Abstracts tagged "Osteoarthritis"

Abstract Number: 0024 • ACR Convergence 2024
Trans-Signaling by Soluble CD14 Sensitizes Chondrocytes to Lipopolysaccharide Stimuli, Increasing Chondrocyte Inflammatory Responses
Anna E. Rapp, Baofeng Hu and Carla Scanzello, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The understanding of osteoarthritis (OA) has evolved significantly over the past decade. Recently attention is being drawn to the role of pattern-recognition receptor (PRR)…
Abstract Number: 0791 • ACR Convergence 2024
Optimizing Knee Osteoarthritis Treatment with the Precision Medicine Approach in a Clinical Trial Dataset
Caroline Walton¹, Forrest Hurley², Liubov Arbeeva³, Stephen Messier⁴, Shannon Mihalko⁴, Jeffrey Katz⁵, Richard Loeser⁶, David Hunter⁷, Leigh Callahan⁸ and Amanda Nelson², ¹UNC School of Medicine, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina, Chapel Hill, Carrboro, NC, ⁴Wake Forest University, Winston Salem, NC, ⁵Brigham and Women's Hospital, Brookline, MA, ⁶University of North Carolina, Chapel Hill, NC, ⁷Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁸University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Precision medicine has previously identified subgroups of clinical trial participants with knee osteoarthritis (kOA) that benefit more from a specific intervention than others. We…
Abstract Number: 1174 • ACR Convergence 2024
Effects of Electroacupuncture on Pain and Joint Deformity in Rat Models of Knee Osteoarthritis: A Study on the Differences in Acupoints Used
Hideshi Ikemoto, Oyunchimeg Chuluunbat, Takayuki Okumo, Naoki Adachi, Tadashi Hisamitsu and Masataka Sunagawa, Showa university, Shinagawa-ku, Tokyo, Japan
Background/Purpose: ADAMTS5, a member of the ADAMTS enzyme family, is a key enzyme in the degradation of cartilage in the early stages of knee osteoarthritis…
Abstract Number: 1195 • ACR Convergence 2024
The Relations of Analgesic Antidepressants Use to Knee or Hip Replacement Among Osteoarthritis Patients Compared to Selective Serotonin Reuptake Inhibitors in a Large Prospective Cohort
Zhiqiang Wang¹, Maggie Westerland², Christine Peloquin³, mike LaValley⁴, Margaret Clancy³, Changhai Ding⁵ and Tuhina Neogi³, ¹Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China (People's Republic), ²Boston University School of Medicine, Boston, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴Boston University School of Public Health, Arlington, MA, ⁵Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, China (People's Republic)
Background/Purpose: Some antidepressants and anticonvulsants are effective in treating pain through mechanisms thought to be independent from their effects on depression, such as tricyclic antidepressants…
Abstract Number: 1211 • ACR Convergence 2024
An Evaluation of the Efficacy, Pharmacokinetics and Safety, of the Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist RTX-GRT7039 – a Placebo-controlled Study in Patients with Osteoarthritis Knee Pain
Thor Ostenfeld¹, Stefan Ivanicius¹, Roman Stancik² and Philip G Conaghan³, ¹Grunenthal GmbH, Aachen, Germany, ²National Institute of Rheumatic Diseases, Piestany, Slovenia, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: The transient receptor potential vanilloid 1 (TRPV1) is a critical driver of osteoarthritis (OA) pain. RTX-GRT7039 is an investigational medicinal product containing the active…
Abstract Number: 1668 • ACR Convergence 2024
Association of Wearable-Sensor Derived Gait Measures with Widespread Pain over 2 Years: A Machine Learning Analysis in the Multicenter Osteoarthritis Study
Kathryn Bacon¹, David Felson², S. Reza Jafarzadeh³, Jeffrey Hausdorff⁴, Eran Gazi⁵, Neil Segal⁶, Cora Lewis⁷, Michael Nevitt⁸ and Deepak Kumar², ¹Boston University, Webster, NH, ²Boston University, Boston, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴Tel Aviv University, Tel Aviv, Israel, Tel Aviv, Israel, ⁵Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁶University of Kansas, Kansas City, KS, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸University of California, San Francisco, San Francisco, CA
Background/Purpose: Gait patterns can put stress on the back and weight bearing joints and can even affect upper extremity joints. Walking involves muscle activation and…
Abstract Number: 2091 • ACR Convergence 2024
Changes in Analgesic Prescriptions for the Treatment of Osteoarthritis During the COVID-19 Pandemic
Derek Ochi¹, Dagoberto Pina², Manmeet Kaur³, Jeffery Fine⁴, Daniel Black⁵ and Barton Wise⁶, ¹Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, Sacramento, CA, ²School of Medicine, University of California Davis, Sacramento, CA, ³Division of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, CA, ⁴Department of Public Health Sciences, University of California Davis, Sacramento, CA, ⁵Innovation Technology - Data Center of Excellence, University of California Davis, Sacramento, CA, ⁶Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis and Department of Orthopaedic Surgery, University of California Davis, Sacramneto, CA
Background/Purpose: Osteoarthritis (OA) is a leading cause of disability. The 2019 American College of Rheumatology (ACR)/Arthritis Foundation (AF) Guideline for the Management of OA recommends…
Abstract Number: 2107 • ACR Convergence 2024
Deep Immunophenotyping of Knee Osteoarthritis Patients Reveals Alterations in T Cell, Treg, and Monocyte Subpopulations
