Abstracts tagged "Osteoarthritis"

Abstract Number: 2199 • 2019 ACR/ARP Annual Meeting
Is There an Association of Serum LDL, HDL and Total Cholesterol with the Development of Knee Osteoarthritis?
Jessica Barlow¹, Xianbang Sun ², Michael Nevitt ³, James Torner ⁴, Beth Lewis ⁵, Nirupa Matthan ⁶, Alice Lichtenstein ⁶ and David Felson ⁷, ¹Boston University School of Medicine, Department of Rheumatology, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of California at San Francisco, San Francisco, CA, ⁴University of Iowa at Iowa City, Iowa City, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Tufts University, Boston, MA, ⁷Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Recent data have suggested an association between elevated serum cholesterol levels, particularly low density lipoprotein (LDL), and the development of osteoarthritis (OA). Within the…
Abstract Number: 2891 • 2019 ACR/ARP Annual Meeting
Cost-effectiveness of Duloxetine for Knee OA Patients Whose Pain Can’t Be Controlled by NSAIDs
James Sullivan¹, Jeffrey Katz ² and Elena Losina ³, ¹Brigham and Women's Hospital, Boston, ²Brigham and Women's Hospital/Harvard Medical School, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Knee OA is a disabling condition affecting over 14 million adults in the US. NSAIDs provide only short-term pain relief, creating the need for…
Abstract Number: 269 • 2019 ACR/ARP Annual Meeting
Attitudes and Beliefs About Opioid Medications: Determining Treatment Use in Osteoarthritis
Ernest Vina¹, Jazmin Dagnino ¹ and C. Kent Kwoh ¹, ¹University of Arizona, Tucson, AZ
Background/Purpose: Considering the growing opioid epidemic in the US, it is imperative to have a good understanding of what patient characteristics predict the use of…
Abstract Number: 1302 • 2019 ACR/ARP Annual Meeting
Subcutaneous Tanezumab vs NSAID for the Treatment of Osteoarthritis: Efficacy and General Safety Results from a Randomized, Double-Blind, Active-Controlled, 80-Week, Phase-3 Study
Marc C. Hochberg¹, John Carrino ², Thomas Schnitzer ³, Ali Guermazi ⁴, Eric Vignon ⁵, David Walsh ⁶, Alexander White ⁷, Satoru Nakajo ⁸, Robert Fountaine ⁹, Anne Hickman ⁹, Glenn Pixton ¹⁰, Lars Viktrup ¹¹, Mark T. Brown ⁹, Christine R. West ⁹ and Kenneth M. Verburg ⁹, ¹University of Maryland School of Medicine, Baltimore, MD, ²Hospital for Special Surgery, New York, NY, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Boston Medical Center, Boston, ⁵Université Claude Bernard Lyon 1, Lyon, France, ⁶Sherwood Forest Hospitals NHS Foundation Trust, Nottingham, United Kingdom, ⁷Progressive Medical Research, Port Orange, FL, ⁸Nakajo Orthopaedic Clinic, Miyagi, Japan, ⁹Pfizer Inc, Groton, CT, ¹⁰Pfizer Inc, Morrisville, NC, ¹¹Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Tanezumab is a monoclonal antibody that inhibits nerve growth factor and is under investigation for chronic pain treatment. Tanezumab administered intravenously was effective and…
Abstract Number: 1324 • 2019 ACR/ARP Annual Meeting
Visceral Fat Deposition Associated with Pain in Osteoarthritis
Shanshan Li ¹, Nancy Desai², Tuhina Neogi ³, Ann Schwartz ⁴, Lavalley Michael ¹, Na Wang ³, Xianbang Sun ¹, Michael Nevitt ⁵, Beth Lewis ⁶, Ali Guermazi ², Frank Roemer ⁷, Neil Segal ⁸ and David Felson ⁹, ¹Boston University, Boston, ²Boston Medical Center, Boston, ³Boston University School of Medicine, Boston, MA, ⁴University of California San Francisco, San Francisco, ⁵University of California at San Francisco, San Francisco, CA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of Erlangen-Nuremberg, Erlangen, Germany, ⁸University of Kansas Medical Center, Kansas City, KS, ⁹Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Animal model studies have demonstrated the significant role of inflammation in the pathogenesis of osteoarthritis (OA) and of pain. Visceral fat, rather than subcutaneous…
