Abstracts tagged "Osteoarthritis"

Abstract Number: 2969 • 2014 ACR/ARHP Annual Meeting
Mortality after Knee Replacement Surgery for Osteoarthritis in a Population-Based Propensity-Score Matched Cohort
Devyani Misra¹, Tuhina Neogi², Na Lu³, David T. Felson³, Thomas Einhorn⁴, Hyon K. Choi⁵, Jessica Maxwell⁶ and Yuqing Zhang³, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Orthopedics, Boston University School of Medicine, Boston, MA, ⁵Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Physical Therapy & Athletic Training, Boston University, Boston, MA
Background/Purpose : Knee replacement (KR) surgery for osteoarthritis (OA) provides improvement in symptoms and function. Whether these improvements translate into survival benefit has been unclear,…
Abstract Number: 1088 • 2014 ACR/ARHP Annual Meeting
Socioeconomic Disparities in Health Outcomes Among Individuals with, or at Risk for, Osteoarthritis from the United States: Data from the Osteoarthritis Initiative
Antoine A. Baldassari¹, Todd Schwartz¹, Rebecca J. Cleveland¹, Joanne M. Jordan² and Leigh F. Callahan³, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ³Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC
Background/Purpose Socioeconomic disparities in health outcomes among people with osteoarthritis are well documented, with some key limitations: existing studies limit their analyses to few outcome…
Abstract Number: 32 • 2014 ACR/ARHP Annual Meeting
Regulation of Senescence and Inflammatory Mediators By N- and C-Terminal Parathyroid Hormone-Related Protein in Osteoarthritic Human Osteoblasts
Maria Isabel Guillén¹, Julia Platas¹, Sergio Portal-Nuñez², Pedro Esbrit³ and M.J. Alcaraz⁴, ¹Pharmacology, University of Valencia, Burjasot, Valencia, Spain, ²Metabolismo mineral y óseo, Fundación Jimenez Diaz, Madrid, Spain, ³Fundación Jimenez Diaz, Madrid, Spain, ⁴University of Valencia, Burjasot, Valencia, Spain
Background/Purpose In osteoarthritis (OA), there is an abnormal remodeling process in subchondral bone associated with an altered osteoblast metabolism. Inflammatory mediators participate in bone remodeling…
Abstract Number: 2947 • 2014 ACR/ARHP Annual Meeting
Adenosine a_2A Receptor As a Potential New Therapeutic Target for the Prevention/Treatment of Osteoarthritis
Carmen Corciulo¹, Aranzazu Mediero², Tuere Wilder³ and Bruce N. Cronstein⁴, ¹Division of Translational Medicine, Department of Medicine, NYU School of Medicine, New York, NY, ²Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ³Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ⁴NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Osteoarthritis results from trauma, mechanical factors or metabolic changes in bone and cartilage. Adenosine, acting via the A2AR, inhibits inflammation and plays a critical…
Abstract Number: 1021 • 2014 ACR/ARHP Annual Meeting
Transthyretin and Amyloid in Cartilage Aging and Osteoarthritis
Yukio Akasaki¹, Oscar Alvarez-Garcia¹, Natalia Reixach², Joel Buxbaum², Yukihide Iwamoto³ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ³Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Background/Purpose Deposition of amyloid is a common aging-associated phenomenon and a key factor in the pathogenesis of several aging-related diseases. Osteoarthritis is the most prevalent…
Abstract Number: 2439 • 2014 ACR/ARHP Annual Meeting
Knee Joint Pathology in Patients with Rheumatoid Arthritis and Osteoarthritis Using a Validated Ultrasound Scoring System: A Cross Sectional Study
Karen Ellegaard¹, Marius Henriksen², Birgit Falk Riecke³, Søren Just⁴, Jakob Espesen⁵, Mohammed Yusuf Naderi⁶ and Henning Bliddal³, ¹Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark, ²Department of Rheumatology, The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark, ³The Parker Institute, Copenhagen, Denmark, ⁴Department of Rheumatology, Svenborg Sygehus, Svendbotg, Denmark, ⁵Odense Universitetshospital, Odense, Denmark, ⁶Department of Rheumatology, Esbjerg Sygehus, Esbjerg, Denmark
Background/Purpose Ultrasound (US) signs of inflammation in joints are synovial hypertrophy, effusion, and Doppler activity (increased perfusion), which have been demonstrated in both osteoarthritis (OA)…
Abstract Number: 977 • 2014 ACR/ARHP Annual Meeting
Randomized Clinical Trial of a Patient and Provider Intervention for Managing Osteoarthritis in Veterans
Kelli D. Allen^1,2, Hayden B. Bosworth^3,4, Amy Jeffreys¹, Cynthia Coffman^3,5, Santanu Datta^4,6, Jennifer McDuffie^1,7, Eugene Oddone^3,4, Jennifer Strauss^1,8 and William S. Yancy Jr.^1,4, ¹Health Services Research, Durham VA Medical Center, Durham, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Health Services Research, Durham VA Medical Center and Duke University Medical Center, Durham, NC, ⁴Department of Medicine, Division of General Internal Medicine, Duke University Medical Center, Durham, NC, ⁵Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, ⁶Health Services Reserach, Durham VA Medical Center and Duke University Medical Center, Durham, NC, ⁷Medicine, Duke University Medical Center, Durham, NC, ⁸Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC
Background/Purpose: Adequate management of osteoarthritis (OA) requires both medical and behavioral strategies. However, some recommended therapies are under-utilized in clinical settings, and there is low…
Abstract Number: 2337 • 2014 ACR/ARHP Annual Meeting
The Cost and Effectiveness of Various Recruitment Strategies in a Mind Body Clinical Trial Among Older Adults with Knee Osteoarthritis
