Abstracts tagged "Osteoarthritis"

Abstract Number: 2801 • 2019 ACR/ARP Annual Meeting
Optimal Threshold of Walking Speed Predictive of Mortality Risk over 9 Years in Knee Osteoarthritis: Data from Osteoarthritis Initiative
Hiral Master¹, Tuhina Neogi ², Lavalley Michael ³, Louise Thoma ⁴, Meredith Christiansen ⁵, Dana Voinier ⁵, Lauren Neely ⁵, Jason Jakiela ⁵ and Daniel White ¹, ¹University of Delaware, Newark, DE, ²Boston University School of Medicine, Boston, MA, ³Boston University, Boston, ⁴University of North Carolina at Chapel Hill, Newark, ⁵University of Delaware, Newark
Background/Purpose: Knee osteoarthritis (OA) is associated with mortality, and walking difficulty is known to mediate this relationship. However, little is known about what specific aspects…
Abstract Number: 1300 • 2019 ACR/ARP Annual Meeting
Predictor of Placebo Response in Hand Osteoarthritis: A Post Hoc Analysis of Two Randomized Controlled Trials
Se Han Ahn¹, Jin Kyun Park ², Kichul Shin ³, Yun Jong Lee ⁴, Yeong-Wook Song ⁵, Yunhee Choi ⁶ and Eun Bong Lee ⁷, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Gwacheon-si, Kyonggi-do, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, Republic of Korea, ³Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea., seoul, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea, ⁶Division of Medical Statistics, Medical Research Collaborating Center, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea., seoul, Republic of Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul
Background/Purpose: Osteoarthritis (OA) in hands is common in middle-aged and elderly population. The mainstay treatment of hand OA is to control the symptoms with a combination of non-pharmacological and…
Abstract Number: 1322 • 2019 ACR/ARP Annual Meeting
Evaluation of Intra-articular CNTX-4975 in Subjects with Painful Bilateral Knee Osteoarthritis: Effects on Pain with Walking and Patient Impression of Change in Pain
Randall Stevens ¹, Kimberly Guedes ¹, Nilam Mistry ¹, Paul Tiseo ², Duncan Lascelles ³, Mario Mendoza¹ and David Ball ⁴, ¹Centrexion Therapeutics Corp, Boston, MA, ²Centrexion Therapeutics Corp, Boston, ³Translational Research in Pain, North Carolina State University, Raleigh, NC, ⁴MAC Clinical Research, Manchester, United Kingdom
Background/Purpose: A double-blind, randomized, placebo-controlled trial (TRIUMPH; NCT02558439) with a single 1 mg intra-articular (IA) injection of CNTX-4975 (highly purified trans-capsaicin) into one knee for…
Abstract Number: 1975 • 2019 ACR/ARP Annual Meeting
Fibrates as Drugs with Senolytic and Autophagic Activity for Osteoarthritis Treatment
Uxia Nogueira-Recalde¹, Irene Lorenzo-Gomez ², Francisco J. Blanco ³, María I. Loza ⁴, Diego Grassi ⁵, Valery Shirinsky ⁶, Ivan Shirinsky ⁶, martin lotz ⁷, Paul D. Robbins ⁸, Eduardo Domínguez ⁴ and Beatriz Carames ², ¹Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, ²Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruna, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, Spain, ⁵Institute for Interdisciplinary Neuroscience (IINS), Bordeaux, Nouvelle-Aquitaine, France, Bordeaux, France, ⁶Scientific Research Institute of Clinical immunology, Novosibirsk, Rusia, Novosibirsk, Russia, ⁷Department of Molecular Medicine. Scripps Research, La Jolla, CA, USA, La Jolla, CA, ⁸Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN
Background/Purpose: . Increasing evidence suggest that osteoarthritis (OA) is associated with hallmarks of ageing, including cellular senescence or defective autophagy, that could promote disease onset.…
Abstract Number: 2175 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Ascending Doses of the Anti-ADAMTS-5 Nanobody®, M6495, in Healthy Male Subjects: A Phase I, Placebo-Controlled, First-in-Human Study
Hans Guehring¹, Torben Balchen ², Kosalaram Goteti ³, Jesper Sonne ⁴, Christoph Ladel ¹, Victor Ona ¹, Flavie Moreau ⁵, Anne Bay-Jensen ⁶ and Asger Reinstrup Bihlet ⁶, ¹Merck KGaA, Darmstadt, Germany, ²DanTrials ApS c/o Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ³EMD Serono Research and Development Institute, Inc., Billerica, MA, ⁴Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ⁵EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁶Nordic Bioscience, Herlev, Denmark
Background/Purpose: Osteoarthritis (OA) is a serious disease characterized by progressive joint failure and cartilage degeneration. In OA, ADAMTS-5 protease is upregulated, resulting in enhanced cleavage…
Abstract Number: 2196 • 2019 ACR/ARP Annual Meeting
Machine Learning Defines the Relationship Between Structural Knee Osteoarthritis and Patient-Important Outcomes: An 8-year Study of 47,858 Knee MRIs from the Osteoarthritis Initiative (OAI)
Michael Bowes¹, Katherine Kacena ², Oras Alabas ³, Alan Brett ¹, Bright Dube ⁴, Neil Bodick ⁵ and Philip G Conaghan ⁶, ¹Imorphics, Manchester, England, United Kingdom, ²BioBridges, Wellesley Hills, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁴University of Leeds, LEEDS, England, United Kingdom, ⁵Flexion Therapeutics, Burlington, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Osteoarthritis (OA) is a slowly progressing disease which may be asymptomatic for many years. Therapy development has been hampered by poor understanding of both…
Abstract Number: 2802 • 2019 ACR/ARP Annual Meeting
High Intensity Interval Training for Knee Osteoarthritis: A Pilot Study