Abstract Number: 1977 • 2019 ACR/ARP Annual Meeting
The Synthesis of Hydrogen Sulfide Is Impaired in Osteoarthritic Chondrocytes from Diabetic Patients and in Vitro in Cells Under High Glucose Environment
Carlos Vaamonde-García¹, Tamara Hermida-Gómez ², Francisco J. Blanco ³, Elena F Burguera ³ and Rosa Meijide-Faílde ¹, ¹Tissue Engineering and Regenerative Medicine Group. University of A Coruña, A Coruña, Spain, ²Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: A growing number of findings indicates that type 2 diabetes is an independent risk factor of osteoarthritis (OA). However, the mechanisms underlying the connection…
Abstract Number: 2177 • 2019 ACR/ARP Annual Meeting
Sarcopenia and the Likelihood of Incident Knee Osteoarthritis and Knee Pain Among Older Adults in the Health ABC Study
James Andrews¹, Laura Gold ¹, Michael Nevitt ², Patrick Heagerty ¹ and Peggy Cawthon ³, ¹University of Washington, Seattle, ²University of California at San Francisco, San Francisco, CA, ³University of California San Francisco, San Francisco
Background/Purpose: Osteoarthritis (OA) disproportionately affects older adults. Sarcopenia, or reduced muscle mass and strength, is strongly associated with reduced physical function and poor clinical outcomes…
Abstract Number: 2200 • 2019 ACR/ARP Annual Meeting
Magnetic Resonance Imaging of Knee Joint Protection Following an Intra-Articular Injection of Lipid-Based Dexamethasone Sodium Phosphate Sustained Release Formulation on Subjects with Knee Osteoarthritis
Sheue-Fang Shih¹, Carl Brown ¹, Tien-Tzu Tai ¹ and Wing Chuang ¹, ¹Taiwan Liposome Company, Ltd., Taipei, Taiwan (Republic of China)
Background/Purpose: The most commonly used intra-articular (IA) corticosteroid for osteoarthritis (OA) is triamcinolone acetonide (TA), but its potential chondrotoxicity restricts injection frequency to 3-4 injections…
Abstract Number: 2926 • 2019 ACR/ARP Annual Meeting
Knee Injury and Transitions Among States of Knee Osteoarthritis in the Johnston County Osteoarthritis Project: A Multi-State Time-To-Event Modeling Approach
Yvonne Golightly¹, Carolina Alvarez ², Liubov Arbeeva ², Rebecca Cleveland ³, Todd Schwartz ⁴, Louise Murphy ⁵, Jordan Renner ⁶, Leigh Callahan ³, Joanne Jordan ² and Amanda Nelson ⁷, ¹University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Research Center, Chapel Hill, NC, ⁴University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁵Centers for Disease Control and Prevention, Division of Population Health, Atlanta, ⁶University of North Carolina at Chapel Hill Department of Radiology, Chapel Hill, NC, ⁷University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Musculoskeletal injury is a known risk factor for osteoarthritis (OA). Cumulative effects of comorbid conditions on the association of injury and OA have not…
Abstract Number: 281 • 2019 ACR/ARP Annual Meeting
Frequency of Ultrasound Features of Knee Osteoarthritis and Their Association with Radiographic Features and Symptoms in a Community-Based Cohort
Nadiya Yerich¹, Carolina Alvarez ², Todd Schwartz ³, Sue Savage-Guin ², Catherine Bakewell ⁴, Minna Kohler ⁵, Janice Lin ⁶, Jonathan Samuels ⁷ and Amanda Nelson ², ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁴Intermountain Medical Center, Salt Lake City, UT, ⁵MGH, Boston, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone Medical Center, New Yort, NY
Background/Purpose: To evaluate the frequency and associations of osteoarthritis (KOA) features on knee ultrasound (KUS) in a community-based cohort study with radiographic and symptomatic data…
Abstract Number: 1303 • 2019 ACR/ARP Annual Meeting
Intra-Articular TPX-100 Significantly Delays Pathological Bone Shape Change at 6 and 12 Months in Moderate to Severe Tibiofemoral OA