Jade V. Goldsmith¹, Lori Lyn Price², Jeffrey B. Driban³, William F. Harvey³ and Chenchen Wang³, ¹Center for Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose : Recruitment and adherence are important and challenging factors that can determine the success of a clinical trial. Mind body therapies are an emerging and…
Abstract Number: 978 • 2014 ACR/ARHP Annual Meeting
Socioeconomic Status Measures Are Associated with Increasing Pain, Stiffness and Physical Function Among Individuals with Knee and Hip Osteoarthritis
Rebecca J. Cleveland¹, Jordan B. Renner², Joanne M. Jordan³ and Leigh F. Callahan⁴, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina Department of Radiology, Chapel Hill, NC, ³University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ⁴Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC
Background/Purpose The determinants of disability progression (DP) among those with knee and/or hip osteoarthritis (OA) are not well known. Our aim was to explore whether…
Abstract Number: 2233 • 2014 ACR/ARHP Annual Meeting
A PHASE 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy Study of Apremilast (CC-10004) in Subjects with Erosive Hand Osteoarthritis
Juergen Rech¹, Francesca Faustini¹, Axel J. Hueber¹, Wolfgang Ochs², Wolfgang Spieler³, Herbert Kellner⁴, Ulf Muller-Ladner⁵, Mathias Grünke⁶, Matthias Schneider⁷ and Georg Schett⁸, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Rheumatologist in private practice, Bayreuth, Germany, ³Osteologie und Rheumatologie, ZeFOR GmbH Zentrum für Forschung, Zerbst, Germany, ⁴Centre for Inflammatory Joint Diseases, Munich, Germany, ⁵Internal Medicine/Rheumatology, Univ Giessen/Kerckhoff-Clinic, Bad Nauheim, Germany, ⁶Division of Rheumatology, University of Munich, Munich, Germany, ⁷Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, ⁸Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose We report on a phase II, multicenter, randomized, double-blind, placebo-controlled, efficacy and safety study in subjects with erosive hand osteoarthritis. Subjects must have had…
Abstract Number: 922 • 2014 ACR/ARHP Annual Meeting
A Potential Role for TLR4 Activation in Osteoarthritis Associated Pain
Rachel E. Miller¹, Shingo Ishihara², Phuong Tran³, Richard J. Miller⁴ and Anne-Marie Malfait⁵, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Rheumatology, Rush University Medical Center, Chicago, IL, ⁴Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁵Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose - Damage associated molecular patterns (DAMPs) result from cellular stress and extracellular matrix breakdown. They may contribute to osteoarthritis (OA) pathogenesis by promoting synovitis…
Abstract Number: 2109 • 2013 ACR/ARHP Annual Meeting
Quality Indicators For Physical Therapy Management In Hip and Knee Osteoarthritis and Rheumatoid Arthritis
Wilfred FH Peter^1,2, Emalie Hurkmans³, Philip van der Wees⁴, Erik Hendriks⁵, Rob de Bie⁵, Leti van Bodegom-Vos⁶ and Theodora P.M. Vliet Vlieland⁷, ¹Departmentof Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ²Amsterdam Rehabilitation Research Center, Reade, centre for rehabilitation and rheumatology, Amsterdam, Netherlands, ³Section Physiotherapy, University of Applied Sciences, Vienna, Austria, ⁴IQ Healthcare, Radboud University, Nijmegen, Netherlands, ⁵Centre for Evidence Based Physiotherapy, University of Maastricht, Maastricht, Netherlands, ⁶Department of Medical Decision Making, Leiden University Medical Center, Leiden, Netherlands, ⁷Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Physical therapy is recommended in several guidelines on the management of osteoarthritis and rheumatoid arthritis. Currently, no specific quality indicators for physical therapy in…
Abstract Number: 766 • 2013 ACR/ARHP Annual Meeting
Cholesterol Accumulation By Synovial Lining Macrophages Results In Ectopic Bone Formation During Experimental Osteoarthritis
Wouter de Munter¹, Arjen B. Blom¹, Monique M. Helsen¹, Birgitte Walgreen¹, Peter M. van Der Kraan¹, Leo A. Joosten², Wim B. van den Berg³ and Peter L. van Lent⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial macrophages have previously shown to play a significant role in the etiopathology of experimental collagenase-induced osteoarthritis (OA). In addition to production of pro-inflammatory…
Abstract Number: 161 • 2013 ACR/ARHP Annual Meeting
H3K9 Demethylation By LSD1 Contributes To IL-1-Induced mPGES-1 Expression In OA Chondrocytes
Fatima Ezzahra El Mansouri¹ and Hassan Fahmi², ¹Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ²Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada
Background/Purpose: Microsomal prostaglandin E synthase-1 catalyzes the terminal step in the biosynthesis of PGE2, which plays a critical role in the pathophysiology of osteoarthritis. To…
Abstract Number: 2121 • 2013 ACR/ARHP Annual Meeting
Total Hip Arthroplasty Outcomes In Patients With Psoriatic Arthritis, Osteoarthritis With Cutaneous Psoriasis, and Osteoarthritis
Lisa A. Mandl¹, Rebecca Zhu², Wei-Ti Huang³, Michael Alexiades⁴, Mark P. Figgie⁵ and Susan M. Goodman¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Clinical Research, Hospital for Special Surgery, New York, NY, ³Biostatistics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY, ⁵Orthopedics, Hospital for Special Surgery, New York, NY
Background/Purpose: Outcomes of total hip replacements (THR) in psoriatic arthritis (PsA) are poorly studied. Previous studies are conflicting, often not separating inflammatory PsA from osteoarthritis…

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