Abstracts tagged "Osteoarthritis"

Abstract Number: 57 • 2016 ACR/ARHP Annual Meeting
Genetic Polymorphism of IL-1RN Encoding the IL-1 Receptor Antagonist Predicts Radiographic Severity of Symptomatic Knee OA
Mukundan Attur¹, Sisi Ma², Jonathan Samuels³, Svetlana Krasnokutsky Samuels⁴, Hua Zhou², Jenny Bencardino⁵, Marc C. Hochberg⁶, Braxton Mitchell⁷, Virginia B. Kraus⁸, Joanne M. Jordan⁹ and Steven B. Abramson¹⁰, ¹Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Rheumatology, NYU - Hospital for Joint Diseases, New York, NY, ⁴Medicine/Rheumatology, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY, ⁵Radiology, NYU Langone Medical Center, New York, NY, ⁶University of Maryland School of Medicine, Baltimore, MD, USA, Baltimore, MD, ⁷Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, ⁸Department of Medicine, Duke University Medical Center, Durham, NC, ⁹Thurston Arthritis Research Center, University of North CArolina at Chapel Hill, Chapel Hill, NC, ¹⁰Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY
Background/Purpose: Growing numbers of studies show increased expression in Osteoarthritis (OA) of inflammatory cytokines, such as IL-1β and TNFα, in joint tissues and peripheral blood…
Abstract Number: 1093 • 2016 ACR/ARHP Annual Meeting
DNA Methylation Defines Joint Specific Differences in Synovial Fibroblasts from OA and RA Patients
Emmanuel Karouzakis¹, Mojca Frank Bertoncelj², Kerstin Klein¹, Christoph Kolling³, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland
Background/Purpose: Recent studies revealed epigenetic changes in DNA methylation associated with rheumatoid arthritis (RA) synovial fibroblasts (SF). In addition, we have shown that SF exhibit…
Abstract Number: 2372 • 2016 ACR/ARHP Annual Meeting
Effect of Oxytocin on Osteoarthritis
christian roux¹, astrid pinzano², didier Pisani³, Patricia panaia-Ferrari⁴, eric Fontas⁵, hedi Ben Yahia⁶, damien ambrosetti⁷, jean-François michiels⁸, veronique Breuil⁹ and ez Zoubir Amri¹⁰, ¹Rheumatology, LAMHESS laboratory, sofia antipolis university, CHU Pasteur 2, Nice, France, nice, France, ²IMoPA Ingénierie Moléculaire et Physiopathologie Articulaire, University nancy lorraine, UMR7365 CNRS-UL, Nancy, France, ³CNRS UMR7277, Inserm U1091, UNS Université Nice Sophia Antipolis Parc Valrose, nice, France, ⁴IBiology and immunology laboratory, university nice sofia antipolis, nice, France, ⁵Direction recherche clinique, CHU de Nice, france, Nice, France, ⁶iBV - Institut de Biologie Valrose. Nice, Nice, France, ⁷Department anatomopathology, nice. university nice sofia antipolis, nice, France, ⁸department anatomo-pathology, Nice, university nice sofia antipolis, Nice, France, ⁹Rheumatology department, Nice, France, ¹⁰CNRS UMR7277, Inserm U1091, UNS Université Nice Sophia Antipolis Parc Valrose, Nice, France
Background/Purpose: The relationship between oxytocine (OT) and osteoarthritis (OA) is poorly studied and remains unknown. However the subchondral bone is considered as a major player in…
Abstract Number: 1099 • 2016 ACR/ARHP Annual Meeting
Synovial Exosomes Induce Osteoclast Differentiation in Rheumatoid arthritis
Ji Eun Song¹, Ji Hye Shin¹, Ki Won Moon², Se Hui Shon¹, Ji Soo Park³, Eun Bong Lee³, Yeong Wook Song^1,3 and Eun Young Lee³, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea, Seoul, Korea, The Republic of, ²Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea, Chuncheon, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Seoul, Korea, The Republic of
Background/Purpose: Exosomes are small membrane vesicles (40-150 nm) of endocytic origin secreted by many types of cells and engage in cell-to-cell communication by transferring proteins,…
Abstract Number: 3048 • 2016 ACR/ARHP Annual Meeting
Pain Severity As a Mediator of the Effect of Depressive Symptoms on Physical Performance in Knee Osteoarthritis
Alan Rathbun¹, Michelle Shardell², Michelle S. Yau³, Mona Baumgarten⁴, Elizabeth Stuart⁵ and Marc Hochberg⁶, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Depression is a significant comorbidity of knee osteoarthritis (OA) that occurs in approximately 20% of OA patients. Depressive symptoms are associated with both subsequent…
Abstract Number: 1154 • 2016 ACR/ARHP Annual Meeting
Promoting Self-Management Techniques for Osteoarthritis Pain: a Pilot Study of Nurse Practitioner Led Coping Skills Training
Christine A. Stamatos^1,2 and Particia Bruckenthal³, ¹Medicine, Division Rheumatology, Northwell Health, Great Neck, NY, ²Northwell Health, Great Neck, NY, ³School of Nursing, Stony Brook University, Stony Brook, NY
Background/Purpose: Arthritis is the leading cause of chronic pain and disability in the United States. Two thirds of patients report inadequate pain control. Coping Skills Training…
Abstract Number: 3253 • 2016 ACR/ARHP Annual Meeting
Minimum Physical Function Needed to Walk 6000 Steps/Day in People with Knee Osteoarthritis
Hiral Master¹, Louise Thoma¹, Meredith Christiansen¹, Emily Polakowski¹, Laura Schmitt¹ and Daniel White², ¹Physical Therapy and Biomechanics and Movement Science, University of Delaware, Newark, DE, ²Department of Physical Therapy, University of Delaware, Newark, DE
