1974 • ACR Convergence 2022

    Which ACR Response Definition Should Be Used for Disease Activity Claims in Approval Studies of Rheumatoid Arthritis? A Systematic Evaluation

    Andreas Kerschbaumer1, Victoria Konzett2, Josef Smolen1 and Daniel Aletaha3, 1Medical University of Vienna, Vienna, Austria, 2Division of Rheumatology / Department of Medicine III / Medical University of Vienna, Vienna, Austria, 3Medical University Vienna, Wien, Austria

    Background/Purpose: The American College of Rheumatology (ACR) response definition was developed in 1995 by Felson et al. as a composite outcome and has been the…
  • Abstract Number: 0293 • ACR Convergence 2022

    Long-term Sustainability of Response to Upadacitinib Among Patients with Active Rheumatoid Arthritis Refractory to Biological Disease-Modifying Anti-Rheumatic Drugs: Results Through 5 Years from SELECT-BEYOND

    Ronald van Vollenhoven1, Stephen Hall2, Alvin Wells3, Sebastian Meerwein4, Yanna Song5, Jessica Suboticki6 and Roy Fleischmann7, 1Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Emeritus Research and Monash University, Melbourne, Australia, 3Aurora Rheumatology and Immunotherapy Center, Franklin, WI, 4AbbVie Deutschland GmbH & Co KG, LUDWIGSHAFEN, Germany, 5AbbVie, Inc., North Chicago, IL, 6AbbVie, Inc., Mettawa, IL, 7Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: The primary treatment goal for patients with rheumatoid arthritis (RA) is sustained remission (REM), but low disease activity (LDA) is considered an appropriate target…
  • Abstract Number: 2014 • ACR Convergence 2022

    Difficult to Treat Rheumatoid Arthritis: Prevalence of Different Objective Patterns, Predictive Characteristics, and Associated Factors in 1-Year Follow-Up

    Einer Sanchez-Prado, ronald Perez, Laura Cuellar, jonatan mareco, Santiago Ruta, Sebastian Magri and Rodrigo Garcia Salinas, Hospital Italiano de La Plata, La Plata, Argentina

    Background/Purpose: Difficult-to-Treat Rheumatoid Arthritis (RA) (D2T), is a concept recently defined by EULAR, it refers to patients who do not achieve the therapeutic target, who…
  • Abstract Number: 0294 • ACR Convergence 2022

    Safety and Efficacy of Upadacitinib in Patients with Rheumatoid Arthritis and Inadequate Response or Intolerance to Biologic DMARDs: Results Through 5 Years from the SELECT-BEYOND Study

    Roy Fleischmann1, Sebastian Meerwein2, Christina Charles-Schoeman3, BERNARD COMBE4, Stephen Hall5, Nasser Khan6, Kyle Carter7, Heidi Camp8 and Andrea Rubbert-Roth9, 1Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, 2AbbVie Deutschland GmbH & Co KG, LUDWIGSHAFEN, Germany, 3Division of Rheumatology, University of California, Los Angeles, Santa Monica, CA, 4Montpellier University, Montpellier, France, 5Emeritus Research and Monash University, Melbourne, Australia, 6AbbVie, Inc., Abbott Park, IL, 7AbbVie, Inc., North Chicago, IL, 8Abbvie, Winnetka, IL, 9Division of Rheumatology, Cantonal Clinic St Gallen, St.Gallen, Switzerland

    Background/Purpose: To evaluate the long-term efficacy and safety of upadacitinib (UPA) over 5 yrs among patients with rheumatoid arthritis (RA) in a long-term extension (LTE)…
  • Abstract Number: 2110 • ACR Convergence 2022

    Guselkumab Efficacy in Psoriatic Arthritis Assessed by Multi-domain Composite Indices: Data from the Phase 3b COSMOS Trial in a TNFi-IR Population

    Laure Gossec1, Mohamed Sharaf2, Elke Theander3, Marlies Neuhold4, Paul Bergmans5, May Shawi6, Michelle Perate7, Christine Contré8 and Laura Coates9, 1Sorbonne Université, Paris, France, 2Johnson & Johnson, Middle East FZ LLC, Dubai, United Arab Emirates, 3Formerly at Janssen Scientific Affairs, LLC, Solna, Sweden, 4Takeda Europe & Canada Business Unit (EUCAN) Medical Affairs, Zurich, Switzerland; formerly at Janssen Scientific Affairs, LLC, Zug, Switzerland, 5Formerly at Janssen, Breda, Netherlands, 6Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 7Janssen Scientific Affairs, LLC, Horsham, PA, 8Formerly at Janssen Scientific Affairs, LLC, Issy-les-Moulineaux, France, Issy-les-Moulineaux, France, 9Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, Oxford, England, United Kingdom

    Background/Purpose: The Phase 3b COSMOS study (NCT03796858) demonstrated the efficacy and safety of guselkumab (GUS), an IL-23 p19 subunit inhibitor, in patients (pts) with psoriatic…
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