Abstracts tagged "Osteoarthritis"

Abstract Number: 1736 • ACR Convergence 2025
Multi-Model Evaluation of the Impact of CD14 on Synovial Inflammation and Pain During PTOA.
Kevin Burt¹, Sanique South², Natalie Adamczyk³, Shingo Ishihara³, Vu Nguyen⁴, Robert Mauck⁴, Anne-Marie Malfait⁵, Timothy Griffin⁶, Rachel Miller⁷ and Carla Scanzello¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Oregon, Eugene, ³Rush University, Chicago, ⁴University of Pennsylvania, Philadelphia, ⁵Rush University, Oak Park, IL, ⁶Oklahoma Medical Research Foundation, Oklahoma City, ⁷Rush University Medical Center, Chicago, IL
Background/Purpose: Soluble CD14, a co-receptor of inflammatory toll-like receptor signaling that is produced primarily by monocytes/macrophages, is present in synovial fluid in patients with OA…
Abstract Number: 0770 • ACR Convergence 2025
Interrelationships of Depression, Pain, and Gait Mechanics and their Associations with Physical Activity Levels Among People with Knee Osteoarthritis
Oiza Peters, Steven Garcia, Joy Itodo, Ogundoyin Ogundiran and kharma Foucher, UNIVERSITY OF ILLINOIS, CHICAGO, Chicago, IL
Background/Purpose: Depression is associated with low physical activity (PA) levels in people with knee osteoarthritis (KOA)1. Pain contributes to both depression and PA levels in…
Abstract Number: 0325 • ACR Convergence 2025
Knee Symptom Phenotyping Incorporating Pain and Function across Different Levels of WOMAC Function in Two Cohorts: Data from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI)
C. Kent Kwoh¹, Amanda Nelson², Rongrong Tang³, Edward J. Bedrick³, Yong Ge¹, Yvonne Golightly⁴, Zong-Ming Li³, Jean Liew⁵, Xiaoxiao Sun¹, Jeffrey Duryea⁶ and Tuhina Neogi⁵, ¹The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Boston University School of Medicine, Boston, MA, ⁶Brigham and Women’s Hospital, Boston, MA
Background/Purpose: Knee pain and functional limitations are the most common symptoms of knee OA. Understanding the various patterns of symptoms (i.e., pain and function changes…
Abstract Number: 0308 • ACR Convergence 2025
Artificial Intelligence Assisted Extraction of Patient-Reported Pain Outcomes in Osteoarthritis Using Prompt Engineering of Large Language Models
Jainesh Doshi¹, Stephen Batter¹, Yiyuan Wu², Alice Santilli¹, Sandhya Kannayiram³, Susan Goodman⁴ and Bella Mehta⁵, ¹Hospital for Special Surgery, New York, ²Weill Cornell Medicine, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁵Hospital for Special Surgery, Weill Cornell Medicine, Jersey City, NJ
Background/Purpose: Unstructured data in physician notes can be incredibly valuable, especially for understanding patient-reported outcomes (PROs), which are often mentioned in these notes.In this study,…
Abstract Number: 2612 • ACR Convergence 2025
Automated, Artificial Intelligence-supported Sonographic Examination of the Hands for the Detection and Quantification of Arthritis and Osteoarthritis in the Hand and Finger Joints in Outpatient Rheumatology Care
Oliver Sander¹, Lea Ormeloh¹, Laura Grünkewitz¹, Martin Gallmann¹, Benedict Blümel¹, Rishi Adhikari¹, Hasan Acar¹, Gamal Chehab¹, Jörg Distler² and Jutta Richter³, ¹Department of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University. Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University., Düsseldorf, Germany, ²University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ³Clinic for Rheumatology and Hiller Research Unit, Heinrich-Heine-University Duesseldorf, Medical Faculty, Duesseldorf, Germany, Düsseldorf, Germany
Background/Purpose: The integration of artificial intelligence (AI) in combination with robotics into clinical diagnostics has the potential to increase precision and efficiency and relieve increasingly…
