Abstracts tagged "Outcome measures"

Abstract Number: 341 • 2018 ACR/ARHP Annual Meeting
Setting Treatment Target for Joint Surgery in Lower Limbs in Patients with Long-Standing Rheumatoid Arthritis Based on Multicenter Prospective Cohort Study; Validation and Reliability of Objective Index of Activity Speed (Timed Up and Go test) for Measuring Physical Function
Toshihisa Kojima¹, Hajime Ishikawa², Masayo Kojima³, Sakae Tanaka⁴, Nobuhiko Haga⁵, Keiichiro Nishida⁶, Masao Yukioka⁷, Jun Hashimoto⁸, Hisaaki Miyahara⁹, Yasuo Niki¹⁰, Tomoatsu Kimura¹¹, Hiromi Oda¹², Shuji Asai¹, Koji Funahashi¹³ and Naoki Ishiguro¹, ¹Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Orthopedic Surgery, Niigata Rheumatic Center, Shibata, Japan, ³Medical education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, ⁴Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Japan, ⁵Rehabilitation Medicine, The University of Tokyo Hospital, Tokyo, Japan, ⁶Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Japan, ⁷Orthopedic Surgery, Yukioka Hospital, Osaka, Japan, ⁸Rheumatology/Orthopaedics, Osaka-Minami Medical Ctr, Kawachinagano, Japan, ⁹Department of Rheumatology and Orthopaedic Surgery, Kyushu Medical Center, Fukuoka, Japan, ¹⁰Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan, ¹¹Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama, Japan, ¹²Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan, ¹³Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Japan
Background/Purpose: Total management including reconstructive joint surgery and rehabilitation should be needed for further improvements of physical function for long-standing RA patients. It is very…
Abstract Number: 2562 • 2018 ACR/ARHP Annual Meeting
Secukinumab Improves Grappa-Omeract Core Domains of Psoriatic Arthritis
Ana-Maria Orbai¹, Iain B. McInnes², Laura C. Coates³, M. Elaine Husni⁴, Dafna D Gladman⁵, Laure Gossec⁶, Luminita Pricop⁷, Olivier Chambenoit⁸, Xiangyi Meng⁸ and Philip J. Mease⁹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²University of Glasgow, Glasgow, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Cleveland Clinic, Cleveland, OH, ⁵Toronto Western Research Institute and University of Toronto, Toronto, ON, Canada, ⁶Université Pierre et Marie Curie and Hôpital Pitié-Salpêtrière, Paris, France, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ, ⁸Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁹Swedish Medical Center and University of Washington, Seattle, WA
Background/Purpose: Secukinumab, a fully human monoclonal antibody that selectively neutralizes IL-17A, has demonstrated efficacy for patients with psoriatic arthritis (PsA) in multiple phase 3 clinical…
Abstract Number: 481 • 2018 ACR/ARHP Annual Meeting
Stepping It up: The Use of Physical Activity Monitors As an Outcome Measure in Juvenile Myositis
Emily Brunner¹, Laura Tasan², Kathryn S. Torok³, Bonny Rockette-Wagner⁴, Christina K. Zigler⁵, Kaila Schollaert-Fitch³, Diane Koontz⁶, Chester V. Oddis⁷ and Rohit Aggarwal⁸, ¹Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ³Pediatric Rheumatology, University of Pittsburgh Med Ctr, Pittsburgh, PA, ⁴University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, ⁶Internal Medicine Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Division of Rheumatology and Clinical Immunology, Department of Medicine, Unviersity of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA, ⁸Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA
Background/Purpose: The use of physical activity monitors (PAM), which objectively quantify free-living movement, may enhance assessment of disease activity in juvenile myositis (JM) clinical trials…
Abstract Number: 2687 • 2018 ACR/ARHP Annual Meeting
Patient-Level Evaluation of Components of the American College of Rheumatology Combined Response Index in Systemic Sclerosis (CRISS) Using Patient-Reported Anchors
Vivek Nagaraja¹, John Powers², Celia J. F. Lin³, Benjamin Brennan⁴, Veronica J. Berrocal⁵ and Dinesh Khanna¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²University of Maryland School of Medicine, Rockville, MD, ³Genentech, Inc., South San Francisco, CA, ⁴School of Public Health, University of Michigan, Ann Arbor, MI, ⁵Div of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Treatment benefit is demonstrated by evidence that interventions have positive impacts on how patients feel, function, and/or survive (FDA Guidance, 21CFR314.510). The ACR CRISS,…
