ACR Meeting Abstracts

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Abstracts tagged "Renal"

  • Abstract Number: 0659 • ACR Convergence 2024

    Obinutuzumab Benefits Patients with Active Lupus Nephritis Irrespective of Baseline Proteinuria Severity: A Post Hoc Analysis of a Phase II Trial

    Richard Furie1, Jorge A. Ross Terres2, Elsa Martins3, Imran Hassan4, Thomas Schindler3, Jay Garg5, William F. Pendergraft III6, Ana Malvar7 and Brad Rovin8, 1Northwell Health, Manhasset, NY, 2Genentech, Inc,, San Francisco, 3F. Hoffmann-La Roche Ltd, Basel, Switzerland, 4Hoffmann-La Roche Ltd, Mississauga, Canada, 5Genentech, Inc., South San Francisco, CA, 6Genentech, Inc., Chapel Hill, NC, 7Organización Médica de Investigación, Buenos Aires, Argentina, 8The Ohio State University, Columbus, OH

    Background/Purpose: Lupus nephritis (LN) is the most common severe organ-threatening manifestation of systemic lupus erythematosus (SLE). The randomized, placebo-controlled, Phase II NOBILITY trial (NCT02550652) demonstrated…
  • Abstract Number: 1569 • ACR Convergence 2024

    Scleroderma Renal Crisis – Different Phenotypes and Patient Trajectories

    Katya Dolnikov1, Kochava Toledano1, Marius Braun2, Doron Markovits1, Sami Giryes1, Yonit Tavor1, Alexandra Balbir-Gurman3 and Yolanda Braun Moscovici1, 1Rheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, HAIFA, Israel, 2Liver Insitute, Beilinson Hospital, Petach Tikva, Petach Tikva, Israel, 3Rheumatology Institute, Rambam Health Care Campus and The Rappaport Faculty of |Medicine, Technion, Haifa, Israel

    Background/Purpose: Scleroderma renal crisis (SRC) is a life-threatening complication that occurs in a minority of patients, particularly those with diffuse cutaneous systemic sclerosis ( SSc).…
  • Abstract Number: 0701 • ACR Convergence 2024

    Diagnostic Performances of Vascular Biomarkers Soluble Fms-like Tyrosine Kinase (sFlt-1) and Placental Growth Factor (PlGF) in Scleroderma Renal Crisis: A Case Control Study

    Aïcha Kante1, Paul Legendre2, Bérangère Joly3, bertrand Dunogue4, Alexandre Hertig5, Benjamin Terrier6, Elodie Massolin7, Felix Ackermann8, Luc Mouthon4, Jean Guibourdenche9 and Benjamin Chaigne10, 1Department of internal medicine, Centre de Compétence Maladies Rares autoimmunes et inflammatoires, Université Paris Cité, Paris, Ile-de-France, France, 2Service immunologie clinique, Centre hospitalier du Mans, Le Mans, France, Le Mans, 3Service d'Hématologie Biologique, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris (APHP.Nord), Université Paris Cité, Paris, Ile-de-France, France, 4Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 5Department of Nephrology, Hôpital Foch, Suresnes, France, Suresnes, Ile-de-France, France, 6Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France, 7UF d'Hormonologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (APHP), Paris, Paris, Ile-de-France, France, 8Department of Internal Medicine, Foch Hospital, Suresnes, France., Suresnes, France, 9APHP-CUP, Hôpital Cochin, F-75014 Paris, Université Paris Cité, Paris, Ile-de-France, France, 10Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, Ile-de-France, France

    Background/Purpose: Scleroderma renal crisis (SRC) is a major vascular complication of systemic sclerosis (SSc), associated with high morbidity and mortality. Few biomarkers are available to predict…
  • Abstract Number: 1642 • ACR Convergence 2024

    A Urinary Biomarker Panel to Predict the Probability of Histologically Active Lupus Nephritis

    Andrea Fava1, Andrew Concoff2, Tyler O'Malley3, Sepehr Taghavi4, Touba Warsi4, Sudha Kumar4, Christine Schleif4 and Michelle Petri5, 1Divison of Rheumatology, Johns Hopkins University, Baltimore, MD, 2Exagen, Inc., Los Angeles, CA, 3Exagen, Vista, CA, 4Exagen, Carlsbad, CA, 5Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Achieving an NIH Activity Index of < 2 upon treatment is associated with less LN flare and thus better long-term kidney survival. Here, we…
  • Abstract Number: 0708 • ACR Convergence 2024

