Abstracts tagged "radiography"

Abstract Number: 2229 • ACR Convergence 2024
Aptamer Based Proteomic Profiling Demonstrates Significant Differences in Methotrexate Responders versus Non-responders in Newly Diagnosed Rheumatoid Arthritis and Adds Potential Value to Clinical Examination
Kaien Gu¹, Leanne Lac¹, Nathalie Carrier², Liam O'Neil¹, Gilles Boire³, Pingzhou Hu⁴ and Carol Hitchon¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²Universite de Sherbrooke, Sherbrooke, QC, Canada, ³Retired, Sherbrooke, QC, Canada, ⁴Western University, London, ON, Canada
Background/Purpose: Despite methotrexate (MTX) being the cornerstone of rheumatoid arthritis (RA) therapy, uncertainty exists around who will respond to MTX. We aimed to determine the…
Abstract Number: 0411 • ACR Convergence 2024
Axial Radiographic Structural Damage in Enthesitis-Related Arthritis in Children and Young Adult Patients
Annelyse de Araújo Pereira¹, Marcelo Pinheiro², Jade Dib Fernandez¹, Ana Sakamoto³, Adham do Amaral e Castro¹ and Maria Teresa Terreri⁴, ¹UNIFESP-EPM, São Paulo, SP, Brazil, ²UNIFESP/ EPM, São Paulo, SP, Brazil, ³Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil, ⁴UNIFESP, São Paulo, SP, Brazil
Background/Purpose: Enthesitis-related arthritis (ERA), a distinct subtype of juvenile idiopathic arthritis (JIA) related to HLA-B27 status and peripheral and axial involvement, presents with insidious onset…
Abstract Number: 2353 • ACR Convergence 2024
Effects of Guselkumab on cDAPSA Disease Activity State and Its Association with Long-Term Radiographic Progression in a Cohort of Patients with Moderately-Highly Active Psoriatic Arthritis: Post Hoc Analyses of Phase 3 Randomized Controlled Studies
Philip Mease¹, Alice Gottlieb², Iain McInnes³, Natalie J. Shiff⁴, Toby Thomas⁵, Emmanouil Rampakakis⁶, Francois Nantel⁷, Frederic Lavie⁸ and Proton Rahman⁹, ¹Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, ²Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA, ³University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, ⁴Janssen Scientific Affairs, LLC / University of Saskatchewan, Adjunct, Community Health and Epidemiology, Horsham, PA, ⁵Janssen Pharmaceuticals, Horsham, PA, ⁶McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, ⁷Nantel MedSci Consult, Montreal, QC, Canada, ⁸Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, ⁹Memorial University of Newfoundland, Faculty of Medicine, Division of Rheumatology, St. John's, Canada
Background/Purpose: In the Phase 3 DISCOVER (D)-1 and -2 studies, guselkumab (GUS; IL-23p19-subunit inhibitor) 100 mg every 4 weeks (Q4W) or Q8W significantly improved joint…
Abstract Number: 0565 • ACR Convergence 2024
Low Vitamin D Serum Level Is a Risk Factor for Ankylosis in Axial Spondyloarthritis: Evidence from a Nested-Case-Control Study
Anthony Lichaa¹, Pauline KRUG¹ and Adrien Nzeusseu Toukap², ¹Cliniques universitaires St-Luc, Brussel, Belgium, ²Cliniques universitaires Saint-Luc,, St.-Lambrechts-Woluwe, Belgium
Background/Purpose: Axial spondyloarthritis (axSpA) is a progressive disease, characterized by chronic inflammation and progressive structural damage. However, the kinetic of progression to ankylosis and much…
Abstract Number: 0847 • ACR Convergence 2024
Sex and Race-Specific Distributions in Medial Fixed Joint Space Width in Healthy Knees from Three Longitudinal Cohorts