Title: Minimum Physical Function Needed To Walk 6000 steps/day In People With Knee Osteoarthritis. Background/Purpose: Adopting a physically active lifestyle provides major health benefits to…
Abstract Number: 1203 • 2016 ACR/ARHP Annual Meeting
Differential Synovial Expression Patterns in Early Osteoarthritis Predict Pain and Progression of Joint Damage
Arjen B. Blom¹, Martijn H. van den Bosch¹, Hans Cats², F van den Hoogen³, Floris PJ Lafeber⁴, Wim B. van den Berg¹, Peter L. van Lent¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ³Rheumatology, Radboud UMC, Nijmegen, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The cause for chronic pain in OA is largely unknown. Over 50% of osteoarthritis (OA) patients show synovial inflammation, even at early stages of…
Abstract Number: 1254 • 2016 ACR/ARHP Annual Meeting
Knee Pain and Patient Preference for Knee Replacement: Healthcare Access Matters
Manjinder Kaur¹, Erin Ashbeck², Di Ran², C. Kent Kwoh³ and Ernest Vina⁴, ¹Internal Medicine, University of Arizona, Tucson, AZ, ²University of Arizona, Tucson, AZ, ³Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁴Rheumatology, University of Arizona, Tucson, AZ
Background/Purpose: Total knee replacement (TKR) is a cost-effective intervention for end-stage knee osteoarthritis (OA). Objectives were to estimate the effect of knee pain severity on…
Abstract Number: 1431 • 2016 ACR/ARHP Annual Meeting
Estimates of Global Status By Physicians and Patients Are More Likely to be Discordant in Osteoarthritis Than in Rheumatoid Arthritis
Isabel Castrejón¹, Joel Block² and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Concordant 0-10 estimates of global status by physicians (DOCGL) and patients (PATGL) are associated with greater expectations for improvement and better outcomes1, and appear…
Abstract Number: 1522 • 2016 ACR/ARHP Annual Meeting
Disease Burden in Rheumatoid Arthritis (RA) Patients Who Have Secondary Osteoarthritis (OA) Is Lower Than in OA but Higher Than in RA with No Secondary OA
Isabel Castrejón¹, Anne-Marie Malfait², Joel Block³ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL, ³Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Recent data indicate that the disease burden experienced by patients with osteoarthritis (OA) is similar to or greater than in rheumatoid arthritis (RA) (EULAR…
Abstract Number: 2031 • 2016 ACR/ARHP Annual Meeting
Dietary Patterns and Radiographic Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Bing Lu¹, Jeffrey Driban², Chang Xu³, Timothy E. McAlindon⁴ and Charles B. Eaton⁵, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Tufts Medical Center, Boston, MA, ³Statistics, Rutgers University, New Brunswick, NJ, ⁴Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁵Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI
Background/Purpose: Although some individual foods and nutrients have been associated with knee osteoarthritis (OA) progression, the association between overall diet and OA progression is unknown.…
Abstract Number: 2133 • 2016 ACR/ARHP Annual Meeting
Simulation of Cartilage Damage in Osteoarthritis Using Patient-Derived Induced Pluripotent Stem Cells
Seung Min Jung¹, Yoojun Nam², Yeri Alice Rim², Yong-Beom Park¹, Seung-Ki Kwok³, Sung-Hwan Park⁴ and Ji Hyeon Ju⁵, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ³[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Osteoarthritis (OA) is a degenerative joint disease, leading to pain and functional limitation. Although OA is a most common form of musculoskeletal disease, the…
Abstract Number: 2179 • 2016 ACR/ARHP Annual Meeting
What Are the Risk Factors for Knee Pain, Radiographic Knee Osteoarthritis and Total Knee Replacement in Professional Footballers?
Sanjay M Parekh^1,2, Gwen S Fernandes^1,2,3, Jonathan P Moses^1,2, Colin Fuller⁴, Brigitte Scammell^1,2,3, Mark Batt^1,2,3, Weiya Zhang^1,2,3 and Michael Doherty^1,2,3, ¹Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, Nottingham, United Kingdom, ³Arthritis Research UK Pain Centre, Nottingham, United Kingdom, ⁴Colin Fuller Consultancy Ltd, Nottingham, United Kingdom
Background/Purpose: Football is the world’s most popular team sport. However, whether professional footballers have a higher prevalence of knee injury and subsequently, knee pain (KP),…
Abstract Number: 116 • 2016 ACR/ARHP Annual Meeting
Racial Differences in Self-Reported Pain and Disability: A Longitudinal Study of Knee Osteoarthritis
Ernest Vina¹, Di Ran², Erin Ashbeck² and C. Kent Kwoh³, ¹Rheumatology, University of Arizona, Tucson, AZ, ²University of Arizona, Tucson, AZ, ³Rheumatology, University of Arizona, College of Medicine, Tucson, AZ
Background/Purpose: Pain and disability from knee osteoarthritis (KOA) has been reported to be greater among African-Americans (AAs) than Whites (WHs), though progression in KOA-related…

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