ACR Meeting Abstracts

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Abstracts tagged "pathogenesis"

  • Abstract Number: 1572 • 2016 ACR/ARHP Annual Meeting

    Relationship Between KDR (VEGFR2) Gene Polymorphisms and Serum KDR Protein Levels in Patients with Rheumatoid Arthritis

    Agnieszka Paradowska-Gorycka1, Barbara Stypinska2, Andrzej Pawlik3, Damian Malinowski3, Katarzyna Romanowska-Próchnicka4, Ewa Haladyj5, Malgorzata Manczak6 and Marzena Olesinska7, 1Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 2Department of Biochemistry and Molecular Biology, National Institute of geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 3Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland, 4Department of Pathophysiology, Medical University of Warsaw and Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 5Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 6Department of Epidemiology and Health Promotion, National Institute of geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, 7Department of Connective Tissue Disease, National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland

    Background/Purpose:  Rheumatoid arthritis (RA) is one of the chronic autoimmune diseases, with genetic and environmental predisposition, and synovial angiogenesis is considered to be a notable…
  • Abstract Number: 1658 • 2016 ACR/ARHP Annual Meeting

    Regulatory Role of  the IL-9/IL-9R System  on Pannus Formation in Psoriatic Arthritis

    Siba P. Raychaudhuri1,2 and Smriti K. Raychaudhuri3, 1Davis, CA, 2Rheumatology, Univ of California, Davis & VAMC Sacramento, Davis, CA, 3Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA

        Background/Purpose:  Earlier we have reported that synovial tissues of psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are enriched with the Th9 cells along…
  • Abstract Number: 2417 • 2016 ACR/ARHP Annual Meeting

    High Dimensional Interrogation of the T Cell Immunome in Polyarticular Juvenile Idiopathic Arthritis Patients 

    Jing Yao Leong1, Justin Tiong2, Joo Guan Yeo2,3, Liyun Lai1, Phyllis Chen3, Loshinidevi D/O Thana Bathi3, Thaschawee Arkachaisri2, Daniel J Lovell4 and Salvatore Albani1,5, 1SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 2Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, 3Singhealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 4PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, 5Duke-National University of Singapore Medical School, Singapore, Singapore

    Background/Purpose: Clinical management of polyarticular JIA with anti-TNF-alpha has been met with moderate success, with up to 50% of patients demonstrating clinically meaningful efficacy. Concerns…
  • Abstract Number: 178 • 2016 ACR/ARHP Annual Meeting

    Alpha-Enolase Promotes Pro-Inflammatory Phenotype of Monocytes-Derived Macrophages

    Pascal Rottenberg1,2, Manuel Fréret1,2, Sébastien Calbo1 and Olivier Vittecoq1,2, 1INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, 2Rheumatology, Rouen University Hospital, Rouen, France

    Background/Purpose:  Monocytes of healthy donors were cultured with M-CSF (gcultured with ENO1, or control BSA, to investigate its effect on monocytes differentiation and macrophages polarization.…
  • Abstract Number: 2558 • 2016 ACR/ARHP Annual Meeting

    Dissociation of the Inhibitory Apoptosis Stimulating Protein of p53 (iASPP) Binding with Transcription Factor p73 Induces Synovial Fibroblast Apoptosis in the Rheumatoid Joint

    Chrong-Reen Wang1, Shih-Yao Chen1, Ai-Li Shiau2, Ming-Fei Liu1 and Chao-Liang Wu3, 1Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, 2Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan

    Background/Purpose:   Apoptosis-resistant synovial fibroblasts (SFs) constitute the major cell component of pannus tissues in rheumatoid arthritis (RA). In tumor cells, the binding of inhibitory…
  • Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting

    CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice

    Sho Sendo1, Jun Saegusa1, Takaichi Okano2, Soshi Takahashi3 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…
  • Abstract Number: 2560 • 2016 ACR/ARHP Annual Meeting

    Sputum Antibody to Malondialdehyde-Acetaldehyde Adduct in Subjects with Established Rheumatoid Arthritis

    Bryant R. England1,2, Peter Maloley3, Eric Daubach3, Michael J. Duryee4, M. Kristen Demoruelle5, Kevin D. Deane5, Geoffrey M. Thiele6 and Ted R Mikuls6, 1Division of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 2VA Nebraska-Western Iowa, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE, 4Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 6Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Anti-malondialdehyde-acetaldehyde adduct (MAA) antibodies target immunogenic products of oxidative stress, are detected in higher concentration in paired synovial fluid vs serum in RA, and…
  • Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting

    Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis

    Asha Mariam Alex1,2, Gary A. Kunkel3, Jorge Flautero Arcos4, Richard Amdur5 and Gail S. Kerr6, 1Rheumatology, Veterans Affairs Medical Center, Washington, DC, 2Rheumatology, Georgetown University Hospital, Washington, DC, 3Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, 4Rheumatology, Howard University Hospital, Washington, DC, 5Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, 6Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC

    Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
  • Abstract Number: 2562 • 2016 ACR/ARHP Annual Meeting

    Human Seroreactivity to Gut Microbiota Antigens in Rheumatoid Arthritis and Controls-Lack of Association with Rheumatoid Arthritis Autoantibodies

    Carol Hitchon1, Charles O. Elson2, David Robinson3, Irene Smolik3 and Hani S. El-Gabalawy1, 1University of Manitoba, Winnipeg, MB, Canada, 2Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, 3Arthritis Center, University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: The human gut microbiome maintains normal immune homeostasis. Changes to the microbiota evolve with aging and have been implicated in the development of autoimmune…
  • Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting

    Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals

    Laura Hunt1, Sahar Musaad1,2, John Stephenson3, Becki Burn2, Isao Matsuura1, Kulveer Mankia1, Jackie L. Nam1 and Paul Emery1, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, 3Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom

    Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers.  Studying individuals at-risk of…
  • Abstract Number: 2578 • 2016 ACR/ARHP Annual Meeting

    Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression

    Ozge Kockara1, Merve Sibel Gungoren2, Erdem Karabulut3, Sebnem Ataman4 and Filiz Akbiyik2, 1Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, 2Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey, 3Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey, 4Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Progressive bone destruction occurs in rheumatoid arthritis (RA) due to imbalance of osteoblast/osteoclast activity. Bone morphogenetic proteins (BMPs) regenerate bone damage by stimulating the…
  • Abstract Number: 570 • 2016 ACR/ARHP Annual Meeting

    A Molecular Timeline for Preclinical RA Pathogenesis Defined By Dysregulated PTPN22, Hypercitrullination, and Aberrant Cytokine/Metabolic Profiles in PBMC of at-Risk Individuals

    Hui-Hsin Chang1, Nishant Dwivedi2, Bo Sun2, Deepak A. Rao3, Jeffrey A. Sparks3, Jennifer Kinslow4, Yuko Okamoto4, Kevin D. Deane5, M. Kristen Demoruelle6, Jill M. Norris7, Elizabeth Karlson2, V. Michael Holers8 and I-Cheng Ho1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4University of Colorado School of Medicine, Aurora, CO, 5Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 6Rheumatology, University of Colorado School of Medicine, Aurora, CO, 7Epidemiology, Colorado School of Public Health, Aurora, CO, 8Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: One unique feature of RA is the presence of ACPA. PTPN22 is a phosphatase that also acts to suppress citrullination independently of its phosphatase…
  • Abstract Number: 2928 • 2016 ACR/ARHP Annual Meeting

    Hypomethylation of an Intragenic Alternative Promoter Contributes to Impaired Treg Function in Rheumatoid Arthritis By Transcriptional Interference with Expression of the Treg-Specific Protein, Glycoprotein a Repetitions Predominant (GARP)

    Alla Skapenko, Jan Leipe and Hendrik Schulze-Koops, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany

    Background/Purpose:  The expression of Treg specific genes, such as the master transcription factor of Tregs, FoxP3 or the Treg specific surface molecule, glycoprotein A repetitions…
  • Abstract Number: 581 • 2016 ACR/ARHP Annual Meeting

    Cell-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?

    Tal Gazitt1, Christian Lood1, Xizhang Sun2, David Feith3, Jeffrey Ledbetter2, Gordon Starkebaum1, Thomas Loughran Jr.4 and Keith B. Elkon1, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Seattle, WA, 3Hematology and Oncology, University of Virginia, Charlottesville, VA, 4Hematology Oncology, University of Virginia, Charlottesville, VA

    BACKGROUND/PURPOSE:Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of anti-citrullinated…
  • Abstract Number: 3017 • 2016 ACR/ARHP Annual Meeting

    Elevated Neutrophil Extracellular Trap Levels Correlate with Anti-CCP3-IgG and Anti-CCP3-IgA Levels in the Sputum of Individuals at-Risk for Future Rheumatoid Arthritis

    M. Kristen Demoruelle1, Monica Purmalek2, Heather Rothfuss3, Michael Weisman4, Lindsay Kelmenson1, Michael Mahler5, Jill M. Norris6, Brian Cherrington3, Mariana Kaplan2, V. Michael Holers1 and Kevin D. Deane1, 1Rheumatology Division, University of Colorado Denver, Aurora, CO, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Zoology and Physiology, University of Wyoming, Laramie, WY, 4Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Research and Development, Inova Diagnostics, San Diego, CA, 6Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: The initial site of anti-citrullinated protein antibody (ACPA) generation in RA has been proposed to be a mucosal site. We have previously demonstrated ACPA…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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