Kent Kwoh¹, Rongrong Tang², Erin Ashbeck³, Edward Bedrick⁴, Yvonne Golightly⁵, Amanda Nelson⁶, Tuhina Neogi⁷, Yong Ge⁸, Zong-Ming Li², Jean Liew⁷, Xiaoxiao Sun⁹, Justin Crawmer¹⁰ and Jeffery Duryea¹¹, ¹University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, University of Arizona College of Medicine - Tucson, Tucson, AZ, ³University of Arizona Mel and Enid Zuckerman College of Public Health, Tucson, AZ, ⁴Department of Epidemiology andBiostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁸Department of Information Sciences, Eller College of Manangement, University of Arizona, Tucson, AZ, ⁹Department of Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, ¹⁰BWH, Boston, MA, ¹¹Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Quantitative radiographic joint space width (JSW) is often used as ameasure of structural outcomes in randomized controlled trials of knee OA (KOA). How JSW…
Abstract Number: 0868 • ACR Convergence 2024
Autoantibodies to Joint-related Proteins Predict Severe Joint Destruction in Difficult-to-treat Rheumatoid Arthritis Patients
Inger Gjertsson¹, Monica Leu Agelii², Outi Sareila³, Erik Lönnblom⁴, Lennart TH Jacobsson⁵, Lei Cheng⁴, Kristina Forslind⁶, Ingiäld Hafström⁷, Maria Andersson⁸ and Rikard Holmdahl⁹, ¹University of Gothenburg, Gothenburg, Sweden, ²Institutionen för medicin, avd för reumatologi och inflammationsforskning, Goteborg, Sweden, ³Karolinska Institutet, Stockholm, Sweden, ⁴Karolinska Institute, Stockholm, Sweden, ⁵Lund University, Malmö, Sweden, ⁶Lund University, Department of Clinical Sciences Lund, Section of Rheumatology, Lund, Sweden, ⁷Karolinska Institutet, Department of Medicine Huddinge, Division of Gastroenterology and Rheumatology, and Karolinska University Hospital, Stockholm, Sweden, ⁸FoU Spenshult, Halmstad, Sweden, ⁹Department of Rheumatology and Inflammation Research, Institute for Medicine, Sahlgrenska Academy, University of Gothenburg, Stockholm, Stockholms Lan, Sweden
Background/Purpose: Although treatment of rheumatoid arthritis (RA) has improved there is still a significant number of patients who never reach low disease activity, known as…
Abstract Number: 1190 • ACR Convergence 2024
Cross-sectional Associations Among Sonographic and Radiographic Features and Symptoms Scores in a Population-Based Cohort
Katherine Yates¹, Carolina Alvarez², Sahar Sawani³, Liubov Arbeeva⁴, Todd Schwartz⁵, Serena Savage-Guin⁶, Jordan Renner⁷, Catherine Bakewell⁸, Minna Kohler⁹, Janice Lin¹⁰, Jonathan Samuels¹¹ and Amanda Nelson³, ¹University of North Carolina Medical Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina, Chapel Hill, Carrboro, NC, ⁵University of North Carolina-Chapel Hill, Chapel Hill, NC, ⁶Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill,, Chapel Hill, NC, ⁷Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁸Intermountain Healthcare, Salt Lake City, UT, ⁹Massachusetts General Hospital, Boston, MA, ¹⁰Stanford University, Palo Alto, CA, ¹¹NYU Langone, Rye Brook, NY
Background/Purpose: Ultrasound (US) allows for visualization of features of knee osteoarthritis (KOA) including osteophytes, meniscal extrusion, synovitis, and cartilage damage. The current analysis aimed to…
Abstract Number: 1198 • ACR Convergence 2024
Impact of Metabolic Syndrome on Knee Osteoarthritis Severity and Progression: A PROCOAC Cohort Study
Natividad Oreiro¹, Ana Raga², Vanesa Balboa-Barreiro³, Ignacio Rego-Perez⁴, Belen Acasuso⁵, Laura Galindo Domínguez⁶ and francisco J Blanco⁷, ¹CHUAC, La Coruna, Galicia, Spain, ²Grupo de Investigación en Reumatología (GIR). INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC). SERGAS, A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioeostadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC)., A Coruña, Spain, ⁴Instituto de Investigacion Biomedica de A Coruña-SERGAS, A Coruña, Spain, ⁵Unidad de Investigacion Clinica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas., Investigation, A Coruña, Spain, A Coruña, Spain, ⁶Instituto de Investigacion Biomedica de A Coruña (INIBIC), A Coruña, Spain, ⁷INIBIC-University of A Coruña, A Coruña, Spain
