Abstracts tagged "Osteoarthritis"

Abstract Number: 1979 • 2019 ACR/ARP Annual Meeting
What Is the Pathogenic Meaning of Chondrocyte Hypertrophy in Osteoarthritis? Effect of Evc Deletion Through Hedgehog Signaling
Ana Lamuedra¹, Paula Gratal ¹, Víctor Luis Ruiz-Perez ², Adrián Palencia-Campos ³, Sergio Portal-Nuñez ⁴, Gabriel Herrero-Beaumont ⁵ and Raquel Largo ⁵, ¹IIS - Fundacion Jimenez Diaz, Madrid, Madrid, Spain, ²Instituto de Investigaciones Biomédicas 'Alberto Sols', Madrid, Madrid, Spain, ³Adrián Palencia Campos [[email protected]], Madrid, Madrid, Spain, ⁴Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, Alcorcón, Madrid, Spain, ⁵IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is mainly characterized by the progressive damage of articular cartilage, where chondrocytes acquire a hypertrophic-like phenotype. Indian Hedgehog levels are increased in…
Abstract Number: 2178 • 2019 ACR/ARP Annual Meeting
Associations Between Baseline and Longitudinal Quantitative Joint Space Width and Incident Hip Osteoarthritis: The Johnston County Osteoarthritis Project
Jacquelyn Smith¹, Carolina Alvarez ¹, Liubov Arbeeva ¹, Jordan Renner ², Louise Murphy ³, Joanne Jordan ¹, Yvonne Golightly ⁴, Jeffrey Duryea ⁵ and Amanda Nelson ¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Department of Radiology, Chapel Hill, NC, ³Centers for Disease Control and Prevention, Division of Population Health, Atlanta, ⁴University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁵Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: To quantify associations between baseline and change in computer-assisted hip quantitative joint space width (qJSW) with incident radiographic (rHOA) or symptomatic (sxHOA) hip OA.Methods:…
Abstract Number: 2203 • 2019 ACR/ARP Annual Meeting
Impact of Hypothetical Changes in the Use of Analgesics on the Burden of Osteoarthritis: A Population-based Microsimulation Study
Jacek Kopec¹, Eric Sayre ², Anya Okhmatovskaia ³, Jolanda Cibere ⁴, Linda Li ⁵, Nick Bansback ⁶, Hubert Wong ⁵ and John Esdaile ⁷, ¹Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Vancouver, BC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Vancouver, Canada, ⁵University of British Columbia, Vancouver, BC, Canada, ⁶University of British Columbia, Vancouver, Canada, ⁷Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada
Background/Purpose: Analgesics are the cornerstone of medical treatment of osteoarthritis (OA) but are associated with serious side effects. A more optimal use of analgesics in…
Abstract Number: 226 • 2018 ACR/ARHP Annual Meeting
Representation of Elderly People and Women in Rheumatoid Arthritis and Osteoarthritis Trials: A Systematic Review and Meta-Analysis Comparing Clinical Trials with Population-Based Studies
Andriko Palmowski¹, Thomas Buttgereit^1,2, Yannick Palmowski³, Sabrina Mai Nielsen^4,5, Maarten Boers⁶, Robin Christensen^4,5 and Frank Buttgereit¹, ¹Department of Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ²Department of Dermatology, Venerology and Allergology, Charité – University Medicine Berlin, Berlin, Germany, ³Center for Musculoskeletal Surgery, Charité – University Medicine Berlin, Berlin, Germany, ⁴Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, ⁵Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁶Department of Epidemiology and Biostatistics, and Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Elderly people (as commonly defined by an age of ≥65 years) and women have been reported to be underrepresented in clinical trials of various…
Abstract Number: 1040 • 2018 ACR/ARHP Annual Meeting
The Potential Role of Choline Kinase Alpha in Osteoarthritis
Roxana Coras^1,2, Liang-Yu Chen³, Elsa Sanchez-Lopez⁴, Martin Lotz⁵, Ru Liu-Bryan^1,3 and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³VA San Diego Healthcare System, San Diego, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and a leading cause of disability. Cartilage degeneration is the central characteristic of OA, and low-grade…
Abstract Number: 1375 • 2018 ACR/ARHP Annual Meeting
