Abstracts tagged "Osteoarthritis"

Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting
CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis
Cheng Zhou^1,2, Vu Nguyen^2,3, Ryan Smalley², Nisha Sambamurthy^1,2, George R. Dodge^2,4 and Carla Scanzello^1,2, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…
Abstract Number: 1368 • 2018 ACR/ARHP Annual Meeting
Diabetes Mellitus Is Not a Risk Factor for Knee Osteoarthritis, a Systematic Review and Meta-Analysis
Cassandra Hong^1,2, Andrew Yu Keat Khor³, Cheryl Ann Pei Wen Ma^2,3, Laura Li Yao Hui³ and Ying Ying Leung^2,3, ¹Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Singapore General Hospital, Singapore, Singapore
Diabetes Mellitus is Not a Risk Factor for Knee Osteoarthritis, a Systematic Review and Meta-analysisBackground/Purpose: Obesity is a strong risk factor for both osteoarthritis (OA)…
Abstract Number: 2952 • 2018 ACR/ARHP Annual Meeting
Major NSAID Toxicity: Derivation and Internal Validation of a Simple Clinical Risk Score
Daniel Solomon¹, Ming Shao², Katherine E Wolski³, Steven E Nissen⁴, M. Elaine Husni⁵ and Nina Paynter⁶, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Cleveland Clinic Foundation, Cleveland, OH, ³Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, ⁴Cardiovascular Medicine, Chair, Cleveland Clinic, Cleveland, OH, ⁵Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ⁶Medicine, Harvard University, Boston, MA
Background/Purpose: NSAIDs and Coxibs represent one of the most commonly prescribed drugs by rheumatologists and are used regularly by >10 million Americans. While most patients…
Abstract Number: 913 • 2018 ACR/ARHP Annual Meeting
Risk Factors for Knee Pain Exacerbation on Walking: A within-Person Knee-Matched Study
Qiang Liu^1,2, David J. Hunter³, Manuela Ferreira⁴, Barton L Wise⁵, Ke Tao¹, Yuqing Zhang⁶ and Jianhao Lin¹, ¹Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, China, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴Institute of Bone and Joint Research | The Kolling Institute, Sydney Medical School, Sydney, Australia, ⁵Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ⁶Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Pain exacerbation on walking is common among patients with knee osteoarthritis and often lead to activity avoidance. To date, few risk factors for pain…
Abstract Number: 1371 • 2018 ACR/ARHP Annual Meeting
Systemic Exposure of Triamcinolone Acetonide Following Bilateral Injection of Extended-Release Triamcinolone Acetonide and Standard Triamcinolone in Patients with Bilateral Knee Osteoarthritis
Alan J. Kivitz¹, Louis Kwong², Tammi Shlotzhauer³, Joelle Lufkin⁴, Teresa Curto⁵ and Scott Kelley⁴, ¹Altoona Center for Clinical Research, Duncansville, PA, ²Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA, ³Rochester Clinical Research, Inc., Rochester, NY, ⁴Flexion Therapeutics, Inc., Burlington, MA, ⁵Cytel Inc., Waltham, MA
Background/Purpose: Current ACR guidelines recommend the use of IACS for short-term acute pain relief in patients (pts) with knee OA.1 Bilateral knee OA can occur…
Abstract Number: 915 • 2018 ACR/ARHP Annual Meeting
The Association between Structural and Symptomatic Progression in Knee Osteoarthritis
Jamie E. Collins¹, Swastina Shrestha² and Elena Losina³, ¹Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA
Background/Purpose: The link between progression of structure and symptoms in knee osteoarthritis (OA) is not well understood. This uncertainty hinders the effort to develop therapies…
Abstract Number: 1372 • 2018 ACR/ARHP Annual Meeting
An Analysis of the Quality and Readability of Online Osteoarthritis Information with Historical Comparison
Kieran Murray¹, Tim Murray², Anna O'Rourke³, Candice Low⁴ and Douglas J. Veale⁴, ¹Rheumatology, Saint Vincent's University Hospital, Dublin 4, Ireland, ²Beaumont Hospital, Dublin, Ireland, ³Saint Vincent's University Hospital, Dublin 4, Ireland, ⁴Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Background/Purpose: OA is the most common cause of disability in people >65 years old.Most patients in the USA use the internet for healthcare information. The…
Abstract Number: 1035 • 2018 ACR/ARHP Annual Meeting
Different Cartilage-Bone Unit in Patients with Primary Osteoarthritis and Secondary Osteoarthritis Caused By Rheumatoid Arthritis
Rasmus Klose-Jensen¹, Anne Friesgaard Christensen², Kresten Krarup Keller³ and Ellen-Margrethe Hauge^3,4, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus C, Denmark, ²Department of Internal Medicine, Lillebaelt Hospital, Vejle, Vejle, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Aarhus, Denmark, ⁴Clinical medicine, Department of Clinical Medicine, Aarhus University Hospital, Århus N, Denmark
