Abstracts tagged "Osteoarthritis"

Abstract Number: 161 • 2013 ACR/ARHP Annual Meeting
H3K9 Demethylation By LSD1 Contributes To IL-1-Induced mPGES-1 Expression In OA Chondrocytes
Fatima Ezzahra El Mansouri¹ and Hassan Fahmi², ¹Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ²Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada
Background/Purpose: Microsomal prostaglandin E synthase-1 catalyzes the terminal step in the biosynthesis of PGE2, which plays a critical role in the pathophysiology of osteoarthritis. To…
Abstract Number: 2121 • 2013 ACR/ARHP Annual Meeting
Total Hip Arthroplasty Outcomes In Patients With Psoriatic Arthritis, Osteoarthritis With Cutaneous Psoriasis, and Osteoarthritis
Lisa A. Mandl¹, Rebecca Zhu², Wei-Ti Huang³, Michael Alexiades⁴, Mark P. Figgie⁵ and Susan M. Goodman¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Clinical Research, Hospital for Special Surgery, New York, NY, ³Biostatistics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY, ⁵Orthopedics, Hospital for Special Surgery, New York, NY
Background/Purpose: Outcomes of total hip replacements (THR) in psoriatic arthritis (PsA) are poorly studied. Previous studies are conflicting, often not separating inflammatory PsA from osteoarthritis…
Abstract Number: 261 • 2013 ACR/ARHP Annual Meeting
Concordance Of Hip Pain With Radiographic Hip Osteoarthritis In An Urban US Community: The Framingham Osteoarthritis Study
Kyu Chan Kim¹, David T. Felson², Katherine D. Linsenmeyer³, Ali Guermazi⁴, Steven C. Vlad⁵, Mary M. Clancy⁶ and Jingbo Niu⁷, ¹Internal Medicine and Rheumatology, Boston Medical Center, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Internal Medicine, Boston Medical Center, Boston, MA, ⁴Boston University, Boston, MA, ⁵Clinical Epidemiology, Boston University, Boston, MA, ⁶School of Medicine, Boston University, Boston, MA, ⁷Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: While it is well known that knee pain and radiographic knee osteoarthritis (OA) are often discordant, little is known of the concordance of hip…
Abstract Number: 150 • 2013 ACR/ARHP Annual Meeting
A Subset Of Osteoarthritis Individuals Has Elevated IL-6 Pathway Activation Associated With Worse Symptoms
Michael Kuziora¹, Zheng Liu², Brandon W. Higgs², Philip Brohawn², Kim Lehmann², Fernanda Pilataxi², Katie Streicher², Lydia Greenlees¹, Meina Liang³, Rozanne Lee⁴, Amy Schneider⁴, Raffaella Faggioni⁴, Yihong Yao² and Koustubh Ranade², ¹Translational Science, MedImmune, LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³Dmpk, MedImmune, LLC, Hayward, CA, ⁴DMPK, MedImmune, LLC, Hayward, CA
Background/Purpose: Elevated levels of the pro-inflammatory cytokine IL-6 have been found in the affected joint of patients with osteoarthritis (OA), although the prevalence of OA…
Abstract Number: 2103 • 2013 ACR/ARHP Annual Meeting
Relationships Between Self-Efficacy, Outcome Expectancy, and Outcomes In Older Adults With Osteoarthritis Of The Knee and Hypertension: Baseline Results
Elizabeth A. Schlenk¹, Deborah Crowley-Lisowski¹, Sarah Twerski¹, Alice Fallon¹, Alyssa Sartore¹, Susan Sereika¹, Joan Rogers², G. Kelley Fitzgerald³ and C. Kent Kwoh⁴, ¹School of Nursing, University of Pittsburgh, Pittsburgh, PA, ²School of Health and Rehabilitation Sciences, Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, ³School of Health and Rehabilitation Sciences, Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ⁴School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Staying Active with Arthritis (STAR), an intervention guided by Bandura’s Self-Efficacy Theory, is being investigated in an ongoing clinical trial of an individually delivered,…
Abstract Number: 263 • 2013 ACR/ARHP Annual Meeting
“Generalized Osteoarthritis”: A Systematic Review
Amanda E. Nelson¹, Michael W. Smith² and Yvonne M. Golightly³, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²Rheumatology, Saint Luke's Hospitals, Kansas City, MO, ³Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC
