ACR Meeting Abstracts

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Abstracts tagged "Pediatric rheumatology"

  • Abstract Number: 1766 • ACR Convergence 2024

    STAT2-Associated Type I Interferonopathy: A Masquerade of Infectious Susceptibility

    Conor Gruber1, Angelica Lee2, Sofija Buta2, Marta Martin Fernandez2, Veronique Houdouin3, Jean-Laurent Casanova4, Alice Hadchouel5, Jacinta Bustamante5 and Dusan Bogunovic2, 1Mount Sinai Hospital, New York, NY, 2Columbia University, New York, NY, 3Robert Debré Hospital, Paris, France, 4Rockefeller University, New York, NY, 5Hôpital Necker-Enfants Malades, Paris, France

    Background/Purpose: Type I IFN (IFN-I) signaling is a potent inflammatory pathway fundamental to antiviral immunity. In humans, loss of IFN-I activity underlies severe viral disease,…
  • Abstract Number: 1925 • ACR Convergence 2024

    Use of Geocoded Social Deprivation Indices to Understand Health Disparities in Pediatric Rheumatology

    William Soulsby and Emily Von Scheven, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Social determinants of health (SDoH) may impact health outcomes via neighborhood-level factors, such as access to medical care and neighborhood safety. Therefore, geocoded measures…
  • Abstract Number: 2187 • ACR Convergence 2024

    Outcomes Following Tonsillectomy in Children with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome

    Kalpana Manthiram1, Ana Ortega-Villa2, Sivia Lapidus3, Mary Bowes2, Tina Romeo4, Kathryn Garguilo5, Laura Failla2, Hemalatha Srinivasalu6, Pamela Mudd7, Roberta DeBiasi8, Amanda Ombrello9, Karyl Barron10, Daniel Kastner11 and Kathryn Edwards5, 1National Institute of Allergy and Infectious Disease, Bethesda, MD, 2National Institute of Allergy and Infectious Diseases, Bethesda, MD, 3Hackensack University Medical Center, Montclair, NJ, 4NIH, Bethesda, MD, 5Vanderbilt University School of Medicine, Nashville, TN, 6Children's National Hospital, Washington, DC, 7Children's National Hospital, Washington, 8Children's National Hospital and Research Institute, Washington, DC, 9National Institutes of Health, Rockville, MD, 10NIAID, NIH, Bethesda, MD, 11National Human Genome Research Institute, Bethesda, MD

    Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. Tonsillectomy leads to cessation of…
  • Abstract Number: 2205 • ACR Convergence 2024

    Presence of Nailfold Capillary Changes Correlates with More Severe Organ Involvement in Juvenile Systemic Scleroderma. Results of the Juvenile Scleroderma Inception Cohort

