ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2213

“Generalized Osteoarthritis”: Update to a Systematic Review

Terese R. Gullo1,2 and Amanda Nelson3, 1Thurston Arthritis Research Center, Chapel Hill, NC, 2Ohio State University College of Medicine, Columbus, OH, 3Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Osteoarthritis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Tuesday, November 7, 2017

Session Title: Osteoarthritis – Clinical Aspects Poster II: Observational and Epidemiological Studies

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: To perform a systematic review of the definitions of generalized osteoarthritis (GOA). An initial systematic review of the literature for GOA was published in 2014 (PMID 24461078); this review is an update to the definitions analyzed in the original work.

Methods: We performed a systematic review in Medline using the terms osteoarthritis, generalized, polyarticular, multiple joint, multi-joint, and others to obtain articles related to GOA, following PRISMA guidelines.  The search was performed 4/18/17 by a professional librarian. The initial searches produced 216 articles for title and abstract review (performed by AEN and TRG), after which 75 underwent full text review (AEN and TRG).  Of these, 39, along with 3 identified through bibliographic review, were included for data extraction (TRG) based on pre-specified criteria including the requirement for a clearly stated definition of OA (clinical, radiographic, or symptomatic) assessed at more than one body site.

Results: In the 42 included articles, 29 large cohorts (n~56,000) were represented along with 7 clinical series (n~28,000), 1 systematic review (n=79 studies) and 2 meta-analyses (n~980,000) across 14 countries and 5 years (2012-2017). The sites assessed, and OA definitions at each site, varied but most often included the hands, knees and hips. Five of the 42 studies explicitly stated a definition for GOA, and 1 gave an implicit definition. No two of these definitions were the same, however all required a minimal number of joints affected without regard to body region (Table). No definitions contained a supporting rationale. Estimates of the prevalence of GOA in these studies ranged from 7-13%.

Although the remaining 36 articles did not provide a definition for GOA, 11 studies did collect data for OA disease characteristics in multiple joints within the individual. For instance, one study tallied the number of painful joint regions to assess the extent of disabling OA at the person level (as opposed to the regional level). Another study listed Clinical OA- number of sites as a categorical variable. Finally, in at least 7 articles the authors used alternate terms to denote multiple joint involvement—among these polyarticular OA and multijoint OA.

Conclusion:   As in 2014, when the initial systematic review was conducted, GOA remains a commonly used term in the literature despite its lack of a clear or widely agreed upon definition. Most studies that discuss GOA do not define it, and for those that do, still no consensus has been reached. Alternate terms have been used, such as multijoint OA, to describe symptoms and/or radiographic features manifested in more than 1 joint in the individual. However, the use of these terms has yet to improve precision in the definition of GOA. It remains appropriate for individual studies to clearly define any terms used to designate OA of multiple joints or joint groups.


Disclosure: T. R. Gullo, None; A. Nelson, None.

To cite this abstract in AMA style:

Gullo TR, Nelson A. “Generalized Osteoarthritis”: Update to a Systematic Review [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/generalized-osteoarthritis-update-to-a-systematic-review/. Accessed April 11, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/generalized-osteoarthritis-update-to-a-systematic-review/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.