Abstracts tagged "Osteoarthritis"

Abstract Number: 187 • 2014 ACR/ARHP Annual Meeting
Revision Arthroplasty in Rheumatoid and Osteoarthritis: Does Methotrexate Decrease Radiographic Lucency in RA Patients?
Mike Wei¹, Douglas N. Mintz², Lisa A. Mandl³, Arielle Fein⁴, Jayme C. Burket⁵, Yuo-Yu Lee⁴, Wei-Ti Huang⁶, Vivian P. Bykerk⁴, Mark P. Figgie⁷, Edward F. DiCarlo⁸, Bruce N. Cronstein⁹ and Susan M. Goodman³, ¹Weill Cornell Medical College, New York, NY, ²Radiology, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵Healthcare Research Institute, Hospital for Special Surgery, New York, NY, ⁶Biostatistics, Hospital for Special Surgery, New York, NY, ⁷Orthopedics, Hospital for Special Surgery, New York, NY, ⁸Pathology, Hospital for Special Surgery, New York, NY, ⁹NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Rheumatoid arthritis (RA) patients have excellent total hip arthroplasty (THA) survival, and methotrexate (MTX), an anti-inflammatory disease modifying drug which may affect bone reabsorption,…
Abstract Number: 1291 • 2014 ACR/ARHP Annual Meeting
Relationships Between Inflammation, Disease Severity and Synovial Fluid Calcium Crystals Detected By Scanning Electronic Microscopy in Early Osteoarthritis
Paola Frallonardo¹, Francesca Oliviero¹, Luca Peruzzo², Leonardo Tauro³, Anna Scanu¹, Mariagrazia Lorenzin¹, Augusta Ortolan¹, Leonardo Punzi⁴ and Roberta Ramonda¹, ¹Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ²Institute for Geosciences and Earth Resources IGG-CNR, Padova, Italy, ³Department of Geosciences, University of Padova, Padova, Italy, ⁴Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose The presence of calcium crystals (CC) in synovial fluid (SF) of osteoarthritis (OA) is a well known and frequent feature (1). However, their role…
Abstract Number: 108 • 2014 ACR/ARHP Annual Meeting
Patient Reported Outcomes Following Total Knee Arthroplasty in Rheumatoid Arthritis and Osteoarthritis
Anand Dusad¹, Sofia Pedro², Kevin Garvin³, Curtis Hartman⁴, James O'Dell⁵, Ted R. Mikuls⁵ and Kaleb Michaud⁶, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Orthopaedic Surgery, University of Nebraska Medical Center, Omaha, NE, ⁴Orthopaedic Surgery and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶University of Nebraska Medical Center and National Data Bank, Omaha, NE
Background/Purpose: Due to the progressive and debilitating nature of knee arthritis, total knee arthroplasty (TKA) is the ultimate outcome. TKA is an effective surgical intervention…
Abstract Number: 1284 • 2014 ACR/ARHP Annual Meeting
Sensitivity to Change of Patient Preference Outcome Measures for Pain in Trials of Patients with Knee Osteoarthritis
Matthew J. Parkes¹, Michael J. Callaghan¹, Terence W. O'Neill¹ and David T. Felson^1,2, ¹Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose A variety of pain and function instruments are often measured in osteoarthritis (OA) clinical trials. Instruments with maximal sensitivity to change are preferred as the…
Abstract Number: 76 • 2014 ACR/ARHP Annual Meeting
Identification of Synovial Genes and Pathways Associated with Disease Progression in a Cohort of Early Symptomatic Osteoarthritis Patients Using a Transcriptomic Approach
Arjen B. Blom¹, Peter L. van Lent¹, Martijn H. van den Bosch², Hans Cats³, Frank H.J. van den Hoogen⁴, Floris P.J.G. Lafeber⁵, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ³Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: If and how the synovial activation that is observed in over 50% of osteoarthritis (OA) patients contributes to irreversible joint pathology, is not known.…
Abstract Number: 1285 • 2014 ACR/ARHP Annual Meeting
Prevalence of Risk Factors for Gastrointestinal Side Effects of Drugs for the Treatment of Pain in Rheumatic Diseases and the Provision of Gastroprotective Treatment – Results of a Large Non-Intervention Study
Gustavo Citera¹, Edgardo Smecuol², Alberto Millán³, Manuel Robles⁴ and Ruben Mantilla⁵, ¹Universidad de Buenos Aires, Buenos Aires, Argentina, ²Hospital Municipal de Gastroenterología, Buenos Aires, Argentina, ³Hospital Universitario de Caracas, Caracas, Venezuela, ⁴Centro Médico Toluca, Toluca, Mexico, ⁵Clínica de Artritis y Rehabilitación (CAYRE), Bogota, Colombia
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are the long established first-line treatment for the management of pain associated with rheumatic diseases but carry a risk of…
Abstract Number: 68 • 2014 ACR/ARHP Annual Meeting
Physical Inactivity to Activity Associated with Less Decline in Physical Function
Abigail Gilbert¹, Jing Song², Pamela A. Semanik³, Rowland W. Chang⁴ and Dorothy D. Dunlop², ¹Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Regular physical activity has been demonstrated to improve quality of life for adults with chronic disease including osteoarthritis. Despite these benefits, half of adults…
Abstract Number: 2969 • 2014 ACR/ARHP Annual Meeting
Mortality after Knee Replacement Surgery for Osteoarthritis in a Population-Based Propensity-Score Matched Cohort
Devyani Misra¹, Tuhina Neogi², Na Lu³, David T. Felson³, Thomas Einhorn⁴, Hyon K. Choi⁵, Jessica Maxwell⁶ and Yuqing Zhang³, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Orthopedics, Boston University School of Medicine, Boston, MA, ⁵Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Physical Therapy & Athletic Training, Boston University, Boston, MA
