Abstracts tagged "Osteoarthritis"

Abstract Number: 428 • 2018 ACR/ARHP Annual Meeting
Significant Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; Results from a Randomised Controlled Phase III Trial of Treatment Effectiveness
Sarah R. Kingsbury¹, Puvan Tharmanathan², Ada Keding², Belen Corbacho², Fiona E Watt³, David L Scott⁴, Edward Roddy⁵, Fraser Birrell⁶, Nigel K Arden⁷, Catherine Arundel², Sarah Ronaldson², Lema Vernon⁸, Catherine Hewitt², Michael Doherty⁹, David Torgerson² and Philip G. Conaghan¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, ²York Trials Unit, University of York, York, United Kingdom, ³Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁴Department of Rheumatology, King's College London, London, United Kingdom, ⁵Staffordshire and Stoke on Trent Partnership NHS Foundation Trust, Newcastle Under Lyme, United Kingdom, ⁶Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom, ⁷Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, University of Oxford, Oxford, United Kingdom, ⁸Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹The University of Nottingham, Nottingham, United Kingdom
Background/Purpose: Current treatments for osteoarthritis (OA) are severely limited. Synovitis is prevalent in OA and is associated with pain. The slow-acting anti-rheumatic drug methotrexate (MTX)…
Abstract Number: 1211 • 2018 ACR/ARHP Annual Meeting
Contribution of Ultrasonography Examination in Symptomatic Radiographic Knee OA
Oriane BAZIN¹, Willy Ngueyon Sime², Alexandra Desvignes³, Emmanuel Spitz⁴, Francis Guillemin⁵, Anne-Christine Rat⁵, Isabelle Chary-Valckenaere⁶ and Damien Loeuille⁷, ¹service de Rhumatologie, CHU Nancy, Vandoeuvre les Nancy, France, ²Université de Lorraine, Nancy, France, ³service de Rhumatologie, Groupement hospitalier Eaubonne -Montmorency, EAUBONNE, France, ⁴Rheumatology Strasbourg, Strasbourg, France, ⁵Université de Lorraine, EA4360, APEMAC, Nancy, France, ⁶Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ⁷Rheumatology, University Hospital of Nancy, NANCY, France
Background/Purpose: To evaluate and to compare ultrasonographic (US) features to clinical data and structural damage in symptomatic radiographic (RX) knee osteoarthritis (OA). Methods: Patients with…
Abstract Number: 1983 • 2018 ACR/ARHP Annual Meeting
Mutations Associated with Clonal Hematopoiesis of Indeterminate Potential Are Found in Peripheral Blood and Synovial Fluid Macrophages from Patients with Rheumatoid and Psoriatic Arthritis
Maria De Santis¹, Matteo Zampini², Natasa Isailovic¹, Elena Generali¹, Giacomo Maria Guidelli¹, Matteo Della Porta² and Carlo Selmi^1,3, ¹Rheumatology and Clinical Immunology Unit, Humanitas Research Hospital, Rozzano (MI), Italy, ²Oncology and Hematology Unit, Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, ³BIOMETRA Department, University of Milan, Milan, Italy
Background/Purpose: Myeloidmutations commonly associated to neoplasia in patients who do not meet the diagnostic criteria for myelodysplastic syndrome are coined as clonal hematopoiesis of indeterminate…
Abstract Number: 1929 • 2017 ACR/ARHP Annual Meeting
Sustained Efficacy of Intra-Articular SB-061, a Novel Matrix Regulator Inspired By Aggrecan, in a Rat Model of Osteoarthritis
Kate Stuart¹, Julia Chen¹, Sharmi Saha¹, Harsha Kabra¹, Athene Chan¹, Kamal Egodoge¹, Jennifer Oskins², Chaohua Lin², Morten Karsdal³, Mark Chambers² and John Paderi¹, ¹Symic Bio, Emeryville, CA, ²Lilly Research Laboratories, Indianapolis, IN, ³Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark
Background/Purpose: No therapy for osteoarthritis (OA) has yet to deliver both structural and symptomatic benefits. Symic is approaching this unmet clinical need with a novel…
Abstract Number: 2264 • 2017 ACR/ARHP Annual Meeting
Low Educational Attainment Is Associated with Poor Patient Status in Rheumatoid Arthritis (RA) or Osteoarthritis (OA) at the Initial Rheumatology Visit, with Remarkably Similar Patterns in Either Diagnosis
Juan Schmukler¹, Jacquelin R. Chua¹, Shakeel M. Jamal¹, Isabel Castrejón¹, Joel A Block¹ and Theodore Pincus², ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Low educational attainment is associated with higher prevalence, morbidity, and mortality of many diseases, including rheumatoid arthritis1 (RA) and osteoarthritis2 (OA). These associations often…
Abstract Number: 1947 • 2017 ACR/ARHP Annual Meeting
Thy1 Is a Positive Regulator of Osteoblast Differentiation and Modulates Bone Homeostasis in Obese Mice
Ananta Paine¹, Collynn Woeller², Nelson Huertas¹, Maria de la Luz Garcia-Hernandez³, Richard Phipps² and Christopher T. Ritchlin⁴, ¹Department of Medicine, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ²Department of Environmental Medicine, School of Medicine and Dentistry,, Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ³Department of Medicine,, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ⁴Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Thy1 (CD90) is a glycosylated, glycophosphatidylinositol (GPI)-anchored membrane protein originally identified as a marker for mouse T cells but subsequent reports noted expression on…
Abstract Number: 2428 • 2017 ACR/ARHP Annual Meeting
Epstein-Barr Virus Infection and Epstein-Barr Virus　Nuclear Antigen 1 Variants in the Synovial Tissue of Rheumatoid Arthritis
Shotaro Masuoka¹, Natsuko Kusunoki¹, Shinichi Kawai² and Toshihiro Nanki¹, ¹Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan, ²Department of Inflammation and Pain Control Research, Toho University School of Medicine, Tokyo, Japan
