ACR Meeting Abstracts

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Abstracts tagged "Outcome measures"

  • Abstract Number: 0523 • ACR Convergence 2023

    Bimekizumab Maintained Stringent Clinical Responses Through Week 52 in Patients with Axial Spondyloarthritis: Results from Two Phase 3 Studies

    Fabian Proft1, Désirée van der Heijde2, Xenofon Baraliakos3, Joerg Ermann4, Carmen Fleurinck5, Ute Massow6, Natasha De Peyrecave7, Vanessa Taieb8, Astrid van Tubergen9 and Victoria Navarro-Compán10, 1Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5UCB Pharma, Oosterzele, Belgium, 6UCB Pharma, Monheim am Rhein, Germany, 7UCB Pharma, Brussels, Belgium, 8UCB Pharma, Colombes, France, 9Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Centre, Maastricht, Netherlands, 10Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain

    Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic rheumatic disease which requires optimal management and disease control. Patients (pts) can experience loss of response in the…
  • Abstract Number: 1055 • ACR Convergence 2023

    Cancer Outcomes in Cancer Patients with Immune Checkpoint Inhibitor-induced Inflammatory Arthritis Treated with Glucocorticoids: Data from the CanRIO Retrospective Cohort

    Vanissa Savarimuthu1, Alexandra Ladouceur2, Oliver Terry1, Janet Roberts3, Janet Pope4, Thomas Appleton4, Sabrina Hoa5, Aurore Fifi-Mah6, Nancy Maltez7, Alexandra Saltman8, Megan Himmel8, Ines Colmegna9, Lindsay Cho10, Emma Schmidt10, Claudie Berger11, Thomas Barnetche12, Lourdes Gonzalez Arreola13, Carrie Ye14, Shahin Jamal15 and Marie Hudson16, 1McGill University, Montreal, QC, Canada, 2Department of Rheumatology of McGill University and CHU-Bordeaux, Montréal, QC, Canada, 3Dalhousie University, Halifax, NS, Canada, 4University of Western Ontario, London, ON, Canada, 5University of Montreal, Brossard, QC, Canada, 6University of Calgary, Calgary, AB, Canada, 7The Ottawa Hospital, Ottawa, ON, Canada, 8University of Toronto, Toronto, ON, Canada, 9The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 10University of British Columbia, Vancouver, BC, Canada, 11RI-MUHC, Montreal, QC, Canada, 12Bordeaux University Hospital, Bordeaux, France, 13Arthritis Research Canada, Vancouver, BC, Canada, 14University of Alberta, Edmonton, AB, Canada, 15Vancouver Coastal Health, Vancouver, BC, Canada, 16McGill University, Montréal, QC, Canada

    Background/Purpose: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of cancer. A drawback of ICI therapy is their off-target effects known as immune-related adverse events…
  • Abstract Number: 1323 • ACR Convergence 2023

    Distinct Treatment Responses in Patients with Rheumatoid Arthritis Receiving Filgotinib 200 Mg over 12 Months: A Post Hoc Analysis of FINCH 1

    Peter C. Taylor1, Yoshiya Tanaka2, Emily Aiello3, Thomas P.A. Debray4, Chris Watson5, Kristina Harris6 and Gerd Burmester7, 1Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Real-world Analytics, Cytel, Toronto, ON, Canada, 4Biostatistics, Galapagos NV, Mechelen, Belgium, 5Medical Affairs, Galapagos Biotech Ltd., Cambridge, United Kingdom, 6Medical Safety, Galapagos NV, Mechelen, Belgium, 7Charité – Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany

    Background/Purpose: FINCH 1 (NCT02889796) was a Phase 3 randomized controlled trial evaluating filgotinib (FIL) in patients with rheumatoid arthritis and an inadequate response to methotrexate…
  • Abstract Number: 1623 • ACR Convergence 2023

    Diffuse Juvenile Systemic Sclerosis Patients Show Distinct Organ Involvement, Antibody Pattern and Have More Severe Disease in the Largest jSSc Cohort of the World. Results from the Juvenile Scleroderma Inception Cohort