    Ivan Foeldvari1, Jens Klotsche2, Kathryn Torok3, Ozgur Kasapcopur4, Amra Adrovic5, Brian Feldman6, Jordi Anton7, Sindhu R. Johnson8, Flavio Sztajnbok9, Maria Teresa Terreri10, Ana Sakamoto11, Valda Stanevica12, Dieneke Schonenberg-Meinema13, Ekaterina Alexeeva14, Maria Katsicas15, Raju Khubchandani16, Sujata Sawhney17, vanessa smith18, Eslam Al-Abadi19, Simone Appenzeller20, Tadey Avcin21, Mikhail Kostik22, Thomas Lehman23, Hana Malcova24, edoardo marrani25, Clare Pain26, Anjali Patwardhan27, Walter Alberto Sifuentes-Giraldo28, Natalia Vasquez-Canizares29, Sima Abu Alsaoud30, Patricia Costa Reis31, Mahesh Janarthanan32, Dana Nemcova33, Maria Jose Santos34 and Nicola Helmus35, 1Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Division of Rheumatology, Scleroderma Center, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, 4Istanbul University-Cerrahpasa, Cerrahpasa Medical School, istanbul, Turkey, 5Cerrahpasa Medical School, Istanbul, Turkey, 6Division of Rheumatology, The Hospital for Sick Children; Departments of Pediatrics and Medicine, Faculty of Medicine; The Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 7Hospital Sant Joan de Déu. Universitat de Barcelona, Esplugues de Llobregat (Barcelona), Spain, 8University of Toronto, Toronto, Canada, 9UFRJ/UERJ, SAO PAULO, Brazil, 10UNIFESP, São Paulo, SP, Brazil, 11Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil, 12Childrens Clinical University Hospital, Zemgales priekšpilseta, Riga, Latvia, 13Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 14National Medical Research Center of Children's Health, Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia, 15Hospital Garrahan, Buenos Aires, Argentina, 16SRCC Childrens Hospital, Mumbai, India, 17Sir Ganga Ram Hospital, Sector 37 noida, Uttar Pradesh, India, 18Ghent University Hospital, Gent, Belgium, 19Birmingham Women’s and Children’s Hospital NHSFT, Birmingham, United Kingdom, 20Unicamp, Campinas, SP, Brazil, 21University Children's Hospital University Medical Center Ljubljana, Ljubljana, Slovenia, 22Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 23Hospital for Special Surgery, New York, NY, 24Motol University Hospital, Prague, Czech Republic, 25Dipartimento Neurofarba, Università di Firenze, Firenze, Italy, 26Alderhey Children's NHS Foundation Trust, Liverpool, United Kingdom, 27University of Missouri-Columbia, Department of Child Health, 404 N Keene Street, Columbia MO 65210, Columbia, 28Hospital Universitario Ramon y Cajal, Madrid, Spain, 29Children’s Hospital at Montefiore, Bronx, NY, 30Caritas baby Hospital, East Jerusalem, Israel, 31Hospital de Santa Maria, Lisbon, Portugal, 32SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH, Chennai, Tamil Nadu, India, 33MD, Prague, Czech Republic, 34Hospital Garcia de Orta and Centro Académico de Medicina de Lisboa, Lisboa, Portugal, 35Hamburg Centre for Pediatric and Adolescence Rheumatology, Hamburg, Germany

    Background/Purpose: Juvenile systemic scleroderma (jSSc) is an orphan disease with a prevalence in 3 in 1 000 000 children. Positive nailfold capillaroscopy (NF+) finding correlate with more…
  • Abstract Number: 2622 • ACR Convergence 2024

    Quality of Care for Childhood-Onset Lupus Nephritis: Suboptimal Completion of Disease Activity Monitoring

    Emily Smitherman1, Justin Leach1, Aimee Hersh2, Melissa Mannion1, Jinoos Yazdany3 and Jeffrey Curtis4, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Utah, Salt Lake City, UT, 3UCSF, San Francisco, CA, 4University of Alabama at Birmingham, Hoover, AL

    Background/Purpose: Poorly controlled childhood-onset lupus nephritis (cLN) can lead to end-stage kidney disease (ESKD), requiring kidney replacement therapies with substantial financial and quality of life…
  • Abstract Number: 0183 • ACR Convergence 2024

    Sensitivity of 2019 EULAR/ACR SLE Criteria and Initial Organ Manifestations for Black and Hispanic Children with Juvenile Systemic Lupus Erythematosus (jSLE) at a Large Tertiary Care Center

    Michelle Butts1, Emily Beil1, Danielle Guffey2, Andrea Ramirez1, Cagri Yildirim-Toruner3, Erin Peckham-Gregory1 and Marietta De Guzman1, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine, Houston, 3Baylor College of Medicine/ Texas Children's Hospital, Houston, TX

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disorder with diverse features, posing classification challenges. In 2019, EULAR and ACR developed new classification criteria to…
  • Abstract Number: 0396 • ACR Convergence 2024