Yvonne Golightly¹, Carolina Alvarez ², Malia Blue ³, Kelli Allen ³, Amanda Nelson ³ and Abbie Smith-Ryan ³, ¹University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Physical activity reduces pain and increases physical function in people with knee osteoarthritis (OA), but few achieve recommended levels of physical activity because of…
Abstract Number: 219 • 2019 ACR/ARP Annual Meeting
A Fibromyalgia Assessment Screening Tool on a Multidimensional Health Assessment Questionnaire (MDHAQ) Which Does Not Include a Self-Report RADAI Painful Joint Count (RADAI), FAST3nJC, Recognizes Fibromyalgia Similarly to Other FAST3 Indices Which Include a RADAI
Theodore Pincus¹, Isabel Castrejon ² and Joel Block ², ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL
Background/Purpose: Fibromyalgia (FM) generally is easily recognized, but a diagnosis may be difficult, particularly in patients with secondary FM who have other primary diagnoses. Criteria…
Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting
Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts
C. Kent Kwoh¹, Amanda Nelson ², Yvonne Golightly ³, Erin Ashbeck ⁴, Liubov Arbeeva ⁵, Na Wang ⁶, Jeffrey Duryea ⁷ and Tuhina Neogi ⁶, ¹University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁴The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁵University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ⁶Boston University School of Medicine, Boston, MA, ⁷Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…
Abstract Number: 1323 • 2019 ACR/ARP Annual Meeting
Autologous Conditioned Serum and Plasma Rich in Growth Factors Show Stronger Evidence of Efficacy Than Other Kinds of Platelet-Rich Plasma
Lilian SOLE¹, Arthur Beck ¹, Thomas Barnetche ² and Pascale Vergne-Salle ³, ¹CHU de Limoges, LIMOGES, France, ²CHU, Toulouse, France, ³CHU limoges, Limoges, France
Background/Purpose: While there is growing evidences for the efficacy of platelet-rich plasma (PRP), there is still no standardized composition. There are 3 major types of…
Abstract Number: 1976 • 2019 ACR/ARP Annual Meeting
Regulation of Interleukin-1β (IL-1β)-induced COX-2 Expression and IL-6 and MMP-1 Production in Human OA Synovial Fibroblasts by Guanylate Binding Protein 5
Mahamudul Haque¹, Madeline McDougal ¹, Anil Singh ¹ and Salahuddin Ahmed ², ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, SPOKANE, WA, ²Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA. Division of Rheumatology, University of Washington School of Medicine, Seattle, WA, Spokane, WA
Background/Purpose: Osteoarthritis (OA) is a chronic degenerative joint disease caused by synovial inflammation and cartilage degradation primarily driven by interleukin-1beta (IL-1β). Studies suggest that TNF-stimulated…
Abstract Number: 2176 • 2019 ACR/ARP Annual Meeting
A Novel Composite Score Reflecting Disease Activity Predicts Future Knee Replacements: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Matthew Harkey ², Lori Lyn Price ³, Grace Lo ⁴, Jincheng Pang ⁵, Ming Zhang ⁶ and Timothy McAlindon ¹, ¹Tufts Medical Center, Boston, MA, ²Tufts Medical Center, University of Massachusetts Medical School, Boston, MA, ³Tufts Medical Center, Tufts University, Boston, MA, ⁴Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁵Pfizer, Inc., Cambridge, MA, ⁶Tufts Medical Center, Wentworth Institute of Technology, Boston, MA
Background/Purpose: While knee osteoarthritis (KOA) leads to cumulative damage to a diarthrodial joint there are also more dynamic processes that fluctuate throughout the disease process…
Abstract Number: 2199 • 2019 ACR/ARP Annual Meeting
Is There an Association of Serum LDL, HDL and Total Cholesterol with the Development of Knee Osteoarthritis?
Jessica Barlow¹, Xianbang Sun ², Michael Nevitt ³, James Torner ⁴, Beth Lewis ⁵, Nirupa Matthan ⁶, Alice Lichtenstein ⁶ and David Felson ⁷, ¹Boston University School of Medicine, Department of Rheumatology, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of California at San Francisco, San Francisco, CA, ⁴University of Iowa at Iowa City, Iowa City, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Tufts University, Boston, MA, ⁷Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Recent data have suggested an association between elevated serum cholesterol levels, particularly low density lipoprotein (LDL), and the development of osteoarthritis (OA). Within the…
Abstract Number: 2891 • 2019 ACR/ARP Annual Meeting
Cost-effectiveness of Duloxetine for Knee OA Patients Whose Pain Can’t Be Controlled by NSAIDs
James Sullivan¹, Jeffrey Katz ² and Elena Losina ³, ¹Brigham and Women's Hospital, Boston, ²Brigham and Women's Hospital/Harvard Medical School, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Knee OA is a disabling condition affecting over 14 million adults in the US. NSAIDs provide only short-term pain relief, creating the need for…
Abstract Number: 269 • 2019 ACR/ARP Annual Meeting
Attitudes and Beliefs About Opioid Medications: Determining Treatment Use in Osteoarthritis
Ernest Vina¹, Jazmin Dagnino ¹ and C. Kent Kwoh ¹, ¹University of Arizona, Tucson, AZ
Background/Purpose: Considering the growing opioid epidemic in the US, it is imperative to have a good understanding of what patient characteristics predict the use of…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].