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Abstracts tagged "pathogenesis and rheumatoid arthritis (RA)"

  • Abstract Number: 153 • 2018 ACR/ARHP Annual Meeting

    Chemotaxis of Vδ2 T Cells to the Joints Contributes to the Pathogenesis of Rheumatoid Arthritis

    Xiao Xinyue1, Wenxiu MO2 and Xuan Zhang3, 1Peking Union Medical College Hospital, Beijing, China, 2Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, 3Rheumatology, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: To explore the role of Vδ2 t cells in the pathogenesis of rheumatoid arthritis (rA) Methods: Sixty-eight patients with RA, 21 patients with osteoarthritis…
  • Abstract Number: 483 • 2017 ACR/ARHP Annual Meeting

    Anti-Peptidylarginine Deiminase-4 Antibodies Are Present in the Sputum of RA Patients and Can Activate Peptidylarginine Deiminase-4 Enzyme Activity

    M. Kristen Demoruelle1, Hong Wang2, Ryan L. Davis2, A. Itzam Marin1, Jill M. Norris3, V. Michael Holers1, Kevin D. Deane1 and Erika Darrah2, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Division of Rheumatology, The Johns Hopkins University, Baltimore, MD, 3Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: Anti-peptidylarginine deiminase (PAD)-4 antibodies (Abs) are present in a portion of RA patients and associate with more severe joint disease, suggesting that they play…
  • Abstract Number: 2829 • 2017 ACR/ARHP Annual Meeting

    Complete Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes Reveals Unanticipated Critical Pathogenic Pathways

    Rizi Ai1, Teresina Laragione2, Deepa Hammaker3, David L. Boyle4, Andre ‎ Wildberg5, Keisuke Maeshima3, Emmanuele Palescandolo6, Vinod Krishna6, Bryan Linggi7, David Pocalyko8, John W. Whitaker9, Percio S. Gulko2, Wei Wang10 and Gary S. Firestein11, 1UC San Diego, La Jolla, CA, 2Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 3Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 4University of California San Diego, La Jolla, CA, 5Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, 6Janssen Pharmaceuticals, Spring House, PA, 7janssen Pharmaceuticals, Spring House, PA, 8Janssen Research, Spring House, PA, 9Janssen Pharmaceuticals, La Jolla, CA, 10Chemistry and Biochemistry, UC San Diego, La Jolla, CA, 11Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: Epigenetics participates in the pathogenesis of rheumatoid arthritis (RA). Epigenetic marks, gene expression and DNA polymorphisms have been investigated but the analyses are limited…
  • Abstract Number: 2914 • 2017 ACR/ARHP Annual Meeting

    Anti-CCP Antibody Levels Are Elevated in Cervicovaginal Fluid in Association with Local Inflammation in Premenopausal Women without RA

    Sonia Khatter1, Heather Berens-Norman2, Courtney Anderson1, Justin August1, Marie L. Feser1, Chelsie Fleischer1, Ashley Visser1, Jill M. Norris3, V. Michael Holers1, Kevin D. Deane1 and M. Kristen Demoruelle1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: Data support that anti-CCP antibodies likely originate at a mucosal site prior to the onset of inflammatory arthritis (IA) in the development of RA.…
  • Abstract Number: 166 • 2016 ACR/ARHP Annual Meeting

    Prevalence of Radiographic Thymic Alteration and Its Clinical Association in Systemic Autoimmune Diseases

    Okinori Murata1, Katsuya Suzuki1, Hiroaki Sugiura2, Yasushi Kondo1, Hidekata Yasuoka1, Kunihiro Yamaoka1 and Tsutomu Takeuchi1, 1Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, 2Keio University School of Medcine, Division of Diagnostic Radiology, Department of Radiology, Tokyo, Japan

    Background/Purpose:  Consecutive and unbiased 500 patients who had visited at our service and had been evaluated by chest CT scan between January 2013 and December…
  • Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting

    Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls

    Emma Weeding1, Londyn Robinson2, Jeremy Sokolove3, Julie Marchesan4, Steven Offenbacher4, William H. Robinson3, Ryan Demmer5, Bryan Michalowicz6 and Jerry A. Molitor7, 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 2University of Minnesota, Minneapolis, MN, 3Stanford University School of Medicine, Stanford, CA, 4Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Epidemiology, Columbia University Mailman School of Public Health, New York, NY, 6Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, 7Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
  • Abstract Number: 913 • 2016 ACR/ARHP Annual Meeting

    Aggregatibacter Actinomycetemcomitans-Induced Hypercitrullination Links Periodontal Infection to Autoimmunity in Rheumatoid Arthritis

    Maximilian F. Konig1,2, Loreto Abusleme3, Jesper Reinholdt4, Robert J. Palmer3, Kevon Sampson1, Ricardo P. Teles5, Peter A. Nigrovic6, Antony Rosen1, Jeremy Sokolove7, Jon T. Giles8, Niki M. Moutsopoulos3 and Felipe Andrade1, 1Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 4Department of Biomedicine, Aarhus University, Aarhus, Denmark, 5Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 6Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 7Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 8Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY

    Background/Purpose: A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites…
  • Abstract Number: 1558 • 2016 ACR/ARHP Annual Meeting

    Lower Expression of a Novel Cytoplasmic Long Noncoding RNA NR_122076 Contributes to Proliferation, Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis

    Yaoyao Zou, Siqi Xu, Qian Qiu, Shan Zeng, Maohua Shi, Youjun Xiao, Mingcheng Huang and Hanshi Xu, Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Guangzhou, China