    Inflammatory Markers of Autoimmune Uveitis in the Eye, Tears and Blood

    Maryrose Hahn1, Madison Mangin2, Kellen Winden3, Pui Lee4, Mindy Lo2, Bharti Nihalani-Gangwani2, Yasmin Massoudi5, Tate Valerio5, Amanda Colombo5, Jessica Scott6, Stephen Anesi6, C. Stephen Foster6, Peter Nigrovic7, sheila Angeles-Han8, Peter Chang6 and Margaret Chang2, 1Boston Children's Hospital, Georgetown, MA, 2Boston Children's Hospital, Boston, MA, 3Boston Children's Hospital, Boston, MA, 4Boston Children's Hospital, Newton, MA, 5Massachusetts Eye Research and Surgery Institution, Waltham, MA, 6Massachusetts Eye Research and Surgery Institution, Waltham, 7Boston Children's Hospital, Brookline, MA, 8Cincinnati Children's Hospital, Cincinnati, OH

    Background/Purpose: Autoimmune uveitis is an inflammatory disorder of the eye that is associated with significant morbidity, including vision-threatening complications and chronic reliance on immunosuppressive therapies.…
  • Abstract Number: 0831 • ACR Convergence 2024

    JDM Proteomic Signature at Disease Onset and Progression Highlights Persistent Dysregulation of Cell Death, Redox and Innate Immune Signaling

    Jessica Neely1, Jeff Dvergsten2, Zilan Zheng1, Chioma Madubata3, Hanna Kim4, Sara Sabbagh5, Sophia Matossian6, Christine Goudsmit6, Celine Berthier6 and Jessica Turnier7, and for the CARRA Registry Investigators and Translational Medicine for Juvenile Myositis Working Group, 1UCSF, San Francisco, CA, 2Duke University Hospital, Hillsborough, NC, 3University of California, San Francisco, San Francisco, CA, 4National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 5Medical College of Wisconsin, Milwaukee, WI, 6University of Michigan, Ann Arbor, MI, 7University of Michigan, Saline, MI

    Background/Purpose: Juvenile dermatomyositis (JDM) patients frequently have incomplete response to therapy. We utilized exploratory proteomics to advance understanding of dysregulated proteins and biological pathways that…
  • Abstract Number: 1264 • ACR Convergence 2024

    Improving Mental Health Care for Youth with Juvenile Dermatomyositis Through Integration of Mental Health Screening into Pediatric Rheumatology Clinic

    Emily Datyner, Lisa Buckley, Brittany Nelson and Alaina Davis, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN

    Background/Purpose: The negative impact of juvenile dermatomyositis (JDM) on emotional health is well-recognized. Barriers to appropriate mental health treatment include limited availability of providers and…
  • Abstract Number: 1282 • ACR Convergence 2024

    Investigating the Genetics of Depression and Anxiety in Children and Adolescents with and Without Systemic Lupus Erythematosus

    Indrani Das1, Nicholas Gold2, Christie Burton1, Jennifer Crosbie1, JingJing Cao1, Daniela Dominguez1, Sefi Kronenberg3, Lawrence Ng2, Alene Toulany1, Hiu-Ki Rachel Tran1, Gwyneth Zai4, Andrea Knight5 and Linda Hiraki2, 1The Hospital for Sick Children, Toronto, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3Holland-Bloorview Kids Rehabilitation Hospital., Toronto, Canada, 4Centre for Addiction and Mental Health, Toronto, Canada, 5Division of Rheumatology, The Hospital for Sick Children; Neurosciences and Mental Health, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with childhood-onset systemic lupus erythematosus (cSLE) have a higher prevalence of depression and anxiety compared to healthy peers. Patients with cSLE also have…
  • Abstract Number: 1767 • ACR Convergence 2024

    Endothelial Cell-Driven JAG/NOTCH Signaling in Localized Scleroderma Patients

    Theresa Hutchins1, Anwesha Sanyal1, Deren Esencan1 and Kathryn Torok2, 1University of Pittsburgh, Pittsburgh, PA, 2Division of Rheumatology, Scleroderma Center, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA

