Abstracts tagged "pathogenesis"

Abstract Number: 2560 • 2016 ACR/ARHP Annual Meeting
Sputum Antibody to Malondialdehyde-Acetaldehyde Adduct in Subjects with Established Rheumatoid Arthritis
Bryant R. England^1,2, Peter Maloley³, Eric Daubach³, Michael J. Duryee⁴, M. Kristen Demoruelle⁵, Kevin D. Deane⁵, Geoffrey M. Thiele⁶ and Ted R Mikuls⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²VA Nebraska-Western Iowa, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁶Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Anti-malondialdehyde-acetaldehyde adduct (MAA) antibodies target immunogenic products of oxidative stress, are detected in higher concentration in paired synovial fluid vs serum in RA, and…
Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting
Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis
Asha Mariam Alex^1,2, Gary A. Kunkel³, Jorge Flautero Arcos⁴, Richard Amdur⁵ and Gail S. Kerr⁶, ¹Rheumatology, Veterans Affairs Medical Center, Washington, DC, ²Rheumatology, Georgetown University Hospital, Washington, DC, ³Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, ⁴Rheumatology, Howard University Hospital, Washington, DC, ⁵Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, ⁶Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC
Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
Abstract Number: 2562 • 2016 ACR/ARHP Annual Meeting
Human Seroreactivity to Gut Microbiota Antigens in Rheumatoid Arthritis and Controls-Lack of Association with Rheumatoid Arthritis Autoantibodies
Carol Hitchon¹, Charles O. Elson², David Robinson³, Irene Smolik³ and Hani S. El-Gabalawy¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Arthritis Center, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: The human gut microbiome maintains normal immune homeostasis. Changes to the microbiota evolve with aging and have been implicated in the development of autoimmune…
Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting
Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals
Laura Hunt¹, Sahar Musaad^1,2, John Stephenson³, Becki Burn², Isao Matsuura¹, Kulveer Mankia¹, Jackie L. Nam¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, ³Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom
Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers. Studying individuals at-risk of…
Abstract Number: 2578 • 2016 ACR/ARHP Annual Meeting
Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression
Ozge Kockara¹, Merve Sibel Gungoren², Erdem Karabulut³, Sebnem Ataman⁴ and Filiz Akbiyik², ¹Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ²Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Progressive bone destruction occurs in rheumatoid arthritis (RA) due to imbalance of osteoblast/osteoclast activity. Bone morphogenetic proteins (BMPs) regenerate bone damage by stimulating the…
Abstract Number: 570 • 2016 ACR/ARHP Annual Meeting
A Molecular Timeline for Preclinical RA Pathogenesis Defined By Dysregulated PTPN22, Hypercitrullination, and Aberrant Cytokine/Metabolic Profiles in PBMC of at-Risk Individuals
Hui-Hsin Chang¹, Nishant Dwivedi², Bo Sun², Deepak A. Rao³, Jeffrey A. Sparks³, Jennifer Kinslow⁴, Yuko Okamoto⁴, Kevin D. Deane⁵, M. Kristen Demoruelle⁶, Jill M. Norris⁷, Elizabeth Karlson², V. Michael Holers⁸ and I-Cheng Ho¹, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴University of Colorado School of Medicine, Aurora, CO, ⁵Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁶Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁷Epidemiology, Colorado School of Public Health, Aurora, CO, ⁸Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: One unique feature of RA is the presence of ACPA. PTPN22 is a phosphatase that also acts to suppress citrullination independently of its phosphatase…
Abstract Number: 2928 • 2016 ACR/ARHP Annual Meeting
Hypomethylation of an Intragenic Alternative Promoter Contributes to Impaired Treg Function in Rheumatoid Arthritis By Transcriptional Interference with Expression of the Treg-Specific Protein, Glycoprotein a Repetitions Predominant (GARP)
Alla Skapenko, Jan Leipe and Hendrik Schulze-Koops, Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: The expression of Treg specific genes, such as the master transcription factor of Tregs, FoxP3 or the Treg specific surface molecule, glycoprotein A repetitions…
Abstract Number: 581 • 2016 ACR/ARHP Annual Meeting
Cell-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?
Tal Gazitt¹, Christian Lood¹, Xizhang Sun², David Feith³, Jeffrey Ledbetter², Gordon Starkebaum¹, Thomas Loughran Jr.⁴ and Keith B. Elkon¹, ¹Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Hematology and Oncology, University of Virginia, Charlottesville, VA, ⁴Hematology Oncology, University of Virginia, Charlottesville, VA
BACKGROUND/PURPOSE:Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of anti-citrullinated…
Abstract Number: 3017 • 2016 ACR/ARHP Annual Meeting
Elevated Neutrophil Extracellular Trap Levels Correlate with Anti-CCP3-IgG and Anti-CCP3-IgA Levels in the Sputum of Individuals at-Risk for Future Rheumatoid Arthritis
M. Kristen Demoruelle¹, Monica Purmalek², Heather Rothfuss³, Michael Weisman⁴, Lindsay Kelmenson¹, Michael Mahler⁵, Jill M. Norris⁶, Brian Cherrington³, Mariana Kaplan², V. Michael Holers¹ and Kevin D. Deane¹, ¹Rheumatology Division, University of Colorado Denver, Aurora, CO, ²Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Zoology and Physiology, University of Wyoming, Laramie, WY, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Research and Development, Inova Diagnostics, San Diego, CA, ⁶Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: The initial site of anti-citrullinated protein antibody (ACPA) generation in RA has been proposed to be a mucosal site. We have previously demonstrated ACPA…
Abstract Number: 584 • 2016 ACR/ARHP Annual Meeting
Glycoprotein VI: A Potential Target for ACPA-Mediated Platelet Activation?
