Abstracts tagged "pain"

Abstract Number: 1662 • ACR Convergence 2020
Do Weight-bearing versus Non-weight-bearing Pain Reflect Different Pain Mechanisms in Knee Osteoarthritis?: The Multicenter Osteoarthritis Study
Jean Liew¹, John Farrar², Na Wang³, Lisa Carlesso⁴, Kosaku Aoyagi³, Laura Frey Law⁵, Cora Lewis⁶, Michael Nevitt⁷ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Pennsylvania, Philadelphia, PA, ³Boston University School of Medicine, Boston, MA, ⁴McMaster University, Hamilton, ON, Canada, ⁵University of Iowa, Iowa City, IA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of California, San Francisco, San Francisco, CA
Background/Purpose: Pain with weightbearing in knee OA is thought to be related to the activation of nociceptors; however, this is not considered the sole mechanism…
Abstract Number: 0157 • ACR Convergence 2020
Early Arthritis Global Assesment: What Differences Exist Between Patients and Physicians?
Cristina Valero¹, Noelia Garcia¹, Juan Pablo Baldivieso², Ana Ortiz³, Sebastian Rodriguez² and Isidoro González-Álvaro³, ¹Hospital Universitario de la Princesa, IIS-Princesa, UAM, Madrid, Madrid, Spain, ²Hospital de La Princesa, Madrid, Madrid, Spain, ³Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Madrid, Spain
Background/Purpose: In recent years there is increasing evidence of the relevance of including the assessment of the different aspects of rheumatoid arthritis (RA) from the…
Abstract Number: 0709 • ACR Convergence 2020
Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee
Alia Obeidat¹, Rachel Miller¹ and Anne-Marie Malfait¹, ¹Rush University, CHICAGO, IL
Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
Abstract Number: 1111 • ACR Convergence 2020
Intra-Articular Mineralization on Knee CT Increases Risk of Knee Pain: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, John Lynch², Mohamed Jarraya³, David Felson¹, Na Wang¹, James Torner⁴, Cora Lewis⁵, Michael Nevitt⁶ and Ali Guermazi¹, ¹Boston University School of Medicine, Boston, MA, ²UCSF, San Francisco, CA, ³Boston University School of Medicine, Boston, ⁴University of Iowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA). Low-grade inflammation related to crystals may contribute to knee pain, including pain fluctuation.…
Abstract Number: 1490 • ACR Convergence 2020
Pain Rating Variability and Response to Treatment in Osteoarthritis Clinical Trials
Camila Pinto¹, Joana Barroso² and Thomas Schnitzer³, ¹Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Despite the known high inter- and intra-patient variability in analgesic responses in chronic pain, most interventional pain studies rely on single time point pain…
Abstract Number: 1716 • ACR Convergence 2020
Predictors of Unacceptable Pain and Unacceptable Pain with Low Inflammation in Early Rheumatoid Arthritis
Anna Eberhard¹, Tor Olofsson², Stefan Bergman³, Thomas Mandl⁴ and Carl Turesson⁵, ¹Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Department of Clinical Sciences Lund, Rheumatology, Lund University, Sweden. Department of Rheumatology, Skåne University Hospital, Lund, Sweden., Lund, Sweden, ³Rheumatology, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden, ⁴Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, ⁵Rheumatology, Department of Clinical Sciences Malmö, Lund University, Department of Rheumatology, Skåne University Hospital, Malmö, Sweden., Malmö, Sweden
Background/Purpose: Pain is a common and debilitating symptom in patients with rheumatoid arthritis (RA). In early RA it is usually due to ongoing inflammation and…
Abstract Number: 0185 • ACR Convergence 2020
Prevalence of Migraine and Neuropathic Pain in Rheumatic Disease
Sylvain Mathieu¹, Marion Couderc¹, Bruno Pereira¹, Jean-Jacques Dubost¹, Sandrine Malochet-Guinamand², Anne Tournadre², Martin Soubrier¹ and Xavier Moisset², ¹CHU Gabriel Montpied, Clermont-Ferrand, France, ²CHU Gabriel Montpied, Clermont-Ferrand
Background/Purpose: The aim of our study was to assess the prevalence of migraine and neuropathic pain in a sample of patients with chronic inflammatory rheumatism…
Abstract Number: 0736 • ACR Convergence 2020
Identification of Salient Resilience Domains Among Adolescents with Chronic Musculoskeletal Pain and Their Parents
Lauren Pianucci¹, Maitry Sonagra², Daneka Stryker³ and Sabrina Gmuca⁴, ¹Arcadia University, Philadelphia, ²Children's Hospital of Philadelphia, Cherry Hill, NJ, ³Drexel University College of Medicine, Philadelphia, PA, ⁴Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Adolescents with chronic musculoskeletal pain (CMP) and their parents have been found to have low to moderate levels of resilience and resilience levels are…
Abstract Number: 1112 • ACR Convergence 2020
Relationship of Depth-Specific Subchondral Bone Mineral Density and Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Jean Liew¹, JD Johnston², Na Wang³, John Lynch⁴, Cora Lewis⁵, James Torner⁶ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Saskatchewan, Saskatoon, SK, Canada, ³Boston University School of Medicine, Boston, MA, ⁴UCSF, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA
Background/Purpose: OA has traditionally been considered a disease of cartilage but early OA changes in subchondral bone may precede cartilage abnormalities. Altered subchondral bone mineral…
Abstract Number: 1553 • ACR Convergence 2020
Optical Tomography Can Accurately Diagnose Lupus Arthritis
Wei Tang¹, Alessandro Marone², Youngwan Kim², Tommy Chen¹, Cathy Guo¹, Leila Khalili¹, Andreas Hielscher² and Anca Askanase³, ¹Columbia University Medical Center, New York, NY, ²Columbia University, New York, NY, ³Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose: Incapacitating inflammatory arthritis occurs in up to 88% of patients with systemic lupus erythematosus (SLE). Arthritis is present in 70-80% of lupus patients in…
Abstract Number: 1726 • ACR Convergence 2020
Assessment of the Components of RAPID3 Patient Reported Outcomes in an Community Rheumatology Practice
Elston He¹, Pratyusha Yalamanchi², William Arnold³ and Erin Arnold⁴, ¹Synovium, Inc., Philadelphia, PA, ²Michigan Medicine, Ann Arbor, MI, ³Retired, Wilmette, IL, ⁴Private Practice, Orthopaedics and Rheumatology of the North Shore, Wilmette, IL
Background/Purpose: Patient reported outcomes are integral to measuring patient response to treatment for rheumatoid arthritis (RA). RAPID3 is a patient reported outcome metric that consists…
Abstract Number: 0187 • ACR Convergence 2020
Regional and Widespread Patterns of Non-articular Pain Are Common at RA Diagnosis and Contribute to Poor Outcomes at 12 Months: A Prospective Study of Pain Patterns in Canadians with RA
Vivian Bykerk¹, Orit Schieir², Marie-France Valois³, Louis Bessette⁴, Gilles Boire⁵, Glen Hazlewood⁶, Carol Hitchon⁷, Edward C Keystone⁸, Diane Tin⁹, Carter Thorne⁹, Janet Pope¹⁰, Susan Bartlett³ and Canadian Early Arthritis Cohort (CATCH) Investigators¹¹, ¹Hospital for Special Surgery, New York, NY, ²Canadian Early Arthritis Cohort Study, Montreal, Canada, ³McGill University, Montreal, Canada, ⁴Laval University, Quebec, Canada, ⁵Universite de Sherbrooke, Sherbrooke, Canada, ⁶University of Calgary, Calgary, AB, Canada, ⁷University of Manitoba, Winnipeg, MB, Canada, ⁸Mount Sinai Hospital, Toronto, ON, Canada, ⁹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹⁰Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, ¹¹Canadian Early Arthritis Cohort (CATCH) Study, Toronto, Canada
Background/Purpose: Persistent pain can occur in early RA patients, despite improvement in synovitis and may be due to coexisting non-articular pain (NAP). Though NAP is…
Abstract Number: 0737 • ACR Convergence 2020
“It’ll Go Away. There’s Nothing Wrong with you:” the Experience of Pain-Related Stigma Among Adolescents with Pain Amplification Syndrome
Emily Wakefield¹, William Zempsky¹, Rebecca Puhl² and Mark Litt³, ¹Connecticut Children's/University of Connecticut School of Medicine, Hartford, CT, ²Rudd Center for Food Policy & Obesity/University of Connecticut, Hartford, CT, ³University of Connecticut School of Medicine, Farmington, CT
Background/Purpose: Chronic pain in adolescence is a complex and significant medical condition, with a reported prevalence of 11-38%.1 Pain amplification syndrome (PAS), which includes fibromyalgia,…
Abstract Number: 1201 • ACR Convergence 2020
Effect of Filgotinib on Pain in Patients with Rheumatoid Arthritis: Results from Phase 3 Clinical Trials
Peter Taylor¹, Arthur Kavanaugh², Peter Nash³, Janet Pope⁴, Beatrix Bartok⁵, Ken Hasegawa⁵, Shangbang Rao⁵, Sander Strengholt⁶ and Rene Westhovens⁷, ¹Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Division of Rheumatology, Allergy, & Immunology, University of California San Diego Medical School, San Diego, CA, ³School of Medicine Griffith University, Brisbane, Queensland, Australia, ⁴Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, ⁵Gilead Sciences, Inc., Foster City, CA, ⁶Galapagos BV, Leiden, Netherlands, ⁷University Hospitals Leuven, Belgium, Leuven, Belgium
Background/Purpose: RA patients (pts) often suffer substantial pain despite ongoing treatment (tx) and regard pain control as a top tx goal. Filgotinib (FIL)—a potent, oral…
Abstract Number: 1635 • ACR Convergence 2020
Profile of Topical Diclofenac Sodium Gel 1% (Voltaren®) Users in a United States Longitudinal Electronic Health Records Database
Amy Kenneally¹, Frédérique Bariguian², Richard Petruschke¹, Arlene Tave³, Jess Edison⁴, Nicholas M. Sicignano⁵ and Francis Barbone¹, ¹GSK Consumer Healthcare, Warren, NJ, ²GSK Consumer Healthcare S.A., Nyon, Switzerland, ³PharmaLex US Corporation, Fairfax, VA, ⁴Walter Reed National Military Medical Center, Bethesda, ⁵Health ResearchTx LLC., Prevose, PA
Background/Purpose: Diclofenac sodium gel 1% (DSG), a topical non-steroidal anti-inflammatory drug (NSAID), is effective for the relief of osteoarthritis (OA) pain in the elbows, wrists,…

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