    Outcomes of Intermittent Intravenous Steroid Use During Infusion Therapy in Systemic Sclerosis

    Vangala Adarsh1, dihowm Fatma1, Eyerusalem Akpan2, Meredith Keller2, Maheswari Muruganandam2, N. Suzanne Emil2, Frank O'Sullivan3, Roderick Fields2 and wilmer sibbitt1, 1UNM, Albuquerque, NM, 2University of New Mexico, Albuquerque, NM, 3University of New Mexico School of Medicine, Albuquerque, NM

    Background/Purpose: Use of high dose corticosteroids in systemic sclerosis (SSc) is considered a significant risk factor for development of scleroderma renal crisis (SRC). Intravenous (IV)…
  • Abstract Number: 1683 • ACR Convergence 2024

    68Ga-FAPI PET/CT Imaging for Assessing Renal Tubulointerstitial Fibrosis in Lupus Nephritis

    Shuyi Yu, Zetao Ding, Haoyu Pan, Jinyi Qian, Zhixia Yang, Xiaohan Wei, Chengde Yang and Hui Shi, Department of Rheumatology and lmmunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China (People's Republic)

    Background/Purpose: To evaluate the feasibility of using fibroblast activating protein inhibitor (FAPI) PET imaging as a molecular tracer and non-invasive tool for assessing renal tubulointerstitial…
  • Abstract Number: 0719 • ACR Convergence 2024

    Risk of Vertebral Fracture in Individuals with Granulomatosis with Polyangiitis and End-Stage Renal Disease

    Joanna El Hajj1, Jennifer Waller1, Yagni Patel1, Wendy Bollag1, Stephanie Baer2 and Rachel Elam3, 1Augusta University, Augusta, GA, 2VA Augusta Healthcare System, Augusta, GA, 3Augusta University, Evans, GA

    Background/Purpose: End-stage renal disease (ESRD) secondary to vasculitis is linked to a higher risk of vertebral fractures compared to other causes of ESRD. It remains…
  • Abstract Number: 1685 • ACR Convergence 2024

    The Renal Activity Index for Lupus (RAIL) Identifies Active Renal Disease in SLE Patients and Its Longitudinal Score Associates with Achievement of Renal Responses in Lupus Nephritis

    Minal Aundhia1, Jinqi Liu2, Ellen Cody3, James Rose4, Angela Merritt1, Megan Quinlan-Waters1, Alyssa Sproles5, Sherry Thornton5, Prasad Devarajan4, Bin Huang6 and hermine brunner7, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Bristol Myers Squibb, Princeton, NJ, 3Children's Wisconsin, Milwaukee, 4Cincinnati Children's Hospital Medical Center, Cincinnati, 5Cincinnati Children's Hospital, Cincinnati, 6Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cinciannati, OH, 7Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: Lupus Nephritis (LN) confers a poor prognosis, and there is a lack of effective non-invasive tests to assess disease activity and treatment response. We…
  • Abstract Number: 0725 • ACR Convergence 2024

    Serum Glial Fibrillary Acidic Protein Could Assess Cross-sectional Vasculitis Activity by Reflecting Renal Involvement in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis

    Lucy Eunju Lee1, Taejun Yoon2, Yong-Beom Park2 and Sang-Won Lee2, 1Yonsei University, Seoul, South Korea, 2Yonsei University College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Glial fibrillary acidic protein (GFAP), an intermediate filament protein produced by astrocytes in the CNS, has been identified as a biomarker for disease activity…
  • Abstract Number: 2008 • ACR Convergence 2024

    A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of a Single Dose of ABP-671 in Participants with Chronic Kidney Disease (CKD)

    ullrich schwertschlag1, william dongfang Shi2, rOBERT PERRY3, Kwabena Ayesu4, rOY WU5, jerry liu6, JinSying Lin7 and Adam Jin8, 1Atombio Science, PALO ALTO, CA, 2Jiangsu Atom Bioscience,, Suzhou, Jiangsu, China (People's Republic), 3Panax Clin Res, Miami Lakes, FL, 4OMEGARLLC, ORLANDO, FL, 5Atom Bioscience, SAN FRANCISCO, CA, 6atombio, San Diego, CA, 7Biostatconsulting, Wuzhong, Suzhou, Jiangsu, China (People's Republic), 8atom biosciences, Wuzhong, Suzhou, Jiangsu, China (People's Republic)

