Abstracts tagged "Osteoarthritis"

Abstract Number: 226 • 2018 ACR/ARHP Annual Meeting
Representation of Elderly People and Women in Rheumatoid Arthritis and Osteoarthritis Trials: A Systematic Review and Meta-Analysis Comparing Clinical Trials with Population-Based Studies
Andriko Palmowski¹, Thomas Buttgereit^1,2, Yannick Palmowski³, Sabrina Mai Nielsen^4,5, Maarten Boers⁶, Robin Christensen^4,5 and Frank Buttgereit¹, ¹Department of Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, ²Department of Dermatology, Venerology and Allergology, Charité – University Medicine Berlin, Berlin, Germany, ³Center for Musculoskeletal Surgery, Charité – University Medicine Berlin, Berlin, Germany, ⁴Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg, Denmark, ⁵Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁶Department of Epidemiology and Biostatistics, and Amsterdam Rheumatology and Immunology Center, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Elderly people (as commonly defined by an age of ≥65 years) and women have been reported to be underrepresented in clinical trials of various…
Abstract Number: 1040 • 2018 ACR/ARHP Annual Meeting
The Potential Role of Choline Kinase Alpha in Osteoarthritis
Roxana Coras^1,2, Liang-Yu Chen³, Elsa Sanchez-Lopez⁴, Martin Lotz⁵, Ru Liu-Bryan^1,3 and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³VA San Diego Healthcare System, San Diego, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and a leading cause of disability. Cartilage degeneration is the central characteristic of OA, and low-grade…
Abstract Number: 1375 • 2018 ACR/ARHP Annual Meeting
Comparative Safety of Flavocoxid (Limbrel) Versus Nsaids Among Osteoarthritis Patients
Justin K Owensby¹, Fenglong Xie¹, Lang Chen¹ and Jeffrey R. Curtis², ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama, Birmingham, AL
Background/Purpose: Flavocoxid is a medical food formulated to assist in the management of patients with osteoarthritis (OA). Safety concerns based on case reports have been…
Abstract Number: 284 • 2018 ACR/ARHP Annual Meeting
Challenges and Barriers to Employment That Persons with Osteoarthritis Face at Work Due to Their Condition
Anne-Christine Rat^1,2, Alison Stewart³, Pam Rogers⁴, Dianne P. Mosher⁵ and Diane Lacaille⁶, ¹Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France, ²Université de Lorraine, EA4360, APEMAC, Nancy, France, ³Arthritis Research Canada, Richmond, BC, Canada, ⁴Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ⁵Med, University of Calgary, Calgary, AB, Canada, ⁶Arthritis Research Canada/University of British Columbia, Medicine/Rheumatology, Richmond, BC, Canada
Background/Purpose: To understand the challenges that people with osteoarthritis (OA) experience at work due to their condition, for the purpose of adapting to OA the…
Abstract Number: 1041 • 2018 ACR/ARHP Annual Meeting
The Anti-Adamts-5 Nanobody®, M6495, Protects Against Cartilage Breakdown in Cartilage and Synovial Joint Tissue Explant Models
Anne Sofie Siebuhr¹, Anne C. Bay-Jensen², Christian S. Thudium², Morten A. Karsdal², Benedikte Serruys³, Daniela Werkmann⁴, Martin Michaelis⁴, Christoph Ladel⁴ and Sven Lindemann⁴, ¹Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Ablynx NV, Zwijnaarde, Belgium, ⁴Merck KGaA, Darmstadt, Germany
Background/Purpose: Osteoarthritis (OA) is associated with cartilage breakdown, where degradation of aggrecan by ADAMTS-5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) is thought to…
Abstract Number: 1380 • 2018 ACR/ARHP Annual Meeting
Complications Following Total Hip Arthroplasty in Inflammatory Versus Osteoarthritis
Shawn Richardson¹, William Schairer², Cynthia Kahlenberg¹, Thomas P. Sculco³, Peter K. Sculco³, Linda A. Russell⁴, Susan M. Goodman¹ and Mark P. Figgie⁵, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, new york, NY, ³Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: THA is commonly performed in patients with a history of inflammatory arthritis. These patients are likely at higher risk of complications, from both the…
Abstract Number: 400 • 2018 ACR/ARHP Annual Meeting
Predictors of Response to a Single Intra-Articular Injection of Mannitol-Modified Cross-Linked Hyaluronic Acid (HANOX-M-XL) in Patients with First Metatarsophalangeal Joint Osteoarthritis (hallux rigidus)