Background/Purpose: The contribution of metabolic factors to the development of osteoarthritis (OA) has not been fully elucidated. The aim of this study is to analyze…
Abstract Number: 1436 • ACR Convergence 2024
The Association of Cigarette Smoking with Radiographic Progression in Psoriatic Arthritis
Fadi Kharouf¹, Hernan Maldonado Ficco², Shangyi Gao³, barry J Sheanne⁴, Daniel Pereira⁵, Richard Cook⁶, Vinod Chandran⁷ and Dafna Gladman⁸, ¹University Health Network and University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ²Hospital San Antonio de Padua, Cordoba, Argentina, ³Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴St James' Hospital, Dublin, Ireland, ⁵University Health Network, Toronto, ON, Canada, ⁶University of Waterloo, Waterloo, Canada, ⁷University of Toronto, Toronto, ON, Canada, ⁸University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: The association between smoking and radiographic damage has been established in axial spondyloarthritis and rheumatoid arthritis, but not in psoriatic arthritis (PsA). We designed…
Abstract Number: 1447 • ACR Convergence 2024
The Frequency of Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Spondyloarthritis in Comparison to Age and Sex-matched Controls and Impact of SpA on Onset Age of DISH
Ummugulsum Gazel¹, Nicole Hryciw², Baljot Chahal³, Seyyid Bilal Acikgoz⁴, Gizem Ayan⁵, Zaid Jibri³, Marcos Loreto Sampaio³ and Sibel Aydin⁶, ¹University of Ottawa, Ottawa, ON, Canada, ²University of Ottawa, Ottawa, Canada, ³University of Ottawa, Radiology, Ottawa, Canada, ⁴University of Ottawa, Rheumatology, Ottawa, ON, Canada, ⁵University of Ottawa, Rheumatology, Ankara, Turkey, ⁶University of Ottawa - Ottawa, Ottawa, ON, Canada
Background/Purpose: Although diffuse idiopathic skeletal hyperostosis (DISH) is classically defined in the thoracic spine and the elderly population, there are case reports on the overlap…
Abstract Number: 1456 • ACR Convergence 2024
Real-World Treat-to-Target Strategy in Psoriatic Arthritis: Baseline Characteristics from the MONITOR-PsA Cohort
Lija James¹, Elnaz Saeedi², Jean-Guillaume Letarouilly¹, Nicola Gullick³, Anne Francis², Deepak Jadon⁴, William Tillett⁵, Yvonne Sinomati², Laura Tucker¹, Nadia Mian², Ines Rombach², Ioana Marian², Maria Sofia Massa² and Laura Coates⁶, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Oxford Clinical Trials Research Unit, University of Oxford, Oxford, United Kingdom, ³Rheumatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, Coventry, United Kingdom, ⁴Cambridge University, Cambridge, United Kingdom, ⁵Royal National Hospital of Rheumatic Diseases; Department of Life Sciences, Centre for Therapeutic Innovation, University of Bath, Bath, United Kingdom, ⁶University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom
Background/Purpose: Psoriatic arthritis (PsA) is a chronic musculoskeletal disease, which can lead to progressive joint pain, joint destruction, and loss of function. Evidence suggests that…
Abstract Number: 1560 • ACR Convergence 2024
Changes of Cerebral Structure and Perfusion Vary in Different Subtypes of Systemic Sclerosis: A Brain Magnetic Resonance Imaging Study
Xinyu Tong¹, Huilin He², Shihan Xu², Zihan Ning¹, Rui Shen¹, Xiaofeng Zeng³, qian wang⁴, Dong Xu⁵, Xihai zhao¹ and Zuoxiang He¹, ¹Tsinghua University, Beijing, China, ²Peking Union Medical College Hospital, Beijing, China, ³Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China, ⁴Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, ⁵Peking Union Medical College Hospital, Dong Cheng District, Beijing, China