John Stack¹, Anne Madigan², Laura Helbert¹, Niamh Redmond¹, Eimear Dunne³, Dermot Kenny³ and Geraldine M. McCarthy², ¹Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ³Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland
Background/Purpose: Arterial thrombosis is a major cause of mortality in rheumatoid arthritis (RA),especially in anti-citrullinated protein antibody (ACPA)-positive patients Recent studies suggest that platelet activation…
Abstract Number: 3019 • 2016 ACR/ARHP Annual Meeting
Sputum Antibodies to Individual Citrullinated Protein/Peptide Antigens Are Elevated in Subjects at-Risk of Future RA and Subjects with Established Disease
Emily Bowers¹, M. Kristen Demoruelle², Michael Weisman³, Jill M. Norris⁴, William H. Robinson⁵, V. Michael Holers² and Kevin D. Deane², ¹Medicine, University of Colorado Denver, Aurora, CO, ²Rheumatology Division, University of Colorado Denver, Aurora, CO, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Stanford University School of Medicine, Stanford, CA
Background/Purpose: Multiple studies demonstrate that ACPAs are elevated in the serum years prior to the onset of seropositive RA during a preclinical period of autoimmunity.…
Abstract Number: 988 • 2016 ACR/ARHP Annual Meeting
Risk of Rheumatoid Arthritis after Transfusion of Blood from Donors Later Diagnosed with Rheumatoid Arthritis: A Retrospective Cohort Study
Søren Andreas Just¹, Kjell Titlestad², Gustaf Edgren³, Klaus Rostgaard⁴, Johan Askling⁵, Hanne Lindegaard¹ and Henrik Hjalgrim⁴, ¹Department of Rheumatology, Department of Rheumatology, Odense University Hospital, Odense, Denmark, Odense, Denmark, ²Department of Clinical Immunology, Department of Clinical Immunology, Odense Unversity Hospital, Odense, Denmark, Odense, Denmark, ³Department of Medical Epidemiology and Biostatistics, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ⁴Epidemiology Research, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark, Copenhagen, Denmark, ⁵Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Rheumatoid Arthritis (RA) is a disease that can have a long sub-clinical phase. During this phase the person with pre-RA could have factors in…
Abstract Number: 3022 • 2016 ACR/ARHP Annual Meeting
Autoantibodies to Peptidylarginine Deiminase 2 Protect Against Radiographic Progression in Patients with Rheumatoid Arthritis
Erika Darrah¹, Jon T. Giles², Ryan Davis¹, Pooja Naik¹, Maximilian Konig¹ and Felipe Andrade¹, ¹Department of Medicine, Division of Rheumatology, The Johns Hopkins University, Division of Rheumatology, Baltimore, MD, ²Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY
Background/Purpose: The mechanisms that drive clinical heterogeneity and outcomes in patients with rheumatoid arthritis (RA) are poorly understood, but precise biomarkers may identify clinically unique…
Abstract Number: 1040 • 2016 ACR/ARHP Annual Meeting
Stressful Life Events : A Trigger for Rheumatoid Arthritis Onset within a Year. a Case-Control Study
Jimmy Gross¹, Nadia Oubaya^2,3, Florent Eymard¹, Alexia Hourdille¹, Xavier Chevalier¹ and Sandra Guignard¹, ¹Department of Rheumatology, APHP Henri Mondor hospital, Créteil, France, ²Public Health Department, F-94000, APHP Henri Mondor hospital, Créteil, France, ³DHU A-TVB, IMRB- EA 7376 CEpiA (Clinical Epidemiology And Ageing Unit), F-94000, Université Paris-Est, UPEC,, Créteil, France
Background/Purpose: To assess the association between recent stressful life events and rheumatoid arthritis (RA) onset. Methods: We conducted a monocentric case-control study of in and…
Abstract Number: 3217 • 2016 ACR/ARHP Annual Meeting
Broad-Based Interrogation of the Serum Proteome Suggests That RA Onset Is Associated with Activation of the Intrinsic Coagulation Cascade
Liam O'Neil¹, Xiaobo Meng², Irene Smolik³, Carol Hitchon² and Hani El-Gabalawy⁴, ¹Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ²University of Manitoba, Winnipeg, MB, Canada, ³Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ⁴University of Manitoba Arthritis Center, Winnipeg, MB, Canada
Background/Purpose: The establishment of longitudinal pre-clinical RA cohorts is beginning to provide important insights into the mechanisms that precede the onset of clinically detectable disease.…

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