Abstracts tagged "Psoriatic arthritis"

Abstract Number: 1776 • 2019 ACR/ARP Annual Meeting
Causal Effect of TNF-α, IL-12p70, IL-17 Levels on the Risk of Psoriatic Arthritis: A Mendelian Randomization Study
Dongze WU¹, Priscilla Wong ¹, Steven H.M. Lam ¹, Isaac T. Cheng ¹, Edmund K. Li ¹, Ling Qin ¹ and Lai-Shan Tam ¹, ¹The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Biologic agents targeting cytokines including TNF-α, IL-12p70 and IL-17 have been proven to be very effective in treating psoriatic arthritis (PsA). Nonetheless, whether these…
Abstract Number: 2447 • 2019 ACR/ARP Annual Meeting
Characteristics of Psoriasis Patients with Subclinical Signs of Musculoskeletal Involvement Detected by Fluorescence Optical Imaging and Confirmed by MRI-assessment
Michaela Koehm¹, Sarah Ohrndorf ², Tanja Rossmanith ³, Hans-Eckhard Langer ⁴, Marina Backhaus ⁵, Gerd Burmester ⁶, Siegfried Wassenberg ⁷, Benjamin Köhler ⁸, Harald Burkhardt ¹ and Frank Behrens ¹, ¹Rheumatology Goethe-University Frankfurt & Fraunhofer IME-TMP, Frankfurt, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Fraunhofer IME-TMP, Frankfurt, Germany, ⁴RHIO, Düsseldorf, Germany, ⁵Park-Klinik Weissensee, Berlin, Germany, ⁶Charité—University Medicine Berlin, Berlin, Germany, ⁷Centre of Rheumatology, Ratingen, Germany, ⁸Rheumazentrum Ratingen, Ratingen, Germany
Background/Purpose: Psoriasis (Pso) is one of the most common chronic inflammatory skin diseases in Europe. Psoriatic arthritis (PsA) is closely associated to Pso whereas the…
Abstract Number: 2467 • 2019 ACR/ARP Annual Meeting
Pain and Anxiety Are Independent Factors Associated to Sleep Impairment in Psoriatic Arthritis: A Multicentric Study in 14 Countries
Penelope Palominos¹, Laura Coates ², Charles Kohem ³, Ana-Maria Orbai ⁴, Josef Smolen ⁵, Maarten de Wit ⁶, Uta Kiltz ⁷, Ying-Ying Leung ⁸, Juan Cañete ⁹, Rossana Scrivo ¹⁰, Andra Balanescu ¹¹, Emmanuelle Dernis ¹², Sandra Talli ¹³, Martin SOUBRIER ¹⁴, Sibel Zehra Aydin ¹⁵, Inna Gaydukova ¹⁶, Umut Kalyoncu ¹⁷ and Laure Gossec ¹⁸, ¹Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul,, Porto Alegra, Brazil, ²University of Oxford, Oxford, United Kingdom, ³Serviço de Reumatologia, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, Baltimore Maryland, ⁵Medical University of Vienna, Vienna, Austria, ⁶Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam University Medical Centre, Amsterdam, Netherlands, ⁷Rheumazentrum Ruhrgebiet/Ruhr University Bochum, Herne, Germany, Herne, Germany, ⁸Department of Rheumatology and Immunology, Singapore General Hospital,, Singapore, Singapore, ⁹Department of Rheumatology, Hospital Clínic, Barcelona, Barcelona, Spain, ¹⁰Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza Università di Roma,, Rome, Italy, ¹¹Sf Maria Hospital, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania, ¹²Rheumatology Department, Le Mans Central Hospital, Le Mans, France, ¹³Rheumatology Department, East-Tallinn Central Hospital, Tallinn, Estonia, ¹⁴CHU Gabriel Montpied, Clermont Ferrand, Auvergne, France, ¹⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ¹⁶North-western State medical university, St Petersburg, Russia, ¹⁷Hacettepe University Department of Rheumatology, Ankara, Turkey, ¹⁸Sorbonne Université and Hôpital Pitié-Salpêtrière, Paris, France
Background/Purpose: Sleep quality is diminished in patients with psoriatic arthritis (PsA) and close to 40% of PsA patients consider sleep impairment a priority domain.This work…
Abstract Number: 2488 • 2019 ACR/ARP Annual Meeting
MDA Versus DAPSA: Applicability in a Real World
rafaela Gonçalves¹, Lays Martins ², henrique mariz ¹, marina brito ³, georgia pereira ³, andrea dantas ³ and Angela Duarte ², ¹clinical hospital of federal university of pernambuco, recife, Pernambuco, Brazil, ²Universidade Federal de Pernambuco, Recife, Brazil, ³clinical hospital of federal university of pernambuco, recife, Brazil
