Abstracts tagged "pathogenesis and rheumatoid arthritis (RA)"

Abstract Number: 153 • 2018 ACR/ARHP Annual Meeting
Chemotaxis of Vδ2 T Cells to the Joints Contributes to the Pathogenesis of Rheumatoid Arthritis
Xiao Xinyue¹, Wenxiu MO² and Xuan Zhang³, ¹Peking Union Medical College Hospital, Beijing, China, ²Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, ³Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: To explore the role of Vδ2 t cells in the pathogenesis of rheumatoid arthritis (rA) Methods: Sixty-eight patients with RA, 21 patients with osteoarthritis…
Abstract Number: 483 • 2017 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase-4 Antibodies Are Present in the Sputum of RA Patients and Can Activate Peptidylarginine Deiminase-4 Enzyme Activity
M. Kristen Demoruelle¹, Hong Wang², Ryan L. Davis², A. Itzam Marin¹, Jill M. Norris³, V. Michael Holers¹, Kevin D. Deane¹ and Erika Darrah², ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, The Johns Hopkins University, Baltimore, MD, ³Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: Anti-peptidylarginine deiminase (PAD)-4 antibodies (Abs) are present in a portion of RA patients and associate with more severe joint disease, suggesting that they play…
Abstract Number: 2829 • 2017 ACR/ARHP Annual Meeting
Complete Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes Reveals Unanticipated Critical Pathogenic Pathways
Rizi Ai¹, Teresina Laragione², Deepa Hammaker³, David L. Boyle⁴, Andre ‎ Wildberg⁵, Keisuke Maeshima³, Emmanuele Palescandolo⁶, Vinod Krishna⁶, Bryan Linggi⁷, David Pocalyko⁸, John W. Whitaker⁹, Percio S. Gulko², Wei Wang¹⁰ and Gary S. Firestein¹¹, ¹UC San Diego, La Jolla, CA, ²Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, ⁶Janssen Pharmaceuticals, Spring House, PA, ⁷janssen Pharmaceuticals, Spring House, PA, ⁸Janssen Research, Spring House, PA, ⁹Janssen Pharmaceuticals, La Jolla, CA, ¹⁰Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ¹¹Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Epigenetics participates in the pathogenesis of rheumatoid arthritis (RA). Epigenetic marks, gene expression and DNA polymorphisms have been investigated but the analyses are limited…
Abstract Number: 2914 • 2017 ACR/ARHP Annual Meeting
Anti-CCP Antibody Levels Are Elevated in Cervicovaginal Fluid in Association with Local Inflammation in Premenopausal Women without RA
Sonia Khatter¹, Heather Berens-Norman², Courtney Anderson¹, Justin August¹, Marie L. Feser¹, Chelsie Fleischer¹, Ashley Visser¹, Jill M. Norris³, V. Michael Holers¹, Kevin D. Deane¹ and M. Kristen Demoruelle¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Department of Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: Data support that anti-CCP antibodies likely originate at a mucosal site prior to the onset of inflammatory arthritis (IA) in the development of RA.…
Abstract Number: 166 • 2016 ACR/ARHP Annual Meeting
Prevalence of Radiographic Thymic Alteration and Its Clinical Association in Systemic Autoimmune Diseases
Okinori Murata¹, Katsuya Suzuki¹, Hiroaki Sugiura², Yasushi Kondo¹, Hidekata Yasuoka¹, Kunihiro Yamaoka¹ and Tsutomu Takeuchi¹, ¹Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ²Keio University School of Medcine, Division of Diagnostic Radiology, Department of Radiology, Tokyo, Japan
Background/Purpose: Consecutive and unbiased 500 patients who had visited at our service and had been evaluated by chest CT scan between January 2013 and December…
Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting
Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls
Emma Weeding¹, Londyn Robinson², Jeremy Sokolove³, Julie Marchesan⁴, Steven Offenbacher⁴, William H. Robinson³, Ryan Demmer⁵, Bryan Michalowicz⁶ and Jerry A. Molitor⁷, ¹Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²University of Minnesota, Minneapolis, MN, ³Stanford University School of Medicine, Stanford, CA, ⁴Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Epidemiology, Columbia University Mailman School of Public Health, New York, NY, ⁶Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, ⁷Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
Abstract Number: 913 • 2016 ACR/ARHP Annual Meeting
Aggregatibacter Actinomycetemcomitans-Induced Hypercitrullination Links Periodontal Infection to Autoimmunity in Rheumatoid Arthritis
Maximilian F. Konig^1,2, Loreto Abusleme³, Jesper Reinholdt⁴, Robert J. Palmer³, Kevon Sampson¹, Ricardo P. Teles⁵, Peter A. Nigrovic⁶, Antony Rosen¹, Jeremy Sokolove⁷, Jon T. Giles⁸, Niki M. Moutsopoulos³ and Felipe Andrade¹, ¹Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁴Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁸Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY
Background/Purpose: A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites…
Abstract Number: 1558 • 2016 ACR/ARHP Annual Meeting
Lower Expression of a Novel Cytoplasmic Long Noncoding RNA NR_122076 Contributes to Proliferation, Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis
Yaoyao Zou, Siqi Xu, Qian Qiu, Shan Zeng, Maohua Shi, Youjun Xiao, Mingcheng Huang and Hanshi Xu, Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China., Guangzhou, China