    Ivan Foeldvari1, Jens Klotsche2, Kathryn Torok3, Ozgur Kasapcopur4, Amra Adrovic5, Brian Feldman6, FLAVIO SZTAJNBOK7, Maria Teresa TErreri8, Ana Sakamoto9, Sindhu Johnson10, Jordi Anton11, Valda Stanevica12, Raju Khubchandani13, Dieneke Schonenberg-Meinema14, Eslam Al-Abadi15, Ekaterina Alexeeva16, Maria Katsikas17, Sujata Sawhney18, Vanessa Smith19, Simone Appenzeller20, Tadey Avcin21, Mikhail Kostik22, Thomas Lehman23, Hana Malcova24, Edoardo Marrani25, Clare Pain26, Natalia Vasquez-Canizares27, Patricia Costa Reis28, Mahesh Janarthanan29, Maria Jose Santos30, Sima Abu Alsaoud31, Christina Battagliotti32, Lillemor Berntson33, blanca e r bica34, Juergen Brunner35, Daniela Kaiser36, Dragana Lazarevic37, Kirsten Minden38, Farzana Nuruzzaman39, Siri Opsahl Hetlevik40, Yosef Uziel41 and Nicola Helmus42, 1Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3University of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, 4Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, 5Istanbul University - Cerrahpasa, Istanbul, Turkey, 6The Hospital for Sick Children, Toronto, ON, Canada, 7UFRJ/UERJ, São Paulo, Brazil, 8UNIFESP, São Paulo, Brazil, 9Federal University of São Paulo (UNIFESP), São Paulo, Brazil, 10Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada, 11Hospital Sant Joan de Déu, Pediatric Rheumatology Department, Universitat de Barcelona, Barcelona, Spain, 12Children's Clinical University Hospital, Zemgales priekšpilseta, Riga, Latvia, 13SRCC Childrens Hospital, Mumbai, India, 14Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 15Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, United Kingdom, 16Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia, 17Hospital de Pediatria Juan P Garrahan, Servicio de Inmunologia/Reumatologia, Buenos Aires, Argentina, 18Sir Ganga Ram Hospital, Uttar Pradesh, India, 19Ghent University Hospital, Gent, Belgium, 20UNICAMP, Campinas, Brazil, 21University Children's Hospital University Medical Center Ljubljana, Ljubljana, Slovenia, 22Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 23Hospital for Special Surgery, New York, NY, 24Motol University Hospital, Prague, Czech Republic, 25University of Florence, Firenze, Italy, 26Alder Hey NHS Trust, Liverpool, United Kingdom, 27Children’s Hospital at Montefiore, Bronx, NY, 28Hospital de Santa Maria, Lisbon, Portugal, 29SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH, Chennai, India, 30Hospital Garcia de Orta, Almada, Lisboa, Portugal, 31Caritas baby Hospital, East Jerusalem, Israel, 32Hospital de Niños Dr Orlando Alassia, Santa Fe, Argentina, 33Dept. of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 34Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 35Medical University Innsbruck; Department of Pediatrics, Pediatric Rheumatology, Innsbruck, Austria, 36Children's Hospital Lucerne, Lucerne, Switzerland, 37Dept of Pediatric Rheumatology and Immunology Clinical Center Nis, Faculty of Medicine, University of Niš, Nis, Serbia, 38Charité University Medicine and German Rheumatism Research Center Berlin, Berlin, Germany, 39Stony Brook Children's Hospital, Stony Brook, NY, 40Oslo University Hospital, Oslo, Norway, 41Pediatric Rheumatology Unit, Meir Medical Center, Kfar Saba, Sackler School of Medicine, Tel Aviv University, Kfar Saba, Israel, 42Hamburg Centre for Pediatric and Adolescence Rheumatology, Hamburg, Germany

    Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1,000,000 children. In adult patients there are significant differences between…
  • Abstract Number: 1980 • ACR Convergence 2023

    Movement Evoked Pain as an Outcome Measure in Patients with Knee Osteoarthritis

    Leila Bagherzadeh1, Schnitzer Thomas2, Santiago Espinosa-Salas1 and Joana Barroso3, 1Northwestern Physical Medicine and Rehabilitation Department, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Anesthesiology; Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Pain, being one of the most crucial symptoms associated with knee OA, serves as a significant outcome measure for the increasing number of studies…
  • Abstract Number: 2282 • ACR Convergence 2023