Abstract Number: 681 • 2018 ACR/ARHP Annual Meeting
Identification of Treatment Naïve Patients with Psoriatic Arthritis Who Will Require a TNF Inhibitor
Dan Gromer¹, Laura C. Coates², Oliver FitzGerald³, Blanca Himes⁴, Philip Helliwell⁵ and Alexis Ogdie⁶, ¹University of Pennsylvania, Medical Student, Philadelphia, PA, ²University of Oxford, Oxford, United Kingdom, ³Department of Rheumatology, St Vincent's University Hospital and Conway Institute, University College Dublin, Ireland, Dublin, Ireland, ⁴Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ⁵LIMM, Section of Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, ⁶Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory disease that affects the skin, joints, and soft tissues. No metrics exist to indicate whether an…
Abstract Number: 2783 • 2018 ACR/ARHP Annual Meeting
EULAR Task Force Recommendations for a Minimum Core Set of Parameters to be Collected in Giant Cell Arteritis Registries and Databases
Lisa Ehlers¹, Johan Askling², Johannes W. J. Bijlsma³, Maria C. Cid⁴, Maurizio Cutolo⁵, Bhaskar Dasgupta⁶, Christian Dejaco^7,8, William G Dixon⁹, Nils Feltelius^10,11, Axel Finckh¹², Kate Gilbert¹³, Sarah Mackie¹⁴, Alfred Mahr¹⁵, Eric L. Matteson¹⁶, Lorna Neill¹⁷, Carlo Salvarani^18,19, Wolfgang A. Schmidt²⁰, Anja Strangfeld²¹, Ronald van Vollenhoven²² and Frank Buttgereit¹, ¹Department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany, ²Unit of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴University of Barcelona, Barcelona, Spain, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ⁶Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, ⁷Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria, Graz, Austria, ⁸Rheumatology, Hospital of Bruneck, Bruneck, Italy, ⁹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ¹⁰Medical Products Agency, Uppsala, Sweden, ¹¹Cross-Committee Task Force on Registries at the European Medicines Agency, London, United Kingdom, ¹²University Hospital of Geneva, Geneva, Switzerland, ¹³Patient Representative from PMRGCAuk, London, United Kingdom, ¹⁴NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom, ¹⁵Internal Medicine, Saint-Louis Hospital, Paris Diderot University, Paris, France, ¹⁶Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ¹⁷Patient Representative from PMR-GCA Scotland, Perth, United Kingdom, ¹⁸Università di Modena e Reggio Emilia, Modena, Italy, ¹⁹Azienda USL-IRCCS di Reggio Emilia and Università di Modena e Reggio Emilia, Reggio Emilia, Italy, ²⁰Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany, ²¹Epidemiology, German Rheumatism Research Center, Berlin, Germany, ²²Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands
Background/Purpose: Giant cell arteritis (GCA) represents the most common form of primary systemic vasculitis, and is frequently associated with comorbidities related either to the disease…
Abstract Number: 723 • 2018 ACR/ARHP Annual Meeting
Patient-Reported Cognitive Screen Does Not Identify Cognitive Sub-Domains: Exploration of the Subscale Structure of the Perceived Deficits Questionnaire in a Systemic Lupus Erythematosus Cohort
Lisa Engel¹, Jiandong Su¹, Emily Nalder², Yael Goverover³, Monique Gignac⁴, Carmela Tartaglia⁵, Nicole Anderson¹ and Zahi Touma¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada, ³Department of Occupational Therapy, New York University, New York, NY, ⁴Instititue for Work and Health, Toronto, ON, Canada, ⁵University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada
Background/Purpose: Identifying patients with Systemic Lupus Erythematosus related cognitive impairment (SLE-CI) is critical as SLE-CI can negatively affect employment, quality of life, and disease self-management.…
Abstract Number: 2857 • 2018 ACR/ARHP Annual Meeting
An Electronic Audit, Reporting, and Data Correction System Improves the Quantity and Quality of Observational Data Collected for US Veterans Enrolled in the Veterans Affairs Rheumatoid Arthritis Registry