Montana Barrett¹, Gabby dyson², Nicholas Hannebutt³, Aleksander Szymczak², Cindy Miranda⁴ and Matlock Jeffries², ¹University of Oklahoma, Cement, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Spencer, OK, ⁴Oklahoma Medical Research Foundation, Yukon, OK
Background/Purpose: Previous studies have suggested low-level chronic inflammation plays a key role in knee osteoarthritis (OA) development and progression, although attention has mostly been focused…
Abstract Number: 0025 • ACR Convergence 2024
Vagus Nerve Stimulation: A Promising Approach to Alleviate Pain and Systemic Inflammation in Slow and Rapid Models of Osteoarthritis
Shivmurat Yadav¹, Timothy Griffin², Matlock Jeffries², Stavros Stavrakis³ and Mary Beth Humphrey⁴, ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³University of Oklahoma, College of Mediicine, Oklahoma City, OK, ⁴University of Oklahoma College of Medicine, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) causes joint pain, stiffness, swelling, and functional impairment. Pain signals reach the brain, influencing inflammatory and immune responses through the parasympathetic efferent…
Abstract Number: 0792 • ACR Convergence 2024
Radiographic and Pain Outcomes from a Phase 3 Trial (OA-07) Evaluating the Efficacy and Safety of Repeat Lorecivivint Injections over 3 Years in Subjects with Knee OA
Yusuf Yazici¹, Jeyanesh Tambiah², Christopher Swearingen³ and Timothy McAlindon⁴, ¹NYU Grossman School of Medicine, La Jolla, CA, ²Biosplice Therapeutics Inc., San Diego, CA, ³Biosplice Therapeutics, Inc, San Diego, CA, ⁴University of Massachusets, Worchester, MA
Background/Purpose: Knee OA has unmet need for safe and efficacious symptom and disease-modifying treatments. Lorecivivint (LOR), an intra-articular (IA) CLK/DYRK inhibitor thought to modulate inflammatory…
Abstract Number: 1176 • ACR Convergence 2024
Exploration of Heterogeneity of Treatment Effects Across Exercise-Based Interventions for Knee Osteoarthritis
Paul Dennis¹, Livia Anderson¹, Cynthia Coffman¹, Sara Webb¹ and Kelli Allen², ¹Durham VA Healthcare System, Durham, NC, ²University of North Carolina, Durham, NC
Background/Purpose: Substantial variability exists in the degree of improvement individual patients experience following exercise-based interventions (EBIs) for knee osteoarthrosis (OA). Yet limited guidance is available…
Abstract Number: 1196 • ACR Convergence 2024
Relation of Different Types of Antidepressants Use to Pain Severity and Measures of Pain Sensitization in Kneeosteoarthritis
Zhiqiang Wang¹, Brooke Mcginley², mike LaValley³, Laura Frey-Law⁴, Beth Lewis⁵, Michael Nevitt⁶, Margaret Clancy⁷, Changhai Ding⁸ and Tuhina Neogi⁷, and MOST investigators, ¹Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China (People's Republic), ²Boston University, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Carver College of Medicine, Iowa City, IA, ⁵School of Kinesiology , Kinesiology College of Education and Human Development, Twin Cities, Minneapolis, MN, ⁶UCSF, Orinda, CA, ⁷Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁸Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, China (People's Republic)
Background/Purpose: The pain experience in osteoarthritis (OA) is multifactorial and includes both somatosensory and affective components. The affective component can be related to depression, a…
Abstract Number: 1217 • ACR Convergence 2024
Medical and Non-Medical Cannabis Use by Rheumatology Patients: A Study of over 2000 Patients in California
Maggie Hui¹, Nicholas Jackson², Angela Pham¹, Keren Chen², David Elashoff², ziva Cooper³ and Veena Ranganath⁴, ¹David Geffen School of Medicine at UCLA, Los Angeles, ²UCLA Department of Medicine Statistics Core, Los Angeles, ³UCLA Center for Cannabis and Cannabinoids, Semel Institute for Neuroscience & Human Behavior, Dept of Psychiatry and Biobehavioral Sciences, Dept of Anesthesiology and Perioperative Medicine, Los Angeles, ⁴UCLA, Los Angeles, CA
Background/Purpose: Approximately 12-20% of Rheumatology patients use cannabis (Fitzcharles 2020, Wipfler 2022, Rampakakis 2023). Despite the legalization of medical cannabis in California more than 2…
Abstract Number: 1730 • ACR Convergence 2024
Osteoarthritis Is a Risk Factor for Inflammatory Arthritis in Cancer Patients Treated with Immune Checkpoint Inhibitors
Daniel Portnoy¹, Matthieu J Piola², Luke Hao², Robert Winchester², Adam Mor² and Yevgeniya Gartshteyn³, ¹Columbia University Irving Medical Center, New Yok, NY, ²Columbia University Irving Medical Center, New York, NY, ³Columbia University Irving School of Medicine, New York, NY
Background/Purpose: Inflammatory arthritis is one of the most common immune-related adverse events (irAEs) resulting from immune checkpoint inhibitors (ICIs). We hypothesized that T cells present…
Abstract Number: 2092 • ACR Convergence 2024
Remote-Delivered Tai Chi and Gut Microbiota in Osteoarthritis: A Randomized Mechanistic Trial
Chenchen Wang¹, Timothy McAlindon², Meghan Short¹, Mei Chung³, Ye Chen¹, Albert Tai¹ and Honorine Ward¹, ¹Tufts Medical Center, Boston, MA, ²University of Massachusets, Worchester, MA, ³Tufts Medical Center, Brighton, MA
Background/Purpose: Previous studies show that Tai Chi achieves clinical improvement for osteoarthritis (OA) through multiple pathways. There is evidence for interaction of the gut microbiota…

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