Abstracts tagged "Osteoarthritis"

Abstract Number: 406 • 2018 ACR/ARHP Annual Meeting
Limiting the Risk of Osteoarthritis after Anterior Cruciate Ligament Injury: Are We Missing the Opportunity to Intervene?
Aileen Davis¹, Rosalind Wong², Krista Steinhart², Janie Astephen Wilson³, Laura Cruz⁴, David Cudmore³, Tim Dwyer⁵, Linda Li⁶, Peter MacDonald⁷, Paul Marks⁴, Laura Nimmon⁸, Darrell Ogilvie-Harris⁴, Nathan Urquhart³ and Jas Chahal⁵, ¹Health Care and Outcomes Research, Krembil Research Institute, University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ²Krembil Research Institute, Health Care and Outcomes Research, Toronto, ON, Canada, ³Dalhousie University, Halifax, NS, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Orthopaedics, University of Toronto, Toronto, ON, Canada, ⁶Arthritis Research Canada, Richmond, BC, Canada, ⁷Pan Am Clinic, Winnipeg, ON, Canada, ⁸University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Fifty percent of people with anterior cruciate (ACL) injury develop knee osteoarthritis (OA) within 6-10 years, even with ligament reconstruction. Despite evidence that targeted…
Abstract Number: 1138 • 2018 ACR/ARHP Annual Meeting
Public Health Impact of Physical Inactivity in the Knee OA Population in the US
Elena Losina¹, Genevieve S. Silva², Karen C. Smith², Jamie E. Collins³, David J. Hunter⁴, Swastina Shrestha², Stephen P. Messier⁵, Edward H. Yelin⁶, Lisa Gale Suter⁷, A. David Paltiel⁸ and Jeffrey N. Katz⁹, ¹Orthopedics, Brigham and Women's Hospital, BU School of Public Health and Harvard Medical School, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Department of Health and Exerc, Wake Forest University, Winston-Salem, NC, ⁶Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ⁷Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, ⁸Yale University, New Haven, CT, ⁹Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: The benefits of physical activity (PA) in persons with OA are well-documented: PA reduces OA pain, improves mental health, and reduces the risk of…
Abstract Number: 1444 • 2018 ACR/ARHP Annual Meeting
Optimization of Ultrasonographic Examination for the Diagnosis of Erosive Rheumatoid Arthritis Versus Erosive Osteoarthritis with Radiography Considered As Gold Standard
Camille Roux¹, Frédérique Gandjbakhch², Audrey Pierreisnard³, Marion Couderc⁴, Cédric Lukas⁵, Racha Masri¹, Jean-Philippe Sommier¹, Isabelle Clerc-Urmès⁶, Cedric Baumann⁷, Isabelle Chary-Valckenaere⁸ and Damien Loeuille¹, ¹Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³APHP, Paris, France, ⁴Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, ⁶CHRU Nancy, Nancy, France, ⁷CHRU Nancy, Vandoeuvre les Nancy, France, ⁸Rheumatology, CHRU Nancy, Vandoeuvres les Nancy, France
Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory joint disease (1,2) responsible for structural damage. Radiography (RX) is considered as the gold standard…
Abstract Number: 411 • 2018 ACR/ARHP Annual Meeting
Kinesiophobia and Physical Function Among Adults with Knee Osteoarthritis: Before and after Strength Training Classes
Aileen Ledingham¹, Michael P. LaValley², Kristin Baker³ and Julie Keysor⁴, ¹Boston University, Boston, MA, ²Biostatistics, Boston University School of Public Health, Boston, MA, ³Franklin Pierce University, Rindge, NH, ⁴Physical Therapy, MGH Institute of Health Professions, Boston, MA
Background/Purpose: Approximately 14 million people in the United States have been clinically diagnosed with symptomatic knee OA. Rising from a chair, negotiating stairs and walking…
Abstract Number: 1163 • 2018 ACR/ARHP Annual Meeting
Patterns of Depressive Symptoms before and after Surgery for Hip, Knee and Lumbar Spine Osteoarthritis
J. Denise Power, Prtha Kudesia, Alina Nadeem, Anthony V. Perruccio, Y. Raja Rampersaud, Nizar Mahomed and Rajiv Gandhi, Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Although pain and decreased function are the primary symptom targets of OA surgeries, OA is also associated with depression. The impact of surgery on…