Comparative Safety of Flavocoxid (Limbrel) Versus Nsaids Among Osteoarthritis Patients
Justin K Owensby¹, Fenglong Xie¹, Lang Chen¹ and Jeffrey R. Curtis², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama, Birmingham, AL
Background/Purpose: Flavocoxid is a medical food formulated to assist in the management of patients with osteoarthritis (OA). Safety concerns based on case reports have been…
Abstract Number: 284 • 2018 ACR/ARHP Annual Meeting
Challenges and Barriers to Employment That Persons with Osteoarthritis Face at Work Due to Their Condition
Anne-Christine Rat^1,2, Alison Stewart³, Pam Rogers⁴, Dianne P. Mosher⁵ and Diane Lacaille⁶, ¹Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France, ²Université de Lorraine, EA4360, APEMAC, Nancy, France, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ⁵Med, University of Calgary, Calgary, AB, Canada, ⁶Arthritis Research Canada/University of British Columbia, Medicine/Rheumatology, Richmond, BC, Canada
Background/Purpose: To understand the challenges that people with osteoarthritis (OA) experience at work due to their condition, for the purpose of adapting to OA the…
Abstract Number: 1041 • 2018 ACR/ARHP Annual Meeting
The Anti-Adamts-5 Nanobody®, M6495, Protects Against Cartilage Breakdown in Cartilage and Synovial Joint Tissue Explant Models
Anne Sofie Siebuhr¹, Anne C. Bay-Jensen², Christian S. Thudium², Morten A. Karsdal², Benedikte Serruys³, Daniela Werkmann⁴, Martin Michaelis⁴, Christoph Ladel⁴ and Sven Lindemann⁴, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Ablynx NV, Zwijnaarde, Belgium, ⁴Merck KGaA, Darmstadt, Germany
Background/Purpose: Osteoarthritis (OA) is associated with cartilage breakdown, where degradation of aggrecan by ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) is thought to…
Abstract Number: 1380 • 2018 ACR/ARHP Annual Meeting
Complications Following Total Hip Arthroplasty in Inflammatory Versus Osteoarthritis
Shawn Richardson¹, William Schairer², Cynthia Kahlenberg¹, Thomas P. Sculco³, Peter K. Sculco³, Linda A. Russell⁴, Susan M. Goodman¹ and Mark P. Figgie⁵, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, new york, NY, ³Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: THA is commonly performed in patients with a history of inflammatory arthritis. These patients are likely at higher risk of complications, from both the…
Abstract Number: 400 • 2018 ACR/ARHP Annual Meeting
Predictors of Response to a Single Intra-Articular Injection of Mannitol-Modified Cross-Linked Hyaluronic Acid (HANOX-M-XL) in Patients with First Metatarsophalangeal Joint Osteoarthritis (hallux rigidus)
Thierry Conrozier¹, Aline Charpentier², Marie Bossert³, Sylvie Mellac-Ducamp⁴ and Laurent Galois⁵, ¹Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France, ²Rheumatology, Nord Franche-Comté Hospital, Belfort, France, ³Rheumatology, Nord Franche Comté Hospital, Belfort, France, ⁴Rheumatology, Nevers General Hospital, Nevers, France, ⁵Orthopaedic and trauma surgery, University Hospital of Nancy, Nancy, France
Background/Purpose: To investigate the potential predictors of response to a single intra-articular injection of mannitol-modified cross-linked hyaluronic acid (HANOX-M-XL) in patients with first metatarsophalangeal joint…
Abstract Number: 1052 • 2018 ACR/ARHP Annual Meeting
Detection of Precursors of RANK- Osteoclast-like Cells (Olcs) in Peripheral Blood and Olcs in Bone Tissue from Rheumatoid Arthritis Patients
Kazuhiro Yokota¹, Shinya Tanaka², Miyoko Sekikawa², Yoshimi Aizaki¹, Kojiro Sato¹, Hiromi Oda² and Toshihide Mimura¹, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan
Background/Purpose: Proinflammatory cytokines play an important role in bone destruction in rheumatoid arthritis (RA), as inferred by the efficacy of biologics. Previously, we reported that…
Abstract Number: 1395 • 2018 ACR/ARHP Annual Meeting
Could the Shortening of the Electronic Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) Questionnaire Improve Its Metric Properties?