Background/Purpose: Background/Purpose: Psoriatic arthritis (PsA) is a progressive, chronic, and potentially irreversible inflammatory disorder. Systematic clinical follow-up of PsA patients is necessary to maintain and…
Abstract Number: 2511 • 2019 ACR/ARP Annual Meeting
What Influences Patients’ Opinion of Remission and Low Disease Activity in Psoriatic Arthritis? Principal Component Analysis of an International Study
Laura Coates¹, Danielle Robinson ², Ana-Maria Orbai ³, Uta Kiltz ⁴, Ying-Ying Leung ⁵, Penelope Palominos ⁶, Juan Cañete ⁷, Rossana Scrivo ⁸, Andra Balanescu ⁹, Emmanuelle Dernis ¹⁰, Sandra Talli ¹¹, Adeline Ruyssen-Witrand ¹², Lihi Eder ¹³, Maarten de Wit ¹⁴, Josef Smolen ¹⁵, Ennio Lubrano ¹⁶ and Laure Gossec ¹⁷, ¹University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ³Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Rheumazentrum Ruhrgebiet/Ruhr University Bochum, Herne, Germany, Herne, Germany, ⁵Department of Rheumatology and Immunology, Singapore General Hospital,, Singapore, Singapore, ⁶Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul,, Porto Alegra, Brazil, ⁷Rheumatology Department, Hospital Clínic and IDIBAPS,, Barcelona, Spain, ⁸Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza Università di Roma,, Rome, Italy, ⁹Sf Maria Hospital, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania, ¹⁰Rheumatology Department, Le Mans Central Hospital, Le Mans, France, ¹¹Rheumatology Department, East-Tallinn Central Hospital, Tallinn, Estonia, ¹²Rheumatology Unit, Toulouse university Hospital, UMR 1027, Inserm, Université Paul Sabatier Toulouse III, Toulouse, France, ¹³Women’s College Hospital and the Department of Medicine, University of Toronto, Toronto, Canada, ¹⁴Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam University Medical Centre, Amsterdam, Netherlands, ¹⁵Medical University of Vienna, Vienna, Austria, ¹⁶15. Academic Rheumatology Unit, Dipartimento di Medicina e Scienze della Salute ’Vincenzo Tiberio’, University of Molise, Campobasso, Italy, ¹⁷Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France
Background/Purpose: In psoriatic arthritis (PsA), the objective of treatment is remission or low disease activity (LDA), but there is little research into patients’ perception of…
Abstract Number: 2880 • 2019 ACR/ARP Annual Meeting
Secukinumab Improves Axial Manifestations in Patients with Psoriatic Arthritis and Inadequate Response to NSAIDs: Primary Analysis of Phase 3 Trial
Xenofon Baraliakos¹, Laura Coates ², Laure Gossec ³, Slawomir Jeka ⁴, Antonio Mera ⁵, Barbara Schulz ⁶, Michael Rissler ⁶, Ayan Das Gupta ⁷, Chiara Perella ⁶ and Effie Pournara ⁸, ¹Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ²University of Oxford, Oxford, United Kingdom, ³Sorbonne Université and Hôpital Pitié-Salpêtrière, Paris, France, ⁴University Hospital Bydgoszcz no 2, CM UMK, Bydgoszcz, Poland, ⁵Division of Rheumatology, Instituto de Investigación Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, Santiago de Compostela, Spain, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Novartis Healthcare Pvt Ltd, Hyderabad, India, ⁸Novartis Pharma AG, Basel, Basel-Stadt, Switzerland
Background/Purpose: Secukinumab (SEC) has provided significant and sustained improvement in the signs and symptoms of active psoriatic arthritis (PsA) and ankylosing spondylitis1. Evidence is limited…
Abstract Number: 291 • 2019 ACR/ARP Annual Meeting
Factors Explaining Patient Perspective in Psoriasis and Psoriatic Arthritis: The Role of Inflammation and Structural Damage Detected by Ultrasound