    Background/Purpose: Localized scleroderma is a rare autoimmune disease primarily affecting the skin and underlying tissue. While its exact pathogenesis remains unclear, studies suggest links to…
  • Abstract Number: 1926 • ACR Convergence 2024

    Race/ethnicity Is Associated with Disease Severity in Pediatric Patients with ANCA-associated Vasculitis Hospitalized in the United States

    Rob Valdovinos1, William Soulsby2 and Emily von Scheven2, 1UCSF Benioff Children's Hospital, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA

    Background/Purpose: Race and ethnicity are societal constructs that contribute to health disparities. Small studies have found that Hispanic patients with ANCA-associated vasculitis (AAV) are more…
  • Abstract Number: 2188 • ACR Convergence 2024

    Parent Verses Patient Perspectives of Health-Related Quality of Life Among Children with Vasculitis

    Clare Peckenpaugh1, Aimee Hersh2, Sara Stern2, Erin Treemarcki2, Peter Merkel3 and Karen James2, 1University of Utah Department of Pediatrics, Salt Lake City, UT, 2University of Utah, Salt Lake City, UT, 3University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Vasculitis is a group of chronic, relapsing diseases that can lead to significant morbidity due to both disease and treatment, impacting patients’ health related…
  • Abstract Number: 2206 • ACR Convergence 2024

    There Is No Difference in Major Organ Involvement Andantibody Pattern Between Diffuse and Limited Subtypejuvenile Onsetsystemic Scleroderma Patients

    Ivan Foeldvari1, Jens Klotsche2, Kathryn Torok3, Ozgur Kasapcopur4, Amra Adrovic5, Brian Feldman6, Flavio Sztajnbok7, Jordi Anton8, Sindhu R. Johnson9, Maria Teresa Terreri10, Ana Sakamoto11, Raju Khubchandani12, Valda Stanevica13, Gülcan Özomay Baykal14, Dieneke Schonenberg-Meinema15, Eslam Al-Abadi16, Ekaterina Alexeeva17, Maria Katsicas18, Sujata Sawhney19, vanessa smith20, Simone Appenzeller21, Tadey Avcin22, Mikhail Kostik23, Thomas Lehman24, Suzanne Li25, Hana Malcova26, edoardo marrani27, Clare Pain28, Anjali Patwardhan29, Walter Alberto Sifuentes-Giraldo30, Natalia Vasquez-Canizares31, Sima Abu Alsaoud32, Patricia Costa Reis33, Hajek, Stefanie Hajek, Stefanie34, Mahesh Janarthanan35, Dana Nemcova36, Siri Opsahl Hetlevik37, Maria Jose Santos38, Cristina Battagliotti39, Lillemor Berntson40, blanca e r bica41, Jürgen Brunner42, Liora Harel43, Gerd Horneff44, Daniela Kaiser45, Dragana Lazarevic46, Farzana Nuruzzaman47, Mihaela Sparchez48 and Nicola Helmus1, 1Hamburg Centre for Pediatric and Adolescence Rheumatology, Hamburg, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Division of Rheumatology, Scleroderma Center, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, 4Istanbul University-Cerrahpasa, Cerrahpasa Medical School, istanbul, Turkey, 5Cerrahpasa Medical School, Istanbul, Turkey, 6Division of Rheumatology, The Hospital for Sick Children; Departments of Pediatrics and Medicine, Faculty of Medicine; The Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 7UFRJ/UERJ, SAO PAULO, Brazil, 8Hospital Sant Joan de Déu. Universitat de Barcelona, Esplugues de Llobregat (Barcelona), Spain, 9University of Toronto, Toronto, Canada, 10UNIFESP, São Paulo, SP, Brazil, 11Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil, 12SRCC Childrens Hospital, Mumbai, India, 13Childrens Clinical University Hospital, Zemgales priekšpilseta, Riga, Latvia, 14Umraniye Training and Research Hospital, Istanbul, Turkey, 15Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 16Birmingham Women’s and Children’s Hospital NHSFT, Birmingham, United Kingdom, 17National Medical Research Center of Children's Health, Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia, 18Hospital Garrahan, Buenos Aires, Argentina, 19Sir Ganga Ram Hospital, Sector 37 noida, Uttar Pradesh, India, 20Ghent University Hospital, Gent, Belgium, 21Unicamp, Campinas, SP, Brazil, 22University Children's Hospital University Medical Center Ljubljana, Ljubljana, Slovenia, 23Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 24Hospital for Special Surgery, New York, NY, 25Hackensack University Medical Center, Hackensack, 26Motol University Hospital, Prague, Czech Republic, 27Dipartimento Neurofarba, Università di Firenze, Firenze, Italy, 28Alderhey Children's NHS Foundation Trust, Liverpool, United Kingdom, 29University of Missouri-Columbia, Department of Child Health, 404 N Keene Street, Columbia MO 65210, Columbia, 30Hospital Universitario Ramon y Cajal, Madrid, Spain, 31Children’s Hospital at Montefiore, Bronx, NY, 32Caritas baby Hospital, East Jerusalem, Israel, 33Hospital de Santa Maria, Lisbon, Portugal, 34Deutsches Zentrum für Kinder- und Jugendrheumatologie, Garmisch-Partenkirchen, Germany, 35SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH, Chennai, Tamil Nadu, India, 36MD, Prague, Czech Republic, 37Oslo University Hospital, Oslo, Norway, 38Hospital Garcia de Orta and Centro Académico de Medicina de Lisboa, Lisboa, Portugal, 39Hospital de Niños Dr Orlando Alassia, Santa Fe, Argentina, 40Dept. of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 41UNIVERSIDADE FEDERAL DO RIO DE JANEIRO, Rio de Janeiro, Brazil, 42Medical University Innsbruck; Department of Pediatrics, Pediatric Rheumatology, Innsbruck, Austria, 43Faculty of Medicine, Tel Aviv University, Tel Aviv; Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel, Petach Tikva, HaMerkaz, Israel, 44Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 45Childrens Hospital Lucerne, Lucerne, Switzerland, 46Dept of Pediatric Rheumatology and Immunology Clinical Center Nis, Faculty of Medicine, University of Niš, Nis, Serbia, 47Stony Brook Children's Hospital, Stony Brook, NY, 48Emergency Clinical Hospital for Children, Cluj-Napoca, Romania

