Abstract Number: 1968 • 2019 ACR/ARP Annual Meeting
A Drug Repurposing Story: New Therapeutic Tools Ready to Block Innate Immune Responses in Osteoarthritis
Background/Purpose: Rheumatic diseases, also known as musculoskeletal pathologies, are steadily rising their prevalence. This worldwide phenomenon is depriving our society of their life quality and…Abstract Number: 2057 • 2019 ACR/ARP Annual Meeting
Cross-sectional Associations of Multiple Joint Osteoarthritis in the Osteoarthritis Initiative
Background/Purpose: Multiple joint osteoarthritis (MJOA) may represent a unique phenotype of osteoarthritis related to systemic factors associated with pathologic aging. We tested the hypothesis that metabolic…Abstract Number: 2189 • 2019 ACR/ARP Annual Meeting
Reference Curves for the Knee Injury and Osteoarthritis Outcome Score in the Middle-aged Dutch Population
Background/Purpose: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire is a widely used patient-reported outcome tool, developed to evaluate short- and long-term knee symptoms…Abstract Number: 2762 • 2019 ACR/ARP Annual Meeting
The Preparation and Recovery Experience from Total Knee Replacement of Patients with Osteoarthritis: A Qualitative Study
Background/Purpose: Up to 30% of patients may have persistent pain post-total knee arthroplasty (TKA). One possible approach to improve these outcomes is to optimize muscle…Abstract Number: 1139 • 2019 ACR/ARP Annual Meeting
Lifetime Direct Medical and Indirect Cost of Knee Osteoarthritis: Impact of Pain and Structural Severity
Background/Purpose: Symptomatic knee OA is a debilitating condition that affects 14 million adults in the US. We estimated the variability of lifetime OA-related direct and…Abstract Number: 1319 • 2019 ACR/ARP Annual Meeting
Impact of ACL Injury Management on the Development of Knee Osteoarthritis: A Meta-analysis
Background/Purpose: Background: The development of knee's osteoarthritis after anterior cruciate ligament ACL injury is now widely recognized. The impact of surgical or rehabilitative management on…Abstract Number: 1970 • 2019 ACR/ARP Annual Meeting
Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic…Abstract Number: 2083 • 2019 ACR/ARP Annual Meeting
Understanding Knee Function and Symptom Management in Individuals with Risk Factors for Knee Osteoarthritis
Background/Purpose: Worse knee function and frequent use of knee symptom management strategies are common in people with symptomatic knee osteoarthritis (SxOA). There are several risk…Abstract Number: 2191 • 2019 ACR/ARP Annual Meeting
Construct Validity of OMERACT Ultrasound Knee Scores with Pain, Other Symptoms, Radiographic and MRI Findings
Background/Purpose: To investigate the construct validity of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain, other symptoms, and OA severity…Abstract Number: 2794 • 2019 ACR/ARP Annual Meeting
Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis predict the incidence and worsening of lumbar spine disc space narrowing…Abstract Number: 1162 • 2019 ACR/ARP Annual Meeting
Changes in Novel Composite Scores of Disease Activity and Cumulative Damage Are Prognostic of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Background/Purpose: Composite imaging scores that reflect cartilage damage, bone marrow lesions (BMLs), and effusion-synovitis may enable us to conceptualize knee osteoarthritis (KOA) disease progression as…Abstract Number: 1320 • 2019 ACR/ARP Annual Meeting
Individual Socio-economic Status and Symptomatic Hip and Knee Osteoarthritis: A Longitudinal Study, Results from the KHOALA Cohort
Background/Purpose: We analyzed the association between individual socio-economic status (SES) variables and clinical symptoms (function, pain and quality of life) in patients with symptomatic knee…Abstract Number: 1972 • 2019 ACR/ARP Annual Meeting
Identification of Distinct Lipidomic Profiles in Synovial Membranes from Inflammatory Arthritis by Mass Spectrometry Imaging
Background/Purpose: Early diagnosis of inflammatory arthritis is associated with improved patient outcomes. However, accurate diagnosis can be challenging because of their complexity and heterogeneous nature.…Abstract Number: 2089 • 2019 ACR/ARP Annual Meeting
Restricting Activity to Evade Knee Symptoms Is Associated with Worse Physical Function and Radiographic Osteoarthritis
Background/Purpose: Activity restriction (i.e. limiting or avoiding normal activity) is a common strategy to reduce, and sometimes eliminate, knee symptoms. Knee symptoms, such as pain,…Abstract Number: 2192 • 2019 ACR/ARP Annual Meeting
Stabilization of Patellar Bone-Shape Correlates Significantly with Reduced Knee Pain Frequency After IA TPX-100 in Subjects with Bilateral Patellofemoral OA
Background/Purpose: Based on data from the Osteoarthritis Initiative (OAI), MRI-based analyses of bone shape changes in the knee predict symptomatic and radiographic progression of knee…
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