Abstracts tagged "Osteoarthritis"

Abstract Number: 1993 • 2019 ACR/ARP Annual Meeting
Inhibition of Choline Kinase Alpha Improves Synovitis and Cartilage Damage in Animal Models of Osteoarthritis
Roxana Coras¹, Leening P Liu ², Serena Z Shi ², Anyan Cheng ³, Alexandra Stubelius ⁴, Elsa Sanchez-Lopez ⁵, Robert Sah ⁶, Ru Liu-Bryan ⁷ and Monica Guma ⁸, ¹Department of Medicine, University of California San Diego, La Jolla, San Diego, CA, ²Department of Bioengineering, University of California San Diego, La Jolla, San Diego, ³Department of Medicine, University of California San Diego, La Jolla, San Diego, ⁴Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, San Diego, ⁵Department of Pharmacology, University of California San Diego, La Jolla, San Diego, ⁶Department of Bioengineering and Medicine, University of California San Diego, La Jolla, San Diego, ⁷San Diego VA/UCSD, La Jolla, CA, ⁸Department of Medicine, School of Medicine. University of California San Diego, La Jolla, United States
Background/Purpose: Osteoarthritis (OA) is a disease of the whole joint, affecting cartilage, ligaments, menisci, bone and synovial tissue. We previously found that choline kinase alpha…
Abstract Number: 2186 • 2019 ACR/ARP Annual Meeting
What Is an Important Difference in Gait Speed in Adults with Knee Osteoarthritis?
Jing Song ¹, David Cella ², Abigail Gilbert³, Rowland Chang ² and Dorothy Dunlop ², ¹Northwestern University Feinberg School of Medicine, Worthington, OH, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³University of North Carolina, Chapel Hill, NC
Background/Purpose: Little is known regarding what difference in functional performance measures are clinically significant in individuals with a chronic medical disease. This study examines the…
Abstract Number: 2757 • 2019 ACR/ARP Annual Meeting
Clinical Effectiveness of Ultrasound-guided Intra-articular Corticosteroid and Local Anaesthetic Injections for Hip Osteoarthritis: A Randomised Controlled Trial (HIT)
Zoe Paskins ¹, Kieran Bromley ², Martyn Lewis ², Gemma Hughes ², Emily Hughes ², Andrea Cherrington ², Alison Hall ², Melanie Holden ³, Raymond Oppong ⁴, Kay Stevenson ², Ajit Menon ⁵, Philip Roberts ⁶, George Peat ², Clare Jinks ⁷, Nadine Foster ², Christian Mallen ⁸ and Edward Roddy⁹, ¹Research Institute for Primary Care and Health Sciences, Keele University, Keele, United Kingdom, ²Keele University, Keele, United Kingdom, ³Research Institute for Primary Care and Health Sciences and Keele CTU, Keele University, Keele, England, United Kingdom, ⁴University of Birmingham, Birmingham, United Kingdom, ⁵Midlands Partnership NHS Foundation Trust, Stoke-on-Trent, United Kingdom, ⁶University Hospitals North Midlands NHS Trust, Stoke-on-Trent, United Kingdom, ⁷Research Institute for Primary Care and Health Sciences, Keele University, Keele, England, United Kingdom, ⁸Research Institute for Primary Care and Health Sciences, Keele University, UK, Keele, United Kingdom, ⁹Research Institute for Primary Care and Health Sciences and Keele Clinical Trials Unit, Keele, United Kingdom
Background/Purpose: Evidence of the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis (OA) is limited and conflicting. The HIT trial compared the clinical effectiveness of…
Abstract Number: 912 • 2019 ACR/ARP Annual Meeting
Co-morbidities Associated with Discordance Between Structural Severity and Pain in Osteoarthritis: Implications for Clinical Trial Design in OA – a Post-Hoc Analysis of Data from Two Randomized Controlled Trials
Jonathan Bjerre-Bastos¹, Inger Byrjalsen ², Morten Karsdal ³, Jeppe Andersen ¹ and Asger Bihlet ¹, ¹Nordic Bioscience Clinical Development, Herlev, Denmark, ²Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience, Copenhagen, Denmark