Tania Gudu¹, Ilaria Padovano ¹, Hélène Gouze ², François Vidal ¹, Emmanuel Mahé ³, Leire Lara Gonzalez ⁴, Alexis Guyot ⁴, Philippe Saiag ⁴, Isabelle Bourgault Villada ⁴, Sophie Ruel-Gagné ¹, Gilles Hayem ¹, Félicie Costantino ⁵, Maxime Breban ⁶ and Maria-Antonietta D’Agostino ⁷, ¹Rheumatology Department, APHP, Ambroise Paré Hospital, Boulogne Billancourt, France, ²Rheumatology Department, APHP, Ambroise Paré Hospital, Bolougne Billancourt, France, ³Dermatology Department, Victor Dupouy Hospital, Argenteuil, France, ⁴Dermatology Department, Ambroise Paré Hospital, Boulogne Billancourt, France, ⁵UMR1173, INSERM/Versailles-Saint Quentin University, France Ambroise Paré Hospital (AP-HP) Department of Rheumatology, Boulogne-Billancourt, France, Boulogne Billancourt, France, ⁶UMR1173, INSERM/Versailles-Saint Quentin University, France Ambroise Paré Hospital (AP-HP) Department of Rheumatology, Boulogne-Billancourt, France, Boulogne Billancourt, ⁷Department of Rheumatology, APHP, Hôpital Ambroise Paré, Paris, France
Background/Purpose: Patient reported outcomes (PROs) reflect patients’ opinion on disease activity, impact of disease, quality of life (QoL), disability and are essential in the assessment…
Abstract Number: 1009 • 2019 ACR/ARP Annual Meeting
PDE4 Inhibition Could Improve Endothelial and Adipose Tissue Dysfunction Associated with Psoriatic Arthritis, Key Processes in Cardiovascular Disease
Ivan Arias de la Rosa¹, Carmen Torres-Granados ¹, Maria del Carmen Abalos-Aguilera ², Ignacio Gomez-Garcia ², Rocio Guzman-Ruiz ³, Maria del Mar Malagon ³, Carlos Perez-Sanchez ⁴, Alejandra Patiño-Trives ², Maria Luque-Tevar ², Alejandro Ibañez-Costa ², Alejandro Escudero ⁵, Eduardo Collantes-Estevez ¹, Chary Lopez-Pedrera ², Maria Dolores Lopez-Montilla ² and Nuria Barbarroja ³, ¹University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³University of Cordoba/IMIBIC/Reina Sofia Hospital and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain, ⁴Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, Cordoba, Spain, ⁵IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain
Background/Purpose: Psoriatic arthritis (PsA) is the rheumatic disease most associated with metabolic disorders, including obesity and metabolic syndrome, where inflammation is a determinant key factor,…
Abstract Number: 1211 • 2019 ACR/ARP Annual Meeting
Improving Exercise Counselling of Patients with Inflammatory Arthritis: A Quality Improvement Project
Anwar Albasri ¹, Tariq Al-Araimi ¹, Stephanie Gottheil¹, Lauren King ¹, Sahil Koppikar ², Justin Shamis ¹, Shirley Lake ³ and Gakhal Natasha ¹, ¹University of Toronto, Toronto, Canada, ²University of Toronto, Markham, ON, Canada, ³Division of Rheumatology, Sunnybrook Hospital, Toronto, ON, Canada
Background/Purpose: Regular aerobic exercise has been shown to improve inflammatory arthritis (IA) symptoms and may reduce the risk of cardiovascular events observed in these patients.…
Abstract Number: 1517 • 2019 ACR/ARP Annual Meeting
Effect of Long-Term Treatment with Secukinumab on Cardio-Metabolic Profile in Patients with Active Ankylosing Spondylitis and Psoriatic Arthritis: Pooled 3 Year Analysis
Iain McInnes¹, Dafna Gladman ², Atul Deodhar ³, Corinne Miceli-Richard ⁴, Peter Nash ⁵, Naveed Sattar ⁶, Nehal Mehta ⁷, Darren Asquith ⁸, Jianyuan Wang ⁹, Hanno Richards ⁹, Luminita Pricop ¹⁰ and Abhijit Shete ⁹, ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, ³Oregon Health & Science University, Portland, OR, ⁴Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, ⁵University of Queensland, Brisbane, Queensland, Australia, ⁶Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ⁷National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁸Novartis Pharmaceuticals UK Limited, Surrey, United Kingdom, ⁹Novartis Pharma AG, Basel, Switzerland, ¹⁰Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Systemic inflammation may influence cardio-metabolic profiles and increases the risk of CV disorders in ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients (pts)1. Treatment…
Abstract Number: 1777 • 2019 ACR/ARP Annual Meeting