    Background/Purpose: In this open-label Phase 1 study, 22 participants were enrolled in 3 cohorts, 10 participants with normal kidney function (eGFR ≥90 ml/min/1.73m2 and no…
  • Abstract Number: 0729 • ACR Convergence 2024

    Factors Associated with Pauci-immune Glomerulonephritis in Patients Undergoing Renal Biopsy with Positive ANCA Results

    Jiyun Lee1, Yeo-Jin Lee2, Mi-Ra Cho3, Young-Eun Kim4, Soo Min Ahn4, Ji Seon Oh3, Yong-Gil Kim3, Chang-Keun Lee3, Bin Yoo3 and Seokchan Hong3, 1University of Ulsan College of Medicine, Seoul, Republic of Korea, 2Asan medical center, Seoul, South Korea, 3Asan Medical Center, Seoul, Republic of Korea, 4Asan medical center, University of Ulsan College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Pauci-immune glomerulonephritis (GN) is a renal manifestation of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). When patients present with positive ANCA results and urinary abnormalities…
  • Abstract Number: 2317 • ACR Convergence 2024

    Chronic Kidney Disease in Patients with Psoriatic Arthritis: A Cohort Study

    Fadi Kharouf1, Shangyi Gao2, Shahad Al-Matar3, Daniel Pereira4, Richard Cook5, Vinod Chandran6 and Dafna Gladman7, 1University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, 2Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 3Toronto Western Hospital, University of Toronto, Toronto, Canada, 4University Health Network, Toronto, ON, Canada, 5University of Waterloo, Waterloo, Canada, 6University of Toronto, Toronto, ON, Canada, 7University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Chronic kidney disease (CKD) is a comorbidity in psoriatic arthritis (PsA). In this study, we aimed to define the prevalence of CKD in patients…
  • Abstract Number: 1085 • ACR Convergence 2024

    Pharmacokinetics and Pharmacodynamics of Tigulixostat in Participants with Mild, Moderate, and Severe Renal Impairment

    Ashish Kumar1, Ali Hariri1, Yunjung Lee2 and Minhyung Lee2, 1LG Chem Life Sciences USA, Boston, MA, 2LG Chem, Seoul, Republic of Korea

    Background/Purpose: Tigulixostat is a potent and highly selective non-purine based xanthine oxidase inhibitor (XOi) being investigated for the management of hyperuricemia in patients with gout.…
  • Abstract Number: 2395 • ACR Convergence 2024

    Validation Cohort of a Tool to Predict Proliferative Histological Class in Lupus Nephritis Based on Clinical and Laboratory Data – LUCAS Study (Lupus Nephritis Class Assessment System)

    Antônio Silaide De Araújo-Júnior1, Emília Sato2, Alexandre Wagner Silva de Souza1, Fábio Jennings1, Gianna Mastroianni Kirsztajn3, Ricardo Sesso3 and Edgard Reis Neto4, 1Division of Rheumatology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., São Paulo, SP, Brazil, 2Universidade Federal de Sao Paulo, São Paulo, SP, Brazil, 3Division of Nephrology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., São Paulo, SP, Brazil, 4Division of Rheumatology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal, São Paulo, SP, Brazil

    Background/Purpose: Lupus nephritis (LN) is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE), and kidney biopsy is the gold…
  • Abstract Number: 1103 • ACR Convergence 2024

    The Role of Renal Dual-Energy CT in Exploring the Gouty Kidney: The RENODECT Study

    Tristan Pascart1, Elie Dauphin1, Chio Yokose2, Charlotte Jauffret3, Hyon K. Choi4 and Jean-François Budzik5, 1Université Catholique de Lille, Lille, Nord-Pas-de-Calais, France, 2Massachusetts General Hospital, Boston, MA, 3Lille Catholic University, Lille, Nord-Pas-de-Calais, France, 4Massachusetts General Hospital, Lexington, MA, 5Lille Catholic University, Lille, France

    Background/Purpose: Chronic kidney disease (CKD) is a common feature in gout, and can have multiple causes, some of which are gout specific, such as gout…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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