    Increased Risk of Systemic Lupus Erythematosus Flare After COVID-19

    Arthur Mageau1, Christel Gerardin2, Kankoe Sallah2, Jean-Francois Timsit1, Thomas Papo1 and Karim Sacre1, 1Université Paris Cité, Paris, France, 2Assistance Publique Hopitaux de Paris, Paris, France

    Background/Purpose: The SARS-CoV2 pandemic reopened the unresolved question of whether and how a viral infection can trigger flares of immune-mediated inflammatory diseases such as systemic…
  • Abstract Number: 2538 • ACR Convergence 2023

    Safety and Efficacy of Sodium-glucose Co-transporter 2 Inhibitors in Patients with Psoriasis and Concomitant Type 2 Diabetes Mellitus: A Population-based Cohort Study

    Pin-Chia Huang1, Debby Cheng2, Megan H Noe3, Jui-En Lo4, Steven T Chen3 and Kevin Sheng-Kai Ma5, 1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 2Harvard Medical School, Boston, MA, 3Department of Dermatology, Massachusetts General Hospital, Boston, MA, 4Center for Global Health, Perelman School of Medicine, Philadelphia, PA, 5Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Psoriasis and type 2 diabetes mellitus (T2D) may share common underlying pathophysiology, in which the pathogenesis of psoriasis is mediated by NOD-like receptor family…
  • Abstract Number: 0246 • ACR Convergence 2023

    Safety & Efficacy of SEL-212 in Patients with Gout Refractory to Conventional Treatment: Primary Outcomes from Two Randomized, Double Blind, Placebo-Controlled, Multicenter Phase 3 Studies

    Herbert Baraf1, Alan Kivitz2, Sheri Rhodes3, Sheldon Leung4, Olu Folarin4, Tania Gonzalez-Rivera5, Joanna Sobierska5, Jacquie Christie5, Anand Patel6, Wesley DeHaan4, Rehan Azeem4 and Peter Traber7, 1The Center for Rheumatology and Bone Research, George Washington University, Rheumatology, Bethesda, MD, 2Altoona Center for Clinical Research, Duncansville, PA, 3Selecta Biosciences, Atlanta, GA, 4Selecta Biosciences, Inc., Watertown, MA, 5Swedish Orphan Biovitrum (Sobi), Stockholm, Sweden, 6Pioneer Research Solutions, Houston, TX, 7Selecta Biosciences, Gladwyne, PA

    Background/Purpose: In patients with refractory gout, the inability to maintain serum uric acid (sUA) levels < 6 mg/dL leads to severe clinical manifestations for which…
  • Abstract Number: 0590 • ACR Convergence 2023

    Comparing Safety and Efficacy of Sodium-Glucose Co-Transporter 2 Inhibitors versus Dipeptidyl Peptidase 4 Inhibitors in Patients with Systemic Lupus Erythematosus and Comorbid Type 2 Diabetes Mellitus

    Jui-En Lo1, Pin-Chia Huang2, George Tsokos3, Vasileios Kyttaris4, Karen Costenbader5 and Kevin Sheng-Kai Ma2, 1Center for Global Health, Perelman School of Medicine, Philadelphia, PA, 2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4BIDMC, Boston, MA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Sodium-glucose co-transporter 2 inhibitors (SGLT2i), originally approved as oral hypoglycemic agents for type 2 diabetes (T2D), have been shown to reduce progression to end-stage…
  • Abstract Number: 1065 • ACR Convergence 2023

    Association Between COVID-19 and Disease-Modifying Antirheumatic Drugs

    Ogheneyoma Akpoviroro1, Nathan Sausers2, Oghenetejiro Akpoviroro3, Queeneth Uwandu1, Myriam Castagne4, Elga Rodrigues4, Lefulesele Khoalone1, sara Humayun1 and Jameson Woodard1, 1Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA, 2Pennsylvania State University, State College, PA, 3Mater Dei Hospital, Msida, Malta, 4Boston University, Boston, MA

