Abstracts tagged "Outcome measures"

Abstract Number: LB07 • ACR Convergence 2025
Adipose-Tissue Derived Mesenchymal Stem Cells vs Hyaluronic Acid in Refractory Knee Osteoarthritis in a low-resource setting: A Phase IIb RCT
Moshiur Rahman Khasru¹, Mohammad Tariqul Islam², AGM Zakaria Nazimuddin Jubery³, Mahbuba Shirin⁴, Fazle Rabbi Chowdhury⁵, Tangila Marzen⁶, Nafi Uzzaman⁷, Md Abu Bakar Siddiq⁸, Md Ashraful Hoque⁹, Masuda Begum¹⁰, Md Moniruzzaman Khan² and Abul Salek¹¹, ¹Musculoskeletal Medicine and Interventional Physiatry Division, Bagladesh Medcial University, Dhaka, Bangladesh, ²Department of Physical Medicine and Rehabilitation, Bangladesh Medical University, Dhaka, Bangladesh, ³Department of Burn and Plastic Surgery, Dhaka Medcial College and Hospital, Dhaka, Bangladesh, ⁴Department of Radiology and Imaging, Bangladesh Medical University, Dhaka, Bangladesh, ⁵Department of Internal Medicine, Bangladesh Medical University, Dhaka, Bangladesh, ⁶Department of Anatomy, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh, ⁷Stem Cell Rearch Group, Department of Physical Medicine and Rehabilitation, Bangladesh Medical University, Dhaka, Bangladesh, ⁸Department of Rheumatology, Royal North Shore Hospital, Faculty of Medicine, University of Sydney, New South Wales, Australia, ⁹Department of Transfusion Medicine, Cumilla Medical College, Cumilla, Bangladesh, ¹⁰Department of Haematology, Banglabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, ¹¹Department of Physical Medicine and Rehabilittaion, Bangladesh Medical University, Dhaka, Bangladesh
Background/Purpose: Knee osteoarthritis (KOA) is a leading cause of disability, with no available disease-modifying treatments. While Hyaluronic Acid (HA) remains widely used, there is little…
Abstract Number: 2420 • ACR Convergence 2025
In-patient Outcomes of Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Syndrome in SLE: US National Inpatient Database (2021-2022)
Nattanicha Chaisrimaneepan¹, Pitchaporn Yingchoncharoen² and Miriam Paz², ¹Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, ²Texas Tech University Health Sciences Center, Lubbock
Background/Purpose: Systemic lupus erythematosus (SLE is an autoimmune disease that attacks different organs. There have been reports of hyperglycemic hyperosmolar syndrome (HHS) from steroid use…
Abstract Number: 2302 • ACR Convergence 2025
Clustering by ESSPRI and PROMIS domain measures defines distinct subtypes and facilitates longitudinal assessment of patients with Sjogren’s disease
Thomas Grader-Beck¹, Jennifer Reed², Priya Patel³, Ji Soo Kim⁴ and Alan Baer⁵, ¹Johns Hopkins, Reisterstown, MD, ²Johns Hopkins, Freeland, MD, ³Johns Hopkins, Annville, PA, ⁴Johns Hopkins, Baltimore, MD, ⁵Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Patient-reported outcomes (PROs) measure a patient’s health-related quality of life. The role of ESSPRI and PROMIS measures in identifying subsets of patients with Sjogren’s…
Abstract Number: 2003 • ACR Convergence 2025
Evaluating Patient Outcomes Pre and Post Pegloticase Initiation among Uncontrolled Gout Patients: Findings from MORE2 Registry and Medicare Fee-For-Service Claims Data
Julia Buchfuhrer¹, Niranjan Kathe², Elizabeth Ibiloye³, Seth Kuranz⁴, Virginia Noxon-Wood⁴, Alexis Woods⁵ and Laurence Gozalo⁴, ¹JB Arthritis and Rheumatology Center, Downey, CA, ²Amgen Inc, San Diego, CA, ³Amgen Inc, Thousand Oaks, CA, ⁴Inovalon, Bowie, MD, ⁵Amgen, Detroit, MI
Background/Purpose: Among patients (pts) with chronic refractory gout (CRG), traditional urate lowering therapies are often inadequate, necessitating advanced therapies. Pegloticase, a recombinant uricase enzyme, rapidly…
Abstract Number: 1531 • ACR Convergence 2025
Achieving Remission and Low Disease Activity with Belimumab Versus Placebo in Patients with SLE Excluding the Glucocorticoid Component from Target Definitions: A Post Hoc Analysis of Five Phase 3 Trials
