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Abstracts tagged "Outcome measures"

  • Abstract Number: 1668 • ACR Convergence 2020

    Long-Term Outcomes in Children Born to Anti-Ro and/or Anti-La Positive Mothers

    Talia Diaz1, Daniela Dominguez2, Edgar Jaeggi3, Andrea Knight4, Carl A. Laskin5, Lawrence Ng6, Franklin Silverio1, Earl D. Silverman7 and Linda Hiraki8, 1Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 2Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, 3Fetal Cardiac Program, The Hospital for Sick Children, Toronto, ON, Canada, 4Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 5Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, 6Division of Rheumatology, Hospital for Sick Children, Toronto, Canada, 7Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Neonatal Lupus Erythematosus (NLE) is an acquired autoimmune disorder associated with the transplacental passage of maternal anti-Ro and/or anti-La antibodies. Previous studies have suggested…
  • Abstract Number: 1893 • ACR Convergence 2020

    Predictors of Response in Secukinumab-treated Patients with Ankylosing Spondylitis: Logistic Regression and Machine Learning Analyses

    Corinne Miceli-Richard1, Denis Poddubnyy2, Atul Deodhar3, Weibin Bao4, Craig Parman5, Brian Porter6 and Effie Pournara5, 1Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, 2Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Oregon Health & Science University, Portland, OR, 4Novartis Pharmaceuticals Corporation, East Hannover, 5Novartis Pharma AG, Basel, Switzerland, 6Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: Predicting outcomes early in the disease course in patients (pts) with ankylosing spondylitis (AS) is challenging, owing to heterogeneity of symptoms, varying disease severity,…
  • Abstract Number: 139 • 2020 Pediatric Rheumatology Symposium

    Ongoing Disease Activity in Juvenile Idiopathic Arthritis (JIA) 18 Years After Disease Onset: A Population-based Nordic Study

    Mia Glerup1, Ellen D Arnstad 2, Veronika Rypdal 3, Suvi Peltoniemi 4, Kristiina Aalto 5, Marite Rygg 6, Susan Nielsen 7, Anders Fasth 8, Lillemor Berntson 9, Ellen Nordal 3 and Troels Herlin 10, 1Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, Aarhus, Denmark, 2Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Tromheim, Norway, 3Department of Pediatrics, University Hospital of North Norway, and Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway., Tromsø, Norway, 4Department of Pediatrics, New Children's Hospital, Helsinki University Hospital, Pediatric Research Center, University of Helsinki, Helsinki, Finland., Helsinki, Finland, 5Department of Pediatrics, New Children's Hospital, Helsinki University Hospital, Pediatric Research Center, University of Helsinki, Helsinki, Finland., HUS, Finland, 6Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway., Trondheim, Norway, 7Department of Pediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Copenhagen, Denmark, 8Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Gothenburg, Sweden, 9Department of Womens and Childrens Health, Uppsala University, Uppsala, Sweden., Uppsala, Sweden, 10Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark., Aarhus N, Denmark

    Background/Purpose: Previously, we showed that ILAR JIA categories defined at disease onset change considerably during the first 8 years of disease course. Whether achieved remission…
  • Abstract Number: 341 • 2019 ACR/ARP Annual Meeting

    Development of a Multivariable Improvement Measure for Gout

    Naomi Schlesinger1, N. Lawrence Edwards 2, Anthony Yeo 3 and Peter Lipsky 4, 1Division of Rheumatology, Department of Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ, 2Department of Medicine, University of Florida, Gainesville, FL, 3Horizon Therapeutics plc, Lake Forest, IL, 4AMPEL BioSolutions, LLC, Charlottesville, VA

    Background/Purpose: Gout is a multifactorial inflammatory disease in which patients experience a wide range of signs and symptoms, including flares, inflammatory arthritis, tophi and disability.…
  • Abstract Number: 356 • 2019 ACR/ARP Annual Meeting

    Gout Flares Become Infrequent During a Treat-to-target Strategy over One Year: Data from the NOR-Gout Study

    Till Uhlig1, Lars Fridtjof Karoliussen 2, Espen A Haavardsholm 2, Tore Kvien 1 and Hilde Hammer 2, 1Diakonhjemmet Hospital, Dept. of Rheumatology / University of Oslo, Faculty of Medicine, Oslo, Norway, 2Diakonhjemmet hospital, Oslo, Norway

    Background/Purpose: Urate lowering therapy (ULT) is expected to prevent new gout flares. Treat-to-target ULT is however often not performed, and more evidence on how often…
  • Abstract Number: 767 • 2019 ACR/ARP Annual Meeting