Abstract Number: 2093 • ACR Convergence 2025
Association of Acetaminophen Use with Clinical Outcomes in Older Adults with Osteoarthritis: A Global Propensity-Matched Retrospective Cohort Analysis
Justin Riley Lam¹, Laith Alomari², Emmanuel Otabor², Michael Hamilton², Bal Subedi³, Maxim Barnett², Fabian Rodriguez Quinonez⁴ and Irene Tan⁵, ¹Albert Einstein Medical Center, Philadelphia, PA, ²Jefferson Einstein Hospital Philadelphia, Philadelphia, PA, ³Jefferson Einstein Montogmery Hospital, Philadelphia, ⁴Einstein Medical Center Philadelphia, Philadelphia, PA, ⁵Einstein Healthcare Network Philadelphia - Jefferson Health, Bala Cynwyd, PA
Background/Purpose: Acetaminophen is widely recommended for osteoarthritis (OA) pain management due to its perceived safety profile. However, its long-term effects on clinical outcomes among older…
Abstract Number: 1960 • ACR Convergence 2025
Item Response Theory to Develop an Ultrasound Composite Score for Knee Osteoarthritis Assessment
Liubov Arbeeva¹, Carolina Alvarez², Jonathan Samuels³, Janice Lin⁴, Minna Kohler⁵, Catherine Bakewell⁶, Todd Schwartz⁷ and Amanda Nelson⁸, ¹University of North Carolina, Chapel Hill, Carrboro, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³NYU Langone, Rye Brook, NY, ⁴Stanford University, Palo Alto, CA, ⁵Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁶Intermountain Healthcare, Salt Lake City, UT, ⁷University of North Carolina-Chapel Hill, Chapel Hill, NC, ⁸University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Semi-quantitative scoring systems have long been used for radiographic findings in osteoarthritis (OA), but limited work has utilized ultrasound (US). The aim of this…
Abstract Number: 1794 • ACR Convergence 2025
OA-associated pain sensitivity is reduced in OA-protected MRL/MpJ mice, partially mediated by the gut microbiome, and transferable via microbiome transplantation
Gabriella Dyson¹, Montana Barrett¹, Nicholas Hanebutt¹, Aleksander Szymczak², Cindy Miranda Brawner¹, Pratibha Dube³, Ausitn Lopez¹, Padmaja Mehta-d'Souza¹ and Matlock Jeffries², ¹Oklahoma Medical Research Foundation, Oklahoma City, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Edmond, OK
Background/Purpose: MRL/MpJ (MRL) mice are protected from developing post-traumatic osteoarthritis (OA) histologic changes. We have previously shown the gut microbiome to play a key role…
Abstract Number: 1734 • ACR Convergence 2025
Intra‑articular Liraglutide Halts Osteoarthritis Progression, Surpassing Dexamethasone in Synovial and Cartilage Protection
Coralie Meurot¹, Celine Martin¹, Margot Vieubled², Indira Toillon³, Claire Deldycke¹, Valentine Cheron¹, Soline Trombetta¹, William Sibran¹, Revital Rattenbach¹ and Francis BERENBAUM⁴, ¹⁴P Pharma, Lille, France, ²⁴P Pharma, Lille, ³Sorbonne University, Paris, France, ⁴Sorbonne University/Inserm/AP-HP/⁴Moving Biotech, Paris, France
Background/Purpose: Osteoarthritis (OA) is an age-related joint disease that cause chronic pain and reduced mobility. Current treatments mainly relieve pain and inflammation, often with corticosteroid…
Abstract Number: 0769 • ACR Convergence 2025
Increased Gait Variability at Preferred Walking Speeds is Associated with Increased Physical Activity Measures in People with Knee Osteoarthritis
Ogundoyin Ogundiran, Steven Garcia, Joy Itodo, Oiza Peters and Kharma Foucher, UNIVERSITY OF ILLINOIS, CHICAGO, Chicago, IL
Background/Purpose: People with knee osteoarthritis (OA) often exhibit reduced physical activity levels and increased fall risk. Gait variability, specifically center of mass (COM) variability is…
Abstract Number: 0324 • ACR Convergence 2025
Bile Acids Metabolism in Symptomatic Hand Osteoarthritis: Data from the Xiangya Osteoarthritis Study and Genetics of OA Consortium