Background/Purpose: Despite distinct aetiologies of joint diseases, the osteoarthritic end-stage of primary osteoarthritis (OA) and rheumatoid arthritis (RA) are described using similar radiological features. However,…
Abstract Number: 1374 • 2018 ACR/ARHP Annual Meeting
The Relationship between Loneliness and Osteoarthritis in US Adults from a Nationally Representative Survey
Adeela Cheema¹, Louise Hawkley², Kristen Wroblewski³ and Kichul Ko⁴, ¹Section of Geriatrics and Palliative Medicine, Department of Medicine, University of Chicago, Chicago, IL, ²NORC, University of Chicago, Chicago, IL, ³Department of Public Health Sciences, University of Chicago, Chicago, IL, ⁴Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL
Background/Purpose: Loneliness in adults is a growing phenomenon across the Western world. It is associated with increased mortality, depression, coronary heart disease and stroke. Moreover,…
Abstract Number: 226 • 2018 ACR/ARHP Annual Meeting
Representation of Elderly People and Women in Rheumatoid Arthritis and Osteoarthritis Trials: A Systematic Review and Meta-Analysis Comparing Clinical Trials with Population-Based Studies
Andriko Palmowski¹, Thomas Buttgereit^1,2, Yannick Palmowski³, Sabrina Mai Nielsen^4,5, Maarten Boers⁶, Robin Christensen^4,5 and Frank Buttgereit¹, ¹Department of Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ²Department of Dermatology, Venerology and Allergology, Charité – University Medicine Berlin, Berlin, Germany, ³Center for Musculoskeletal Surgery, Charité – University Medicine Berlin, Berlin, Germany, ⁴Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, ⁵Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁶Department of Epidemiology and Biostatistics, and Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Elderly people (as commonly defined by an age of ≥65 years) and women have been reported to be underrepresented in clinical trials of various…
Abstract Number: 1040 • 2018 ACR/ARHP Annual Meeting
The Potential Role of Choline Kinase Alpha in Osteoarthritis
Roxana Coras^1,2, Liang-Yu Chen³, Elsa Sanchez-Lopez⁴, Martin Lotz⁵, Ru Liu-Bryan^1,3 and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³VA San Diego Healthcare System, San Diego, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and a leading cause of disability. Cartilage degeneration is the central characteristic of OA, and low-grade…
Abstract Number: 1375 • 2018 ACR/ARHP Annual Meeting
Comparative Safety of Flavocoxid (Limbrel) Versus Nsaids Among Osteoarthritis Patients
Justin K Owensby¹, Fenglong Xie¹, Lang Chen¹ and Jeffrey R. Curtis², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama, Birmingham, AL
Background/Purpose: Flavocoxid is a medical food formulated to assist in the management of patients with osteoarthritis (OA). Safety concerns based on case reports have been…
Abstract Number: 284 • 2018 ACR/ARHP Annual Meeting
Challenges and Barriers to Employment That Persons with Osteoarthritis Face at Work Due to Their Condition
Anne-Christine Rat^1,2, Alison Stewart³, Pam Rogers⁴, Dianne P. Mosher⁵ and Diane Lacaille⁶, ¹Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France, ²Université de Lorraine, EA4360, APEMAC, Nancy, France, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ⁵Med, University of Calgary, Calgary, AB, Canada, ⁶Arthritis Research Canada/University of British Columbia, Medicine/Rheumatology, Richmond, BC, Canada
Background/Purpose: To understand the challenges that people with osteoarthritis (OA) experience at work due to their condition, for the purpose of adapting to OA the…
Abstract Number: 1041 • 2018 ACR/ARHP Annual Meeting
The Anti-Adamts-5 Nanobody®, M6495, Protects Against Cartilage Breakdown in Cartilage and Synovial Joint Tissue Explant Models
Anne Sofie Siebuhr¹, Anne C. Bay-Jensen², Christian S. Thudium², Morten A. Karsdal², Benedikte Serruys³, Daniela Werkmann⁴, Martin Michaelis⁴, Christoph Ladel⁴ and Sven Lindemann⁴, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Ablynx NV, Zwijnaarde, Belgium, ⁴Merck KGaA, Darmstadt, Germany
Background/Purpose: Osteoarthritis (OA) is associated with cartilage breakdown, where degradation of aggrecan by ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) is thought to…
Abstract Number: 1380 • 2018 ACR/ARHP Annual Meeting
Complications Following Total Hip Arthroplasty in Inflammatory Versus Osteoarthritis
Shawn Richardson¹, William Schairer², Cynthia Kahlenberg¹, Thomas P. Sculco³, Peter K. Sculco³, Linda A. Russell⁴, Susan M. Goodman¹ and Mark P. Figgie⁵, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, new york, NY, ³Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: THA is commonly performed in patients with a history of inflammatory arthritis. These patients are likely at higher risk of complications, from both the…

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