Background/Purpose: Emerging evidence indicates that long noncoding RNAs (lncRNAs) play critical regulatory roles in various human diseases, especially in cancers and inflammatory disorders. However, the…
Abstract Number: 2563 • 2016 ACR/ARHP Annual Meeting
Hypoxia Induce Slug Expression Via JAK/STAT3 Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyungjin Kim¹, Hyemin Jeong², Jaejoon Lee², Hoon-Suk Cha¹, Eun-Mi Koh³, Eun-Jung Park⁴ and Young Hee Eun¹, ¹Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Division of Rheumatology, Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Jeju, South Korea
Background/Purpose: Accumulating evidence implicates hypoxia in the pathogenesis of rheumatoid arthritis (RA). The effect of hypoxia on the expression of Slug, a transcriptional repressor that…
Abstract Number: 2575 • 2016 ACR/ARHP Annual Meeting
The Presence of Staphylococcal Toxins in the Urine of Patients with Rheumatoid Arthritis
Laura Grace¹, Marwan Bukhari², Robert Lauder³, Lisa Bishop^4,5 and Adam Taylor¹, ¹Lancaster Medical School, Lancaster University, Lancaster, United Kingdom, ²Royal Lancaster Infirmary, Lancaster, United Kingdom, ³Biomedical & Life Sciences, Lancaster University, Lancaster, United Kingdom, ⁴Biomedical and Life Sciences, Lancaster University, Lancaster, United Kingdom, ⁵University Hopsitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is a disease of unknown etiology;with a pathogenesis that is due to a mixture of genetic, immunological and environmental factors. A…
Abstract Number: 966 • 2015 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Smoking Is Not Associated with Anti-Citrullinated Protein Antibodies per Se, but with the Concurrent Presence of Rheumatoid Factor, Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies
Tineke van Wesemael¹, Ammar Muhammad¹, Sofia ajeganova^2,3, Jennifer Humphreys⁴, Deborah P.M. Symmons^5,6, Alex J Macgregor⁷, Ingiäld Hafström², Leendert Trouw¹, T. W. J. Huizinga¹, Björn Svensson⁸, René E. M. Toes¹, Suzanne M. Verstappen⁹ and Diane van der Woude¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Department of Medicine Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden, ³Rheumatology, Leiden University Medical Center, LEIDEN, Netherlands, ⁴Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit,, Manchester, United Kingdom, ⁵Centre for Musculoskeletal Research, University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ⁶NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁷Rheumatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom, ⁸Section of Rheumatology, Department of Clinical Sciences,, University of Lund, Lund, Sweden, ⁹Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose : In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, the development of anti-citrulline autoimmunity and anti-citrullinated protein antibodies…
Abstract Number: 529 • 2015 ACR/ARHP Annual Meeting
Immunoglobulin-a and Immunoglobulin-G Isotypes of Anti-CCP Antibodies Are Present in the Sputum of Subjects at Risk for Future Development of RA
Kristen Demoruelle¹, Linh Ho², Michael H. Weisman³, Ryan W. Gan⁴, Mark C. Parish¹, Marie L. Feser¹, Chelsie Fleischer¹, Michael Mahler⁵, Andrea Seaman⁵, Jill M. Norris⁴, V. Michael Holers¹ and Kevin D. Deane¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Inova Diagnostics, San Diego, CA
Background/Purpose: Serum elevations of anti-CCP prior to inflammatory arthritis (IA) in RA suggest that anti-CCP is generated at a site outside of the joints. Data…
Abstract Number: 528 • 2015 ACR/ARHP Annual Meeting
RA33 Challenges the Paradigm of Autoantigen Selection in Rheumatoid Arthritis
Maximilian F. Konig¹, Jon Giles², Peter A. Nigrovic³ and Felipe Andrade¹, ¹Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Antibodies against citrullinated proteins (ACPAs) are the autoimmune hallmark of rheumatoid arthritis (RA), and can precede the onset of symptomatic disease by years. By…
Abstract Number: 2721 • 2015 ACR/ARHP Annual Meeting
Elevated Subgingival Levels of Periodontal Pathogens in Rheumatoid Arthritis Patients, Particularly Leptotrichia species in New-Onset Disease
Sheila Arvikar¹, Hatice Hasturk², Daniel Nguyen², Klemen Strle³, Marcy B. Bolster⁴, Deborah Collier⁵, Allen C. Steere⁶ and Alpdogan Kantarci², ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Applied Oral Health Sciences, Forsyth, Cambridge, MA, ³Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures, shares pathogenic mechanisms with rheumatoid arthritis (RA) and may trigger its onset. Most studies…
Abstract Number: 2713 • 2015 ACR/ARHP Annual Meeting
A Novel Paradigm in the Clinical Context of Rheumatoid Arthritis: Role of Tfh and Th17 Cells in Autoimmunity
Magdalena Budziakowska¹, Arif Shahzad¹, Jerry Pounds¹, Shikha Singla¹, Jerald M. Zakem^1,2, Kismet Collins¹, Tamika Webb-Detiege¹, William E. Davis^1,2, Zongbing You³, Robert Quinet^1,2 and Xin Zhang⁴, ¹Rheumatology, Ochsner Medical Center, New Orleans, LA, ²University of Queensland School of Medicine, Brisbane, Australia, ³Tulane University Health Science Center, New Orleans, LA, ⁴Laboratory of Cellular Immunology, Institution of Translational Research, Ochsner Medical Center, New Orleans, LA
Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life…