Jiatian Li¹, Jing Ye¹, Tuo Yang¹, david Hunter², Weiya Zhang³, Michael Doherty³, Yuqing Zhang⁴, Zidan Yang¹, Hui Li¹, Yilun Wang¹, Dongxing Xie¹, Ziying Wu⁵, Wei Li¹, Zeqin Wen¹, Changjun Li¹, Chao Zeng¹, Guanghua Lei¹ and Jie Wei¹, ¹Xiangya Hospital, Central South University, Changsha, Hunan, China (People's Republic), ²Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ³School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁴Massachusetts General Hospital, Quincy, MA, ⁵Xiangya Hospital, Central South University, Chang Sha, China (People's Republic)
Background/Purpose: Although gut microbiome dysbiosis has been implicated in symptomatic hand OA (SHOA), the potential contribution of bile acids (BAs), key metabolites in host-microbiota interactions,…
Abstract Number: 0307 • ACR Convergence 2025
Cytokine Profiling of Molecular Endotypes of Knee Osteoarthritis: Insights from the IMI-APPROACH cohort
Monica T. Hannani¹, Jaume Bacardit², Jonathan Larkin³, Virpi Glumoff³, Morten A. Karsdal¹, Anne-Christine Bay-Jensen¹, Ali Mobasheri³ and Christian Thudium⁴, ¹Nordic Bioscience A/S, Herlev, Denmark, ²Newcastle University, Newcastle upon Tyne, United Kingdom, ³University of Oulu, Oulu, Finland, ⁴Nordic Bioscience, Herlev, Denmark
Background/Purpose: There has been a surging interest in characterizing subpopulations of osteoarthritis (OA) to facilitate recruitment of the right subgroups for drug development. The APPROACH…
Abstract Number: 2605 • ACR Convergence 2025
Do Patients Recall Their Rheumatic Diagnoses Accurately? A Comparison by Disease Type
Sydney Liles¹, Samantha Namit², Jennifer Copson³, Matthew Librizzi², Sophia Baionno², Nurten Gizem Tore², Yvonne Lee⁴ and Daniel K. White¹, ¹University of Delaware, Newark, DE, ²University of Delaware, Newark, ³University of Delaware, Wilmington, DE, ⁴Northwestern University, Chicago, IL
Background/Purpose: Rheumatic diseases represent a major public health concern in the United States due to their high prevalence and their association with disability. Observational studies…
Abstract Number: 2092 • ACR Convergence 2025
Associations Among Biomarkers, Cytokines, and Ultrasound Features of Knee Osteoarthritis: A Cross-Sectional Analysis in the Johnston County Health Study
Jasmine Kimber¹, Carolina Alvarez², Virginia Kraus³, Janet Huebner³, Liubov Arbeeva⁴, Todd Schwartz⁵, Yvonne Golightly⁶, Richard Loeser⁷ and Amanda Nelson¹, ¹University of North Carolina at Chapel HIll, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³Duke University, Durham, NC, ⁴University of North Carolina, Chapel Hill, Carrboro, NC, ⁵University of North Carolina-Chapel Hill, Chapel Hill, NC, ⁶University of Nebraska Medical Center, Omaha, NE, ⁷University of North Carolina, Chapel Hill, NC
Background/Purpose: Osteoarthritis (OA) is a leading cause of disability worldwide, characterized by progressive joint degeneration, chronic pain and functional impairment (PMID: 24024017). While imaging modalities…
Abstract Number: 1948 • ACR Convergence 2025
Enhanced Prediction of Knee Osteoarthritis Progression through Deep Learning-Based Multimodal Data Fusion
Daniela Herrera¹, Ahmad Almhdie-Imjabbar², Hechmi Toumi³ and Eric Lespessailles⁴, ¹PRIMMO- University Hospital Center of Orleans, Olreans, France, ²University Hospital Center of Orleans, Orleans, France, ³PRIMMO- University Hospital Center of Orleans, Orleans, France, ⁴CHU Orléans, Orléans, France
Background/Purpose: Effective diagnosis and management of knee osteoarthritis (KOA) increasingly rely on integrating diverse data sources, including imaging and clinical information. The practice of combining…

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