Background/Purpose : Knee replacement (KR) surgery for osteoarthritis (OA) provides improvement in symptoms and function. Whether these improvements translate into survival benefit has been unclear,…
Abstract Number: 1088 • 2014 ACR/ARHP Annual Meeting
Socioeconomic Disparities in Health Outcomes Among Individuals with, or at Risk for, Osteoarthritis from the United States: Data from the Osteoarthritis Initiative
Antoine A. Baldassari¹, Todd Schwartz¹, Rebecca J. Cleveland¹, Joanne M. Jordan² and Leigh F. Callahan³, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ³Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC
Background/Purpose Socioeconomic disparities in health outcomes among people with osteoarthritis are well documented, with some key limitations: existing studies limit their analyses to few outcome…
Abstract Number: 32 • 2014 ACR/ARHP Annual Meeting
Regulation of Senescence and Inflammatory Mediators By N- and C-Terminal Parathyroid Hormone-Related Protein in Osteoarthritic Human Osteoblasts
Maria Isabel Guillén¹, Julia Platas¹, Sergio Portal-Nuñez², Pedro Esbrit³ and M.J. Alcaraz⁴, ¹Pharmacology, University of Valencia, Burjasot, Valencia, Spain, ²Metabolismo mineral y óseo, Fundación Jimenez Diaz, Madrid, Spain, ³Fundación Jimenez Diaz, Madrid, Spain, ⁴University of Valencia, Burjasot, Valencia, Spain
Background/Purpose In osteoarthritis (OA), there is an abnormal remodeling process in subchondral bone associated with an altered osteoblast metabolism. Inflammatory mediators participate in bone remodeling…
Abstract Number: 2132 • 2013 ACR/ARHP Annual Meeting
Short-Run Transitions In Pain States: Reflections Of Multiple Outcome Clinical Measures of Inadequate Pain Relief among Patients With Knee Osteoarthiritis
Stephanie Taylor¹, Christopher Black², Paul M. Peloso³, Philip G. Conaghan⁴, Leah Stokes², Mart A.F.J. van de Laar⁵, François Rannou⁶, Nigel K. Arden⁷ and Panagiotis Mavros², ¹Global Health Outcomes, Merck & Co., Inc., Whitehouse Station, NJ, ²Global Health Outcomes, Merck, Whitehouse Station, NJ, ³Clinical Research, Merck Sharp & Dohme Corp., Rahway, NJ, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Rheumatology, University of Twente & Medisch Spectrum Twente, Enschede, Netherlands, ⁶Physical Medicine and Rehabilitation Service, Paris-Descartes University, Cochin Hospital, Paris, France, ⁷NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: Despite the importance of pain management in osteoarthritis (OA), there has been limited evidence confirming the adequacy of measuring pain relief in clinical practice setting. The objective of…
Abstract Number: 982 • 2013 ACR/ARHP Annual Meeting
Preferred Strategies For Delivering Treatment Information To People With Rheumatoid Arthritis, Osteoarthritis and Osteoporosis
Maria A. Lopez-Olivo¹, Robert Volk², Maria Jibaja-Weiss³ and Maria E. Suarez-Almazor⁴, ¹General Internal Medicine, University of Texas. M.D Anderson Cancer Center, Houston, TX, ²General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Office of Outreach and Health Disparities, Baylor College of Medicine, Houston, TX, ⁴The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: To explore the perceptions of people with rheumatoid arthritis (RA), osteoarthritis (OA), and osteoporosis (OP) regarding their preferred delivery methods for obtaining treatment information…
Abstract Number: 2135 • 2013 ACR/ARHP Annual Meeting
Musculoskeletal Pain Explains Differences In Function At Time Of Surgery In Black TKR and THR Patients
Anthony Porter¹, Wenjun Li², Leslie R. Harrold¹, Milagros Rosal³, Philip Noble⁴, David Ayers², Patricia D. Franklin² and Jeroan Allison⁵, ¹University of Massachusetts Medical School, Worcester, MA, ²Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ³Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA, ⁴Baylor College of Medicine, Houston, TX, ⁵Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: The existence of racial disparities in total knee (TKR) and total hip (THR) replacement outcomes is well established but not well understood. The burden…
Abstract Number: 771 • 2013 ACR/ARHP Annual Meeting
The S100A9 Inhibitor Paquinimod (ABR-215757) Reduces Synovial Activation, Osteophyte Formation and Cartilage Damage In Experimental Osteoarthritis
Rik Schelbergen¹, Arjen B. Blom¹, Tomas Leanderson², Helena Eriksson³, Wim B. van den Berg⁴ and Peter L.E.M. van Lent¹, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Immunology Group, Lund University, Lund, Sweden, ³BioScience, Active Biotech AB, Lund, Sweden, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial activation is present in a large subset of osteoarthritis (OA) patients and it is thought to play an important role in the development…
Abstract Number: 2136 • 2013 ACR/ARHP Annual Meeting
Does Functional Gain and Pain Relief After TKR and THR Differ By Patient Obese Status?
Wenjun Li¹, Leslie R. Harrold², Jeroan Allison³, Courtland Lewis⁴, Thomas Bowen⁵, Patricia D. Franklin¹ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, ⁴Hartford Hospital, Hartford, CT, ⁵Geisinger, Danville, PA
Background/Purpose: Obesity is an important predictor of functional status and pain after total knee (TKR) and total hip (THR) replacement. However, variations in pre-post TKR…

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