Background/Purpose: Development of new disease-modifying drugs in osteoarthritis (DMOADs) has proven difficult and is complicated by heterogeneous study populations and insensitive endpoints of structural change,…
Abstract Number: 1315 • 2019 ACR/ARP Annual Meeting
Relation of MRI-detected Structural Damage in the Patellofemoral Joint to Pain and Performance Based Function: The MOST Study
Jessica Maxwell¹, Tuhina Neogi ², Kay Crossley ³, Erin Macri ⁴, Daniel White ⁵, Ali Guermazi ⁶, Frank Roemer ⁷, Michael Nevitt ⁸, Beth Lewis ⁹, James Torner ¹⁰ and Joshua Stefanik ¹¹, ¹Northeastern University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³La Trobe University, Victoria, Australia, ⁴Erasmus MC, Rotterdam, Netherlands, ⁵University of Delaware, Newark, DE, ⁶Boston Medical Center, Boston, ⁷University of Erlangen-Nuremberg, Erlangen, Germany, ⁸University of California at San Francisco, San Francisco, CA, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰University of Iowa at Iowa City, Iowa City, ¹¹Northeastern University, Boston
Background/Purpose: Osteoarthritis (OA) of the knee is one of the most common causes of disability in the U.S. Often overlooked, OA specific to the patellofemoral…
Abstract Number: 1946 • 2019 ACR/ARP Annual Meeting
Metabolic Regulation in Cybrids Obtained from Healthy and Osteoarthritic (OA) Patients: Impaired Metabolic Flexibility in OA Process
Andrea Dalmao-Fernández¹, Jenny Lund ², Tamara Hermida-Gómez ³, María E. Vázquez-Mosquera ¹, Ignacio Rego-Pérez ⁴, Francisco J. Blanco ⁴ and Mercedes Fernandez-Moreno ⁵, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain, ²Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway, ³Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain
Background/Purpose: Background: Osteoarthritis (OA) is the most frequent joint disease.The OA is a heterogeneous disorder. With acceptance of the joint as an organ, the pathogenesis…
Abstract Number: 2049 • 2019 ACR/ARP Annual Meeting
National Estimates of Pain Medication Use in Patients with Osteoarthritis
Mohammed Saeed¹, ¹Capital Health, Trenton, NJ
Background/Purpose: The epidemiology of pain medication use among patients with osteoarthritis is not well explored. Chronic kidney disease (CKD) modifies choice of analgesics. The aim…
Abstract Number: 2187 • 2019 ACR/ARP Annual Meeting
A Low Cartilage Formation & Repair Endotype Predicts Radiographic Progression in Symptomatic Knee Osteoarthritis Patients and Identifies Optimal Responders to a Potential OA Treatment
Yunyun Luo ¹, Jonathan Samuels ², Svetlana Krasnokutsky ³, Inger Byrjalsen ¹, Jeppe Andersen ⁴, Asger Bihlet ⁵, Yi He ¹, Morten Karsdal ⁶, Steven Abramson ⁷, Mukundan Attur ³ and Anne Bay-Jensen¹, ¹Nordic Bioscience, Herlev, Denmark, ²NYU Langone Medical Center, New Yort, NY, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Nordic Bioscience, Clinical development, Herlev, Denmark, ⁵Nordic Bioscience Clinical Development, Herlev, Denmark, ⁶Nordic Bioscience, Copenhagen, Denmark, ⁷NYU School of Medicine and NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: Osteoarthritis (OA) is a highly heterogeneous disease, which suggest that multiple endotypes exist. Identification and characterization of such endotypes may assist in precision medicine…
Abstract Number: 2759 • 2019 ACR/ARP Annual Meeting
Stopping NSAIDs for Arthritis Pain (SNAP): A Randomized Withdrawal Trial Comparing NSAIDs to Cognitive Behavioral Therapy
