ACR Meeting Abstracts

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Abstracts tagged "Pediatric rheumatology"

  • Abstract Number: 0035 • ACR Convergence 2022

    Anti-Peroxiredoxin 6 and Anti- Myosin Light Polypeptide 6 Autoantibodies with Interstitial Lung Disease and Severe Disease in Juvenile Dermatomyositis

    Rie Karasawa1, James Jarvis2, Toshiko Sato1, Megumi Tanaka1, Terrance P O'Hanlon3, Payam Noroozi-Farhadi4, Willy A. Flegel5, Kazuo Yudoh1 and Lisa G Rider3, 1Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, 2Department of Pediatrics, University at Buffalo Clinical and Translational Research Center, Buffalo, NY, 3Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, 4NIEHS, NIH, Garrett Park, MD, 5NIH, Garrett Park, MD

    Background/Purpose: Juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM) are among the most common forms of inflammatory rheumatic diseases in children. Anti-endothelial cell antibodies (AECA)…
  • Abstract Number: 0516 • ACR Convergence 2022

    Identifying Current Assessment and Treatment Strategies in Juvenile Systemic Sclerosis: An International Effort to Improve Patient Outcomes

    Natalia Vasquez Canizares1, Clare Pain2, Marinka Twilt3, Amra Adrovic Yildiz4, Simone Appenzeller5, Edoardo Marrani6, Emanuela Del Giudice7, Antonella Petaccia8, Francesca Tirelli9, Gabriele Simonini10, Marco Cattalini11, Ozgur Kasapcopur12, Raju Khubchandani13, Kathryn Torok14, Betul Sozeri15, Biagio Castaldi16, Katherine Clarke17, Phuoc Duong17, Aybuke Gunalp18, meiping lu19, Hanna Lythgoe2, Amanda Robinson14, Lauren Robinson20, Paulo Rogerio Julio21, Susan Shenoi22, Emily Willis23, Mustafa Çakan15, Valentina Leone24, Rongjun Zheng19, Phillip Lawrence17, Franziska Rosser25, Sarah Mayell2, Lusine Ambartsumyan26, Aurelia Minuti27, Francesco Zulian28 and Suzanne Li29, 1Children's Hospital at Montefiore/ Albert Einstein College of Medicine, New York, NY, 2Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom, 3Alberta Children's Hospital, Calgary, AB, Canada, 4School of Medicine, KOC University, Istanbul, Turkey, 5Unicamp, Campinas, São Paulo, Brazil, 6AOU Meyer, Florence, Italy, 7Sapienza University of Rome, Pediatric and Neonatology Unit, Maternal and Child Department, Rome, Italy, 8Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy, 9Women's and Child's Health, University Hospital of Padova, Padova, Italy, 10Meyer Children's Hospital, Florence, Italy, 11Pediatric Clinic, University of Brescia, Brescia, Italy, 12Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Istanbul, Turkey, 13SRCC Children's Hospital, Mumbai, India, 14Pediatric Rheumatology, Children's Hospital of UPMC, Pittsburgh, PA, 15University of Health Sciences, Istanbul, Turkey, 16Women's and Child's Health, University Hospital of Padova, Padua, Italy, 17Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, 18Istanbul University Cerrahpaşa Medical School, Istanbul, Turkey, 19Children’s Hospital of Zhejiang University Medical School, Zhejiang, China, 20Hospital for Special Surgery, New York, NY, 21University of Campinas, Campinas, São Paulo, Brazil, 22Seattle Children's Hospital and Research Center / University of Washington, Seattle, WA, 23Royal Manchester Children’s Hospital, Manchester, United Kingdom, 24Ismett, UPMC, Palermo, Italy, 25University of Pittsburgh, Children’s Hospital of UPMC, Pittsburgh, PA, 26Seattle Children's Hospital, University of Washington, Seattle, WA, 27D. Samuel Gottesman Library Research and Education, Albert Einstein College of Medicine, Bronx, NY, 28University of Padua, Padua, Italy, 29Hackensack Meridian School of Medicine, Joseph M. Sanzari Children's Hospital, West Orange, NJ

    Background/Purpose: Juvenile Systemic Sclerosis (jSSc) is an autoimmune and fibrosing disease associated with significant morbidity and mortality risk. Data on treatment is limited and based…
  • Abstract Number: 0869 • ACR Convergence 2022

    Behavioral Health Outcomes and Social Determinants of Health in Children with Juvenile Arthritis Compared to Children with Diabetes and Healthy Children

    Francesca Lupini1, Eleanor Mackey2, Tamar Rubinstein3, Stephanie Merwin1 and Sangeeta Sule1, 1Children's National Hospital, Washington, DC, 2Children's National Hosptial, Washington, DC, 3Albert Einstein College of Medicine, White Plains, NY

    Background/Purpose: Autoimmune illnesses, such as arthritis and diabetes, share some common characteristics, such as daily impact and the invisible nature, which may increase risk for…
  • Abstract Number: 1302 • ACR Convergence 2022