    Background/Purpose:  Emerging evidence indicates that long noncoding RNAs (lncRNAs) play critical regulatory roles in various human diseases, especially in cancers and inflammatory disorders. However, the…
  • Abstract Number: 2563 • 2016 ACR/ARHP Annual Meeting

    Hypoxia Induce Slug Expression Via JAK/STAT3 Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Hyungjin Kim1, Hyemin Jeong2, Jaejoon Lee2, Hoon-Suk Cha1, Eun-Mi Koh3, Eun-Jung Park4 and Young Hee Eun1, 1Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 3Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 4Department of Medicine, Division of Rheumatology, Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Jeju, South Korea

    Background/Purpose: Accumulating evidence implicates hypoxia in the pathogenesis of rheumatoid arthritis (RA). The effect of hypoxia on the expression of Slug, a transcriptional repressor that…
  • Abstract Number: 2575 • 2016 ACR/ARHP Annual Meeting

    The Presence of Staphylococcal Toxins in the Urine of Patients with Rheumatoid Arthritis

    Laura Grace1, Marwan Bukhari2, Robert Lauder3, Lisa Bishop4,5 and Adam Taylor1, 1Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, 2Royal Lancaster Infirmary, Lancaster, United Kingdom, 3Biomedical & Life Sciences, Lancaster University, Lancaster, United Kingdom, 4Biomedical and Life Sciences, Lancaster University, Lancaster, United Kingdom, 5University Hopsitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom

    Background/Purpose:  Rheumatoid arthritis (RA) is a disease of unknown etiology;with a pathogenesis that is due to a mixture of genetic, immunological and environmental factors. A…
  • Abstract Number: 966 • 2015 ACR/ARHP Annual Meeting

    In Rheumatoid Arthritis, Smoking Is Not Associated with Anti-Citrullinated Protein Antibodies per Se, but with the Concurrent Presence of Rheumatoid Factor, Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies

    Tineke van Wesemael1, Ammar Muhammad1, Sofia ajeganova2,3, Jennifer Humphreys4, Deborah P.M. Symmons5,6, Alex J Macgregor7, Ingiäld Hafström2, Leendert Trouw1, T. W. J. Huizinga1, Björn Svensson8, René E. M. Toes1, Suzanne M. Verstappen9 and Diane van der Woude1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Department of Medicine Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden, 3Rheumatology, Leiden University Medical Center, LEIDEN, Netherlands, 4Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit,, Manchester, United Kingdom, 5Centre for Musculoskeletal Research, University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, 6NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 7Rheumatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom, 8Section of Rheumatology, Department of Clinical Sciences,, University of Lund, Lund, Sweden, 9Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom

    Background/Purpose : In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, the development of anti-citrulline autoimmunity and anti-citrullinated protein antibodies…
  • Abstract Number: 529 • 2015 ACR/ARHP Annual Meeting

    Immunoglobulin-a and Immunoglobulin-G Isotypes of Anti-CCP Antibodies Are Present in the Sputum of Subjects at Risk for Future Development of RA

    Kristen Demoruelle1, Linh Ho2, Michael H. Weisman3, Ryan W. Gan4, Mark C. Parish1, Marie L. Feser1, Chelsie Fleischer1, Michael Mahler5, Andrea Seaman5, Jill M. Norris4, V. Michael Holers1 and Kevin D. Deane1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 4Epidemiology, Colorado School of Public Health, Aurora, CO, 5Inova Diagnostics, San Diego, CA

    Background/Purpose: Serum elevations of anti-CCP prior to inflammatory arthritis (IA) in RA suggest that anti-CCP is generated at a site outside of the joints. Data…
  • Abstract Number: 528 • 2015 ACR/ARHP Annual Meeting

    RA33 Challenges the Paradigm of Autoantigen Selection in Rheumatoid Arthritis

    Maximilian F. Konig1, Jon Giles2, Peter A. Nigrovic3 and Felipe Andrade1, 1Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 2Rheumatology, Columbia University Medical Center, NY, NY, 3Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Antibodies against citrullinated proteins (ACPAs) are the autoimmune hallmark of rheumatoid arthritis (RA), and can precede the onset of symptomatic disease by years. By…
  • Abstract Number: 2721 • 2015 ACR/ARHP Annual Meeting

    Elevated Subgingival Levels of Periodontal Pathogens in Rheumatoid Arthritis Patients, Particularly Leptotrichia species in New-Onset Disease

    Sheila Arvikar1, Hatice Hasturk2, Daniel Nguyen2, Klemen Strle3, Marcy B. Bolster4, Deborah Collier5, Allen C. Steere6 and Alpdogan Kantarci2, 1Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, 3Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 4Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 6Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures, shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. Most studies…
  • Abstract Number: 2713 • 2015 ACR/ARHP Annual Meeting

    A Novel Paradigm in the Clinical Context of Rheumatoid Arthritis: Role of Tfh and Th17 Cells in Autoimmunity

    Magdalena Budziakowska1, Arif Shahzad1, Jerry Pounds1, Shikha Singla1, Jerald M. Zakem1,2, Kismet Collins1, Tamika Webb-Detiege1, William E. Davis1,2, Zongbing You3, Robert Quinet1,2 and Xin Zhang4, 1Rheumatology, Ochsner Medical Center, New Orleans, LA, 2University of Queensland School of Medicine, Brisbane, Australia, 3Tulane University Health Science Center, New Orleans, LA, 4Laboratory of Cellular Immunology, Institution of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life…
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