Abstracts tagged "Osteoarthritis"

Abstract Number: 953 • 2015 ACR/ARHP Annual Meeting
Effectiveness of a Progressive Resistence Strength Programme on Hand Osteoarthritis: A Randomized Crontrolled Trial
Michele V. Nery¹, Anamaria Martinez², Fabio Jennings³, Marcelo Souza² and Jamil Natour², ¹Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology Division, Federal University of Sao Paulo, Sao Paulo, Brazil, ³Disciplina de reumatologia, Universidade Federal de São Paulo, Sao Paulo, Brazil
Background/Purpose: Hand osteoarthritis (OA) is highly prevalent, affecting 55-70% of the population over 55 years with an age-related progressive increase. The OA of interphalangeal (IF)…
Abstract Number: 2617 • 2015 ACR/ARHP Annual Meeting
Serum 14-3-3eta Protein Elevation in Osteoarthritis Suggests Misclassification or Concurrent Inflammatory Arthritis
Olga S. Zhukov¹, Jonnielyn G. Rivera¹, Rania W. Abolhosn¹, Robert J. Lagier², Charles M. Rowland³, Joanna M. Popov¹, Kaleb Michaud⁴ and Stanley J. Naides¹, ¹Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, ²Research Support, Alameda, Quest Diagnostics Alameda, Alameda, CA, ³Research Support, Quest Diagnostics Alameda, Alameda, CA, ⁴Rheumatology & Immunology, University of Nebraska Medical Center and National Data Bank, Omaha, NE
Background/Purpose: Tissue distribution of the chaperonin 14-3-3η (eta) is limited to synovial tissue and brain. Synovium releases proinflammatory 14-3-3η into synovial fluid and serum in…
Abstract Number: 1150 • 2015 ACR/ARHP Annual Meeting
Novel Chitosan Hydrogels for the Treatment of Osteoarthritis: Mechanical Support, Lubrication and Prevention of Cartilage Degradation in a Rabbit Model of Osteoarthritis
Yves Henrotin^1,2, Frédéric Oprenyeszk¹, Fanny Comblain³, Jean-Emile Dubuc⁴, Christelle Boileau⁵, Mickaël Chausson⁶, Renaud Lecler⁶, Guillem Rocasalbas⁶, Pierre Douette⁶ and Sandrine Gautier⁶, ¹Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium, ²Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium, ³University of Liège, Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium, ⁴Clinical University Saint Luc, Orthopaedic Department, Clinical University Saint Luc, Brussels, Belgium, ⁵Artialis S.A.,11 Avenue de l’Hôpital, Tour Giga+3, Liege, Belgium, ⁶Synolyne Pharma, rue Haute Claire 4, Herstal, Belgium
Background/Purpose: Chitosan, a glucosamine polysaccharide, is a good candidate for viscosupplementation in OA joints. Herein, we report the physico-chemical properties and the effects of an…
Abstract Number: 3086 • 2015 ACR/ARHP Annual Meeting
The Same Multidimensional Patient Health Assessment Questionnaire Used to Assess RAPID3 in Rheumatoid Arthritis, Osteoarthritis and Other Rheumatic Diseases Can Provide Quantitative Clues to Recognize and Document Comorbid Fibromyalgia
Kathryn A. Gibson¹, Annie Huang² and Theodore Pincus², ¹Liverpool Hospital, Liverpool, Australia, ²Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: An MDHAQ/RAPID3 (Multidimensional Health Assessment Questionnaire/Routine Assessment of Patient Index Data) is a 2 sided, 1 page questionnaire which is completed by patients in…
Abstract Number: 126 • 2015 ACR/ARHP Annual Meeting
Patients with Osteoarthritis and Rheumatoid Arthritis Seen at 4 Different Routine Rheumatology Care Sites at This Time Have Similar and Patient and Physician Global Estimates of Severity, and Scores for Functional Disability, Pain, and RAPID3
Carlos El-Haddad¹, Isabel Castrejón², Kathryn A. Gibson³, Yusuf Yazici⁴, Martin Bergman⁵ and Theodore Pincus², ¹Rheumatology, Liverpool Hospital, NSW, Australia, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³Liverpool Hospital, Liverpool, Australia, ⁴NYU Hospital for Joint Diseases, New York, NY, ⁵Division of Rheumatology, Taylor Hospital, Ridley Park, PA