    Assessment of the Transition of Care from Pediatric to Adult Rheumatology in a Tertiary Center

    Serdal Ugurlu1, Ali Yagiz Ayla1, Helin Idil Besiroglu2, Feyza Nur Azman1, Bugra Egeli3, Hatice Eren1, Ibrahim Durucan2, Arif Alkan2, Sila Ozturk1, Sercan Ergun1, Amra Adrovic Yildiz4, Kenan Barut5, Fatih Haslak1, Sezgin Sahin1, Mehmet YILDIZ1, Huri Ozdogan6 and Ozgur Kasapcopur7, 1Istanbul University-Cerrahpaşa, Istanbul, Turkey, 2Istanbul University-Cerrahpaşa Medical Faculty, Istanbul, Turkey, 3Children's Hospital of Los Angeles, Los Angeles, CA, 4School of Medicine, KOC University, Istanbul, Turkey, 5Istanbul University-Cerrahpasa, Istanbul, Turkey, 6Istanbul University-Cerrahpaşa Medical Faculty Department of Internal Medicine Division of Rheumatology, Istanbul, Turkey, 7Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Istanbul, Turkey

    Background/Purpose: Taking the responsibility for their own health should be an important goal for the patients in the health care transition process. The Transition Readiness…
  • Abstract Number: 1376 • ACR Convergence 2022

    Eculizumab Is Safe as an Adjunctive Therapy in Systemic Lupus Erythematosus with Severe Refractory Nephritis with or Without Thrombotic Microangiopathy in Children

    Maria Pereira1, Angela Chun1, Leigh Stubbs1 and Marietta De Guzman2, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine/ Texas Children's Hospital, Houston, TX

    Background/Purpose: Eculizumab is a monoclonal antibody that prevents the cleavage of C5, which inhibits the formation of the terminal complement complex. It is approved in…
  • Abstract Number: 1928 • ACR Convergence 2022

    Idiopathic Pulmonary Capillaritis Within the Spectrum of Pediatric Diffuse Alveolar Hemorrhage

    Angela Chun1, Tiphanie vogel1, Andrea Ramirez1, Marietta De Guzman2, Eyal Muscal1 and Manuel Silva-Carmona3, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, 3Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening syndrome with bleeding from the pulmonary microvasculature. It is classified as pulmonary capillaritis if histology shows neutrophilic…
  • Abstract Number: 2035 • ACR Convergence 2022

    Elucidating the Factors That Influence the Use of Minor Salivary Gland Biopsy for the Evaluation of Childhood Sjögren’s Disease

    Dizon Brian1, Matthew Basiaga2, Sara Stern3, Akaluck Thatayatikom4, seunghee cha5, Scott Lieberman6, Hemalatha Srinivasalu7 and on behalf of CARRA and the childhood Sjogren's workgroup8, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2Mayo Clinic, Inver Grove Heights, MN, 3University of Utah, Salt Lake City, UT, 4AdventHealth, Orlando, FL, 5University of Florida, Gainesville, FL, 6University of Iowa, Iowa City, IA, 7Children's National Hospital, Washington, DC, 8Childhood Arthritis and Rheumatology Research Alliance, Bethesda, MD

    Background/Purpose: Sjögren's disease is a rare condition in children. Diagnosis is often delayed because of the lack of pediatric-specific guidelines for childhood Sjögren's disease (cSjD).…
  • Abstract Number: 0036 • ACR Convergence 2022

    Patient-specific and Disease-related Determinants for Cardiovascular Disease (CVD) Risk Stratification in the APPLE (Atherosclerosis Prevention in Paediatric Lupus Erythematosus) Clinical Trial Cohort

    Junjie Peng1, George Robinson1, Stacy P Ardoin2, Laura Schanberg3, Elizabeth Jury1 and Coziana Ciurtin4, 1University College London, London, United Kingdom, 2Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, 3Duke University Medical Center, Durham, NC, 4Centre for Adolescent Rheumatology Versus Arthritis, Department of Medicine, University College London, London, United Kingdom

    Background/Purpose: The risk of developing cardiovascular disease (CVD) through atherosclerosis in juvenile-onset systemic lupus erythematosus (JSLE) patients is significantly increased. This study aimed to stratify…
  • Abstract Number: 0517 • ACR Convergence 2022

    Cortical Surface Area Correlates with Cognitive Efficiency and Disease Measures in Childhood-Onset Systemic Lupus Erythematosus

    Santiago Arciniegas1, Sarah Mossad2, Tala El Tal3, Victoria Lishak4, Stephanie Fevrier5, Ibrahim Mohamed6, Joanna Law2, Lawrence Ng2, Paris Moaf2, Helen Branson2, Adrienne Davis2, Linda Hiraki7, Deborah Levy8, ashley Danguecan2, George Ibrahim5 and Andrea Knight3, 1University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 5The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, 6The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, 7The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive difficulties are common in children with childhood-onset SLE (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase understanding of…
  • Abstract Number: 0872 • ACR Convergence 2022

