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Abstracts tagged "Prognostic factors and rheumatoid arthritis (RA)"

  • Abstract Number: 71 • 2018 ACR/ARHP Annual Meeting

    Association of Shared Epitope and Poor Prognostic Factors in RA

    Evo Alemao1, Joshua Bryson1, Christine K Iannaccone2, Michelle Frits2, Nancy A. Shadick3 and Michael Weinblatt2, 1Bristol-Myers Squibb, Princeton, NJ, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: There is a strong genetic association between RA and human leukocyte antigen (HLA) regions, particularly HLA-DRB1 alleles with the shared epitope (SE). SE alleles…
  • Abstract Number: 1456 • 2018 ACR/ARHP Annual Meeting

    Neutrophil Activation Is Associated with Disease Activity and Predicts Development of Erosive Disease and Extra Articular Manifestations in Rheumatoid Arthritis

    Mary Bach1,2, Tiffany Pan3, J. Lee Nelson3,4 and Christian Lood5, 1VA Puget Sound Health Care System, Seattle, WA, 2Division of Rheumatology, University of Washington, Seattle, WA, 3Fred Hutchinson Cancer Research Center, Seattle, WA, 4Division of Rheumatology, University of Washington, SEATTLE, WA, 5Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil activation is associated with inflammation and autoimmunity, including rheumatoid arthritis (RA), where neutrophil infiltration into joints participates in tissue destruction and development of…
  • Abstract Number: 1480 • 2018 ACR/ARHP Annual Meeting

    Prognosis of Pneumonia in Rheumatoid Arthritis Patient: An Analysis of Using a Nationwide Administrative Database

    Eishi Uechi1,2 and Kiyohide Fushimi2, 1Division of Rheumatology, Tomishiro Central Hospital, Okinawa, Japan, 2Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

    Background/Purpose: Pneumonia is the leading cause of mortality in RA patients. No research has been conducted on the prognosis of pneumonia in RA patients. This…
  • Abstract Number: 1455 • 2017 ACR/ARHP Annual Meeting

    Investigation of Poor Prognostic Factors Among Rheumatoid Arthritis Patients in Turkbio Registry

    Nevsun Inanc1, Zeynep Erturk1, Gulsen Ozen1, Ediz Dalkilic2, Suleyman Serdar Koca3, Gerçek Can4, Ahmet Karatas5, Yavuz Pehlivan6, Ayten Yazici7, Ayse Cefle7, Servet Akar8, Soner Senel9, Burak Oz3, Nurullah Akkoc10, Haner Direskeneli1 and Fatos Onen11, 1Rheumatology, Marmara University, School of Medicine, Rheumatology, Istanbul, Turkey, 2Department of Internal Medicine, Division of Rheumatology, Uludag University, School of Medicine, Rheumatology, Bursa, Turkey, 3Rheumatology, Firat University, School of Medicine, Rheumatology, Elazig, Turkey, 4Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, 5Department of Rheumatology, Firat University, School of Medicine, Rheumatology, Elazig, Turkey, 6Rheumatology, Uludag University, School of Medicine, Rheumatology, Bursa, Turkey, 7Rheumatology, Kocaeli University, School of Medicine, Rheumatology, Kocaeli, Turkey, 8Rheumatology, Izmir Katip Celebi University, School of Medicine, Rheumatology, Izmir, Turkey, 9Rheumatology, Kayseri Erciyes University, School of Medicine, Rheumatology, Kayseri, Turkey, 10Rheumatology, Private Practice, Rheumatology, İzmir, Turkey, 11Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey

    Background/Purpose: TURKBIO is the Turkish version of Danish DANBIO rheumatologic database which has been established in 2011.In 2016,the EULAR RA management guideline recommended assessment of…
  • Abstract Number: 1468 • 2017 ACR/ARHP Annual Meeting

    Abatacept Retention Rates, Overall and By Participating Country, and Prognostic Factors of Retention in Patients with RA: 2-Year Results from a Real-World Observational Study

    Rieke Alten1, HM Lorenz2, X Mariette3, HG Nüßlein4, M Galeazzi5, F Navarro6, M Chartier7, Y Elbez8, C Rauch9 and M Le Bars7, 1Schlosspark-Klinik University Medicine, Berlin, Germany, 2University Hospital, Heidelberg, Germany, 3Université Paris-Sud, Paris, France, 4University of Erlangen, Nürnberg, Germany, 5University of Siena, Siena, Italy, 6Hospital Universitario Virgen Macarena, Seville, Spain, 7Bristol-Myers Squibb, Rueil-Malmaison, France, 8Excelya, Boulogne-Billancourt, France, 9Bristol-Myers Squibb, Munich, Germany