The Deubiquitinase TRABID Is a Potential Therapeutic Target in Spondyloarthritis
Daniele Mauro¹, Federica Macaluso ², Alessandra Nerviani ³, Marie-Astrid Boutet ³, Aroldo Rizzo ⁴, Riccardo Alessandro ², Giuliana Guggino ², Costantino Pitzalis ³ and Francesco Ciccia ⁵, ¹Centre for Experimental Medicine & Rheumatology, Queen Mary University of London, London, England, United Kingdom, ²University of Palermo, Italy, Palermo, Italy, ³Centre for Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom, ⁴Pathology Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy., Palermo, Italy, ⁵University of Campania L. Vanvitelli, Naples, Italy
Background/Purpose: Interleukin 12 (IL-12) and 23 (IL-23) may play a pivotal role in the pathogenesis of inflammatory diseases, including Spondyloarthritis (SpA). In mice, the deubiquitinase…
Abstract Number: 2448 • 2019 ACR/ARP Annual Meeting
Factors Associated with Discordance Between Patient and Rheumatologist Assessment of Disease Activity in Psoriatic Arthritis Considered in Remission
Marie Moly¹, Cédric Lukas ², Jacques Morel ¹, Bernard Combe ³ and Gaël Mouterde ⁴, ¹CHU Montpellier, Montpellier, France, ²Rheumatology department, CHU Montpellier, Univ Montpellier, Montpellier, France, ³CHU Montpellier, Montpellier University, Montpellier, France, ⁴CHU Montpellier and Univ Montpellier, Montpellier, France
Background/Purpose: Assessment of disease activity in psoriatic arthritis (PsA) requires evaluation of multiple aspects and can be difficult. Perception of disease activity by patient and…
Abstract Number: 2468 • 2019 ACR/ARP Annual Meeting
JAK-STAT Signaling System in Pannus Formation of Psoriatic Arthritis: A Therapeutic Target
Siba Raychaudhuri¹ and Smritikana Raychaudhuri ², ¹UC Davis School of Medicine, Sacramento, CA, ²UC Davis School of Medicine, Davis, CA
Background/Purpose: Psoriatic arthritis (PsA) involves inflammation of the joint synovium where synovial cells (FLS) are the target for T cell activated cytokines for pannus formation.…
Abstract Number: 2489 • 2019 ACR/ARP Annual Meeting
Differences in Clinical Characteristics, Quality of Life, Disability, and Work Productivity in Psoriatic Arthritis Patients by Gender: Findings from a Cross-sectional Survey in the US and Europe
Laure Gossec¹, Jessica Walsh ², Kaleb Michaud ³, Steve Peterson ⁴, Elizabeth Holdsworth ⁵, Chetan Karyekar ⁴, Nicola Booth ⁶, Jessalyn Kemp ⁷, Soumya Chakravarty ⁸, Shelly Kafka ⁹ and Alexis Ogdie ¹⁰, ¹Sorbonne Université and Hôpital Pitié-Salpêtrière, Paris, France, ²Division of Rheumatology, University of Utah, Salt Lake City, UT, ³University of Nebraska Medical Center, Omaha, NE, ⁴Janssen Global Services, LLC, Horsham, PA, ⁵Adelphi Real World, Manchester, England, United Kingdom, ⁶Adelphi Real World, Bollington, United Kingdom, ⁷Adelphi Real World, Manchester, United Kingdom, ⁸Janssen Scientific Affairs, LLC; Drexel University College of Medicine, Horsham; Philadelphia, PA, ⁹Janssen Scientific Affairs, LLC, Horsham, PA, ¹⁰Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Psoriatic arthritis (PsA) prevalence is equal in men and women, though gender may play a role in driving mechanisms of PsA leading to differences…
Abstract Number: 2512 • 2019 ACR/ARP Annual Meeting
A Qualitative Study of Clinicians’ Perspectives on Barriers to Implementation of Treat to Target in Psoriatic Arthritis
Julie Taylor ¹, Laura Coates² and Emma Dures ¹, ¹Department of Nursing and Midwifery, University of the West of England, Bristol and Academic Rheumatology, University Hospitals NHS Trust, Bristol, England, United Kingdom, ²University of Oxford, Oxford, United Kingdom
Background/Purpose: European League Against Rheumatism Treatment recommendations support implementing a treat-to-target (T2T) approach in psoriatic arthritis (PsA) based on the findings of the TICOPA trial.…

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