    Outcome Measures in Large-Vessel Vasculitis: Relationships Between Patient, Physician, Imaging, and Laboratory-Based Domains

    Casey A. Rimland1, Kaitlin Quinn 2, Joel S. Rosenblum 3, Mollie Schwartz 4, K Bates Gribbons 5, Elaine Novakovich 6, Antoine Sreih 7, Peter Merkel 7, Mark A. Ahlman 8 and Peter C. Grayson 9, 1National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, Chapel Hill, NC, 2Georgetown University Hospital/National Institutes of Health, Washington, DC, 3National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, Bethesda, MD, 4University of Maryland, Baltimore, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 6National Institutes of Health, Bethesda, MD, 7University of Pennsylvania, Philadelphia, PA, 8Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, Bethesda, MD, 9National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health, Bethesda, MD, Bethesda, MD

    Background/Purpose: Large-vessel vasculitis (LVV) is characterized by inflammation of the aorta and its major branches. The most common forms of LVV include giant cell arteritis…
  • Abstract Number: 1655 • 2019 ACR/ARP Annual Meeting

    Histologic Features Correlate with the Modified Rodnan Skin Score, Serum Inflammatory Markers, and Patient Reported Outcomes in Patients with Early, Diffuse Cutaneous Systemic Sclerosis

    Kimberly Showalter1, Cynthia Magro 2, Dana Orange 3, Yaxia Zhang 4, Phaedra Agius 5, Jackie Finik 6, Robert Spiera 1 and Jessica Gordon 1, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, 3Rockefeller University, New York, 4Hospital for Special Surgery, New York, 5New York Genome Center, New York City, 6Hospital for Special Surgery, New York, NY, New York, NY

    Background/Purpose: The association between systemic sclerosis (SSc) skin histology and clinical findings is not fully characterized. In two SSc trials, we developed a scoring system…
  • Abstract Number: 2473 • 2019 ACR/ARP Annual Meeting

    Implementing the Psoriatic Arthritis Disease Activity Score (PASDAS) in Routine Clinical Practice: (im)possible?

    Michelle Mulder1, Alfons den Broeder 1, Berbke van Ginneken 1, Elien Mahler 1, Frank van den Hoogen 1, Johanna Vriezekolk 1 and Mark Wenink 1, 1Sint Maartenskliniek, Nijmegen, Netherlands

    Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease, with involvement of at least five health domains: peripheral joint disease, enthesitis, dactylitis, axial involvement, and skin…
  • Abstract Number: 2840 • 2019 ACR/ARP Annual Meeting

    Reliability, Validity and Responsiveness of PROMIS PF-20 in Patients with Inflammatory Myopathy

    Didem Saygin1, Chester Oddis 1, Nicole Neiman 1, Diane Koontz 1, Siamak Moghadam-Kia 1 and Rohit Aggarwal 1, 1University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a group of rare, debilitating systemic diseases characterized by proximal muscle weakness, which limit activities of daily living and…
  • Abstract Number: 1446 • 2018 ACR/ARHP Annual Meeting

    The Optimal Joint Set for Ultrasound Assessment of Synovitis in RA: Results from the Rasch Measurement Model

    Elizabeth M.A. Hensor1,2, Alan Tennant3, Philip G. Conaghan1,2, Hilde B Hammer4, Richard J. Wakefield1,2 and Maria Antonietta D'Agostino1,5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds, United Kingdom, 3Swiss Paraplegic Research, Nottwil, Switzerland, 4Rheumatology, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Rheumatology, Versailles-Saint Quentin en Yvelines University- APHP, Ambroise-Paré Hospital, Boulogne-Billancourt, France

    Background/Purpose: The recently introduced composite OMERACT-EULAR power Doppler (PD)/grey scale (GS) ultrasound (PDUS) scoring system for RA with a proposed 18 joint set was developed…
  • Abstract Number: 2906 • 2018 ACR/ARHP Annual Meeting

    Synovitis Focused Ultrasound in Rheumatoid Arthritis: A Joint Reduction Strategy

    Daniel Kuo1, Gurjit Kaeley2, Ami Ben-Artzi3, Jenny Brook4, Astrid Floegel-Shetty4, David Elashoff4 and Veena K. Ranganath1, 1Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Rheumatology, University of Florida College of Medicine, Jacksonville, Jacksonville, FL, 3Rheumatology, Cedars Sinai Medical Center, Beverly Hills, CA, 4Department of Medicine Statistics Core, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Musculoskeletal ultrasound is increasingly being used as a tool to assess inflammatory burden in rheumatoid arthritis (RA). Ultrasound-based outcome measures include power Doppler (PD)…
  • Abstract Number: 1455 • 2018 ACR/ARHP Annual Meeting