    Incidence, Risk Factors, and Outcomes of Eosinophilia on IL-1 and IL-6 Inhibitors in Systemic and Non-Systemic Juvenile Idiopathic Arthritis

    Holly Wobma1, Maria Taylor2, Ki Pui Lam1, Helene Brown1, Siobhan Case1, Mia Chandler1, Margaret Chang1, Ezra Cohen1, Megan Day-Lewis1, Olha Halyabar1, Jonathan Hausmann1, Melissa Hazen3, Erin Janssen1, Pui Lee1, Mindy Lo1, Esra Meidan1, Jordan Roberts1, Mary Beth F. Son1, Robert Sundel1, Fatma Dedeoglu1, Peter Nigrovic1, Alicia Casey4, Joyce Chang1 and lauren henderson1, 1Division of Immunology, Boston Children's Hospital, Boston, MA, 2Division of Immunology, Boston Children's Hospital, Brighton, MA, 3Boston Children's Hospital, Boston, MA, 4Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA

    Background/Purpose: Children with systemic juvenile idiopathic arthritis (sJIA) exposed to IL1/6 inhibitors may develop eosinophilia with an atypical rash, reportedly in association with HLA-DRB1*15:XX. There…
  • Abstract Number: 1303 • ACR Convergence 2022

    Planning Transition in Times of Transition: Is There a Virtual Pathway from Pediatric to Adult Care?

    Ben Danna, Monique Maher, Miriah Gillispie-Taylor and Tiphanie Vogel, Baylor College of Medicine, Houston, TX

    Background/Purpose: The BRIDGE (Baylor Rheumatology Initiative: Developing and Guiding Engagement) program is a quality improvement initiative to develop a safe, comprehensive pathway for our patients…
  • Abstract Number: 1377 • ACR Convergence 2022

    Mental Health Screening in Juvenile Myositis: Preliminary Analysis of a Multicenter Pilot Study

    Kaveh Ardalan1, Lindsay Olson1, Jeffrey Dvergsten2, Ann Reed1, Alison Manning1, Gary Maslow1, Aruna Rikhi1, Brian Feldman3, ashley Danguecan4, Sarah Mossad4, Luana Flores Pereira4, Susan Shenoi5, Stacey Haynes5, Joanna Patten5 and Andrea Knight6, 1Duke University School of Medicine, Durham, NC, 2Duke University Hospital, Durham, NC, 3Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Toronto, ON, Canada, 5Seattle Children's Hospital and Research Center / University of Washington, Seattle, WA, 6The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Qualitative studies in juvenile myositis (JM) suggest high rates of emotional distress but the prevalence of mental health comorbidities is not well described. We…
  • Abstract Number: 1929 • ACR Convergence 2022

    Outcomes and Safety of Anakinra for the Treatment of Multisystem Inflammatory Syndrome in Children

    Dizon Brian1, Christopher Redmond2, Emily Gotschlich3, Sangeeta Sule4, Tova Ronis4, Kathleen Vazzana5, Matthew Sherman6, Rachael Connor7, Abigail Bosk4, Niti Dham4, Ashraf Harahsheh4, Elizabeth Wells4, Roberta DeBiasi4 and Hemalatha Srinivasalu4, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institutes of Health, Rockville, MD, 3FDA, Washington, DC, 4Children's National Hospital, Washington, DC, 5Arnold Palmer Hospital for Children, Orlando, FL, 6Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH); Children’s National Hospital, Washington, DC, 7Children's National Medical Center, Washington, DC

    Background/Purpose: Multisystem inflammatory syndrome in children (MIS-C) is a clinical entity distinct from primary COVID-19 infection that resembles Kawasaki disease (KD) and toxic shock syndrome.…
  • Abstract Number: 2057 • ACR Convergence 2022

    Outpatient Visit Adherence and Impact on Disease-related Morbidity in Childhood-onset Systemic Lupus Erythematosus (cSLE)

    Meghan Nelson1, Colleen Mosley2, D. Sofia Villacis-Nunez3, Kelly Rouster-Stevens3 and Amit Thakral3, 1Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine; Children's Healthcare of Atlanta, Atlanta, GA, 2Children’s Healthcare of Atlanta, Atlanta, GA, 3Division of Pediatric Rheumatology, Department of Pediatrics, Emory University School of Medicine; Children’s Healthcare of Atlanta, Atlanta, GA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that is associated with significant disease damage, morbidity, and mortality. In comparison to the adult…
  • Abstract Number: 0040 • ACR Convergence 2022

    Plasma Proteomic Signatures in Juvenile Dermatomyositis Highlight Novel Proteins and a Protein Module That Associate with Skin and Global Disease Activity

    Marianne Kerski1, Celine Berthier1, Alex Tsoi1, Sarah Vandenbergen1, Madison McClune1, Corey Powell1, J. Michelle Kahlenberg1 and Jessica Turnier2, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Saline, MI

    Background/Purpose: Juvenile dermatomyositis (JDM) patients display heterogenous disease phenotypes and treatment response patterns. Our study used a multiplexed proteomics assay for measurement of 3072 proteins…
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