Abstract Number: 42 • 2019 ACR/ARP Annual Meeting
Subclinical Oral Inflammation Is Common Across the Spectrum of Oral Findings in Rheumatoid Arthritis Patients, Whereas Porphyromonas Gingivalis Antibodies Are Primarily a Marker for Clinical Periodontitis
Background/Purpose: Periodontitis and immune responses to periodontal pathogens such as Porphyromonas gingivalis (Pg) are associated with rheumatoid arthritis (RA) but the mechanisms underlying these connections…Abstract Number: 487 • 2017 ACR/ARHP Annual Meeting
ARE ANTI-Citrullinated Protein Antibody Levels Associated with Periodontal Disease in Rheumatoid Arthritis?
Background/Purpose: Positivity of anti-citrullinated peptides antibodies (ACPA) indicates severity in Rheumatoid Arthritis (RA). There is evidence for chronic periodontitis (PD) in RA autoimmune response by…Abstract Number: 494 • 2017 ACR/ARHP Annual Meeting
The Oral Microbiome Is Altered in Patients with Rheumatoid Arthritis
Background/Purpose: The mouth is the second most abundantly colonized mucosal surface in the human body. Periodontitis, a polymicrobial infectious and inflammatory disease of tooth-supporting structures,…Abstract Number: 1072 • 2017 ACR/ARHP Annual Meeting
Mutated Peptidylarginine Deiminase from Porphyromonas Gingivalis Is a Target in Rheumatoid Arthritis and Citrullinates Major RA-Autoantigens
Background/Purpose: Previous reports showed that peptidylarginine deiminase (PPAD) form Porphyromonas gingivalis (P.g.) is not able to citrullinate proteins internally. Mutated PPAD (mPPAD) from P.g. involved…Abstract Number: 2995 • 2017 ACR/ARHP Annual Meeting
Pathogens in the Inflammatory Process of Periodontal Disease and Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) and periodontal disease (PD) are both diseases of inflammation that can result in bone loss when the inflammatory process is…Abstract Number: 518 • 2015 ACR/ARHP Annual Meeting
Antibody Responses to Citrullinated Porphyromonas Gingivalis Peptidylarginine Deiminase: Associations with Disease Risk Factors and Severity in Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoimmunity to citrullinated proteins. Porphyromonas gingivalis (Pg) has been proposed as an epidemiologic link between RA and periodontitis…Abstract Number: 523 • 2015 ACR/ARHP Annual Meeting
Elevated Antibody Response to Porphyromonas Gingivalis Detected in Sera Years before the Clinical Onset of Rheumatoid Arthritis
Background/Purpose: Chronic periodontitis has been associated with rheumatoid arthritis (RA), and Porphyromonas gingivalis has been proposed as the mechanistic link, due to its unique property…Abstract Number: 524 • 2015 ACR/ARHP Annual Meeting
Plasma Concentrations of Antibodies to Porphyromonas Gingivalis Are Increased before Onset of Symptom of Rheumatoid Arthritis
Background/Purpose: Chronic periodontitis has been considered as an important determinant in both occurrence and severity of rheumatoid arthritis (RA). It has been hypothesized that citrullination…Abstract Number: 527 • 2015 ACR/ARHP Annual Meeting
Characterisation of the Antibody Response to a Citrullinated Peptide – Derived from the Porphyromonas Gingivalis Peptidyl Arginine Deiminase Enzyme – in Patients with Rheumatoid Arthritis
Background/Purpose: It has been hypothesized that Porphyromonas gingivalis - the only known pathogen to express a citrullinating enzyme (called P.PAD) - is etiologically linked to…Abstract Number: 2782 • 2014 ACR/ARHP Annual Meeting
Autoantibodies from Single Circulating Plasmablasts React with Citrullinated Antigens and Porphyromonas Gingivalis in Rheumatoid Arthritis
Background/Purpose Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) and also believed to play a pathogenic role in RA. Porphyromonas gingivalis (P.…Abstract Number: 1475 • 2014 ACR/ARHP Annual Meeting
Porphyromonas Gingivalis and Bone Turnover Biomarkers in Rheumatoid Arthritis
Background/Purpose: Periodontitis (PD) associated with P. gingivalis has been implicated as a risk factor for rheumatoid arthritis (RA). We have previously demonstrated that RA patients…Abstract Number: 1402 • 2014 ACR/ARHP Annual Meeting
Parameters of Periodontitis Correlate with Anti-Citrullinated Protein Antibodies and P. Gingivalis Antibody Titers in Patients with Early or Chronic Rheumatoid Arthritis
Background/Purpose Emerging evidence suggests that periodontitis and periodontal pathogens, such as Porphyromonas gingivalis (Pg), may be an environmental trigger for rheumatoid arthritis (RA). We found…Abstract Number: 339 • 2014 ACR/ARHP Annual Meeting
Toll-like Receptor Dependent Autoantigens and Vesicles from P.Gingivalis in Animal Models of RA to Modulate Collagen and Collagen Antibody Induced Arthritis
Background/Purpose A variety of animal models suggest that TLR signaling is important in the pathogenesis of RA and the generation of specific autoantibodies. This study…Abstract Number: 1378 • 2013 ACR/ARHP Annual Meeting
Associations Of Periodontitis (PD) With Established Seropositive Rheumatoid Arthritis are Independent of Smoking and Other Risk Factors
Background/Purpose: Periodontitis (PD) has been proposed as a risk factor in RA. Reports have suggested that this association may be due to confounding from smoking…Abstract Number: 1360 • 2013 ACR/ARHP Annual Meeting
Evaluation Of Biomarkers Involved In Periondontal Disease Including Porphyromonas Gingivalis Antibodies To Predict Response To Infliximab In Rheumatoid Arthritis Patients
Background/Purpose: This study evaluates biological markers of rheumatoid arthritis (RA) severity including matrix metalloproteinase 3 (MMP-3) and Porphyromonas gingivalis (P. gingivalis) serology during infliximab therapy…