    Development of a Predictive Model of Radiological Damage in Patients with Rheumatoid Arthritis Based on Artificial Intelligence

    Jose M Lezcano1, José Ivorra-Cortes2, Alfredo Madrid3, Raquel Lopez-Mejías4, Javier Martin5, Benjamín Fernández-Gutiérrez6, Miguel Angel González-Gay7, Alejandro Balsa8, Isidoro Gonzalez-Alvaro9, Fernando Salazar10, Lydia A Alcazar11 and Luis Rodriguez-Rodriguez11, 1Helix BioS CEO, Madrid, Spain, 2Rheumatology, University Hospital la Fe, Valencia, Spain, 3Rheumatology Department, and Instituto de Investigación Sanitaria (IdISSC), Hospital Clínico San Carlos, Madrid, Spain, 4Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 5Instituto de Parasitología y Biomedicina López Neyra, Granada, Spain, 6Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, 7School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, 8Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, 9Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 10International Centre for Numerical Methods in Engineering (CIMNE), Madrid, Spain, 11Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased mortality and disability. Although different factors have been associated with prognosis, it is…
  • Abstract Number: 2911 • 2018 ACR/ARHP Annual Meeting

    Patient-Reported Outcomes Measurement Information System (PROMIS®) Global Health Short Form Is Responsive to Patient Reported Changes in SLE Health Status

    Shanthini Kasturi1, Jackie Szymonifka2, Jessica R. Berman3, Kyriakos A. Kirou3, Alana B. Levine3, Lisa R Sammaritano4 and Lisa A. Mandl4, 1Medicine/Rheumatology, Tufts Medical Center, Boston, MA, 2Hospital for Special Surgery, New York, NY, 3Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, 4Hospital for Special Surgery/Weill Cornell Medicine, New York, NY

    Background/Purpose: The accurate and efficient serial measurement of patient centered outcomes is a priority in the clinical care of SLE. Patient-Reported Outcomes Measurement Information Systems…
  • Abstract Number: 1512 • 2018 ACR/ARHP Annual Meeting

    Reduction in Power Doppler Ultrasound Score with Tocilizumab Treatment Associates with Improvement in the Protective Profile of HDL in Patients with Rheumatoid Arthritis

    Christina Charles-Schoeman1, Gurjit Kaeley2, Jennifer Wang3, Ani Shahbazian3, Jenny Brook4, David Elashoff4 and Veena K. Ranganath5, 1Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2UF Health Jacksonville, Jacksonville, FL, 3University of California, Los Angeles, Los Angeles, CA, 4Department of Medicine Statistics Core, UCLA David Geffen School of Medicine, Los Angeles, CA, 51000 VETERAN BLVD., RM 32-59, UCLA, Los Angeles, CA

    Background/Purpose: Musculoskeletal ultrasound (MSUS) can detect synovitis by Power doppler (PDUS) and can predict erosive progression on xrays in rheumatoid arthritis (RA) patients. We previously…
  • Abstract Number: 2924 • 2018 ACR/ARHP Annual Meeting

    Spinal Radiographic Progression in Early Axial Spondyloarthritis: 5-Year Data from the DESIR Cohort

    Sofia Ramiro1, Désirée van der Heijde2, Alexandre Sepriano3, Miranda van Lunteren4, Anna Molto5, Maria Antonietta D'Agostino6, Damien Loeuille7, Maxime Dougados8, M. Reijnierse9 and Pascal Claudepierre10, 1Zuyderland Medical Center, Heerlen & Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Centre, Leiden, Netherlands, 3Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, 6Department of Rheumatology, Assistance publique-Hôpitaux de Paris Ambroise Paré Hospital, Boulogne-Billancourt , Université Versailles Saint Quentin en Yvelines, Paris, France, 7Rheumatology, University Hospital of Nancy, NANCY, France, 8Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France, 9Radiology, Leiden University Medical Center, Leiden, Netherlands, 10Hôpital Henri Mondor, Créteil, France

    Background/Purpose: Spinal radiographic progression has been investigated in patients with r-axSpA, but not yet as thoroughly in early axSpA. We aimed to analyse the progression…
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