Background/Purpose: RA generally is regarded by physicians and the public as a more severe problem than OA. However, OA has been ranked as the 11th…
Abstract Number: 1258 • 2015 ACR/ARHP Annual Meeting
Identification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed By Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract
Fanny Comblain¹, Cécile Lambert¹, Isabelle Lesponne², Christelle Sanchez¹, Jean-Emile Dubuc³ and Yves Henrotin^4,5, ¹University of Liège, Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium, ²Royal Canin Research Center, Aimargues, France, ³Clinical University Saint Luc, Orthopaedic Department, Clinical University Saint Luc, Brussels, Belgium, ⁴Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Marche-en-Famenne, Belgium, ⁵Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, Liege, Belgium
Background/Purpose: The goal of treatment in OA is to reduce pain and improve function. There is no cure for the disease, but some attempts to…
Abstract Number: 3250 • 2015 ACR/ARHP Annual Meeting
Systemic Inflammation and Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Laura Frey-Law², Devyani Misra¹, Michael C. Nevitt³, Lars Arendt-Nielsen⁴, Emily K. Quinn⁵ and Cora E. Lewis⁶, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²UIowa, Iowa City, IA, ³Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁴Aalborg University, Aalborg, Denmark, ⁵Data Coordinating Center, Boston University School of Public Health, Boston, MA, ⁶Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but its cause in humans is not well-understood. We recently demonstrated that local…
Abstract Number: 138 • 2015 ACR/ARHP Annual Meeting
Identification and Documentation of Secondary Osteoarthritis in Patients with Primary Inflammatory Arthritides Using a Patient MDHAQ/RAPID3 and a Physician Estimate of Joint Damage to Recognize Patient Complexity and Inform Management Decisions
Kathryn A. Gibson¹, Annie Huang², Katherine J. Bryant³ and Theodore Pincus², ¹Liverpool Hospital, Liverpool, Australia, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³University of New South Wales, Sydney, Australia
Background/Purpose: Patients with inflammatory arthritides may have secondary osteoarthritis (OA), which affects decisions concerning clinical management. For example, in one study, about 20% of patients…
Abstract Number: 1589 • 2015 ACR/ARHP Annual Meeting
Impact of Osteoarthritis of the Hand on Disease Activity Scores and Health Status in Patients with Rheumatoid Arthritis
Hector Fabricio Espinosa Ortega¹, Cesar Alejandro Arce Salinas² and Emmanuel Ruiz Medrano³, ¹Rheumatology, Hospital Central Sur Alta Especialidad Pemex, Mexico City, Mexico, ²Rheumatology, Hospital Central Sur de Alta Especialidad Pemex, Mexico, Mexico, ³Hospital Central Sur de Alta Especialidad Pemex, Mexico, Mexico
Background/Purpose: Rheumatoid arthritis (RA) is a polyarticular autoimmune inflammatory disease characterized for pain, joint edema and functional limitation. Some items in evaluation could be affected…
Abstract Number: 3252 • 2015 ACR/ARHP Annual Meeting
Impact of Knee Pain Frequency on Physical Function in the Osteoarthritis Initiative
Jin Zhou¹, Erin Ashbeck², Lynn Hamilton² and C. Kent Kwoh³, ¹Epidemiology & Biostatistics, University of Arizona, Tucson, AZ, ²Arthritis Center, University of Arizona, Tucson, AZ, ³Rheumatology, University of Arizona, Tucson, AZ
Background/Purpose: Knee pain is a prominent symptom among patients with knee osteoarthritis (OA), but the impact of knee pain frequency on physical function has been…