    Background/Purpose: ACTION (NCT02109666) was the first prospective international non-interventional study designed to provide long-term real-world data on abatacept retention in patients (pts) with RA. The…
  • Abstract Number: 2386 • 2017 ACR/ARHP Annual Meeting

    The Risk Factors of Newly Developing/Worsening Pulmonary Abnormalities in Rheumatoid Arthritis

    Ayae Tanaka1, Kazuhiro Kurasawa1, Yuta Takamura1, Tomoyuki Miyao1, Ryutaro Yamazaki2, Satoko Arai1, Takayoshi Owada1, Reika Maezawa1 and Masafumi Arima1, 1Rheumatology, Dokkyo Medical University, Mibu, Tochigi, Japan, 2Rheumatology, Dokkyo Medical University, Mibu, tochigi, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects various organs including the lung. The pulmonary involvement is critical for prognosis of the…
  • Abstract Number: 2405 • 2017 ACR/ARHP Annual Meeting

    Biological Function Integrated Prediction of Severe Radiographic Progression in Rheumatoid Arthritis: A Nested Case Control Study

    Young Bin Joo1, Yul Kim2, Youngho Park3, Kwangwoo Kim4, Jeong Ah Ryu5, Seunghun Lee6, So-Young Bang7, Hye-Soon Lee8, Gwan-Su Yi9 and Sang-Cheol Bae7, 1Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), 2Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of (South), 3Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 44Department of Biology, Kyung Hee University, Seoul, Korea, Republic of (South), 5Department of Radiology, Hanyang University Hospital, Seoul, Korea, Republic of (South), 617 Haengdang-Dong, Seongdong-G, Hanyang University Hospital, Seoul, Korea, Republic of (South), 7Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 8Hanyang University Guri Hospital, Gyeonggi-do, Korea, Republic of (South), 9Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of (South)

    Background/Purpose: Radiographic progression is reported to be highly heritable in rheumatoid arthritis (RA). However, previous study using genetic loci showed an insufficient accuracy of prediction…
  • Abstract Number: 2421 • 2017 ACR/ARHP Annual Meeting

    Aberrant Expression of CaMK4 in CD4 Positive T Cells Predicts Poor Response to Treatment in Patients with Active Rheumatoid Arthritis

    Tomohiro Koga1, Tomohito Sato1, Masataka Umeda2, Shoichi Fukui2, Ayako Nishino1, Shinya Kawashiri2, Naoki Iwamoto2, Kunihiro Ichinose2, Mami Tamai1, Tomoki Origuchi3, Hideki Nakamura2 and Atsushi Kawakami4, 1Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, 4Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease arising from a breakdown of peripheral tolerance, which leads to aberrant Th1- or Th17-driven immune…
  • Abstract Number: 2452 • 2017 ACR/ARHP Annual Meeting

    In Real-World Clinical Practice, Patients Switching from IV to SC Abatacept Maintain Clinical Efficacy after Switch

    Rieke Alten1, HM Lorenz2, X Mariette3, H Nüßlein4, M Galeazzi5, F Navarro6, M Chartier7, J Heitzmann8, C Rauch9 and M Le Bars7, 1Schlosspark-Klinik University Medicine, Berlin, Germany, 2University Hospital, Heidelberg, Germany, 3Université Paris-Sud, Paris, France, 4University of Erlangen-Nuremberg, Nuremberg, Germany, 5University of Siena, Siena, Italy, 6Hospital Universitario Virgen Macarena, Seville, Spain, 7Bristol-Myers Squibb, Rueil-Malmaison, France, 8Excelya, Boulogne-Billancourt, France, 9Bristol-Myers Squibb, Munich, Germany

    Background/Purpose: Patients (pts) with RA may be able to switch from IV to SC abatacept with no loss of efficacy or safety concerns, but data…
  • Abstract Number: 1361 • 2017 ACR/ARHP Annual Meeting

    How Often Do Rheumatologists Use Valid Prognostic Factors of Rheumatoid Arthritis? the Progresar Project

