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Abstracts tagged "PAD"

  • Abstract Number: 77 • 2018 ACR/ARHP Annual Meeting

    Single Nucleotide Polymorphism in the Gene Encoding Peptidylarginine Deiminase 4 Correlates with Reduced Neutrophil Extracellular Traps and Anti-Histone Antibodies in Rheumatoid Arthritis

    Aisha M. Mergaert1, Mandar Bawadekar2, Thai Q. Nguyen1, Steven J. Schrodi3,4 and Miriam A. Shelef2,5, 1University of Wisconsin - Madison, Madison, WI, 2Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, 3Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, 4Computation and Informatics in Biology and Medicine, University of Wisconsin - Madison, Madison, WI, 5William S. Middleton Memorial Veterans Hospital, Madison, WI

    Background/Purpose: In neutrophils, peptidylarginine deiminase 4 (PAD4) citrullinates histones allowing chromatin unraveling and neutrophil extracellular trap (NET) formation. NETs are increased and display proteins targeted…
  • Abstract Number: 1461 • 2018 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase-4 Antibodies Are Not Associated with Worse RA Activity, Symptoms or Impacts

    Dana DiRenzo1, Erika Darrah2, Susan J. Bartlett3,4, Clifton O. Bingham III4 and Laura C. Cappelli1, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Medicine/Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, 4Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose:   Antibodies to peptidylarginine deiminase (PAD) enzymes have been implicated in the pathogenesis of RA. Previous studies have shown that patients with PAD4 antibodies…
  • Abstract Number: 1471 • 2018 ACR/ARHP Annual Meeting

    ECV304 Cells Self-Citrullinate Proteins Targeted By Anti-Citrullinated Protein/Peptide Autoantibodies from Rheumatoid Arthritis Patients

    Natalia Regine de Franca Shimabukuro1,2, Maximilien Lora1, Mariana Useche3, Zhijie Zhou4, Joyce Rauch5, Luis Eduardo Coelho Andrade2, Henri Menard1 and Ines Colmegna6, 1The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Federal University of São Paulo, São Paulo, Brazil, 3Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4Aurora Medical Centre, Oshkosh, WI, 5Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 6The Research Institute of the McGill University Health Centre, Division of Rheumatology, Department of Medicine, McGill University, Montreal, Quebec, Canada, Montreal, QC, Canada

    Background/Purpose: Anti-citrullinated protein/peptide autoantibodies (ACPAs) define a major subset of rheumatoid arthritis (RA) patients. Cyclic citrullinated peptides (CCP) are commonly used as the antigen for…
  • Abstract Number: 2056 • 2018 ACR/ARHP Annual Meeting

    Citrullination Is Not a Determinant in the Lack of Tolerance to Peptidylarginine Deiminase 2 and 4 in Rheumatoid Arthritis

    Pooja Naik1, Ryan Davis2, Jon T. Giles3, Felipe Andrade4 and Erika Darrah5, 1Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Columbia University, New York, NY, 4Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Department of Medicine/Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Peptidylarginine deiminase (PAD) 2 and 4 are targets of the humoral response in RA. However, the mechanisms by which these enzymes become immunogenic in…
  • Abstract Number: 2794 • 2018 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminases Are Required for Normal Immunoglobulin G Half-Life

    Mandar Bawadekar1 and Miriam A. Shelef1,2, 1Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, 2William S. Middleton Memorial Veterans Hospital, Madison, WI

    Background/Purpose: Antibodies are a cornerstone of immunity and pathologic in autoimmunity. Immunoglobulin G (IgG) can undergo multiple different post-translation modifications, some of which can alter…
  • Abstract Number: 1363 • 2017 ACR/ARHP Annual Meeting

    Disease Duration and Shared Epitope, but Not Smoking History, Are Associated with Peptidylarginine Deiminase 4-Antibody Development in Rheumatoid Arthritis

    Laura Cappelli1, Maximilian Konig1, Pooja Naik2, Arvin Saleh3, Allan C. Gelber3, Clifton O. Bingham III4 and Erika Darrah5, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Rheumatology, Johns Hopkins University, Baltimore, MD, 5Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Clinical characteristics and biomarkers help clinicians predict disease features in rheumatoid arthritis (RA). Both peptidylarginine deiminase 4 (PAD4) antibodies and smoking have been associated…
  • Abstract Number: 2430 • 2017 ACR/ARHP Annual Meeting

    For Each HLA-DRB1 Genotype, the Likelihood to Develop RA Correlates with the Probability of Binding at Least a Peptide from PAD4

    Isabelle Auger1, Nathalie Balandraud2 and Jean Roudier3, 1INSERM UMRs 1097, Marseille, France, 2Rheumatology, APHM, Marseilles, France, 3Arthrites auto-immunes, INSERM UMRs 1097, Marseille, France

    HLA-DRB1 genotypic risk to develop ACPA positive RA correlates with capability of encoded HLA-DRB1 chains to bind Peptidyl Arginyl Deiminase (PAD4) peptides, not citrullinated Fibrinogen…
  • Abstract Number: 483 • 2017 ACR/ARHP Annual Meeting

    Anti-Peptidylarginine Deiminase-4 Antibodies Are Present in the Sputum of RA Patients and Can Activate Peptidylarginine Deiminase-4 Enzyme Activity

    M. Kristen Demoruelle1, Hong Wang2, Ryan L. Davis2, A. Itzam Marin1, Jill M. Norris3, V. Michael Holers1, Kevin D. Deane1 and Erika Darrah2, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Division of Rheumatology, The Johns Hopkins University, Baltimore, MD, 3Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: Anti-peptidylarginine deiminase (PAD)-4 antibodies (Abs) are present in a portion of RA patients and associate with more severe joint disease, suggesting that they play…
  • Abstract Number: 1072 • 2017 ACR/ARHP Annual Meeting

