ACR Meeting Abstracts

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Abstracts tagged "pregnancy"

  • Abstract Number: 1900 • 2019 ACR/ARP Annual Meeting

    Assessing Commercial Titers of anti-Ro60 and Ro52 Antibodies to Risk Stratify Surveillance of Anti-Ro/SSA Antibody Positive Pregnancies

    Kimberly Robins 1, Rohit Bhan1, Catherine Trad 1, Rebecca Cohen 1, Miao Chang 1, Benjamin Wainwright 1, Mala Masson 1, Shilpi Mehta-Lee 1, Peter Izmirly 1, Robert Clancy 1, Bettina Cuneo 2 and Jill Buyon 1, 1NYU School of Medicine, New York, 2Children's Hospital Colorado, Aurora

    Background/Purpose: Pregnancy counseling of all anti-Ro positive women includes advice regarding the development of congenital heart block (CHB), albeit the risk is only 2% for…
  • Abstract Number: 1901 • 2019 ACR/ARP Annual Meeting

    Serious Infections in Offspring Exposed in Utero to Non-TNFi Biologics and Tofacitinib

    Evelyne Vinet1, Yvan St-Pierre 1, Cristiano S. Moura 1, Jeffrey Curtis 2 and Sasha Bernatsky 3, 1McGill University Health Centre, Montreal, QC, Canada, 2University of Alabama at Birmingham, Birmingham, AL, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: During pregnancy, maternal circulating immunoglobulins G (IgG) are actively transported across the placenta through their Fc portion. Thus, TNFi and other biologics harbouring an Fc…
  • Abstract Number: 2414 • 2018 ACR/ARHP Annual Meeting

    The Global Antiphospholipid Syndrome Score in Women with Systemic Lupus Erythematosus and Adverse Pregnancy Outcomes

    Karen Schreiber1, Massimo Radin2, Irene Cecchi3, Elena Rubini4, Dario Roccatello5, Søren Jacobsen6, Maria Jose Cuadrado7 and Savino Sciascia8, 1Department of Thrombosis and Haemophilia, Guy's and St Thomas' Hospital, London, United Kingdom., London, United Kingdom, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bosco Hospital, Turin, Italy., Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6University of Copenhagen, Copenhagen, Denmark, 7Clinica Universidad de Navarra, Madrid, Spain, 8Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy

    Background/Purpose: Systemic lupus erythematosus (SLE) and antiphospholipid antibodies (aPL) are associated with pregnancy complications. Methods: 143 women ever pregnant with SLE who presented in our…
  • Abstract Number: 2421 • 2018 ACR/ARHP Annual Meeting

    Pregnancy Outcomes in Women with Rheumatic Diseases and Thrombophilia Treated in a Multidisciplinary Unit

    Isabel Añón Oñate1, Irene Notario1, Miguel Ángel Ferrer1, Lorena Pérez1, María Ramírez1 and Rafael Cáliz2, 1Rheumatology, Hospital Universitario Virgen de las Nieves, Granada, Spain, 2Hospital Universitario Virgen de las Nieves, Granada, Spain

    Background/Purpose: To evaluate the efficacy of the treatment on the pregnancy outcomes of women with Rheumatic Diseases and Thrombophilia from a Spanish cohort. Their pregnancies…
  • Abstract Number: 2426 • 2018 ACR/ARHP Annual Meeting

    Defining a Standardized Core Data Set for Pregnancy Registers in Rheumatic Diseases – an European Approach

    Yvette Meißner1, Anja Strangfeld1, Nathalie Costedoat-Chalumeau2,3, Frauke Förger4,5, Anna Moltó6, Marianne Wallenius7,8 and Rebecca Fischer-Betz9, 1Programme Area Epidemiology, German Rheumatism Research Center, Berlin, Germany, 2Université Paris-Descartes, Paris, France, 3Internal Medicine, Hopital Cochin, Paris, France, 4University of Bern, Bern, Switzerland, 5Rheumatology, Clinical Immunology and Allergology, Inselspital-University Hospital, Bern, Switzerland, 6Rheumatology B Department, Paris Descartes University, Cochin Hospital, AP-HP,Paris, Paris, France, 7Norwegian University of Science and Technology, Trondheim, Norway, 8St. Olav's University Hospital, Trondheim, Norway, 9Department of Rheumatology and Hiller Research Unit, University Hospital Duesseldorf, Duesseldorf, Germany