    Background/Purpose: Describe patients(pts) hospitalized with COVID-19C(C19) who were on disease modifying antirheumatic drugs (DMARDs) before admission(BA); assess if clinical outcomes differed from pts without BA…
  • Abstract Number: 1368 • ACR Convergence 2023

    Development of the Sjögren’s-related Quality of Life (SRQoL) to Assess Health-related Quality of Life (HRQoL) in Sjögren’s

    Benjamin A Fisher1, Linda Stone2, Jessica Marvel3, Pushpendra Goswami4, Monia Steenackers4, Gayle Kenney4, Chiara Perella5, Wolfgang Hueber4, Chloe Howse6, Elizabeth Gargon6, Aishwarya Chohan6, Megan Mayhew6 and Nicola Williamson6, 1University of Birmingham, Birmingham, United Kingdom, 2The British Sjogren’s Syndrome Association, Birmingham, United Kingdom, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4Novartis Pharma AG, Basel, Switzerland, 5Novartis Pharma AG, Riehen, Switzerland, 6Adelphi Values Patient-Centered Outcomes, Bollington, United Kingdom

    Background/Purpose: Sjögren's is a heterogenous chronic auto-immune disease, characterized by excessive dryness of the eyes and mouth, as well as systemic complications which can significantly…
  • Abstract Number: 1624 • ACR Convergence 2023

    Racial Disparities Impact Achieving LLDAS and Glucocorticoid Use in Pediatric Lupus: A CARRA Registry Study

    William Soulsby1, Rebecca Olveda1, Jie He2, Laura Berbert2, Edie Weller2, Kamil Barbour3, Kurt Greenlund3, Laura Schanberg4, Emily von scheven1, Aimee Hersh5, Mary Beth Son6, Joyce Chang2 and Andrea Knight7, 1University of California San Francisco, San Francisco, CA, 2Boston Children's Hospital, Boston, MA, 3Centers for Disease Control and Prevention, Atlanta, GA, 4Duke University School of Medicine, Durham, NC, 5University of Utah, Salt Lake City, UT, 6Division of Immunology, Boston Children's Hospital, Boston, MA, 7The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Social determinants of health (SDoH) contribute to disparate outcomes in both adult and pediatric systemic lupus erythematosus (pSLE), including length of hospitalization, mortality, and…
  • Abstract Number: 1988 • ACR Convergence 2023

    Extended-Release versus Immediate-Release Triamcinolone Acetonide for Osteoarthritis of the Knee with Comorbid Diabetes Type 2 Diabetes Mellitus: A Post Hoc Analysis

    Andrew Spitzer1, Helena Rodbard2, Sheikh Usman Iqbal3, Masato Nakazawa3, Mary DiGiorgi3 and Roy Winston3, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2Endocrine and Metabolic Consultants, Rockville, MD, 3Pacira BioSciences, Inc., Tampa, FL

    Background/Purpose: Intraarticular (IA) corticosteroids are generally considered safe and effective to treat osteoarthritis of the knee (OAK) but may cause hyperglycemia that may last for…
  • Abstract Number: 2288 • ACR Convergence 2023

    Scoping Literature Review and Focus Groups Interviews to Identify Candidate Domains for the SLE OMERACT Core Domain Set