Liana Fraenkel¹, Eugenia Buta ², Joseph Goulet ³, Matthew Brennan ³, Alicia Heapy ³ and Lisa Suter ³, ¹Yale School of Medicine and VA Connecticut Healthcare System, New Haven, ²Yale University/VA CT Healthcare System, New Havne, ³Yale University/VA CT Healthcare System, New Haven
Background/Purpose: NSAIDs are associated with uncertain long-term benefits and significant toxicity in patients with knee osteoarthritis (OA). Our objective was to evaluate if discontinuing NSAIDs…
Abstract Number: 913 • 2019 ACR/ARP Annual Meeting
Depression as a Moderator of Analgesic Effectiveness in Knee Osteoarthritis
Alan Rathbun¹, Michelle Shardell ², Joseph Gallo ³, Alice Ryan ¹, Elizabeth Stuart ³, Megan Schuler ⁴, Michelle Yau ⁵ and Marc C. Hochberg ¹, ¹University of Maryland School of Medicine, Baltimore, MD, ²National Institute on Aging, Baltimore, MD, ³Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁴RAND Corporation, Boston, MA, ⁵Hebrew SeniorLife Institute for Aging Research, Boston, MA
Background/Purpose: Depression often accompanies knee osteoarthritis (OA), exacerbating the severity and persistence of pain, and may negatively affect clinical outcomes associated with analgesic treatment. This…
Abstract Number: 1316 • 2019 ACR/ARP Annual Meeting
Frail Patients Have Less Pain After Total Hip Replacement
Lisa Mandl¹, Charles Cornell ¹, Michael Cross ¹, Alejandro Gonzalez Della Valle ¹, Mark Figgie ¹, Seth Jerabek ¹, Marianna Frey ², John Roberts IV ³, Justin Do ³, Mayu Sasaki ³, Nathaniel Hupert ⁴, Jackie Finik ³ and Steven Magid ¹, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, ²Hospital for Special Surgery, New York, NY, New York, ³Hospital for Special Surgery, New York, NY, New York, NY, ⁴Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: To determine whether frailty is associated with patient outcomes 1 year after total hip replacement (THR).Methods: Patients ≥65yo scheduled for elective primary THR for…
Abstract Number: 1961 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative
Alejandro Duran-Sotuela¹, Mercedes Fernandez-Moreno ², María E. Vázquez-Mosquera ³, Paula Ramos-Louro ¹, Andrea Dalmao-Fernández ³, Sara Relaño ¹, Natividad Oreiro ¹, Francisco J. Blanco ¹ and Ignacio Rego-Pérez ¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain
Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in…
Abstract Number: 2056 • 2019 ACR/ARP Annual Meeting
Opioids Use Among Medicare Beneficiaries with Knee Osteoarthritis: Prevalence and Correlates of Chronic Use
Elena Losina¹, Shuang Song ² and Jeffrey Katz ³, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital/Harvard Medical School, Boston
Background/Purpose: Osteoarthritis (OA) of the knee is prevalent among Medicare beneficiaries. Effective pain control is critical for managing this chronic disease. In the last decade,…
Abstract Number: 2188 • 2019 ACR/ARP Annual Meeting
The Association of Plasma Fatty Acids Levels with Hand and Knee Osteoarthritis
Marieke Loef¹, Andreea Ioan-Facsinay ¹, Dennis O Mook-Kanamori ², Ko Willems van Dijk ¹, Renée de Mutsert ¹, Margreet Kloppenburg ¹ and Frits R Rosendaal ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity is one of the most important risk factors for osteoarthritis, and is strongly associated with increased levels of circulating fatty acids, which may…
Abstract Number: 2760 • 2019 ACR/ARP Annual Meeting
A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200-0 (Vehicle, No Capsaicin)
Michael Billard ¹, John Todhunter ¹, Margaret Fleming ¹, Tim Warneke¹, Yuhui Qiu ², Nhu Ly ², William Aronstein ² and William Moore ¹, ¹Vizuri Health Sciences, LLC, Columbia, MD, ²CTI Clinical Trial & Consulting, Covington, KY
Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal…

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