    Background/Purpose: Robust data on the outcomes of pregnancy and influence of drug exposure in various inflammatory rheumatic diseases (IRD) are needed. Joint analyses of data…
  • Abstract Number: 2427 • 2018 ACR/ARHP Annual Meeting

    Adequate Vaccine Response According to the Italian Schedule Among the Offspring of Women Affected By Rheumatoid Arthritis and Treated throughout Pregnancy By Certolizumab Pegol: Case Series

    Marianna Meroni1, Maria De Santis2, Elena Generali2, Angela Ceribelli3, Marta Caprioli3, Giacomo Maria Guidelli2, Natasa Isailovic2, Gaetano Maria Fara4, Carlo Selmi2 and Maurizio Cutolo5, 1Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Italy, 2Rheumatology and Clinical Immunology Unit, Humanitas Research Hospital, Rozzano (MI), Italy, 3Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano (MI), Italy, 4Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy, 5Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy

    Background/Purpose: Certolizumab pegol (CTZ) is a TNFα inhibitor indicated for the treatment of women affected by rheumatoid arthritis (RA) throughout the whole pregnancy. Some concern,…
  • Abstract Number: 2432 • 2018 ACR/ARHP Annual Meeting

    Peripartum Issues in the Inflammatory Arthritis (IA) Patient: A Survey of the Rapport (Rheumatoid Arthritis Pharmacovigilence Program and Outcomes Research in New Therapies) Registry

    Tharindri Dissanayake1, Stephanie Keeling2 and Walter P. Maksymowych3, 1Department of Medicine, University of Alberta, Division of Rheumatology, Edmonton, AB, Canada, 2Department of Medicine, University of Alberta, University of Alberta, Edmonton, AB, Canada, 3CaRE Arthritis, Edmonton, AB, Canada

    Background/Purpose: Multiple issues surround the peripartum period for IA patients including medication use, risk of disease flare and potential impact on neonatal outcomes. We aimed…
  • Abstract Number: 2438 • 2018 ACR/ARHP Annual Meeting

    Risk and Severity of Adverse Pregnancy Outcomes in Women with Systemic Sclerosis in Taiwan

    Chen I Hsieh1, Shue Fen Luo2 and Chang-Fu Kuo3, 1Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 2Chang Gung University, Taoyuan County, Taiwan, 3Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Background/Purpose: Patients with different autoimmune rheumatic diseases are subject to different pregnancy outcomes because of deviant immunity. Systemic sclerosis is known to be associated with…
  • Abstract Number: 2850 • 2018 ACR/ARHP Annual Meeting

    Human Toll-like Receptor 8 Adversely Affects Placental Development and Pregnancy Outcomes in a Mouse Model of Systemic Lupus Erythematosus

    Naomi I. Maria1, Shani Martinez1 and Anne Davidson2, 1Center for Autoimmunnity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY, 2Center for Autoimmunity, Musculoskeletal & Hematopoietic Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Systemic Lupus Erythematosus (SLE) predominantly affects women of childbearing age and is associated with adverse pregnancy outcomes including pre-eclampsia, intrauterine fetal growth restriction (IUGR),…
  • Abstract Number: 286 • 2018 ACR/ARHP Annual Meeting

    The Prevalence and Treatment Patterns of Women of Childbearing Age with Rheumatic Diseases

    Edward Lee1, Robert Suruki2, Brian Carpenter3, Ty Harkness3, Daniel Luk4 and Mohamed Yassine1, 1UCB Pharma, Smyrna, GA, 2UCB Pharma, Raleigh, NC, 3Charles River Associates, New York, NY, 4Charles River Associates, Boston, MA

