Abstracts tagged "Osteoarthritis"

Abstract Number: 0328 • ACR Convergence 2025
High synovial fluid leukocyte counts and markers of TLR activation correlate with poorer response to injections in patients with knee OA
Lance Murphy¹, Baofeng Hu², Vu Nguyen³, Bryant England⁴, Katherine Wysham⁵, Mercedes Quinones⁶, Joshua Baker³ and Carla Scanzello³, ¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²University of Pennsylvania, Wynnewood, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁶Washington DC VA Medical Center, Bethesda, MD
Background/Purpose: Toll-like receptors (TLRs) are pattern-recognition receptors of the innate immune response and are important in driving the initial activation of myeloid lineage cells to…
Abstract Number: 0313 • ACR Convergence 2025
People with Knee Osteoarthritis Infrequently Seek Medical Care for Arthritis, Even Those With Severe Disease
Grace Lo¹, Shunshun Yan², Julieann Patarini³, Timothy McAlington⁴, Charles Eaton⁵ and Jeffrey Driban⁶, ¹Baylor College of Medicine / MEDVAMC, Houston, TX, ²Baylor College of Medicine, Houston, ³UMass Chan Medical School, Worcester, MA, ⁴UMass Chan School of Medicine, Arlington, MA, ⁵Brown University, Providence, RI, ⁶University of Massachusetts Chan Medical School, Marlborough, NH
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, a condition associated with substantial disability. Providers are often uncomfortable managing arthritis, and patients with…
Abstract Number: 2624 • ACR Convergence 2025
Results of Large Multi-Site Pragmatic Clinical Trial Comparing Corticosteroids or Blinded Lidocaine-only Injections in Treating Osteoarthritis of the Knee
Joshua Baker¹, Katherine Wysham², Mercedes Quinones³, Bryant England⁴, Kaitian Jin¹, Marianna Olave⁵, Sarah Wetzel⁶, Rachel Gillcrist⁷, Criswell Lavery¹, Natalie Keller⁸, Kimberly Hayes⁹, Bridget Kramer⁴, Hannah Brubeck¹⁰, Bibiana Ateh¹¹, Daniel K. White¹², Alexis Ogdie¹³, Rui Xiao¹, Tuhina Neogi¹⁴ and Carla Scanzello¹, ¹University of Pennsylvania, Philadelphia, PA, ²VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ³Washington DC VA Medical Center, Bethesda, MD, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Brown University, Philadelphia, PA, ⁶Drexel University, Pittsburgh, PA, ⁷Dartmouth College, Lebanon, NH, ⁸University of Oklahoma, Philadelphia, PA, ⁹Teachers College, Columbia University, Philadelphia, PA, ¹⁰VA Puget Sound Health Care System, Seattle, WA, ¹¹Washington VA Medical Center, Washington, District of Columbia, ¹²University of Delaware, Newark, DE, ¹³Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, ¹⁴Boston University School of Medicine, Boston, MA
Background/Purpose: Intra-articular corticosteroids are widely used for routine management of chronic pain from knee osteoarthritis (KOA), though estimates of their benefit vary widely. We aimed…
Abstract Number: 2097 • ACR Convergence 2025
Trajectories of psychological symptoms during an 18-month Diet + Exercise intervention in overweight or obese adults with osteoarthritis
Lily Alomari¹, Daniel Beavers², Kate Queen³, Shannon Mihalko⁴, Gary Miller⁴, Elena Losina⁵, Paul DeVita⁶, david Hunter⁷, Jovita Newman⁴, Sara Quandt⁸, Mary Lyles⁸, Sandra Soto³, Joanne Jordan⁹, Leigh Callahan³, Stephen Messier¹⁰ and Becki Cleveland¹¹, ¹Kansas City University, Raleigh, ²Wake forest university, Winston Salem, ³UNC, Chapel Hill, ⁴WFU, Winston Salem, ⁵BWH, Boston, MA, ⁶East Carolina University, Greenville, ⁷Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁸WFU, Winston-Salem, ⁹University of North Carolina at Chapel Hill, Chapel Hill, NC, ¹⁰WFU, Winston-Salem, NC, ¹¹University of North Carolina, Chapel Hill, NC
