Abstract Number: 153 • 2018 ACR/ARHP Annual Meeting
Chemotaxis of Vδ2 T Cells to the Joints Contributes to the Pathogenesis of Rheumatoid Arthritis
Background/Purpose: To explore the role of Vδ2 t cells in the pathogenesis of rheumatoid arthritis (rA) Methods: Sixty-eight patients with RA, 21 patients with osteoarthritis…Abstract Number: 483 • 2017 ACR/ARHP Annual Meeting
Anti-Peptidylarginine Deiminase-4 Antibodies Are Present in the Sputum of RA Patients and Can Activate Peptidylarginine Deiminase-4 Enzyme Activity
Background/Purpose: Anti-peptidylarginine deiminase (PAD)-4 antibodies (Abs) are present in a portion of RA patients and associate with more severe joint disease, suggesting that they play…Abstract Number: 2829 • 2017 ACR/ARHP Annual Meeting
Complete Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes Reveals Unanticipated Critical Pathogenic Pathways
Background/Purpose: Epigenetics participates in the pathogenesis of rheumatoid arthritis (RA). Epigenetic marks, gene expression and DNA polymorphisms have been investigated but the analyses are limited…Abstract Number: 2914 • 2017 ACR/ARHP Annual Meeting
Anti-CCP Antibody Levels Are Elevated in Cervicovaginal Fluid in Association with Local Inflammation in Premenopausal Women without RA
Background/Purpose: Data support that anti-CCP antibodies likely originate at a mucosal site prior to the onset of inflammatory arthritis (IA) in the development of RA.…Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting
Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls
Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…Abstract Number: 913 • 2016 ACR/ARHP Annual Meeting
Aggregatibacter Actinomycetemcomitans-Induced Hypercitrullination Links Periodontal Infection to Autoimmunity in Rheumatoid Arthritis
Background/Purpose: A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites…Abstract Number: 1558 • 2016 ACR/ARHP Annual Meeting
Lower Expression of a Novel Cytoplasmic Long Noncoding RNA NR_122076 Contributes to Proliferation, Migration and Invasion of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis
Background/Purpose: Emerging evidence indicates that long noncoding RNAs (lncRNAs) play critical regulatory roles in various human diseases, especially in cancers and inflammatory disorders. However, the…Abstract Number: 2563 • 2016 ACR/ARHP Annual Meeting
Hypoxia Induce Slug Expression Via JAK/STAT3 Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Background/Purpose: Accumulating evidence implicates hypoxia in the pathogenesis of rheumatoid arthritis (RA). The effect of hypoxia on the expression of Slug, a transcriptional repressor that…Abstract Number: 2575 • 2016 ACR/ARHP Annual Meeting
The Presence of Staphylococcal Toxins in the Urine of Patients with Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a disease of unknown etiology;with a pathogenesis that is due to a mixture of genetic, immunological and environmental factors. A…Abstract Number: 166 • 2016 ACR/ARHP Annual Meeting
Prevalence of Radiographic Thymic Alteration and Its Clinical Association in Systemic Autoimmune Diseases
Background/Purpose: Consecutive and unbiased 500 patients who had visited at our service and had been evaluated by chest CT scan between January 2013 and December…Abstract Number: 528 • 2015 ACR/ARHP Annual Meeting
RA33 Challenges the Paradigm of Autoantigen Selection in Rheumatoid Arthritis
Background/Purpose: Antibodies against citrullinated proteins (ACPAs) are the autoimmune hallmark of rheumatoid arthritis (RA), and can precede the onset of symptomatic disease by years. By…Abstract Number: 529 • 2015 ACR/ARHP Annual Meeting
Immunoglobulin-a and Immunoglobulin-G Isotypes of Anti-CCP Antibodies Are Present in the Sputum of Subjects at Risk for Future Development of RA
Background/Purpose: Serum elevations of anti-CCP prior to inflammatory arthritis (IA) in RA suggest that anti-CCP is generated at a site outside of the joints. Data…Abstract Number: 966 • 2015 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Smoking Is Not Associated with Anti-Citrullinated Protein Antibodies per Se, but with the Concurrent Presence of Rheumatoid Factor, Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies
Background/Purpose : In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, the development of anti-citrulline autoimmunity and anti-citrullinated protein antibodies…Abstract Number: 1929 • 2015 ACR/ARHP Annual Meeting
Somatic Mutations in Clonally Expanded Cytotoxic Lymphocytes in Patients with Newly Diagnosed Rheumatoid Arthritis
Background/Purpose: In rheumatoid arthritis (RA), the mechanisms initiating immune dysregulation leading to joint damage are incompletely understood. Previous studies show that large CD8+ T cell…Abstract Number: 1936 • 2015 ACR/ARHP Annual Meeting
STAT3-Regulated Gene Expression in Circulating CD4+ T Cells Discriminates RA Patients Independently of Clinical Parameters in Early Arthritis: A Validation Study
Background/Purpose: A previously described transcriptional signature present in circulating CD4+ T cells of early rheumatoid arthritis (RA) patients implicated STAT3 signalling as an early pathophysiological…
ACR Meeting Abstracts