Abstract Number: 1922 • 2018 ACR/ARHP Annual Meeting
Characterization of the Pharmacology and Pharmacokinetics of Cntx-4975, a High-Purity, Synthetic Trans-Capsaicin in Clinical Development for the Treatment of Moderate to Severe OA Knee Pain
James Campbell, Randall Stevens and Peter Hanson, Centrexion Therapeutics, Boston, MA
Background/Purpose: CNTX-4975, a highly purified, synthetic trans-capsaicin and long-acting, non-opioid analgesic in phase 3 trials for moderate to severe OA knee pain, has demonstrated safety…
Abstract Number: 424 • 2018 ACR/ARHP Annual Meeting
Occult Extractable Synovial Fluid in Inflammatory and Non-Inflammatory Arthritis of the Knee
Noelle Rolle¹, Irum Jan², Wilmer Sibbitt Jr.¹, Philip Band³, William Hayward⁴, Maheswari Muruganandam¹, N. Suzanne Emil¹, Monthida Fangtham¹, Roderick Fields¹ and Arthur Bankhurst¹, ¹Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, ²Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, ³NYU School of Medicine, New York, NY, ⁴The Department of Exercise and Sport Sciences, New Mexico Highlands University, Las Vegas, NM
Background/Purpose: We hypothesized that mechanical compression of the knee in rheumatoid arthritis (RA) and osteoarthritis (OA) would mobilize occult extractable fluid and improve arthrocentesis success.Methods:…
Abstract Number: 1165 • 2018 ACR/ARHP Annual Meeting
Restless Sleep Trajectories over 8 Years: Data from the Osteoarthritis Initiative
Jing Song¹, Julia (Jungwha) Lee¹, Yvonne C. Lee², Alison H. Chang¹, Pamela Semanik³, Linda S. Ehrlich-Jones¹, Rowland W. Chang¹ and Dorothy D. Dunlop¹, ¹Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³College of Nursing, Rush University, Chicago, IL
Background/Purpose: Sleep disturbance has been recognized as a major public health issue. Evidence has shown that individuals with osteoarthritis (OA) are more likely to have…
Abstract Number: 1947 • 2018 ACR/ARHP Annual Meeting
Do Changes in Pain Sensitization and Depressive Symptoms Mediate the Effect of Extreme Weight Loss on Knee Pain Improvement?
S. Reza Jafarzadeh¹, Tuhina Neogi¹, Joshua J. Stefanik², Margaret M. Clancy¹, Jing-Sheng Li³ and David T. Felson¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Department of Physical Therapy, University of Delaware, Newark, DE, ³College of Health and Rehabilitation Sciences: Sargent College, Boston University, Boston, MA
Background/Purpose: We previously showed that the one-year effects of weight loss on knee pain reduction were not mediated by changes in structural features of osteoarthritis…
Abstract Number: 428 • 2018 ACR/ARHP Annual Meeting
Significant Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; Results from a Randomised Controlled Phase III Trial of Treatment Effectiveness
Sarah R. Kingsbury¹, Puvan Tharmanathan², Ada Keding², Belen Corbacho², Fiona E Watt³, David L Scott⁴, Edward Roddy⁵, Fraser Birrell⁶, Nigel K Arden⁷, Catherine Arundel², Sarah Ronaldson², Lema Vernon⁸, Catherine Hewitt², Michael Doherty⁹, David Torgerson² and Philip G. Conaghan¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, ²York Trials Unit, University of York, York, United Kingdom, ³Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁴Department of Rheumatology, King's College London, London, United Kingdom, ⁵Staffordshire and Stoke on Trent Partnership NHS Foundation Trust, Newcastle Under Lyme, United Kingdom, ⁶Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom, ⁷Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, University of Oxford, Oxford, United Kingdom, ⁸Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹The University of Nottingham, Nottingham, United Kingdom
Background/Purpose: Current treatments for osteoarthritis (OA) are severely limited. Synovitis is prevalent in OA and is associated with pain. The slow-acting anti-rheumatic drug methotrexate (MTX)…