Grant W. Cannon^1,2, Jorge Rogas², Neill Bell³, Joshua Baker⁴, Gail S. Kerr⁵, Angelo Gaffo⁶, J. Steuart Richards⁷, Jennifer Barton⁸, Pascale Schwab⁸, Ted R. Mikuls⁹, Namrata Singh¹⁰, Liron Caplan¹¹, Deana Lazaro¹², Andreas Reimold¹³ and Brian Sauer², ¹Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ³Salt Lake City VA Medical Center and University of Utah, Dallas VA Medical Center, Dallas, TX, ⁴Philadelphia VA Medical Center and University of Pennsylvania, Philadelphia, PA, ⁵Washington VA Medical Center, Georgetown and Howard Universities, Washington, DC, ⁶Birmingham VA and University of Alabama at Birmingham, Birmingham, AL, ⁷Pittsburgh VA Medical Center and University of Pittsburgh, Pittsburgh, PA, ⁸VA Portland Health Care System and Oregon Health and Science, Portland, OR, ⁹VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ¹⁰Internal Medicine, Iowa City VA Medical Center and University of Iowa, Iowa City, IA, ¹¹Div of Rheumatology, Denver VA Medical Center and University of Colorado, Aurora, CO, ¹²Brooklyn VA Medical Center and SUNY Downstate, Brooklyn, NY, ¹³Rheumatology, Dallas VA Medical Center and University of Texas - Southwestern, Dallas, TX
Background/Purpose: The Veterans Affairs (VA) Rheumatoid Arthritis (RA) (VARA) registry is an observational cohort study of US Veterans with RA at 11 VA Medical…
Abstract Number: 1261 • 2018 ACR/ARHP Annual Meeting
Development a Core Domain Set to Assess Shared Decision Making Interventions in Rheumatology: An OMERACT White Paper to Facilitate Endorsement
Karine Toupin-April¹, Jennifer Barton^2,3, Liana Fraenkel⁴, Alexa Meara⁵, Linda Li⁶, Peter Brooks⁷, Maarten de Wit⁸, Dawn Stacey^9,10, France Légaré¹¹, Beverly Shea^9,12,13, Anne Lyddiatt¹⁴, Catherine Hofstetter¹⁵, Robin Christensen¹⁶, Marieke Scholte-Voshaar^17,18, Maria Suarez-Almazor¹⁹, Annelies Boonen²⁰, Tanya Meade^21,22, Lyn March²², Janet Elizabeth Jull⁹, Willemina Campbell²³, Rieke Alten²⁴, Suvi Karuranga²⁵, Esi Morgan²⁶, Jessica Kaufmann²⁷, Sophie Hill²⁷, Lara J. Maxwell^9,10, Dorcas Beaton²⁸, Yasser El-Miedany²⁹, Shikha Mittoo³⁰, Susan J. Bartlett³¹, Jasvinder A. Singh³² and Peter Tugwell³³, ¹Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada, ²VA Portland Health Care System, Portland, OR, ³Oregon Health & Science University, Portland, OR, ⁴Yale University School of Medicine, New Haven, CT, ⁵Internal Medicine/Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Arthritis Research Canada, Richmond, BC, Canada, ⁷The University of Melbourne, Victoria, Australia, ⁸EULAR standing committee of PARE, Zurich, Switzerland, ⁹University of Ottawa, Ottawa, ON, Canada, ¹⁰The Ottawa Hospital Research Institute, Ottawa, ON, Canada, ¹¹Université Laval, Montreal, QC, Canada, ¹²Bruyere Research Institute, Ottawa, ON, Canada, ¹³School of Epidemiology, Public Health, and Preventive Medicine, Faculty of Medicine, University of Ottawa, and Ottawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, ON, Canada, ¹⁴Musculoskeletal Group, Cochrane Collaboration, Hamilton, ON, Canada, ¹⁵OMERACT patient research partner group, Ottawa, ON, Canada, ¹⁶Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ¹⁷University of Twente, Enschede, ON, Netherlands, ¹⁸OMERACT patient research partner group, Enschede, Netherlands, ¹⁹Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, ²⁰Department of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands, Maastricht, Netherlands, ²¹Western Sydney University, New South Wales, Australia, ²²University of Sydney, New South Wales, Australia, ²³OMERACT patient research partner group, Toronto, ON, Canada, ²⁴University Medicine Berlin, Berlin, Germany, ²⁵Access to Medicine Foundation, Haarlem, Netherlands, ²⁶University of Cincinnati, Cincinnati, OH, ²⁷La Trobe University, Victoria, Australia, ²⁸Mobility Program Clinical Research Unit, St Michael's Hospital, Toronto, ON, Canada, ²⁹Ain Shams University, Cairo, Egypt, ³⁰Involved medicine, Toronto, ON, Canada, ³¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³²Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³³Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada
Background/Purpose: Shared decision making (SDM) improves decisional outcomes and patient-physician communication and holds great potential for improving the management of various rheumatology conditions. However, the…