Background/Purpose: To perform a systematic review of definitions, risk factors, and outcomes in "generalized osteoarthritis" (GOA). Methods: We performed a systematic review of Medline literature…
Abstract Number: 2108 • 2013 ACR/ARHP Annual Meeting
Pre- and Postoperative Physical Therapy In Total Hip and Knee Replacement Surgery: A Multi Center Study
Wilfred FH Peter^1,2, Claire Tilbury³, Rutger Tordoir⁴, Suzan Verdegaal⁵, Ron Onstenk⁶, Menno Benard⁷, Stephan Vehmeijer⁸, Enrike van der Linden-van der Zwaag¹, Eric Vermeulen¹, Rob Nelissen¹ and Thea VlietVlieland⁹, ¹Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ²Reade, center for rehabilitation and rheumatology, Amsterdam, Nicaragua, ³Departement of Orthopedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Departement of orthopedics, Rijnland Hospital, Leiderdorp, Netherlands, ⁵Departement of Orthopedics, Rijnland Hospital, Leiderdorp, Netherlands, ⁶Department of Orthopedics, Het Groene Hart Hospital, Gouda, Netherlands, ⁷Departement of Orthopedics, Reinier de Graaf Hospital, Delft, Netherlands, ⁸Department of Orthopedics, Reinier de Graaf Hospital, Delft, Netherlands, ⁹Department of Orthopaedics, Leids University Medical Center, Leiden, Netherlands
Background/Purpose: Physical therapy shown to be effective after Total Hip and Knee Arthroplasty. Less evidence is available for preoperative physical therapy in Total Hip and…
Abstract Number: 264 • 2013 ACR/ARHP Annual Meeting
The Proportion Of Knee Osteoarthritis Patients In Southern Sweden That Seek Medical Car
Aleksandra Turkiewicz¹, Maria Gerhardsson de Verdier², Gunnar Engström³, Stefan Lohmander¹ and Martin Englund¹, ¹Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ²Astra Zeneca R&D Molndal, Molndal, Sweden, Molndal, Sweden, ³Dept of Cardiovascular epidemiology, Clinical Sciences, Lund University, Lund, Sweden
Background/Purpose: To provide estimates of the proportion of subjects with knee osteoarthritis (OA) that seek healthcare for knee OA or joint pain within an 8-year…
Abstract Number: 2913 • 2013 ACR/ARHP Annual Meeting
The Validity Of Patient-Reported Short-Term Complications Following Total Hip and Knee Arthroplast
Leslie R. Harrold¹, David Ayers², Regis O'Keefe³, Courtland Lewis⁴, Vincent Pellegrini⁵ and Patricia D. Franklin², ¹University of Massachusetts Medical School, Worcester, MA, ²Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ³University of Rochester Medical Center, Rochester, NY, ⁴Hartford Hospital, Hartford, CT, ⁵Medical University of South Carolina, Charleston, SC
Background/Purpose: Given the absence of national longitudinal data on patients who undergo total joint arthroplasty (TJA) and the limitations of hospital databases to capture information…
Abstract Number: 1887 • 2013 ACR/ARHP Annual Meeting
Interleukin-1 Receptor Antagonist (IL-1Ra) Plasma Levels Predict Radiographic Progression Of Symptomatic Knee Osteoarthritis Over 24 Months
Mukundan Attur¹, Alexander Statnikov^2,3, Jonathan Samuels⁴, Svetlana Krasnokutsky¹, Jeffrey D. Greenberg¹, Zhiguo Li², Leon Rybak⁵, Constantin F. Aliferis^2,6 and Steven B. Abramson⁷, ¹Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York, NY, ²Center for Health Informatics and Bioinformatics, NYU Langone Medical Center, New York, NY, ³Division of Translational Medicine, NYU Langone Medical Center, New York, NY, ⁴Division of Rheumatology, Department of Medicine, NYU Langone Medical Center, New York, NY, ⁵Department of Radiology, NYU Langone Medical Center, New York, NY, ⁶Department of Pathology, NYU Langone Medical Center, New York, NY, ⁷Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Osteoarthritis is multi-factorial complex degenerative joint disease that leads to permanent joint damage. We and others have shown elevated levels of inflammatory and anti-inflammatory…
Abstract Number: 253 • 2013 ACR/ARHP Annual Meeting