Background/Purpose: Psychological symptoms (PsySx) have been associated with osteoarthritis (OA), and exercise may improve PsySx. We aimed to identify unique trajectories of PsySx over the…
Abstract Number: 2081 • ACR Convergence 2025
Radiologic surveillance in the Phase II RCT of LEVI-04, a novel neurotrophin-3 inhibitor, in people with knee osteoarthritis: exclusions at screening
Ali Guermazi¹, Philip Conaghan², C Michael Perkins³, Claire Herholdt⁴, Iwona Bombelka⁵ and Simon Westbrook⁶, ¹Boston University, West Roxbury, MA, ²University of Leeds, Leeds, United Kingdom, ³Levicept, Sandwich, United Kingdom, ⁴Levicept Ltd, Ashtead, United Kingdom, ⁵Levicept, Sandwich, Kent, United Kingdom, ⁶Levicept Ltd, Sandwich, United Kingdom
Background/Purpose: LEVI-04 is a first-in-class fusion protein (p75NTR-Fc) that supplements the endogenous p75NTR binding protein, providing analgesia via inhibition of NT-3 activity. Like p75NTR, LEVI-04…
Abstract Number: 1801 • ACR Convergence 2025
Matrikine Activation of Synovial Fibroblasts Promotes Monocyte Migration and Stimulates an OA Chondrocyte Phenotype
Richard Loeser¹, Jorge Fernandez Davila¹, Philip Coryell², Susan Chubinskaya³ and Doug Phanstiel⁴, ¹University of North Carolina, Chapel Hill, NC, ²University of North Carolina-Chapel Hill, Chapel Hill, NC, ³University of Texas Medical Branch, Galveston, TX, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Protease cleavage of matrix proteins generates matrix fragments including fibronectin fragments (FN-f) found in OA cartilage and synovial fluid. Matrix fragments or “matrikines” activate…
Abstract Number: 1738 • ACR Convergence 2025
Coexpression and Infiltration of Endoplasmic Reticulum Stress Proteins Together With CD34+ Fibroblast-like Synoviocytes In Human Inflamed Synovial Membranes
Zoe Gendebien¹, Pauline Salpetier², Celine Deroyer², Genevieve Paulissen², Alexandre Hego², Gaetan Lefevre², Christophe Poulet², Sophie Neuville², Patrick Durez³, Patrice Hemon⁴, Nadege Marec⁵, Elettra Bianchi², Philippe Delvenne², Clio ribbens² and Dominique de Seny², ¹ULiege, Liège, Belgium, ²ULiege, Liege, Belgium, ³Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatologie, Brussels, Brussels Hoofdstedelijk Gewest, Belgium, ⁴Brest, Brest, Belgium, ⁵Brest, Brest, France
Background/Purpose: A strong crosstalk exists between endoplasmic reticulum (ER) stress and synovitis. Several ER chaperone proteins, besides their function in protein folding, can play a…
Abstract Number: 0787 • ACR Convergence 2025
The Cost-effectiveness of Physical Therapy for Patients with Meniscal Tear and Osteoarthritis
Samantha Chin¹, Sasha Aronson¹, Jamie Collins¹, Faith Selzer¹, Ying Heidi Yang¹, Leslie Bisson², Antonia Chen³, Morgan Jones⁴, Clare Norton¹, Karen Smith¹, Kurt Spindler⁵, Jeffrey Katz⁶ and Elena Losina⁷, ¹Brigham and Women's Hospital, Boston, MA, ²University of Buffalo, Buffalo, ³Brigham and Women's Hospital, Newton, MA, ⁴Mass General Brigham, Boston, ⁵Cleveland Clinic, Cleveland, ⁶Brigham and Women's Hospital, Brookline, MA, ⁷BWH, Boston, MA
Background/Purpose: Based on several RCTs comparing outcomes of arthroscopic partial meniscectomy (APM) to non-operative management in persons with meniscal tears and OA, physical therapy (PT)…
Abstract Number: 0329 • ACR Convergence 2025
Machine Learning-Based Model to Predict Rapid Structural Progression in Knee Osteoarthritis
