ACR Meeting Abstracts

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Abstracts tagged "Pediatric rheumatology"

  • Abstract Number: 2202 • ACR Convergence 2024

    Evolving Phenotypic and Genotypic Spectrum of Human ISG15 and USP18 Deficiencies

    Alhanouf Alsaleem1, Wafaa Abdulghaffar2, Lujain Akbar3, Meshal Alhassan4, Fatimah Alkhars5 and Sulaiman Al-Mayouf6, 1KFSH&RC, Riyadh, Saudi Arabia, 2KFSHRC, RIYADH, RIYADH, 3RIYADH, RIYADH, Saudi Arabia, 4Imam Abdulrahman Bin Faisal University, DAMMAM, 5Maternity and children hospital, ALHASSA, 6KFSHRRC, Riyadh, Saudi Arabia

    Background/Purpose: Loss of negative regulator in ISG15 and USP18 results in recently described immunodysregulatory disorders with diversity of clinical characteristics related to enhanced IFN-a/b immunity.…
  • Abstract Number: 2574 • ACR Convergence 2024

    Tear Biomarkers for Monitoring Disease Activity and Progression of Noninfectious Chronic Anterior Uveitis in Children

    Mariia Pavlenko1, Ilaria Maccora2, Mekibib Altaye3, hermine brunner4, Alexandra Duell3, Megan Quinlan-Waters3, Alyssa Sproles1, Sherry Thornton5, Virginia Miraldi Utz3 and sheila Angeles-Han6, 1Division of Rheumatology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, 2?PhD student, in the Area of Drugs and Innovative Treatments, NeuroFARBA Department, University of Florence. Meyer Children's Hospital, Florence Italy, Firenze, Florence, Italy, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 5Cincinnati Children's Hospital, Cincinnati, 6Cincinnati Children's Hospital, Cincinnati, OH

    Background/Purpose: Childhood chronic anterior uveitis (CAU) can be idiopathic (iCAU) or associated with Juvenile Idiopathic Arthritis (JIA-U). Ocular complications occur in 50% of affected children. …
  • Abstract Number: 0392 • ACR Convergence 2024

    Evaluation for the Presence of Antibodies to Malondialdehyde-Acetaldehyde Adduct in Juvenile Idiopathic Arthritis and Its Subtypes

    Geoffrey Thiele1, Panteha Hayati Rezvan2, Michal Cidon2, Carlos Hunter3, Michael Duryee3, Ted Mikuls3 and Geoffrey Thiele3, 1Children's Hospital of Los Angeles, Omaha, NE, 2Children's Hospital of Los Angeles, Los Angeles, CA, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Studies of rheumatoid arthritis (RA) have shown that malondialdehyde-acetaldehyde (MAA) protein adducts and anti-MAA immune responses play a pathogenic role in disease progression. Expression of…
  • Abstract Number: 0700 • ACR Convergence 2024

    Prospective Evaluation of Capillaroscopy in Healthy Children

    Tessa Dufour1, Maurizio Cutolo2, Dieneke Schonenberg-Meinema3, Kaat Wyckstandt4, Adela Sarbu5, joke dehoorne6, Steven Wallaert7 and vanessa smith8, 1University Hospital Ghent, Gent, Belgium, 2Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genova, Italy, 3Amsterdam University Medical Center, Amsterdam, Netherlands, 4University Hospital Ghent, Ghent, Belgium, 5University hospital Bern, Bern, Switzerland, 6University Hospital Ghent, Ghent, 7Ghent University, Ghent, Belgium, 8Ghent University Hospital, Gent, Belgium

    Background/Purpose: Capillaroscopy is a well-established tool in the diagnosis of adult-onset rheumatic diseases and global consensus on standardisation of execution and interpretation performing capillaroscopy  have…
  • Abstract Number: 1261 • ACR Convergence 2024

    Association of Muscle Biopsies and Functional Recovery Trajectories in Children with Juvenile Dermatomyositis

    Shannon O'Connor1, Ilaria Maccora2, Megan Quinlan-Waters1, hermine brunner3, sheila Angeles-Han4, grant schulert1 and leah kottyan1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2?PhD student, in the Area of Drugs and Innovative Treatments, NeuroFARBA Department, University of Florence. Meyer Children's Hospital, Florence Italy, Firenze, Florence, Italy, 3Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 4Cincinnati Children's Hospital, Cincinnati, OH