    Background/Purpose: In adult systemic sclerosis they are significant differences in clinical presentation of diffuse and limited subtype. In juvenile systemic sclerosis (jSSc) are the differences less…
  • Abstract Number: 2623 • ACR Convergence 2024

    Cardiovascular Health Is Suboptimal in Most Patients with Juvenile-Onset Lupus and Dermatomyositis: Baseline Visit Findings from the Lupus Erythematous and Dermatomyositis Stress and Cardiovascular Health Cohort Study

    Kaveh Ardalan1, Angel Davalos2, Hwanhee Hong2, Bryce Reeve2, Christoph Hornik2, M. Athony Moody2, Donald Lloyd-Jones3, Eveline Wu4, Audrey Ward1, Rebecca Sadun5, Jeff Dvergsten6, Ann Reed2, Mark Connelly7 and Laura Schanberg8, 1Duke University School of Medicine, Durham, NC, 2Duke University School of Medicine, Durham, 3Northwestern University Feinberg School of Medicine, Chicago, 4University of North Carolina School of Medicine, Chapel Hill, NC, 5Duke University, Durham, NC, 6Duke University Hospital, Hillsborough, NC, 7Children’s Mercy Kansas City/University of Missouri-Kansas City School of Medicine, Kansas City, 8Duke University Medical Center, DURHAM, NC

    Background/Purpose: Juvenile lupus (JSLE) and dermatomyositis (JDM) are associated with premature cardiovascular disease (CVD). The American Heart Association (AHA) cardiovascular health (CVH) score is the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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