Thierry Conrozier¹, Aline Charpentier², Marie Bossert³, Sylvie Mellac-Ducamp⁴ and Laurent Galois⁵, ¹Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France, ²Rheumatology, Nord Franche-Comté Hospital, Belfort, France, ³Rheumatology, Nord Franche Comté Hospital, Belfort, France, ⁴Rheumatology, Nevers General Hospital, Nevers, France, ⁵Orthopaedic and trauma surgery, University Hospital of Nancy, Nancy, France
Background/Purpose: To investigate the potential predictors of response to a single intra-articular injection of mannitol-modified cross-linked hyaluronic acid (HANOX-M-XL) in patients with first metatarsophalangeal joint…
Abstract Number: 1052 • 2018 ACR/ARHP Annual Meeting
Detection of Precursors of RANK- Osteoclast-like Cells (Olcs) in Peripheral Blood and Olcs in Bone Tissue from Rheumatoid Arthritis Patients
Kazuhiro Yokota¹, Shinya Tanaka², Miyoko Sekikawa², Yoshimi Aizaki¹, Kojiro Sato¹, Hiromi Oda² and Toshihide Mimura¹, ¹Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Department of Orthopaedic Surgery, Saitama Medical University, Saitama, Japan
Background/Purpose: Proinflammatory cytokines play an important role in bone destruction in rheumatoid arthritis (RA), as inferred by the efficacy of biologics. Previously, we reported that…
Abstract Number: 1395 • 2018 ACR/ARHP Annual Meeting
Could the Shortening of the Electronic Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) Questionnaire Improve Its Metric Properties?
Maud Wieczorek¹, Christine Rotonda¹, Jonathan Epstein^1,2, Francis Guillemin^1,2 and Anne-Christine Rat^1,3, ¹Université de Lorraine, EA4360, APEMAC, Nancy, France, ²Inserm, CIC-1433 Epidémiologie Clinique, Vandoeuvre-lès-Nancy, France, ³Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France
Background/Purpose: The aim of this study was to assess the validity of a short version of the electronic OAKHQOL questionnaire in a combined analysis with…
Abstract Number: 405 • 2018 ACR/ARHP Annual Meeting
Feasibility of Enabling Self-Management and Coping with Arthritic Pain Using Exercise (ESCAPE-Pain) Programme for Knee Osteoarthritis in Malaysia
Muhammad Kamil Che Hasan^1,2, Emma Stanmore² and Chris Todd², ¹Kulliyyah (Faculty) of Nursing, International Islamic University Malaysia (IIUM), Kuantan Pahang, Malaysia, ²Division of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, United Kingdom
Background/Purpose: In Malaysia around one in ten older people are diagnosed with osteoarthritis (OA), with the knee being one of the most commonly affected areas.…
Abstract Number: 1137 • 2018 ACR/ARHP Annual Meeting
Prediction Models for Poor Function Outcomes over 10 Years in Persons at High Risk for Knee Osteoarthritis
Leena Sharma¹, Orit Almagor¹, Alison H. Chang¹, C. Kent Kwoh², Michael C. Nevitt³, Marc C. Hochberg⁴, Rebecca D. Jackson⁵, Charles B. Eaton⁶, Jane A. Cauley⁷, Julie Szymaszek⁸ and Joan S. Chmiel¹, ¹Northwestern University, Chicago, IL, ²University of Arizona, Tucson, AZ, ³UCSF, San Francisco, CA, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Ohio State University, Columbus, OH, ⁶Family Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI, ⁷University of Pittsburgh, PIttsburgh, PA, ⁸Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Among persons at high risk for knee osteoarthritis (OA), identifying those who will have function decline is important; instituting prevention strategies in all…
Abstract Number: 1443 • 2018 ACR/ARHP Annual Meeting
Ultrasonographic Criteria for the Diagnosis of Erosive Rheumatoid Arthritis Disease Using Osteoarthritic Patients As Controls Compared to Validated Radiographic Criteria
Camille Roux¹, Frédérique Gandjbakhch², Audrey Pierreisnard³, Marion Couderc⁴, Cédric Lukas⁵, Racha Masri¹, Jean-Philippe Sommier¹, Isabelle Clerc-Urmès⁶, Cedric Baumann⁷, Isabelle Chary-Valckenaere⁸ and Damien Loeuille⁹, ¹Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³APHP, Paris, France, ⁴Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, Lapeyronie Hospital and EA2415 Montpellier University, Montpellier, France, ⁶CHRU Nancy, Nancy, France, ⁷CHRU Nancy, Vandoeuvre les Nancy, France, ⁸Rheumatology, CHRU Nancy, Vandoeuvres les Nancy, France, ⁹Rheumatology, University Hospital of Nancy, NANCY, France
Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory joint disease (1,2) responsible for structural damage. Radiography (RX) is considered as the gold standard…
Abstract Number: 406 • 2018 ACR/ARHP Annual Meeting
Limiting the Risk of Osteoarthritis after Anterior Cruciate Ligament Injury: Are We Missing the Opportunity to Intervene?