Background/Purpose: The characteristics of brain impairment in different subtypes of systemic sclerosis (SSc) (dcSSc, diffuse cutaneous SSc; lcSSc, limited cutaneous SSc) remain unclear. This study aimed to characterize cerebral structure and perfusion…
Abstract Number: L20 • ACR Convergence 2023
Telitacicept, a Human Recombinant Fusion Protein Targeting and Neutralizing B Lymphocyte Stimulator (BlyS) and a Proliferation-Inducing Ligand (APRIL), in Rheumatoid Arthritis (RA) Patients with an Inadequate Response to Methotrexate (MTX): A Randomized, Double-Blind, Phase 3 Study
Li Wang¹, Dong Xu², Jianmin Fang³, Qing Zuraw⁴ and Fengchun Zhang¹, ¹Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, Dong Cheng District, China, ³RemeGen Co, Ltd., Yantai, China, ⁴RemeGen Biosciences, Inc., San Francisco, CA
Background/Purpose: Telitacicept is a recombinant fusion protein targeting and neutralizing BLyS and APRIL. This phase 3, randomized, double-blind study evaluated the efficacy and safety of…
Abstract Number: 1401 • ACR Convergence 2023
The Association of 3VAS/4VAS and DAPSA with Radiographic Progression in Early PsA
Gonul Hazal Koc¹, Marc r. Kok², Jolanda J. Luime¹, ilja Tchetverikov³, William R Tillett⁴, Fazira R. Kasiem¹, Lindy A. Korswagen⁵, J. Bijsterbosch⁶, Yvonne P. M. Goekoop-Ruiterman⁷, Maikel van oosterhout⁸, P. Baudoin⁹, Petra Kok¹⁰, radboud J.e.m. Dolhain¹¹ and marijn vis¹, ¹Erasmus Medical Center, Rotterdam, Netherlands, ²Maasstad Hospital, Rotterdam, Netherlands, ³Albert Sweitzer Hospital, Dordrecht, Netherlands, ⁴Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁵Franciscus Gasthuis & Vlietland, Rotterdam, Netherlands, ⁶Amphia Hospital, Rotterdam, Netherlands, ⁷Haga Ziekenhuis, The Hague, Netherlands, ⁸Groene Hart Ziekenhuis, Gouda, Netherlands, ⁹Reumazorg Zuid West Nederland, Roosendaal, Netherlands, ¹⁰Reinier de Graaf Gasthuis, Delft, Netherlands, ¹¹Rheumatology, Erasmus MC, Rotterdam, Netherlands
Background/Purpose: A feasible, widely accepted, comprehensive disease activity measure is needed for daily use in psoriatic arthritis (PsA). Current measures are either complex (Psoriatic Arthritis…
Abstract Number: 1868 • ACR Convergence 2023
Long-term Efficacy of a 2-year MRI Treat-to-target Strategy on Radiographic Joint Damage Progression in Rheumatoid Arthritis Patients in Clinical Remission – Five Year Follow-up of the IMAGINE-RA Randomized Clinical Trial
Signe Møller-Bisgaard¹, Kim Hørslev-Petersen², Lykke Ørnbjerg¹, Bo Ejbjerg³, Merete L Hetland¹, Jakob Moeller⁴, Robin Christensen⁵, Sabrina Mai Nielsen⁶, Daniel Glinatsi⁷, Mikael Boesen⁸, Kristian Stengaard-Pedersen⁹, Ole Rintek Madsen¹⁰, Bente Jensen¹¹, Jan Alexander Villadsen², Ellen-Margrethe Hauge⁹, Oliver Hendricks², Hanne Merete Lindegaard¹², Niels Steen Krogh¹³, Anne Grethe Jurik⁹, Henrik Thomsen⁴ and Mikkel Østergaard¹⁴, ¹Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, ²Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, ³Slagelse Hospital, Slagelse, Denmark, ⁴Herlev-Gentofte Hospital, Herlev, Denmark, ⁵Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen, Denmark, ⁶The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ⁷Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Sweden, ⁸Copenhagen University Hospital, Bispebjerg and Frederiksberg Hospital, Naerum, Denmark, ⁹Aarhus University Hospital, Aarhus, Denmark, ¹⁰Herlev-Gentofte Hospital, Gentofte, Denmark, ¹¹Bispebjerg-Frederiksberg Hospital, Frederiksberg, Denmark, ¹²Odense Hospital, Odense, Denmark, ¹³ZiteLab ApS, Frederiksberg, Denmark, ¹⁴Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Radiographic joint damage progresses in 20-30% of rheumatoid arthritis (RA) patients despite fulfilling clinical remission criteria (1). Osteitis assessed on MRI is a well…

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