Background/Purpose: Epstein-Barr virus (EBV) infection causes various malignant tumors such as B cell lymphoma and epithelial cell cancer. Previous reports showed several variants in carboxyl-terminal…
Abstract Number: 2179 • 2017 ACR/ARHP Annual Meeting
Comparing Observed with Expected Assessments of Osteoarthritic Pain over Time: Application of Successive Prediction to Data from the Osteoarthritis Initiative
Steven Mongin¹, Naoko Onizuka², Lisa Langsetmo³ and Anna Shmagel⁴, ¹Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³University of Minnesota School of Public Health, Minneapolis, MN, ⁴Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose: High variability in patient-reported outcome scores presents a major challenge in the design and interpretation of clinical studies in osteoarthritis (OA). We present a…
Abstract Number: 2766 • 2017 ACR/ARHP Annual Meeting
Physical Therapy Vs. Internet-Based Exercise Training for Patients with Knee Osteoarthritis: Results of a Randomized Controlled Trial
Kelli Allen¹, Liubov Arbeeva², Leigh F. Callahan³, Yvonne M. Golightly⁴, Adam P. Goode⁵, Bryan Heiderscheit⁶, Carla Hill⁷, Kim Huffman⁸, Herbert Seversen⁹ and Todd A. Schwartz¹⁰, ¹Rheumatology, University of North Carolina at Chapel Hill and Durham VA Medical Center, Durham, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁴Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵O, Duke University, Durham, NC, ⁶Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI, ⁷University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁸School of Medicine, Division of Rheumatology, Immunology and Molecular Physiology and Durham VA Medical Center, Duke University, Durham, NC, ⁹Oregon Research Institute, Durham, OR, ¹⁰Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: The majority of adults with osteoarthritis (OA) are inactive, highlighting the need for continued efforts to promote regular engagement in exercise. Few studies have…
Abstract Number: 217 • 2017 ACR/ARHP Annual Meeting
Keeping a Balance: Social Engagement and Care Giving
Elizabeth M. Badley^1,2, Dov Millstone² and Anthony V. Perruccio^2,3,4, ¹Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ²Health Care & Outcomes Research, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Institute of Health Policy, Management & Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: Arthritis is associated with pain and disability. As a result there has been some interest in examining the receipt of care among those with…
Abstract Number: 2181 • 2017 ACR/ARHP Annual Meeting
Is a Decrease in MRI-Defined Inflammation Associated with a Decrease in Pain in Patients with Hand Osteoarthritis? a Two-Year Follow-up Study
S. van Beest¹, W. Damman¹, R. Liu¹ and M. Kloppenburg², ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Joint pain in hand osteoarthritis (OA) is associated with synovitis in cross-sectional studies. Therefore we hypothesized that synovitis could be a target for treatment.…
Abstract Number: 2849 • 2017 ACR/ARHP Annual Meeting
Pain and Functional Trajectories in Symptomatic Knee Osteoarthritis over a 12-Week Period of Non-Pharmacological Exercise Interventions
Augustine Lee¹, William F. Harvey², Xingyi Han¹, Lori Lyn Price^3,4, Jeffrey B. Driban¹, Raveendhara R. Bannuru¹ and Chenchen Wang², ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA, ³Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA
Background/Purpose: Exercise is the recommended treatment for knee osteoarthritis (OA). However, heterogeneous patterns in treatment response are poorly understood. Our purpose was to identify pain…
Abstract Number: 220 • 2017 ACR/ARHP Annual Meeting
English Language Proficiency and Total Joint Replacement Outcomes: Is There a Relationship?
Bella Y. Mehta¹, Jackie Szymonifka², Shirin A. Dey², Stephen Grassia³, Lisa A. Mandl⁴, Anne R. Bass⁴, Linda A. Russell⁴, Michael L. Parks⁵, Mark P. Figgie⁵, Yuo-Yu Lee⁶, Joseph T. Nguyen⁶ and Susan M. Goodman⁴, ¹Hospital for Special Surgery/Columbia University Mailman School of Public Health, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Medicine, Hospital for Special Surgery, New York, NY, ⁴Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁶Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY
Background/Purpose: Healthcare disparities are recognized for surgical outcomes in patients with Limited English Proficiency (LEP) (1). The purpose of this study is to assess the…
Abstract Number: 2193 • 2017 ACR/ARHP Annual Meeting
Physical Activity and Disease Progression in Persons with or at Higher Risk for Knee Osteoarthritis
Prakash Jayabalan^1,2, Gerald W. Rouleau¹, Masha Kocherginsky¹, Dorothy D. Dunlop¹, Julia (Jungwha) Lee¹, Rowland W. Chang¹ and Leena Sharma¹, ¹Northwestern University, Chicago, IL, ²Shirley Ryan AbilityLab, Chicago, IL
Background/Purpose: The benefits of physical activity in the general population and among persons with knee osteoarthritis (OA) are well-established. However, it remains unclear if inactivity…
Abstract Number: 2851 • 2017 ACR/ARHP Annual Meeting
General and Abdominal Obesity As Risk Factors for Late-Life Mobility Limitation Among Women with Total Knee or Hip Replacement for Osteoarthritis
Aladdin Shadyab¹, Wenjun Li², Charles Eaton³ and Andrea LaCroix⁴, ¹Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁴Family Medicine and Public Health, University of California, San Diego School of Medicine, La Jolla, CA
Background/Purpose: The population is rapidly aging, and by 2060, more than 12 million women will be ages 85 years and older in the United States.…

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