    Teresa Oton-Sanchez1, Loreto Carmona2, Sara Luján3, Ana Royo3, Jose Luis Baquero4 and Santiago Muñoz-Fernandez5, 1InMusc. Instituto de Salud Músculo-Esquelética, Madrid, Spain, 2Instituto de Salud Musculoesquelética (InMusc), Madrid, Spain, 3Medical Department Bristol-Myers Squibb, Madrid, Spain, 4Scientific Department Scientia Salus, Madrid, Spain, 5Rheumatology, Hospital Universitario Infanta Sofia. Universidad Europea, Madrid, Spain

    Background/Purpose: Prognostic factors facilitate decisions on treatment and follow-up of patients with rheumatoid arthritis (RA). Rheumatologists might use factors with poor link to evidence in…
  • Abstract Number: 1375 • 2017 ACR/ARHP Annual Meeting

    Foot Arthritis : Poor Prognosis Factor in RA

    Sung-Hae Chang1, Sung Won Lee2, Mi-Il Kang3 and Seong Yong Kim4, 1Soonchunhyang University Cheonan Hospital, Cheonan, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea, Republic of (South), 3Dankuk University Hospital, Cheonan, Korea, Republic of (South), 4Application Statistics, Hoseo University, Cheonan, Korea, Republic of (South)

    Background/Purpose: The objective of the current study is to evaluate the clinical importance of foot and ankle joint arthritis.Methods: Data from Korean Biologic Registry (KoBio)…
  • Abstract Number: 504 • 2016 ACR/ARHP Annual Meeting

    Clinical Significance of Multiple Autoantibody Specificities in Rheumatoid Arthritis: The Role of Anti-Citrullinated Alpha-Enolase and Anti-Interferon Inducible Protein 16 Antibodies

    Alessia Alunno1, Onelia Bistoni1, Federico Pratesi2, Valeria Caneparo3, Fabiana Topini1, Ilaria Puxeddu2, Marco De Andrea4, Santo Landolfo4, Paola Migliorini2 and Roberto Gerli1, 1Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 2Department of Clinical and Experimental Medicine, Clinical Immunology Unit, University of Pisa, Pisa, Italy, 3Department of Translational Medicine, Virology Unit, Novara Medical School, Novara, Italy, 4Department of Public Health and Pediatric Sciences, Viral Pathogenesis Unit, Turin Medical School, Torino, Italy

    Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) auto-antibodies (auto-Abs) represent the current gold standard for the diagnosis of rheumatoid arthritis (RA). However, growing evidence suggests that a…
  • Abstract Number: 552 • 2016 ACR/ARHP Annual Meeting

    Disability in Early Rheumatoid Arthritis, Course and Predictors  

    Therese Hansson1,2, Christina Book1,2, Lennart T.H. Jacobsson1,3 and Carl Turesson1,2, 1Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, 3Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden

    Background/Purpose: Patient reported outcome measures (PROMs), including the Health Assessment Questionnaire Disability Index (HAQ-DI), are valuable and reliable instruments for assessment of disease severity and…
  • Abstract Number: 3151 • 2016 ACR/ARHP Annual Meeting

    The Diagnostic and Predictive Value of Anti-Acetylated Peptide Antibodies in RA Patients Starting Methotrexate Treatment

    Paul Studenic1, Stephan Blüml2, Holger Bang3, Manuel Unger4, Karim Raza5, Daniel Aletaha6, Josef S. Smolen7,8 and Günter Steiner9, 1Department of Internal Medicine 3, Division of Rheumatology and Geriatric Medicine, Medical University Vienna, Vienna, Austria, 2Internal Medicine 3; Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Rsearch & Development, Orgentec Diagnostika GmbH, Mainz, Germany, 4Department of Internal Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria, 5University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, 6Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 72nd Department of Medicine, Hietzing Hospital, Vienna, Austria, 8Department of Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria, 9Internal Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria

    Background/Purpose: Anti-acetylated-peptide antibodies (AAPA) have recently been described in rheumatoid arthritis (RA) patients and may be used as a further diagnostic marker in patients with…
  • Abstract Number: 532 • 2015 ACR/ARHP Annual Meeting

    Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression: Preliminary Results

    Ozge Kockara1, Sebnem Ataman2, Merve Sibel Gungoren3, Filiz Akbiyik3 and Erdem Karabulut4, 1Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, 2Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, 3Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey, 4Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease that leads to bone erosion. Bone morphogenetic proteins (BMPs) have favourable effects in the recovery of bone…
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