Abstracts tagged "Osteoarthritis"

Abstract Number: 1946 • 2019 ACR/ARP Annual Meeting
Metabolic Regulation in Cybrids Obtained from Healthy and Osteoarthritic (OA) Patients: Impaired Metabolic Flexibility in OA Process
Andrea Dalmao-Fernández¹, Jenny Lund ², Tamara Hermida-Gómez ³, María E. Vázquez-Mosquera ¹, Ignacio Rego-Pérez ⁴, Francisco J. Blanco ⁴ and Mercedes Fernandez-Moreno ⁵, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain, ²Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway, ³Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain
Background/Purpose: Background: Osteoarthritis (OA) is the most frequent joint disease.The OA is a heterogeneous disorder. With acceptance of the joint as an organ, the pathogenesis…
Abstract Number: 2049 • 2019 ACR/ARP Annual Meeting
National Estimates of Pain Medication Use in Patients with Osteoarthritis
Mohammed Saeed¹, ¹Capital Health, Trenton, NJ
Background/Purpose: The epidemiology of pain medication use among patients with osteoarthritis is not well explored. Chronic kidney disease (CKD) modifies choice of analgesics. The aim…
Abstract Number: 2187 • 2019 ACR/ARP Annual Meeting
A Low Cartilage Formation & Repair Endotype Predicts Radiographic Progression in Symptomatic Knee Osteoarthritis Patients and Identifies Optimal Responders to a Potential OA Treatment
Yunyun Luo ¹, Jonathan Samuels ², Svetlana Krasnokutsky ³, Inger Byrjalsen ¹, Jeppe Andersen ⁴, Asger Bihlet ⁵, Yi He ¹, Morten Karsdal ⁶, Steven Abramson ⁷, Mukundan Attur ³ and Anne Bay-Jensen¹, ¹Nordic Bioscience, Herlev, Denmark, ²NYU Langone Medical Center, New Yort, NY, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Nordic Bioscience, Clinical development, Herlev, Denmark, ⁵Nordic Bioscience Clinical Development, Herlev, Denmark, ⁶Nordic Bioscience, Copenhagen, Denmark, ⁷NYU School of Medicine and NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: Osteoarthritis (OA) is a highly heterogeneous disease, which suggest that multiple endotypes exist. Identification and characterization of such endotypes may assist in precision medicine…
Abstract Number: 2759 • 2019 ACR/ARP Annual Meeting
Stopping NSAIDs for Arthritis Pain (SNAP): A Randomized Withdrawal Trial Comparing NSAIDs to Cognitive Behavioral Therapy
Liana Fraenkel¹, Eugenia Buta ², Joseph Goulet ³, Matthew Brennan ³, Alicia Heapy ³ and Lisa Suter ³, ¹Yale School of Medicine and VA Connecticut Healthcare System, New Haven, ²Yale University/VA CT Healthcare System, New Havne, ³Yale University/VA CT Healthcare System, New Haven
Background/Purpose: NSAIDs are associated with uncertain long-term benefits and significant toxicity in patients with knee osteoarthritis (OA). Our objective was to evaluate if discontinuing NSAIDs…
Abstract Number: 913 • 2019 ACR/ARP Annual Meeting
Depression as a Moderator of Analgesic Effectiveness in Knee Osteoarthritis
Alan Rathbun¹, Michelle Shardell ², Joseph Gallo ³, Alice Ryan ¹, Elizabeth Stuart ³, Megan Schuler ⁴, Michelle Yau ⁵ and Marc C. Hochberg ¹, ¹University of Maryland School of Medicine, Baltimore, MD, ²National Institute on Aging, Baltimore, MD, ³Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁴RAND Corporation, Boston, MA, ⁵Hebrew SeniorLife Institute for Aging Research, Boston, MA
Background/Purpose: Depression often accompanies knee osteoarthritis (OA), exacerbating the severity and persistence of pain, and may negatively affect clinical outcomes associated with analgesic treatment. This…
Abstract Number: 1316 • 2019 ACR/ARP Annual Meeting
Frail Patients Have Less Pain After Total Hip Replacement
Lisa Mandl¹, Charles Cornell ¹, Michael Cross ¹, Alejandro Gonzalez Della Valle ¹, Mark Figgie ¹, Seth Jerabek ¹, Marianna Frey ², John Roberts IV ³, Justin Do ³, Mayu Sasaki ³, Nathaniel Hupert ⁴, Jackie Finik ³ and Steven Magid ¹, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, ²Hospital for Special Surgery, New York, NY, New York, ³Hospital for Special Surgery, New York, NY, New York, NY, ⁴Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: To determine whether frailty is associated with patient outcomes 1 year after total hip replacement (THR).Methods: Patients ≥65yo scheduled for elective primary THR for…
Abstract Number: 1961 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative
Alejandro Duran-Sotuela¹, Mercedes Fernandez-Moreno ², María E. Vázquez-Mosquera ³, Paula Ramos-Louro ¹, Andrea Dalmao-Fernández ³, Sara Relaño ¹, Natividad Oreiro ¹, Francisco J. Blanco ¹ and Ignacio Rego-Pérez ¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain
Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in…
Abstract Number: 2056 • 2019 ACR/ARP Annual Meeting
