Abstracts tagged "Osteoarthritis"

Abstract Number: 1188 • 2017 ACR/ARHP Annual Meeting
Initial Estimates of Efficacy of Intra-Articular 2.5% Polyacrylamide Hydrogel for the Treatment of Knee Osteoarthritis: An Observational Proof-of-Concept Study
Marius Henriksen^1,2, Anders Overgaard¹ and Henning Bliddal³, ¹The Parker Institute, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark, ²Department of physical therapy, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark, ³The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
Background/Purpose: There is a draught of available effective treatments of knee osteoarthritis (OA) and tests of new therapies are needed. Polyacrylamide hydrogel (PAAG) is a…
Abstract Number: 2211 • 2017 ACR/ARHP Annual Meeting
Investigation of Self-Reported Painful Joint Count As an Outcome Measure in Hand Osteoarthritis
F.P.B. Kroon¹, J.L. van der Plas¹, S. van Beest¹, W. Damman¹ and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Hand osteoarthritis (OA) research is in need of disease-specific validated instruments to measure patient-reported outcomes. Self-reported painful joint count (PJC) could be useful to…
Abstract Number: 1189 • 2017 ACR/ARHP Annual Meeting
Favorable Human Safety, Pharmacokinetics and Pharmacodynamics of the Adamts-5 Inhibitor GLPG1972, a Potential New Treatment in Osteoarthritis
Ellen van der Aar¹, Sonia Dupont², Liesbeth Fagard¹, Marina De Smet¹, David Amantini², Staffan Larsson³, André Struglics³, L. Stefan Lohmander⁴, Frédéric Vanhoutte¹ and Julie Desrivot², ¹Galapagos NV, Mechelen, Belgium, ²Galapagos SASU, Romainville, France, ³Clinical Sciences, Lund University, Lund, Sweden, ⁴Orthopaedics, Clinical Sciences Lund, Lund University, Lund, Sweden
Background/Purpose: Increased aggrecanase activity is a well-known trigger factor for osteoarthritis (OA), initiating loss of cartilage aggrecan that precedes more severe cartilage degradation. A disintegrin…
Abstract Number: 2213 • 2017 ACR/ARHP Annual Meeting
“Generalized Osteoarthritis”: Update to a Systematic Review
Terese R. Gullo^1,2 and Amanda Nelson³, ¹Thurston Arthritis Research Center, Chapel Hill, NC, ²Ohio State University College of Medicine, Columbus, OH, ³Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: To perform a systematic review of the definitions of generalized osteoarthritis (GOA). An initial systematic review of the literature for GOA was published in…
Abstract Number: 1197 • 2017 ACR/ARHP Annual Meeting
Exploring Determinants Predicting Response to Intra-Articular Hyaluronic Acid Treatment in Symptomatic Knee Osteoarthritis
Jean-Pierre Pelletier¹, Jean-Pierre Raynauld¹, François Abram², Marc Dorais³, Philippe Delorme⁴ and Johanne Martel-Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame-de-l’Île-Perrot, QC, Canada, ⁴ArthroLab Inc., Montreal, QC, Canada
Background/Purpose: A major challenge regarding intraarticular hyaluronic acid (IAHA) treatment in knee osteoarthritis (OA) is identifying patients who will benefit most. This study aimed to…
Abstract Number: 2214 • 2017 ACR/ARHP Annual Meeting
Contrary to Current Understanding of Osteoarthritis Pathogenesis, Only Gender and Radiographic Status Predict Progression: A Machine Learning Study of 9,254 Knees from the Osteoarthritis Initiative
Michael A Bowes¹, Oras Alabas², Gwenael Guillard¹, Graham R. Vincent¹, Alan Brett³ and Philip G. Conaghan⁴, ¹Imorphics Ltd, Manchester, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, United Kingdom, Leeds, United Kingdom, ³Imorphics Ltd, MANCHESTER, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Currently there are a large number of postulated predictors for OA progression, proposed on the basis of relatively small studies (100’s), and measurement approaches…
Abstract Number: 1204 • 2017 ACR/ARHP Annual Meeting
Radiographic Outcomes Were Associated with Pain and Function Responses: Post-Hoc Analysis of Results from a Phase 2 Study of a Small Molecule Wnt Pathway Inhibitor, SM04690, for Knee Osteoarthritis Treatment
Yusuf Yazici¹, Timothy E. McAlindon², Allan Gibofsky³, Nancy E. Lane⁴, Nebojsa Skrepnik⁵, Eddie Armas⁶, Christopher J. Swearingen¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Marc Hochberg⁷, ¹Samumed, LLC, San Diego, CA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, ⁴Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, ⁵Tuscon Orthopedics Institute, Tuscon, AZ, ⁶Well Pharma Medical Research, Miami, FL, ⁷Head, Division of Rheumatology & Clinical Immunology; Vice Chair, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, disability and joint deformity due to articular cartilage degradation and bone remodeling. Wnt signaling is involved in…
Abstract Number: 2215 • 2017 ACR/ARHP Annual Meeting
Effect of Single 6 Ml Intraarticular Injection of Hylan G-F 20 in Patients with Knee Osteoarthritis: Results of a Single Centre Study
SUNIL KUMAR PANDEY¹ and SAT PAL SINGH², ¹ORTHOPEDIC DEPARTMENT, SAFDARJUNG HOSPITAL, VMMC, NEW DELHI, NEW DELHI, India, ²DEPARTMENT OF MEDICINE, SAFDARJUNG HOSPITAL,VMMC, NEW DELHI, NEW DELHI, India
Background/Purpose: To evaluate the effect of single 6ml intraarticular injection of hylan G-F 20 in patients with knee osteoarthritis. Author: Dr. Pandey Sunil Kumar*, Dr.…