Aileen Davis¹, Rosalind Wong², Krista Steinhart², Janie Astephen Wilson³, Laura Cruz⁴, David Cudmore³, Tim Dwyer⁵, Linda Li⁶, Peter MacDonald⁷, Paul Marks⁴, Laura Nimmon⁸, Darrell Ogilvie-Harris⁴, Nathan Urquhart³ and Jas Chahal⁵, ¹Health Care and Outcomes Research, Krembil Research Institute, University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ²Krembil Research Institute, Health Care and Outcomes Research, Toronto, ON, Canada, ³Dalhousie University, Halifax, NS, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Orthopaedics, University of Toronto, Toronto, ON, Canada, ⁶Arthritis Research Canada, Richmond, BC, Canada, ⁷Pan Am Clinic, Winnipeg, ON, Canada, ⁸University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Fifty percent of people with anterior cruciate (ACL) injury develop knee osteoarthritis (OA) within 6-10 years, even with ligament reconstruction. Despite evidence that targeted…
Abstract Number: 1138 • 2018 ACR/ARHP Annual Meeting
Public Health Impact of Physical Inactivity in the Knee OA Population in the US
Elena Losina¹, Genevieve S. Silva², Karen C. Smith², Jamie E. Collins³, David J. Hunter⁴, Swastina Shrestha², Stephen P. Messier⁵, Edward H. Yelin⁶, Lisa Gale Suter⁷, A. David Paltiel⁸ and Jeffrey N. Katz⁹, ¹Orthopedics, Brigham and Women's Hospital, BU School of Public Health and Harvard Medical School, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁵Department of Health and Exerc, Wake Forest University, Winston-Salem, NC, ⁶Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ⁷Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, ⁸Yale University, New Haven, CT, ⁹Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: The benefits of physical activity (PA) in persons with OA are well-documented: PA reduces OA pain, improves mental health, and reduces the risk of…
Abstract Number: 1444 • 2018 ACR/ARHP Annual Meeting
Optimization of Ultrasonographic Examination for the Diagnosis of Erosive Rheumatoid Arthritis Versus Erosive Osteoarthritis with Radiography Considered As Gold Standard
Camille Roux¹, Frédérique Gandjbakhch², Audrey Pierreisnard³, Marion Couderc⁴, Cédric Lukas⁵, Racha Masri¹, Jean-Philippe Sommier¹, Isabelle Clerc-Urmès⁶, Cedric Baumann⁷, Isabelle Chary-Valckenaere⁸ and Damien Loeuille¹, ¹Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ²UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³APHP, Paris, France, ⁴Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ⁵Rheumatology, CHU Lapeyronie and EA2415, Montpellier University, University of Montpellier, France, ⁶CHRU Nancy, Nancy, France, ⁷CHRU Nancy, Vandoeuvre les Nancy, France, ⁸Rheumatology, CHRU Nancy, Vandoeuvres les Nancy, France
Background/Purpose: Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory joint disease (1,2) responsible for structural damage. Radiography (RX) is considered as the gold standard…

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