Ioannis Parodis¹, Julius Lindblom², Roger A. Levy³, Alexander Tsoi¹, Margherita Zen⁴, Dionysis Nikolopoulos⁵, Munther Khamashta⁶, Ryan Tomlinson⁷, Anca Askanase⁸, Ronald van Vollenhoven⁹ and Mandana Nikpour¹⁰, ¹Karolinska Institutet and Karolinska University Hospital, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden, ³GSK, Specialty Care, Global Medical Affairs, Collegeville, PA, ⁴University of Padua, Department of Medicine, Division of Rheumatology, Padua, Italy, ⁵Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, ⁶GSK, Medical Affairs, Dubai, United Arab Emirates, ⁷GSK, Development – R&D, Collegeville, PA, ⁸Columbia University Medical Center, New York, NY, ⁹Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Centers, Department of Rheumatology, Amsterdam, Netherlands, ¹⁰University of Sydney School of Public Health and Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, Victoria, Australia
Background/Purpose: An integrated post hoc analysis of five Phase 3 trials in adults with SLE showed greater benefit of belimumab (BEL) than placebo (PBO), plus…
Abstract Number: 1291 • ACR Convergence 2025
Gastrointestinal Tract Involvement in Juvenile Systemic Sclerosis: Results from an International Scoping Review of Outcome Measures
Lauren Robinson¹, Lusine Ambartsumyan², Emily Willis³, Aybuke Gunalp⁴, Simone Appenzeller⁵, Ozgur Kasapcopur⁶, Sarah Ishaq⁷, Natalia Vasquez Canizares⁸ and Suzanne Li⁹, ¹Hospital for Special Surgery, New York, NY, ²Seattle Children's Hospital, Seattle, WA, ³Royal Manchester Children's Hospital, Manchester, United Kingdom, ⁴Cerrahpasa Medicine School, Cerrahpasa, Istanbul, Turkey, ⁵Unicamp, Campinas, São Paulo, Brazil, ⁶Istanbul University-Cerrahpasa, Cerrahpasa Medical School, istanbul, Turkey, ⁷Osteopathic Medicine , Touro College of Osteopathic Medicine, New York, NY, ⁸Children's Hospital at Montefiore, New York, NY, ⁹Joseph M. Sanzari Children's Hospital and Hackensack Meridian School of Medicine, Hackensack, NJ

Background/Purpose: Gastrointestinal (GI) tract involvement is nearly universal in patients with systemic sclerosis (SSc) leading to significant morbidity and mortality. In a North American juvenile…
Abstract Number: 1031 • ACR Convergence 2025
Trends and Gender Disparities in Rheumatoid Arthritis Burden in the United States: A Population-Based Time-Trend Analysis Using the Global Burden of Disease Database, 1990–2021
Satani Sharkas¹, Dina Murad² and Dariush Jahandideh³, ¹Boston Medical Center - Brighton, Brighton, MA, ²Tufts Medical Center, Boston, MA, ³Boston Medical Center - Brighton, Boston
Background/Purpose: Rheumatoid arthritis (RA) is a growing public health concern in the United States, with increasing prevalence and disease burden over recent decades. This study…
Abstract Number: 0748 • ACR Convergence 2025
Does The Number Of Arteries Affected At The Disease Onset Predict Relapses Of Giant Cell Arteritis?
Iztok HOLC¹, Metka Koren Krajnc², Marko Gačnik³ and Anja Lah⁴, ¹University Medical Center Maribor, ²⁰⁰⁰ Maribor, Slovenia, ²University Medical center, Maribor, Slovenia, ³University Medical Center Maribor, Braslovče, Slovenia, ⁴University Medical Center Maribor, Laporje, Slovenia
Background/Purpose: Giant cell arteritis (GCA) is a chronic vasculitis where relapses frequently occur. The rates of relapses of GCA have not been defined by now.We…
Abstract Number: 0376 • ACR Convergence 2025
An Internet-Delivered, Arthritis-Tailored Cognitive Behavioral Therapy for Insomnia Program for People with Co-Morbid Sleep Disturbance: Comparing Baseline Characteristics of Cannabis Users and Non-Users
Nicole Andersen¹, Diane Lacaille², Josee Savard³, Elham Rahme¹, Paul Fortin⁴ and Deborah Da Costa⁵, ¹McGill University, Montreal, QC, Canada, ²Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, ³Université Laval, Quebec, Canada, ⁴Centre ARThrite - CHU de Québec - Université Laval, Quebec, QC, Canada, ⁵McGill University, Pointe-Claire, QC, Canada
Background/Purpose: The use of cannabis among individuals with rheumatologic conditions has gained increasing attention due to potential effects on pain, mood, and overall quality of…
Abstract Number: 2393 • ACR Convergence 2025
Improving Clinical Outcomes In SLE Arthritis Trials: Post-Hoc Analysis Of A Prospective Intervention Study
Samuel Wood¹, Khaled Mahmoud², Md Yuzaiful Md Yusof², Philip Conaghan², Elizabeth Hensor² and Ed Vital³, ¹University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, ²University of Leeds, Leeds, United Kingdom, ³University of Leeds, Leeds, England, United Kingdom