Dawn McGuire¹, Michael Bowes ², Alan Brett ², Neil Segal ³, Meghan Miller ⁴, David Rosen ⁴ and Yoshinari Kumagai ⁴, ¹OrthoTrophix, Orinda, CA, ²Imorphics, Manchester, England, United Kingdom, ³University of Kansas Medical Center, Kansas City, KS, ⁴OrthoTrophix, Oakland, CA
Background/Purpose: Pathological bone shape changes in the femur precede cartilage changes in knee OA and predict disease onset and progression to joint failure (Neogi 2013;…
Abstract Number: 1325 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Japanese Subjects of the ADAMTS-5 Inhibitor S201086/GLPG1972, a Potential New Treatment in OA
Agnès Lalande ¹, Nadya Kuzniatsova-Mouchette ², Florian Chassereau ¹, Julia Geronimi ¹, Staffan Larsson ³, Andre Struglics ³, Stefan Lohmander ³ and Maria Pueyo¹, ¹Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, France, ²Institut de Recherches Internationales Servier, Suresnes, France, Suresnes, ³Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden, Lund, Sweden
Background/Purpose: The disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) is a key enzyme in OA (Verma P, et al. J Cell Biochem 2011;112:3507-14). In preclinical models…
Abstract Number: 1979 • 2019 ACR/ARP Annual Meeting
What Is the Pathogenic Meaning of Chondrocyte Hypertrophy in Osteoarthritis? Effect of Evc Deletion Through Hedgehog Signaling
Ana Lamuedra¹, Paula Gratal ¹, Víctor Luis Ruiz-Perez ², Adrián Palencia-Campos ³, Sergio Portal-Nuñez ⁴, Gabriel Herrero-Beaumont ⁵ and Raquel Largo ⁵, ¹IIS - Fundacion Jimenez Diaz, Madrid, Madrid, Spain, ²Instituto de Investigaciones Biomédicas 'Alberto Sols', Madrid, Madrid, Spain, ³Adrián Palencia Campos [[email protected]], Madrid, Madrid, Spain, ⁴Applied Molecular Medicine Institute (IMMA), Universidad San Pablo-CEU, Alcorcón, Madrid, Spain, ⁵IIS-Fundación Jiménez Díaz, Madrid, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is mainly characterized by the progressive damage of articular cartilage, where chondrocytes acquire a hypertrophic-like phenotype. Indian Hedgehog levels are increased in…
Abstract Number: 2178 • 2019 ACR/ARP Annual Meeting
Associations Between Baseline and Longitudinal Quantitative Joint Space Width and Incident Hip Osteoarthritis: The Johnston County Osteoarthritis Project
Jacquelyn Smith¹, Carolina Alvarez ¹, Liubov Arbeeva ¹, Jordan Renner ², Louise Murphy ³, Joanne Jordan ¹, Yvonne Golightly ⁴, Jeffrey Duryea ⁵ and Amanda Nelson ¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Department of Radiology, Chapel Hill, NC, ³Centers for Disease Control and Prevention, Division of Population Health, Atlanta, ⁴University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁵Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: To quantify associations between baseline and change in computer-assisted hip quantitative joint space width (qJSW) with incident radiographic (rHOA) or symptomatic (sxHOA) hip OA.Methods:…
Abstract Number: 2203 • 2019 ACR/ARP Annual Meeting
Impact of Hypothetical Changes in the Use of Analgesics on the Burden of Osteoarthritis: A Population-based Microsimulation Study
Jacek Kopec¹, Eric Sayre ², Anya Okhmatovskaia ³, Jolanda Cibere ⁴, Linda Li ⁵, Nick Bansback ⁶, Hubert Wong ⁵ and John Esdaile ⁷, ¹Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Vancouver, BC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Arthritis Research Canada and the University of British Columbia, Vancouver, Canada, ⁵University of British Columbia, Vancouver, BC, Canada, ⁶University of British Columbia, Vancouver, Canada, ⁷Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada
Background/Purpose: Analgesics are the cornerstone of medical treatment of osteoarthritis (OA) but are associated with serious side effects. A more optimal use of analgesics in…

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