Abstract Number: 1875 • 2017 ACR/ARHP Annual Meeting
Assessment of Structural Damage of the Thumb Base in Patients with Hand Osteoarthritis: Comparing the Newly Developed Omeract Magnetic Resonance Imaging Scoring System with Standard Radiography
S. van Beest¹, F.P.B. Kroon¹, W. Damman¹, R. Liu¹, H.M. Kroon² and M. Kloppenburg³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Thumb base osteoarthritis (OA) is characterized by structural damage, most commonly evaluated by radiography. However radiography is insensitive. Magnetic resonance (MR) imaging could be…
Abstract Number: 2247 • 2017 ACR/ARHP Annual Meeting
Secondary Fibromyalgia Is Not Associated with Higher Likelihood of Patient-Physician Discordance in Global Assessment in Patients with Osteoarthritis and Rheumatoid Arthritis
Isabel Castrejón, Shakeel M. Jamal and Najia Shakoor, Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Pain is the strongest driver of patient-physician discordance in global assessment in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Having secondary fibromyalgia (FM),…
Abstract Number: 57 • 2016 ACR/ARHP Annual Meeting
Genetic Polymorphism of IL-1RN Encoding the IL-1 Receptor Antagonist Predicts Radiographic Severity of Symptomatic Knee OA
Mukundan Attur¹, Sisi Ma², Jonathan Samuels³, Svetlana Krasnokutsky Samuels⁴, Hua Zhou², Jenny Bencardino⁵, Marc C. Hochberg⁶, Braxton Mitchell⁷, Virginia B. Kraus⁸, Joanne M. Jordan⁹ and Steven B. Abramson¹⁰, ¹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Rheumatology, NYU - Hospital for Joint Diseases, New York, NY, ⁴Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁵Radiology, NYU Langone Medical Center, New York, NY, ⁶University of Maryland School of Medicine, Baltimore, MD, USA, Baltimore, MD, ⁷Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, ⁸Department of Medicine, Duke University Medical Center, Durham, NC, ⁹Thurston Arthritis Research Center, University of North CArolina at Chapel Hill, Chapel Hill, NC, ¹⁰Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY
Background/Purpose: Growing numbers of studies show increased expression in Osteoarthritis (OA) of inflammatory cytokines, such as IL-1β and TNFα, in joint tissues and peripheral blood…
Abstract Number: 1093 • 2016 ACR/ARHP Annual Meeting
DNA Methylation Defines Joint Specific Differences in Synovial Fibroblasts from OA and RA Patients
Emmanuel Karouzakis¹, Mojca Frank Bertoncelj², Kerstin Klein¹, Christoph Kolling³, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland
Background/Purpose: Recent studies revealed epigenetic changes in DNA methylation associated with rheumatoid arthritis (RA) synovial fibroblasts (SF). In addition, we have shown that SF exhibit…
Abstract Number: 2372 • 2016 ACR/ARHP Annual Meeting
Effect of Oxytocin on Osteoarthritis
christian roux¹, astrid pinzano², didier Pisani³, Patricia panaia-Ferrari⁴, eric Fontas⁵, hedi Ben Yahia⁶, damien ambrosetti⁷, jean-François michiels⁸, veronique Breuil⁹ and ez Zoubir Amri¹⁰, ¹Rheumatology, LAMHESS laboratory, sofia antipolis university, CHU Pasteur 2, Nice, France, nice, France, ²IMoPA Ingénierie Moléculaire et Physiopathologie Articulaire, University nancy lorraine, UMR7365 CNRS-UL, Nancy, France, ³CNRS UMR7277, Inserm U1091, UNS Université Nice Sophia Antipolis Parc Valrose, nice, France, ⁴IBiology and immunology laboratory, university nice sofia antipolis, nice, France, ⁵Direction recherche clinique, CHU de Nice, france, Nice, France, ⁶iBV - Institut de Biologie Valrose. Nice, Nice, France, ⁷Department anatomopathology, nice. university nice sofia antipolis, nice, France, ⁸department anatomo-pathology, Nice, university nice sofia antipolis, Nice, France, ⁹Rheumatology department, Nice, France, ¹⁰CNRS UMR7277, Inserm U1091, UNS Université Nice Sophia Antipolis Parc Valrose, Nice, France
Background/Purpose: The relationship between oxytocine (OT) and osteoarthritis (OA) is poorly studied and remains unknown. However the subchondral bone is considered as a major player in…
Abstract Number: 1099 • 2016 ACR/ARHP Annual Meeting
Synovial Exosomes Induce Osteoclast Differentiation in Rheumatoid arthritis
Ji Eun Song¹, Ji Hye Shin¹, Ki Won Moon², Se Hui Shon¹, Ji Soo Park³, Eun Bong Lee³, Yeong Wook Song^1,3 and Eun Young Lee³, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea, Seoul, Korea, The Republic of, ²Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea, Chuncheon, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Seoul, Korea, The Republic of
Background/Purpose: Exosomes are small membrane vesicles (40-150 nm) of endocytic origin secreted by many types of cells and engage in cell-to-cell communication by transferring proteins,…
Abstract Number: 3048 • 2016 ACR/ARHP Annual Meeting
Pain Severity As a Mediator of the Effect of Depressive Symptoms on Physical Performance in Knee Osteoarthritis
Alan Rathbun¹, Michelle Shardell², Michelle S. Yau³, Mona Baumgarten⁴, Elizabeth Stuart⁵ and Marc Hochberg⁶, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Depression is a significant comorbidity of knee osteoarthritis (OA) that occurs in approximately 20% of OA patients. Depressive symptoms are associated with both subsequent…

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