Maria Fernanda Gonzalez Hernandez¹, Ignacio rego Pérez², Isabel Rodríguez Valle³, Jorge Vázquez García⁴, Vanesa Balboa⁵, Sara Relaño Fernández⁴, María C. de Andrés⁶, Lucía Lourido⁷, Valentina Calamia⁷, Rocio Paz González⁴, Patricia Quaranta⁷, Patricia Fernández-Puente⁴, Nicola Veronese⁸, Cristina Ruiz-Romero⁹, Natividad Oreiro¹⁰ and francisco J Blanco¹¹, ¹Instituto de Investigacion Biomedica de A Coruna (INIBIC), A coruña, Galicia, Spain, ²Department of Rheumatology, Rheumatology Research Group (GIR) Biomedical Re-search Institute (INIBIC), A Coruña, Spain, ³Instituto de Investigacion Biomedica de A Coruna (INIBIC), Coruña, Galicia, Spain, ⁴Instituto de Investigacion Biomedica de A Coruna (INIBIC), coruña, Spain, ⁵Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, coruña, Spain, ⁶Instituto de Investigación Biomédica de A Coruña (INIBIC), Grupo de Investigación de Reumatología (GIR), A Coruña, Spain, ⁷Instituto de Investigacion Biomedica de A Coruna (INIBIC), coruna, Spain, ⁸Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, palermo, Italy, ⁹Department of Rheumatology, Rheumatology Research Group (GIR) Biomedical Re-search Institute (INIBIC),, A Coruña, Spain, ¹⁰CHUAC, La Coruna, Spain, ¹¹INIBIC-University of A Coruña, A Coruña, Galicia, Spain
Background/Purpose: Osteoarthritis (OA) is the most common chronic joint disorder, characterized by structural cartilage and bone damage that often causes pain and disability. However, the…
Abstract Number: 0311 • ACR Convergence 2025
Time series analysis of continuous accelerometry data to determine the impact of symptomatic multiple joint osteoarthritis (MJOA) in the naturally occurring canine model
Elizabeth Kawecki-Wright¹, Liubov Arbeeva², Christina Stevens¹, Masataka Enomoto¹, Amanda Nelson³, Margaret Gruen¹ and Duncan Lascelles¹, ¹North Carolina State University, RALEIGH, NC, ²University of North Carolina, Chapel Hill, Carrboro, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Pet dogs are a promising translational model for naturally occurring multiple joint osteoarthritis (MJOA). We characterized the impact of symptomatic (sx) MJOA, over the…
Abstract Number: 2623 • ACR Convergence 2025
Disease Activity is a Novel Imaging Biomarker Associated with Knee Pain: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Jonggyu Baek², Julieann Patarini², Emily Kirillov³, Nhung Vo³, Michael Richard³, Ming Zhang⁴, Matthew Harkey⁵, Grace Lo⁶, Kate Lapane², Shao-Hsien Liu², Charles Eaton⁷, James Mackay⁸, Joshua Harvey² and Timothy McAlington⁹, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²UMass Chan Medical School, Worcester, MA, ³Tufts Medical Center, Boston, MA, ⁴Boston University, Westford, MA, ⁵Michigan State University, East Lansing, MI, ⁶Baylor College of Medicine / MEDVAMC, Houston, TX, ⁷Brown University, Pawtucket, RI, ⁸University of Cambridge; Norwich Medical School, San Diego, CA, ⁹UMass Chan School of Medicine, Arlington, MA
Background/Purpose: Barriers to developing effective osteoarthritis (OA) therapies include the lack of standardized definitions for disease progression and structural endpoints that reliably predict changes in…
Abstract Number: 2096 • ACR Convergence 2025
Gamification and Social Incentivization to Promote Physical Activity in Adults with Knee Osteoarthritis: Results from a Multi-Site Randomized Trial