Abstract Number: 2871 • 2018 ACR/ARHP Annual Meeting
Comprehensive Provider Judgement Is a Significant Determinant of Major Therapeutic Change in Patients with Moderate to Severe Rheumatoid Arthritis
Jacob R. Stever¹, Brian C. Sauer¹ and Grant W. Cannon², ¹Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ²Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT
Background/Purpose: We have previously reported an evaluation of 941 US Veterans in the Veterans Affairs (VA) Rheumatoid Arthritis (RA) (VARA) registry that 559 (59%)…
Abstract Number: 1878 • 2017 ACR/ARHP Annual Meeting
The Utility of the Omeract Ultrasound Tenosynovitis Scoring System in Multicenter Clinical Trials
Mads Ammitzbøll-Danielsen¹, Mikkel Østergaard¹, Esperanza Naredo², Annamaria Iagnocco³, Ingrid Moller⁴, Maria Antonietta D'Agostino⁵, Frédérique Gandjbakhch⁶ and Lene Terslev⁷, ¹Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ²Rheumatology, Joint and Bone Research Unit, IIS-FJD, Hospital Universitario Fundación Jiménez Díaz., Madrid, Spain, ³Academic Rheumatology Unit, Università degli Studi di Torino, Torino, Italy, ⁴Rheumatology, Instituto Poal, Barcelona, Spain, ⁵Department of Rheumatology, Assistance publique-Hôpitaux de Paris Ambroise Paré Hospital, Boulogne-Billancourt , Université Versailles Saint Quentin en Yvelines, Paris, France, ⁶Department of Rheumatology, APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France, ⁷Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark
Background/Purpose :Tenosynovitis is very common in patients with RA and is associated with lower physical function. Several studies have confirmed the limitations of clinical examination…
Abstract Number: 2211 • 2017 ACR/ARHP Annual Meeting
Investigation of Self-Reported Painful Joint Count As an Outcome Measure in Hand Osteoarthritis
F.P.B. Kroon¹, J.L. van der Plas¹, S. van Beest¹, W. Damman¹ and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Hand osteoarthritis (OA) research is in need of disease-specific validated instruments to measure patient-reported outcomes. Self-reported painful joint count (PJC) could be useful to…
Abstract Number: 2238 • 2017 ACR/ARHP Annual Meeting
Mapping Paindetect, a Neuropathic Pain Screening Tool, to Patient-Reported Outcomes Measurement Information System (PROMIS) 29 in Patients with Rheumatoid Arthritis: Developing a Neuropathic Pain Scale As a Measure of Treatment Outcome
Yong Gil Hwang¹, Lei Zhu², Ajay Wasan³ and Larry W. Moreland¹, ¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Departments of Anesthesiology and Psychiatry, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: To investigate relationships between painDETECT (PDQ), neuropathic pain screening tool, and patient-reported outcomes measurement information system (PROMIS) 29 in patients with rheumatoid arthritis…
Abstract Number: 2293 • 2017 ACR/ARHP Annual Meeting
Can We Predict Achievement of Clinically Inactive Disease and Sustained Remission in Children with Juvenile Idiopathic Arthritis?
Stephanie Shoop-Worrall¹, Suzanne M Verstappen², Janet E. McDonagh³, Wendy Thomson⁴ and Kimme L. Hyrich¹, ¹The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ²Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ³Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom
Background/Purpose: Identifying predictors for clinically inactive disease (CID) and sustained remission would allow rapid escalation of therapies for children less likely to achieve these states.…
Abstract Number: 229 • 2017 ACR/ARHP Annual Meeting
Divergent Measures of Lupus Disease Damage and Severity Among Asians in an Ethnically Diverse Cohort
Laura Trupin¹, Patricia P. Katz², Cristina Lanata², Lindsey A. Criswell², Charles G. Helmick³, Maria Dall'Era² and Jinoos Yazdany¹, ¹Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ²Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ³Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is not well characterized among Asian Americans, particularly among subgroups of Asians. We aim to compare measures of disease status,…

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