Maud Wieczorek¹, Christine Rotonda¹, Jonathan Epstein^1,2, Francis Guillemin^1,2 and Anne-Christine Rat^1,3, ¹Université de Lorraine, EA4360, APEMAC, Nancy, France, ²Inserm, CIC-1433 Epidémiologie Clinique, Vandoeuvre-lès-Nancy, France, ³Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France
Background/Purpose: The aim of this study was to assess the validity of a short version of the electronic OAKHQOL questionnaire in a combined analysis with…
Abstract Number: 405 • 2018 ACR/ARHP Annual Meeting
Feasibility of Enabling Self-Management and Coping with Arthritic Pain Using Exercise (ESCAPE-Pain) Programme for Knee Osteoarthritis in Malaysia
Muhammad Kamil Che Hasan^1,2, Emma Stanmore² and Chris Todd², ¹Kulliyyah (Faculty) of Nursing, International Islamic University Malaysia (IIUM), Kuantan Pahang, Malaysia, ²Division of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, United Kingdom
Background/Purpose: In Malaysia around one in ten older people are diagnosed with osteoarthritis (OA), with the knee being one of the most commonly affected areas.…
Abstract Number: 1137 • 2018 ACR/ARHP Annual Meeting
Prediction Models for Poor Function Outcomes over 10 Years in Persons at High Risk for Knee Osteoarthritis
Leena Sharma¹, Orit Almagor¹, Alison H. Chang¹, C. Kent Kwoh², Michael C. Nevitt³, Marc C. Hochberg⁴, Rebecca D. Jackson⁵, Charles B. Eaton⁶, Jane A. Cauley⁷, Julie Szymaszek⁸ and Joan S. Chmiel¹, ¹Northwestern University, Chicago, IL, ²University of Arizona, Tucson, AZ, ³UCSF, San Francisco, CA, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Ohio State University, Columbus, OH, ⁶Family Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI, ⁷University of Pittsburgh, PIttsburgh, PA, ⁸Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Among persons at high risk for knee osteoarthritis (OA), identifying those who will have function decline is important; instituting prevention strategies in all…
Abstract Number: 1443 • 2018 ACR/ARHP Annual Meeting
Ultrasonographic Criteria for the Diagnosis of Erosive Rheumatoid Arthritis Disease Using Osteoarthritic Patients As Controls Compared to Validated Radiographic Criteria
Camille Roux¹, Frédérique Gandjbakhch², Audrey Pierreisnard³, Marion Couderc⁴, Cédric Lukas⁵, Racha Masri¹, Jean-Philippe Sommier¹, Isabelle Clerc-Urmès⁶, Cedric Baumann⁷, Isabelle Chary-Valckenaere⁸ and Damien Loeuille⁹, ¹Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³APHP, Paris, France, ⁴Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, Lapeyronie Hospital and EA2415 Montpellier University, Montpellier, France, ⁶CHRU Nancy, Nancy, France, ⁷CHRU Nancy, Vandoeuvre les Nancy, France, ⁸Rheumatology, CHRU Nancy, Vandoeuvres les Nancy, France, ⁹Rheumatology, University Hospital of Nancy, NANCY, France
Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory joint disease (1,2) responsible for structural damage. Radiography (RX) is considered as the gold standard…

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