Kimberly Hayes¹, Bryant England², Katherine Wysham³, Mercedes Quinones⁴, Marianna Olave⁵, Sarah Wetzel⁶, Hannah Brubeck⁷, Rachel Gillcrist⁸, Criswell Lavery⁹, Natalie Keller¹⁰, Bibiana Ateh¹¹, Bridget Kramer², Rui Xiao⁹, Kaitian Jin⁹, Alexis Ogdie¹², Daniel K. White¹³, Tuhina Neogi¹⁴, Carla Scanzello⁹ and Joshua Baker⁹, ¹Teachers College, Columbia University, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁴Washington DC VA Medical Center, Bethesda, MD, ⁵Brown University, Philadelphia, PA, ⁶Drexel University, Pittsburgh, PA, ⁷VA Puget Sound Health Care System, Seattle, WA, ⁸Dartmouth College, Lebanon, NH, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰University of Oklahoma, Philadelphia, PA, ¹¹Washington VA Medical Center, Washington, District of Columbia, ¹²Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, ¹³University of Delaware, Newark, DE, ¹⁴Boston University School of Medicine, Boston, MA
Background/Purpose: Promotion of physical activity is important in the management of knee osteoarthritis (KOA), though effective strategies for behavioral change to promote exercise are lacking.…
Abstract Number: 2080 • ACR Convergence 2025
Foot laterality does not modify outcome of knee and/or hip osteoarthritis
Simon Fondin¹, Armand Eyraud¹, Estelle Nkonda¹, Anne-Christine Rat², Bruno Fautrel³, SELLAM JEREMIE⁴, Christian Roux⁵, Jacques Pouchot⁶, Joel Coste⁷, Francis Guillemin⁸ and Alain SARAUX⁹, ¹Centre Hospitalier Regional Universitaire (CHU) de Brest, Brest, France, ²Caen University hospital, UMR ¹⁰⁷⁵ Caen normandy university, Caen, France, ³Sorbonne Université - APHP, Department of Rheumatology, Hôpital Pitié-Salpêtrière, Inserm UMRS ¹¹³⁶-⁵, PARIS, France, Paris, France, ⁴Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-⁷⁵⁰¹² Paris, France, /Rheumatology Department, AP-HP Saint-Antoine Hospital, ¹⁸⁴, rue du Faubourg Saint-Antoine, ⁷⁵⁰¹², Paris, France., Paris, France, ⁵CHU Nice, Nice, France, ⁶AP-HP, Rueil Malmaison, France, ⁷APHP, Paris, France, ⁸CHU Nancy, Nancy, France, ⁹CHU Brest, Brest, France
Background/Purpose: Hip and knee osteoarthritis (OA) are among the leading causes of global disability. Global OA is more prevalent on the right side. This discordance…
Abstract Number: 1797 • ACR Convergence 2025
SEV-101 Exosomes Isolated from Induced Pluripotent Stem Cell – Derived Hyaline Cartilage Tissue – Characterization of Immunomodulatory and Chondro-proliferative Effects In Vitro
Parthasarathy Rangarajan¹, Beth Lindborg², Amanda Vegoe³, Yi Wen Chai⁴, Anna Tran¹, Magie Steinhoff¹, Bernhard Hering¹, Timothy O'Brien⁵ and Sabarinathan Ramachandran⁶, ¹Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, ²Sarcio, Inc., St. Paul, ³Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, St. Paul, ⁴Stem Cell Institute, University of Minnesota, Minneapolis, ⁵Department of Veterinary Population Medicine and Stem Cell Institute, University of Minnesota, Sarcio, Inc, Minneapolis, ⁶Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN
Background/Purpose: SEV-101 are exosomes that are isolated from cultures of Induced Pluripotent Stem Cell (iPSC)-derived hyaline cartilage tissue. Gene expression profiles of the tissue are…
Abstract Number: 1739 • ACR Convergence 2025
Acute Transcriptomic Response of Synovium and Dorsal Root Ganglia to Joint Injury
Michael Newton¹, Lai Wang², Anne-Marie Malfait³, Rachel Miller² and Tristan Maerz⁴, ¹University of Michigan, South Lyon, MI, ²Rush University Medical Center, Chicago, IL, ³Rush University, Oak Park, IL, ⁴University of Michigan, Ann Arbor, MI
Background/Purpose: In arthritic synovium, emerging clinical evidence suggests crosstalk between synovial cells and dorsal root ganglion (DRG) neurons drives nerve sprouting and pain sensitization [Bai+…

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