    Wils Nielsen1, Vibeke Strand2, Lee Simon3, Maya Desai4, Ioannis Parodis5, Alfred Kim6, Daniel Wallace7, Yashaar Chaichian8, Sandra Navarra9, Cynthia Aranow10, Meggan MacKay10, Kimberly Trotter11, Oshrat Tayer-Shifman12, Ali Duarte-Garcia13, Lai-Shan Tam14, Manuel Ugarte-Gil15, Guillermo Pons-Estel16, John Reynolds17, Mandana Nikpour18, Danae Papachristos19, Alberta Hoi20, Alison Hendry21, Juanita Romero-Diaz22, Rosalind Ramsey-Goldman23, Hanan Alrayes24, Ibrahim Almaghlouth25, Aarabi Thayaparan26, Carolina Munoz-Grajales27, Aaron Howe28, Behdin Nowrouzi-Kia28, Melanie Anderson29, Dennisse Bonilla29, Julian Thumboo30, Marta Mosca31, Martin Aringer32, Sindhu Johnson33, Aaron Drucker34, Eric Morand35, Ian Bruce36 and Zahi Touma28, 1University of Toronto, Markham, ON, Canada, 2Stanford University, Portola Valley, CA, 3SDG LLC, West Newton, MA, 4OCAD University, Toronto, ON, Canada, 5Karolinska Institutet, Stockholm, Sweden, 6Washington University School of Medicine, St. Louis, MO, 7Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, 8Stanford University, San Mateo, CA, 9University of Santo Tomas Hospital, Joint and Bone Center, Manila, Philippines, 10Feinstein Institutes for Medical Research, Manhasset, NY, 11University of Chicago, Chicago, IL, 12Meir Medical Center, Raanana, Israel, 13Mayo Clinic, Rochester, MN, 14The Chinese University of Hong Kong, New Territories, China, 15Universidad Cientifica del Sur, Lima, Peru, 16RELESSAR, Rosario, Argentina, 17University of Birmingham, Birmingham, United Kingdom, 18The University of Melbourne at St. Vincent’s Hospital Melbourne, Departments of Medicine and Rheumatology, Melbourne, Australia, 19Mater Hospital, Brisbane, Australia, 20Monash University, Department of Medicine, Sub-faculty of Clinical and Molecular Medicine, Melbourne, Australia, 21Te Whatu Ora, Counties Manukau District, Middlemore Hospital, Auckland, New Zealand, 22Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 23Northwestern University, Chicago, IL, 24Riyadh Military - Prince Soltan Military Medical City ( PSMMC ) - Olaya, Riyadh, Saudi Arabia, 25King Saud University, Riyadh, Saudi Arabia, 26Schroeder Arthritis Institute, Krembil Research Institute, Markham, ON, Canada, 27UHN/TWH, Toronto, ON, Canada, 28University of Toronto, Toronto, ON, Canada, 29University Health Network, Toronto, ON, Canada, 30Singapore General Hospital; Duke-NUS Medical School, Singapore, Singapore, 31Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 32Faculty of Medicine TU Dresden, Dresden, Germany, 33Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada, 34Women's College Hospital, Toronto, ON, Canada, 35Monash University, Centre for Inflammatory Diseases, Melbourne, Australia, 36University of Manchester, Manchester, United Kingdom

    Background/Purpose: We established the OMERACT SLE Working Group in 2021 which includes over 150 members representing over 25 countries and 5 continents to develop a…
  • Abstract Number: 2551 • ACR Convergence 2023

    Remission and Low Disease Activity (LDA) in Patients with SLE Treated with Belimumab (BEL): Results from a Large Integrated Analysis

    Ioannis Parodis1, Julius Lindblom1, Roger A. Levy2, Margherita Zen3, Nursen Cetrez1, Alvaro Gomez4, Shereen Oon5, Christine Henning6, Munther Khamashta7, Holly A. Quasny8, Deven Chauhan9, Anca Askanase10, Ronald van Vollenhoven11 and Mandana Nikpour12, 1Karolinska Institutet, Stockholm, Sweden, 2GlaxoSmithKline, Global Medical Affairs, Collegeville, PA, 3University of Padua, Division of Rheumatology, Department of Medicine, Padua, Italy, 4Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 5University of Melbourne at St Vincent’s Hospital, Departments of Rheumatology and Medicine, Fitzroy, Australia, 6GlaxoSmithKline, US Medical Affairs, Durham, NC, 7GSK Gulf, Medical Affairs Department, Dubai, United Arab Emirates, 8GlaxoSmithKline, Research & Development, Durham, NC, 9GlaxoSmithKline, Value Evidence and Outcomes, Brentford, United Kingdom, 10Columbia University Medical Center, New York, NY, 11Amsterdam Rheumatology and Immunology Center and Amsterdam University Medical Centers, Department of Rheumatology, Amsterdam, Netherlands, 12The University of Melbourne at St. Vincent’s Hospital Melbourne, Departments of Medicine and Rheumatology, Melbourne, Australia

    Background/Purpose: A key treatment goal in SLE management is the attainment of remission or LDA,1 for which various definitions exist, including “Definitions of Remission in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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