Higher Leg Extensor Muscle Power Output Is Associated With Reduced Pain and Better Quality Of Life In Patients With Symptomatic Knee Osteoarthritis
Kieran F. Reid¹, Lori Lyn Price², William F. Harvey³, Jeffrey B. Driban³, Roger A. Fielding¹ and Chenchen Wang³, ¹Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Muscle strength, the maximal force generating capacity of skeletal muscle, has been widely characterized in patients with knee osteoarthritis. However, skeletal muscle power, defined…
Abstract Number: 2720 • 2013 ACR/ARHP Annual Meeting
Providing Comprehensive, Comparative Post-TJR Outcome Feedback To Surgeons For Quality Monitoring and Value Decisions
Patricia D. Franklin¹, Bruce Barton², Leslie R. Harrold³, Wenjun Li¹, Regis O'Keefe⁴, Jeroan Allison² and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, ³University of Massachusetts Medical School, Worcester, MA, ⁴University of Rochester Medical Center, Rochester, NY
Background/Purpose: With the CMS decision to publicly report hospital-specific post-operative total joint replacement (TJR) events and readmissions, surgeons and hospitals need comprehensive post-hospital data by…
Abstract Number: 1817 • 2013 ACR/ARHP Annual Meeting
The Clinical Burden Of Generalized Osteoarthritis Represented By Activity Limitations and Health Related Quality Of Life: A Cross-Sectional Study
Nienke Cuperus¹, Thea Vliet Vlieland², Elien Mahler¹, Clarinda Kersten¹, Thomas Hoogeboom³ and Els van den Ende¹, ¹Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Department of Orthopaedics, University Medical Center Leiden, Leiden, Netherlands, ³Department of Epidemiology, CAPHRI school for public health and primary care, CCTR centre for Care Technology Research, Maastricht University, Maastricht, Netherlands
Background/Purpose: A growing body of evidence shows that generalized osteoarthritis (GOA) is fairly common, however research and clinical practice recommendations are mainly focused on a…
Abstract Number: 101 • 2013 ACR/ARHP Annual Meeting
Trends In Prescription Of Opioids From 2003-2009 In Persons With Knee Osteoarthritis
Elizabeth Wright¹, Jeffrey N. Katz², Stanley Abrams³, Daniel H. Solomon⁴ and Elena Losina⁵, ¹Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, ³Orthopedics and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ⁴Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA, ⁵Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Osteoarthritis (OA) of the knee is a painful condition affecting ~13% of persons >65 years of age. OA is often accompanied by comorbidities. Effective…
Abstract Number: 2668 • 2013 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Dose Ranging Study Comparing FX006, An Intra-Articular (IA) Sustained-Release Formulation Of Triamcinolone Acetonide (TCA), To An Approved Injectable Suspension Of TCA In Patients With Osteoarthritis (OA) Of The Knee
Neil Bodick¹, Joelle Lufkin¹, Christina Willwerth¹, Pierre Lachance², Gregory Jasey³, Anil Gupta⁴, Anthony Chris⁵, Marc Russo⁶, Michael O'Mahony⁷, Sam Henein⁸, Louise Murdoch⁹, Ferdinandus de Looze¹⁰, David Hunter¹¹ and Michael Clayman¹, ¹Flexion Therapeutics, Burlington, MA, ²Clinique St-Louis (Recherche) Inc, Quebec, QC, Canada, ³North Walkerville Orthopaedic Associates, Windsor, ON, Canada, ⁴Anil K. Gupta Medicine Professional Corporation, Toronto, ON, Canada, ⁵Aim Health Group, Waterloo, ON, Canada, ⁶Hunter Clinical Research, Broadmeadow, Australia, ⁷London Road Diagnostic Clinic and Medical Centre, Sarnia, ON, Canada, ⁸SKDS Research Inc., Newmarket, ON, Canada, ⁹Emeritus Research, Malvern East, Australia, ¹⁰AusTrials Pty Limited, Sherwood, Australia, ¹¹Royal North Shore Hospital, St. Leonards, Australia
Background/Purpose: FX006 is a novel sustained-release formulation of TCA in poly(lactic-co-glycolic) acid microspheres intended to maintain therapeutic concentrations in the joint up to 3 months…

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