    Background/Purpose: Juvenile dermatomyositis (JDM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness, a distinct rash, and an increased risk of calcinosis, with long-term…
  • Abstract Number: 1278 • ACR Convergence 2024

    The Effects of Fatigue on Self-Reported Mental and Physical Health in Childhood-Onset Systemic Lupus Erythematosus: A Cross-Sectional Study

    Hunter Hogarth1, Jida Jaffan1, Tala El Tal2, Oscar Mwizerwa1, Asha Jeyanathan1, Ibrahim Mohamed3, Lawrence Ng4, Paris Moaf5, Joanna Law5, Louise Boulard6, Ashley Danguecan7, Adrienne Davis8, Linda Hiraki4, Deborah Levy4 and Andrea Knight9, 1The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, Toronto, ON, Canada, 2The Hospital For Sick Children & Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 3The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada, 5The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 6Neurosciences and Mental Health Program, SickKids Research Institute; The Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 7The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 8Division of Pediatric Emergency Medicine, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 9Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Fatigue is a prevalent and distressing symptom in childhood-onset systemic lupus erythematosus (cSLE), affecting up to 74% of patients with potential for adverse effects…
  • Abstract Number: 1764 • ACR Convergence 2024

    Reduction in Circulating Neutrophil Extracellular Traps and Restored Degradation Post-treatment in Pediatric Lupus

    Tatiana Borja1, Bharati Matta2, Lydia Thomas3, Jenna Battaglia4, Amanda Huang5, Kim Simpfendorfer6, Hongxiu Wen5, Joyce Hui-Yuen7, Boris Reizis8, Sohei Makita8 and Betsy Barnes5, 1Northwell- Cohen Children's Medical Center, Elmhurst, NY, 2The Feinstein Institutes for Medical Research, Manhasset, NY, 3Northwell Health - Cohen Children's Medical Center, Lake Success, NY, 4Feinstein Institutes for Medical Science, Manhasset, 5Feinstein Institutes for Medical Science, Manhasset, NY, 6Feinstein Institutes for Medical Research, Manhasset, NY, 7Northwell Health, Cohen Children's Medical Center, Great Neck, NY, 8New York University Grossman School of Medicine, New York, NY

    Background/Purpose: Pediatric lupus (pSLE) is a multisystemic, chronic, autoimmune disease in which over 50% of pSLE patients develop lupus nephritis (pLN). Neutrophil extracellular traps (NETs)…
  • Abstract Number: 1853 • ACR Convergence 2024

    Mutated Nod2 Enhances Pathogenic Th17 Responses That Promote Experimental Blau Syndrome

    Leah Huey1, Emily Vance1, Kofi Asare-Konadu2 and Ruth Napier3, 1Oregon Health & Science University, Portland, OR, 2Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 3Department of Molecular Microbiology and Immunology and Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, VA Portland Health Care System, Portland, OR

    Background/Purpose: Blau syndrome, a pediatric rheumatological disease characterized by uveitis, arthritis, and dermatitis, is caused by a single point mutation in the gene NOD2. Nod2…
  • Abstract Number: 2181 • ACR Convergence 2024

    Large Pediatric Cohort with ANCA-associated Vasculitis at a Single Institution: Patient Characteristics, Clinical Course, and Outcomes

    Jessica Bloom1, Anna Monley2, Sarah Reingold3, Robert Fuhlbrigge1 and Peter Merkel4, 1University of Colorado, Denver, CO, 2University of Colorado, Aurora, CO, 3Denver Health, Denver, CO, 4University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is an understudied, chronic inflammatory disease in children with significant morbidity and mortality. There are few large pediatric cohorts…
  • Abstract Number: 2203 • ACR Convergence 2024

    The Association of Autoantibodies with Clinical Manifestations and Long-term Outcomes in Juvenile- and Adult-onset Systemic Sclerosis

    Hideaki Tsuji1, Ryosuke Hiwa1, Mirei Shirakashi2, Shuji Akizuki3, Ran Nakashima1, Akira Onishi4, Hajime Yoshifuji1, Masao Tanaka4 and Akio Morinobu5, 1Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, 3Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto City, Japan, 4Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan, 5Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Kyoto, Japan

    Background/Purpose: Our aim is to explore whether clinical features and long-term outcomes depend on autoantibodies in juvenile- and adult-onset systemic sclerosis (SSc), since they were…
  • Abstract Number: 2602 • ACR Convergence 2024