Opioids Use Among Medicare Beneficiaries with Knee Osteoarthritis: Prevalence and Correlates of Chronic Use
Elena Losina¹, Shuang Song ² and Jeffrey Katz ³, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital/Harvard Medical School, Boston
Background/Purpose: Osteoarthritis (OA) of the knee is prevalent among Medicare beneficiaries. Effective pain control is critical for managing this chronic disease. In the last decade,…
Abstract Number: 2188 • 2019 ACR/ARP Annual Meeting
The Association of Plasma Fatty Acids Levels with Hand and Knee Osteoarthritis
Marieke Loef¹, Andreea Ioan-Facsinay ¹, Dennis O Mook-Kanamori ², Ko Willems van Dijk ¹, Renée de Mutsert ¹, Margreet Kloppenburg ¹ and Frits R Rosendaal ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity is one of the most important risk factors for osteoarthritis, and is strongly associated with increased levels of circulating fatty acids, which may…
Abstract Number: 2760 • 2019 ACR/ARP Annual Meeting
A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200-0 (Vehicle, No Capsaicin)
Michael Billard ¹, John Todhunter ¹, Margaret Fleming ¹, Tim Warneke¹, Yuhui Qiu ², Nhu Ly ², William Aronstein ² and William Moore ¹, ¹Vizuri Health Sciences, LLC, Columbia, MD, ²CTI Clinical Trial & Consulting, Covington, KY
Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal…
Abstract Number: 1129 • 2019 ACR/ARP Annual Meeting
Direct Medical and Societal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States
Jamie Huizinga¹, Elizabeth Stanley ¹, Shuang Song ¹, James Sullivan ², Jeffrey Katz ³ and Elena Losina ⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital/Harvard Medical School, Boston, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Symptomatic knee OA affects 14 million adults in the US. Recent estimates suggest that about 40% of people with knee OA are taking prescription…
Abstract Number: 1317 • 2019 ACR/ARP Annual Meeting
Frail Patients Have Worse Function After Total Knee Replacement
Lisa Mandl¹, Charles Cornell ¹, Michael Cross ¹, Alejandro Gonzalez Della Valle ¹, Mark Figgie ¹, Seth Jerabek ¹, Marianna Frey ², John Roberts IV ³, Justin Do ³, Mayu Sasaki ³, Nathaniel Hupert ⁴, Jackie Finik ³ and Steven Magid ¹, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, ²Hospital for Special Surgery, New York, NY, New York, ³Hospital for Special Surgery, New York, NY, New York, NY, ⁴Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: To determine whether frailty is associated with patient outcomes 1 year after total knee replacement (TKR).Methods: Patients ≥65yo scheduled for elective primary TKR for…
Abstract Number: 1968 • 2019 ACR/ARP Annual Meeting
A Drug Repurposing Story: New Therapeutic Tools Ready to Block Innate Immune Responses in Osteoarthritis
Eloi Franco-Trepat¹, Ana Alonso-Pérez ¹, Maria Guillán-Fresco ¹, Alberto Jorge-Mora ², Ana Lois Iglesias ³, Oreste Gualillo ⁴ and Rodolfo Gómez ¹, ¹Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, ²Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, ³Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Galicia, Spain, ⁴Institute IDIS - NEIRID Lab - SERGAS, Santiago de Compostela, Spain
Background/Purpose: Rheumatic diseases, also known as musculoskeletal pathologies, are steadily rising their prevalence. This worldwide phenomenon is depriving our society of their life quality and…
Abstract Number: 2057 • 2019 ACR/ARP Annual Meeting
Cross-sectional Associations of Multiple Joint Osteoarthritis in the Osteoarthritis Initiative
Charles Eaton¹, Mary Roberts ², Jeffrey Driban ³, Michael Nevitt ⁴, Jeffrey Duryea ⁵ and Timothy McAlindon ⁶, ¹Warren Alpert Medical School of Brown University, Pawtucket, RI, ²Center for Primary Care and Prevention, Pawtucket, ³Tufts Medical Center, Boston, ⁴University of California at San Francisco, San Francisco, CA, ⁵Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA, ⁶Tufts Medical Center, Boston, MA
Background/Purpose: Multiple joint osteoarthritis (MJOA) may represent a unique phenotype of osteoarthritis related to systemic factors associated with pathologic aging. We tested the hypothesis that metabolic…
Abstract Number: 2189 • 2019 ACR/ARP Annual Meeting
Reference Curves for the Knee Injury and Osteoarthritis Outcome Score in the Middle-aged Dutch Population
Marieke Loef¹, Féline PB Kroon ¹, Stephan Böhringer ¹, Frits R Rosendaal ¹ and Margreet Kloppenburg ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
Background/Purpose: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire is a widely used patient-reported outcome tool, developed to evaluate short- and long-term knee symptoms…

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