    Background/Purpose: Emerging data on exposure of infants to therapeutics through placental transfer and breastmilk could impact the management of women of childbearing age (WoCBA) with…
  • Abstract Number: 5 • 2017 ACR/ARHP Annual Meeting

    Clinical Utility of the Global Antiphospholipid Syndrome Score (GAPSS) for Risk Stratification: A Pooled Analysisfrom 2273 Patients

    Savino Sciascia1, Massimo Radin2, Giovanni Sanna3, Irene Cecchi4, Dario Roccatello5 and Maria Laura Bertolaccini6, 1Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, 2Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 3Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, London, United Kingdom, 4Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 5Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, 6Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, United Kingdom, London, United Kingdom

    Background/Purpose: Recently, our group conceived a risk score for clinical manifestations of APS [the global APS score or GAPSS] that takes into account the combination…
  • Abstract Number: 1295 • 2017 ACR/ARHP Annual Meeting

    Pregnancy Outcome in Patients with SLE Compared to Patients with Other Inflammatory Rheumatic Diseases: Real World Data from a Prospective Pregnancy Register

    Rebecca Fischer-Betz1, Christina Bungartz2, Matthias Schneider1, Jutta Richter1, Anja Weiss2, Angela Zink3 and Anja Strangfeld4, 1Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany, 4Epidemiology, German Rheumatism Research Center, Berlin, Germany

    Background/Purpose: SLE pregnancies are complicated due to risk for maternal disease exacerbation and potential for fetal and neonatal complications. With careful pre-pregnancy counseling and monitoring…
  • Abstract Number: 1299 • 2017 ACR/ARHP Annual Meeting

    Patient-Reported Disease Activity and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus and Rheumatoid Arthritis

    Nathaniel Harris1, Amanda M. Eudy2 and Megan E. B. Clowse2, 1Duke University School of Medicine, Durham, NC, 2Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC

    Background/Purpose: Patient-reported measures of disease activity may provide useful adjuncts to physician-reported measures in identifying pregnancies at greater risk for adverse pregnancy outcomes. Little is…
  • Abstract Number: 1309 • 2017 ACR/ARHP Annual Meeting

    Characteristics and Outcomes of Prospectively Reported Pregnancies Exposed to Certolizumab Pegol from a Safety Database

    Megan E. B. Clowse1, Angela E. Scheuerle2, Christina D Chambers3, Anita Afzali4, Alexa Kimball5, John J. Cush6, Maureen Cooney7, Laura Shaughnessy7, Mark Vanderkelen8 and Frauke Förger9, 1Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC, 2UT Southwestern Medical Center, Dallas, TX, 3UC San Diego School of Medicine, San Diego, CA, 4University of Washington Harborview Medical Center, Seattle, WA, 5Beth Israel Deaconess Medical Center, Boston, MA, 6Baylor Scott & White Research Institute, Dallas, TX, 7UCB Pharma, Raleigh, NC, 8UCB Pharma, Braine-l’Alleud, Belgium, 9Inselspital, University of Bern, Bern, Switzerland

    Background/Purpose: Anti-tumor necrosis factor medications (anti-TNFs) are effective in controlling chronic inflammatory diseases, but information about their use and safety in pregnancy is limited. Consequently,…
  • Abstract Number: 1812 • 2017 ACR/ARHP Annual Meeting

    Preeclampsia and Incident Cardiovascular Disease in SLE Pregnancy

    Julia F Simard1, Marios Rossides2, Elizabeth V. Arkema3, Elisabet Svenungsson4, Anna-Karin Wikstrom5, Murray Mittleman6 and Jane E. Salmon7, 1Division of Epidemiology, Health Research and Policy Department, Stanford School of Medicine, Stanford, CA, 2Medicine Solna, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden, 3Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 4Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 5Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, 6Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, 7Medicine/Rheumatology, Hospital of Special Surgery, New York, NY

    Background/Purpose: Pre-pregnancy cardiovascular health has been associated with preeclampsia during pregnancy, as well as future cardiovascular disease (CVD). Preeclampsia is related to endothelial dysfunction, hypertension,…
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