Background/Purpose: Musculoskeletal (MSK) manifestations of SLE are the most frequently assessed domain in clinical trials. Optimal MSK assessment is contested; candidates include the binary or…
Abstract Number: 2282 • ACR Convergence 2025
Effect of Online Continuing Education on Advancing Care for Rheumatoid Arthritis: A Real-World Outcome Analysis
Nimish Mehta¹, Katie Lucero², Freddy Green³ and Karen Badal⁴, ¹Medscape, Three Bridges, NJ, ²Medscape, Newark, ³Medscape, London, United Kingdom, ⁴Medscape, New York, NY
Background/Purpose: In recent years, an increasing number of cytokines and their function in the pathophysiology of immunologic conditions have been identified, leading to the development…
Abstract Number: 1983 • ACR Convergence 2025
Documenting Transition: A Review and Intervention to Increase the Receipt of Transition Summary Letters
Kyla Blasingame¹, David McDonald¹, Karissa Chesky¹, Jimin Kim¹, charles lee¹, Tiphanie Vogel¹ and Miriah Gillispie-Taylor², ¹Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine/Texas Children's Hospital, Houston, TX
Background/Purpose: The transition from pediatric to adult care poses unique challenges for patients with childhood-onset disease, many of whom were young at presentation and do…
Abstract Number: 1521 • ACR Convergence 2025
Kidney-Related Outcomes With Obinutuzumab in Patients With Active Lupus Nephritis: A Pre-Specified Exploratory Analysis of the Clinical Trial Data
Brad Rovin¹, William Pendergraft², Liz Lightstone³, Eric Daugas⁴, Richard Furie⁵, Theodore Omachi², Imran Hassan⁶, Elsa Martins⁷, Thomas Schindler⁷, Jay Garg², Luis Quintana⁸, Piotr Leszczyński⁹ and Ana Malvar¹⁰, ¹The Ohio State University, Columbus, OH, ²Genentech, Inc., South San Francisco, CA, ³Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, England, United Kingdom, ⁴Department of Nephrology, Hospital Bichat - Claude-Bernard, Paris, France, ⁵Division of Rheumatology, Northwell Health, Great Neck, NY, ⁶Hoffmann-La Roche Ltd, Mississauga, ON, Canada, ⁷F. Hoffmann-La Roche Ltd, Basel, Switzerland, ⁸Department of Nephrology, Hospital Clinic, Barcelona, Spain, ⁹Department of Internal Medicine and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland, ¹⁰Organización Médica de Investigación, Buenos Aires, Argentina
Background/Purpose: Lupus nephritis (LN) is the most common, severe, organ-threatening manifestation of systemic lupus erythematosus (SLE). The randomized, double-blind, placebo-controlled, Phase III REGENCY trial (NCT04221477)…
Abstract Number: 1290 • ACR Convergence 2025
Adverse Childhood Experiences: Prevalence and Relationship to Disease and Mental Health Outcomes in Childhood-Onset Systemic Lupus Erythematosus (cSLE)
Jin Xuan Zhou¹, Stephanie Fevrier², Paris Moaf², Lawrence Ng³, Asha Jeyanathan⁴, Louise Boulard², Deborah Levy¹, Linda Hiraki¹, Ashley Danguecan⁵ and Andrea Knight⁵, ¹The Hospital for Sick Children, Toronto, ON, Canada, ²Hospital for Sick Children, Toronto, Canada, ³The Hospital for Sick Children, Toronto, Canada, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, Canada, ⁵Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is an autoimmune disease characterized by multi-organ inflammation, alongside high frequencies of mood disorders and cognitive impairment. Adverse Childhood…
Abstract Number: 0660 • ACR Convergence 2025
Effects of Deucravacitinib on Dysregulated Autoimmune Gene Modules That Correlate With Skin Disease Severity and Treatment Response in Patients With Cutaneous Manifestations of Lupus Erythematosus: Biomarker Results From a Global, Randomized, Placebo-Controlled Phase 2 Study
J. Michelle Kahlenberg¹, Victoria Werth², Joerg Wenzel³, John Schwarz⁴, Jinqi Liu⁴ and Brandon Johnson⁴, ¹University of Michigan, Ann Arbor, MI, ²University of Pennsylvania, Philadelphia, PA, ³Department of Dermatology and Allergy, University Hospital of Bonn, Bonn, Germany, ⁴Bristol Myers Squibb, Princeton, NJ
Background/Purpose: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor approved in moderate to severe plaque psoriasis, has demonstrated significant improvements in cutaneous manifestations…

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