    Mutated Peptidylarginine Deiminase from Porphyromonas Gingivalis Is a Target in Rheumatoid Arthritis and Citrullinates Major RA-Autoantigens

    Madeleine Jenning1, Bianka Marklein1, Jimmy Ytterberg2, Gerd R. Burmester1 and Karl Skriner1, 1Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, 2Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Previous reports showed that peptidylarginine deiminase (PPAD) form Porphyromonas gingivalis (P.g.) is not able to citrullinate proteins internally. Mutated PPAD (mPPAD) from P.g. involved…
  • Abstract Number: 470 • 2016 ACR/ARHP Annual Meeting

    Crucial Involvement of Citrullinated Proteins and ACPA in the Development of Peptide-Glucose-6-Phosphate Isomerase Induced Arthritis

    Hoshimi Kawaguchi1, Isao Matsumoto1, Hiroshi Ebe1, Naoto Umeda1, Yuya Kondo1, Hiroto Tsuboi2 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Division of Clinical Immunology, Doctoral Programs in Clinical Science, Graduated School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Various citrullinated proteins and anti-citrullinated protein antibodies (ACPA) are increased in patients with rheumatoid arthritis (RA). ACPA have high specificity for RA, and are…
  • Abstract Number: 570 • 2016 ACR/ARHP Annual Meeting

    A Molecular Timeline for Preclinical RA Pathogenesis Defined By Dysregulated PTPN22, Hypercitrullination, and Aberrant Cytokine/Metabolic Profiles in PBMC of at-Risk Individuals

    Hui-Hsin Chang1, Nishant Dwivedi2, Bo Sun2, Deepak A. Rao3, Jeffrey A. Sparks3, Jennifer Kinslow4, Yuko Okamoto4, Kevin D. Deane5, M. Kristen Demoruelle6, Jill M. Norris7, Elizabeth Karlson2, V. Michael Holers8 and I-Cheng Ho1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 4University of Colorado School of Medicine, Aurora, CO, 5Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 6Rheumatology, University of Colorado School of Medicine, Aurora, CO, 7Epidemiology, Colorado School of Public Health, Aurora, CO, 8Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: One unique feature of RA is the presence of ACPA. PTPN22 is a phosphatase that also acts to suppress citrullination independently of its phosphatase…
  • Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway

    Meng Sun1, Vijay Joshua1, Akilan Krishnamurthy1, Yanying Liu2, Aase Hensvold1, Sergiu-Bogdan Catrina3, Caroline Ospelt4, Vivianne Malmström5, Khaled Amara1, Johanna Steen1, Muhammad Sohel Mia1, Marianne Engström1, Heidi Wähämaa1, Jimmy Ytterberg1, Bence Rethi1 and Anca I Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, 3Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, 5Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…
  • Abstract Number: 3022 • 2016 ACR/ARHP Annual Meeting

    Autoantibodies to Peptidylarginine Deiminase 2 Protect Against Radiographic Progression in Patients with Rheumatoid Arthritis

    Erika Darrah1, Jon T. Giles2, Ryan Davis1, Pooja Naik1, Maximilian Konig1 and Felipe Andrade1, 1Department of Medicine, Division of Rheumatology, The Johns Hopkins University, Division of Rheumatology, Baltimore, MD, 2Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY

    Background/Purpose:  The mechanisms that drive clinical heterogeneity and outcomes in patients with rheumatoid arthritis (RA) are poorly understood, but precise biomarkers may identify clinically unique…
  • Abstract Number: 3148 • 2016 ACR/ARHP Annual Meeting

    Peptidylarginine Deiminase 2 Is Required for Tumor Necrosis Factor Alpha Induced Citrullination and Arthritis, but Not Neutrophil Extracellular Trap Formation

    Mandar Bawadekar1, Daeun Shim1, Ryan Rebernick1, Chloe Peyton1, Chad J. Johnson2, Thomas F. Warner3, Dres Damgaard4, Claus Henrik Nielsen5, Anthony P. Nicholas6, Ger JM Pruijn7, Jeniel E. Nett8 and Miriam A. Shelef1,9, 1Department of Medicine, Division of Rheumatology, University of Wisconsin-Madison, Madison, WI, 2Department of Medicine, University of Wisconsin-Madison, Madison, WI, 3Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 4Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, 5Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, 6Neurology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, 7Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands, 8Medicine and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, 9William S. Middleton Memorial Veterans Hospital, Madison, WI

    Background/Purpose: The presence of anti-citrullinated protein antibodies in rheumatoid arthritis points to a potential role for citrullination in disease pathogenesis. Peptidylarginine deiminases (PADs) catalyze the…
  • Abstract Number: 527 • 2015 ACR/ARHP Annual Meeting

    Characterisation of the Antibody Response to a Citrullinated Peptide – Derived from the Porphyromonas Gingivalis Peptidyl Arginine Deiminase Enzyme – in Patients with Rheumatoid Arthritis

    Nastya Kharlamova1, Xia Jiang2, Natalia Sherina3, Monika Hansson4, K. Lundberg5 and Lars Alfredsson6, 1Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, 2Rheumatology, karolinska institutet, skärholmen, Sweden, 3Rheumatology, karolinska institutet, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 5Karolinska Institute, Stockholm, Sweden, 6The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: It has been hypothesized that Porphyromonas gingivalis - the only known pathogen to express a citrullinating enzyme (called P.PAD) - is etiologically linked to…
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