Abstract Number: 1211 • 2018 ACR/ARHP Annual Meeting
Contribution of Ultrasonography Examination in Symptomatic Radiographic Knee OA
Oriane BAZIN¹, Willy Ngueyon Sime², Alexandra Desvignes³, Emmanuel Spitz⁴, Francis Guillemin⁵, Anne-Christine Rat⁵, Isabelle Chary-Valckenaere⁶ and Damien Loeuille⁷, ¹service de Rhumatologie, CHU Nancy, Vandoeuvre les Nancy, France, ²Université de Lorraine, Nancy, France, ³service de Rhumatologie, Groupement hospitalier Eaubonne -Montmorency, EAUBONNE, France, ⁴Rheumatology Strasbourg, Strasbourg, France, ⁵Université de Lorraine, EA4360, APEMAC, Nancy, France, ⁶Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ⁷Rheumatology, University Hospital of Nancy, NANCY, France
Background/Purpose: To evaluate and to compare ultrasonographic (US) features to clinical data and structural damage in symptomatic radiographic (RX) knee osteoarthritis (OA). Methods: Patients with…
Abstract Number: 1983 • 2018 ACR/ARHP Annual Meeting
Mutations Associated with Clonal Hematopoiesis of Indeterminate Potential Are Found in Peripheral Blood and Synovial Fluid Macrophages from Patients with Rheumatoid and Psoriatic Arthritis
Maria De Santis¹, Matteo Zampini², Natasa Isailovic¹, Elena Generali¹, Giacomo Maria Guidelli¹, Matteo Della Porta² and Carlo Selmi^1,3, ¹Rheumatology and Clinical Immunology Unit, Humanitas Research Hospital, Rozzano (MI), Italy, ²Oncology and Hematology Unit, Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, ³BIOMETRA Department, University of Milan, Milan, Italy
Background/Purpose: Myeloidmutations commonly associated to neoplasia in patients who do not meet the diagnostic criteria for myelodysplastic syndrome are coined as clonal hematopoiesis of indeterminate…
Abstract Number: 433 • 2018 ACR/ARHP Annual Meeting
Impact of Bariatric Surgery on Rheumatic Diseases: A Systematic Review and Meta-Analysis
Marie Moly¹, Bernard Combe¹, Thomas Barnetche², Claire Daien¹, Jacques Morel³, Cédric Lukas¹, Cécile Gaujoux-Viala⁴ and Charlotte Hua⁴, ¹Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ²Rheumatology, University Hospital Pellegrin, Bordeaux, Bordeaux, France, ³Department of Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ⁴Rheumatology, University Hospital Carémeau , Nimes, Nimes, France
Background/Purpose: Obesity increase the incidence of rheumatic diseases (1-3). Bariatric surgery (BS) improve obesity-related comorbidities (4). The aim of our study was to assess currently…
Abstract Number: 1357 • 2018 ACR/ARHP Annual Meeting
Flexion Contractures Are Associated with Worse Pain, Stiffness, and Function in Patients with Knee Osteoarthritis
T Mark Campbell¹, Marc Monsour² and Guy Trudel³, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) causes pain, disability, and affects ~20% of the population in the United States [Wallace 2017]. Knee flexion contractures (FCs) are limitations…
Abstract Number: 2008 • 2018 ACR/ARHP Annual Meeting
Vascular Adhesion Protein-1 (VAP-1) As Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis
Eirini Bournazou¹, Jonathan Samuels², Hua Zhou³, Svetlana Krasnokutsky Samuels⁴, Jyoti Patel⁵, Jenny Bencardino⁶, Leon Rybak⁷, Steven Abamson⁸, Uwe Junker⁹, Karen Brown¹ and Mukundan Attur⁵, ¹Roche Innovation Center, New York, NY, ²Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY, ³Bioinformatics, New York University, New York, NY, ⁴NYU School of Medicine, New York, NY, ⁵Rheumatology Research, NYU Langone Orthopedic Hospital, New York, NY, ⁶Radiology, NYU Langone Medical Center, New York, NY, ⁷Department of Radiology, NYU Langone Medical Center, New York, NY, ⁸Rheumatology, NYU Langone Health, New York, NY, ⁹Roche Innovation Center, Basel, Switzerland
Background/Purpose: To investigate the expression of vascular adhesion protein -1 (VAP-1) in joint tissues and serum in knee osteoarthritis (OA) patients and examine whether VAP-1…

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