    Genetics of Sex Dimorphism in Clinical Manifestations of Systemic Lupus Erythematosus

    Caseng Zhang1, Nicholas Gold2, Raffaella Carlomagno3, JingJing Cao4, Daniela Dominguez4, Dafna Gladman5, Mariko Ishimori6, Caroline Jefferies7, Diane Kamen8, Sylvia Kamphuis9, Marisa Klein-Gitelman10, Andrea Knight11, Chia-Chi Lee12, Deborah Levy2, Lawrence Ng2, Karen Onel13, Andrew Paterson4, Christine Peschken14, Janet Pope15, Earl Silverman16, Zahi Touma17, Murray Urowitz18, Daniel Wallace19, Joan Wither20 and Linda Hiraki2, 1University of Ottawa, Ottawa, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3Lausanne University Hospital, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, Canada, 5University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Cedars-Sinai Health System, Los Angeles, CA, 7Cedars-Sinai Medical Center, Beverly Hills, CA, 8Medical University of South Carolina, Charleston, SC, 9Erasmus University Medical Center, Rotterdam, Netherlands, 10Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 11Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 12Cedars-Sinai Medical Center, Los Angeles, CA, 13HSS, New York, NY, 14University of Manitoba, Winnipeg, MB, Canada, 15University of Western Ontario, London, ON, Canada, 16Silverman, Toronto, ON, Canada, 17University of Toronto, Toronto, ON, Canada, 18Self employed, Toronto, ON, Canada, 19Cedars Sinai Medical Center, Studio City, CA, 20University Health Network, Toronto, ON, Canada

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex chronic autoimmune disease with multi-organ involvement and a strong female predominance. Prior studies demonstrated sex dimorphism in…
  • Abstract Number: 0393 • ACR Convergence 2024

    Effectiveness of Secukinumab in TMJ Symptoms in Children with JPsA and ERA: A Secondary Data Analysis of JUNIPERA

    Marianne Kerski1, Smriti Mohan1, Cynthia Vizcaya2, Reema Sutariya3, Weibin Bao3 and Matthew Stoll4, 1University of Michigan, Ann Arbor, MI, 2Novartis Pharmaceutical Corporation, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Early recognition and treatment of temporomandibular joint (TMJ) arthritis in children with juvenile idiopathic arthritis (JIA) is of high importance given its impact on…
  • Abstract Number: 0829 • ACR Convergence 2024

    Epstein-Barr Virus Infection Triggers Hyperinflammation and Cytokine Storm in Healthy Children

    Kailey Brodeur1, Meng Liu2, Rachel Weng2, Evan Hsu2, Lauren Henderson3, Fatma Dedeoglu2, Jane Newburger3, Peter Nigrovic4, Mary Beth Son4 and Pui Lee5, 1Boston Children's Hospital, Cumberland, RI, 2Boston Children's Hospital, Boston, MA, 3Boston Children's Hospital, Watertown, MA, 4Boston Children's Hospital, Brookline, MA, 5Boston Children's Hospital, Newton, MA

    Background/Purpose: Epstein-Barr virus (EBV) is common pathogen responsible for infectious mononucleosis but also triggers hemophagocytic lymphohistiocytosis (HLH). This variation in the immune response to EBV…
  • Abstract Number: 1262 • ACR Convergence 2024

    The Relationship Between Child Opportunity Index and Burden of Pediatric Systemic Lupus Erythematosus

    Ayah Eltoum1, Livie Timmerman2, Melissa Mannion1 and Emily Smitherman1, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Gardendale, AL

    Background/Purpose: Outcomes for systemic lupus erythematosus are known to be associated with sociodemographic indicators. The Child Opportunity Index (COI) is a well-validated measure of neighborhood…
  • Abstract Number: 1279 • ACR Convergence 2024

    Cerebrovascular Accidents in Pediatric and Adult Systemic Lupus Erythematosus: A Comparison of Epidemiology and Outcomes

    Ekemini Ogbu1, Jareen Meinzen-Derr2, Michael Wagner2, Rashmi Sahay2, Dhriti Sharma2, J Michael Taylor2, Sudhakar Vadivelu3, Mekibib Altaye2 and hermine brunner1, 1Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3University of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: Cerebrovascular accidents (CVA) are one of the most devastating neurologic manifestations of childhood-onset systemic lupus erythematosus (cSLE).  The spectrum of CVA in cSLE (CVAcSLE)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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