Abstract Number: 182 • 2015 ACR/ARHP Annual Meeting
Agreement Between Ultrasound and Radiography for the Detection of Rhizarthrosis
Maria de los Angeles Gallardo¹, Facundo Vergara¹, Emmanuel Bertiller², Javier Rosa³, Santiago Ruta¹, Ricardo Garcia-Monaco⁴ and Enrique R. Soriano⁵, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ³Rheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Radiology and Imagenology Department, Hospital italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Trapeziometacarpal (TMC) joint is a common site of osteoarthritis (OA)(rhizarthrosis). Its diagnosis is based on clinical and radiological (X-ray) features. It is not clear…
Abstract Number: 2008 • 2015 ACR/ARHP Annual Meeting
WISP1 Aggravates Osteoarthritis By Modulation of TGF-β Signaling and Positive Regulation of Canonical Wnt Signaling
Martijn H. van den Bosch¹, Arjen Blom¹, Azusa Maeda², Tina Kilts², Wim van den Berg¹, Floris Lafeber³, Peter van Lent¹, Marian Young² and Peter van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²NIDCR/NIH, Bethesda, MD, ³Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is suggested to be involved in joint destruction. Previously, we found synovial overexpression of Wnt ligands in experimental…
Abstract Number: 215 • 2015 ACR/ARHP Annual Meeting
Calcium Hydroxyapatite Crystals Inhibit Interleukin-6- and Interferon-γ –Induced Anti-Osteoclastogenic Signaling in Human Osteoclast Precursors
Geraldine M. McCarthy¹, Clare C. Cunningham², Emma M. Corr³ and Aisling Dunne³, ¹University College Dublin, Dublin, Ireland, ²School of Biochemistry and Immunology, Trinity College Dublin, Dubln, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular calcium hydroxyapatite (HA) crystals are present in the majority of osteoarthritic (OA) joints. They activate macrophages, synovial fibroblasts and articular chondrocytes, resulting in…
Abstract Number: 2092 • 2015 ACR/ARHP Annual Meeting
Knee Pain Burden Is Associated with Decreased Moderate to Vigorous Physical Activity: Data from the Osteoarthritis Initiative
Javad Razjouyan¹, Bijan Najafi², Erin Ashbeck³, Dorothy D. Dunlop⁴, Julia (Jungwha) Lee⁵, Lynn Hamilton³ and C. Kent Kwoh⁶, ¹Consortium on Advanced Motion Performance (iCAMP), Department of Surgery, University of Arizona, Tucson, AZ, ²Department of Surgery and Department of Biomedical Engineering, University of Arizona, Tucson, AZ, ³Arthritis Center, University of Arizona, Tucson, AZ, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, University of Arizona, Tucson, AZ
Knee Pain Burden is Associated with Decreased Motor Performance: Data from the Osteoarthritis InitiativeBackground/Purpose: The influence of knee pain perception on daily life motor performance…
Abstract Number: 314 • 2015 ACR/ARHP Annual Meeting
A Double-Blind, Randomized, Controlled, Four Parallel Arm, Dose-Finding Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Single Intra-Articular (IA) Injections of Fasitibant in Patients with Symptomatic OA of the Knee
Claudia Gabriele Werner¹, Karel Pavelka², Andrea Nizzardo³, Cristina Rossi³, Simona Scartoni³, Maria Paola Contini³, Serena di Molfetta³, Monica Bertolotti³, Angela Capriati³ and Carlo Alberto Maggi⁴, ¹Clinical Research, A. Menarini Research & Business Service GmbH, Berlin, Germany, ²Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ³Clinical Research Department, Menarini Ricerche S.p.A., Florence, Italy, ⁴Menarini Ricerche S.p.A., Florence, Italy
Background/Purpose: Fasitibant (FAS) is a competitive, potent and selective antagonist of the bradykinin B2 receptor administered IA for SOAK. In response to positive outcomes in…

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