Abstracts tagged "Osteoarthritis"

Abstract Number: 1972 • ACR Convergence 2020
NGF-Responsive Neurons Are Sensitized in Experimental Osteoarthritis
Rachel Miller¹, Shingo Ishihara¹, Alia Obeidat¹ and Anne-Marie Malfait¹, ¹Rush University, Chicago, IL
Background/Purpose: Nerve growth factor (NGF) is under investigation as a promising target for osteoarthritis (OA) pain. NGF exerts its potent pro-algesic effects through sensitization of…
Abstract Number: 0081 • ACR Convergence 2020
Prevalence of Systemic Autoimmune Diseases in Polycystic Ovary Syndrome
Saika Sharmeen¹, Hafsa Nomani², Erin Taub³ and Qingping Yao³, ¹Stony Brook University Renaissance School of Medicine, Dix Hills, NY, ²Stony Brook University Renaissance School of Medicine, West Babylon, NY, ³Stony Brook University Renaissance School of Medicine, Stony Brook, NY
Background/Purpose: Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormality, chronic anovulation, hyperandrogenism, and obesity. Due to the hormonal imbalance, we hypothesize that patients with…
Abstract Number: 0609 • ACR Convergence 2020
Impact of Depressive Symptoms, Anti-depression Treatment on Direct Medical Costs Among Medicare Beneficiaries with Knee Osteoarthritis (KOA)
Shuang Song¹, Jeffrey Katz² and Elena Losina², ¹Brigham and Women's Hospital, Brighton, MA, ²Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA
Background/Purpose: Depressive symptoms are prevalent among knee OA (KOA) patients and likely lead to additional medical costs. We sought to quantify the prevalence of depressive…
Abstract Number: 0934 • ACR Convergence 2020
Warfarin Use and Risk of Knee and Hip Replacements
Priyanka Ballal¹, Christine Peloquin¹, Cindy Boer² and Tuhina Neogi¹, ¹Boston University School of Medicine, Boston, MA, ²Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Vitamin K is an essential co-factor in the post-translational gamma-carboxylation of glutamic acid to form gamma-carboxy-glutamic acid (Gla) residues. This confers functionality to vitamin…
Abstract Number: 1111 • ACR Convergence 2020
Intra-Articular Mineralization on Knee CT Increases Risk of Knee Pain: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, John Lynch², Mohamed Jarraya³, David Felson¹, Na Wang¹, James Torner⁴, Cora Lewis⁵, Michael Nevitt⁶ and Ali Guermazi¹, ¹Boston University School of Medicine, Boston, MA, ²UCSF, San Francisco, CA, ³Boston University School of Medicine, Boston, ⁴University of Iowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA). Low-grade inflammation related to crystals may contribute to knee pain, including pain fluctuation.…
Abstract Number: 1458 • ACR Convergence 2020
Slower Current Walking Speed Is Associated with Progression in Radiographic Knee Osteoarthritis: The Johnston County Osteoarthritis Project
Lindsey Duca¹, Liubov Arbeeva², Yvonne Golightly³, Louise Murphy⁴, Charles Helmick⁴ and Kamil Barbour⁵, ¹Centers for Disease Control and Prevention, Chamblee, GA, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Dept of Epidemiology, Chapel Hill, NC, ⁴Centers for Disease Control and Prevention, Atlanta, GA, ⁵CDC, Atlanta, GA
Background/Purpose: Poorer physical functioning as a single baseline measurement has been associated with increased risk of radiographic knee osteoarthritis (rKOA) progression, but it is unknown…
Abstract Number: 1549 • ACR Convergence 2020
Joint Damage and Malalignment Determine Articular Tenderness More Than Inflammation in Rheumatoid Arthritis, Psoriatic Arthritis or Osteoarthritis in Established Disease
Mihaela Popescu¹, Victoria Schimpl², Gabriela Supp³, Martina Durechova³, Paul Studenic³, Michael Zauner³, Josef Smolen³, Daniel Aletaha⁴, Peter Mandl³ and Irina Gessl³, ¹Hôpital Maisonneuve-Rosemont, Montreal, Canada, ²Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria, ⁴Division of Rheumatology, Department of Medicine III, Medical University of Vienna,, Vienna, Austria
Background/Purpose: To determine whether clinical tenderness can be considered a sign of inflammatory joint activity in patients with rheumatoid arthritis (RA), osteoarthritis (OA) or psoriatic…
Abstract Number: 1653 • ACR Convergence 2020
Bilateral vs Unilateral Total Knee Arthroplasty: Racial Variation in Utilization and In-Hospital Major Complication Rates
Bella Mehta¹, Kaylee Ho², Jennifer Bido³, Stavros Memtsoudis³, Michael Parks⁴, Susan Goodman¹, Linda Russell⁵ and Said Ibrahim⁶, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Weill Cornell Medicine, New York, ³Hospital for Special Surgery, New York, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁶Weill Cornell Medicine, Cleveland, OH
Background/Purpose: Compared to White Patients, African Americans (AAs) are reported to have lower utilization and higher complication rates outcomes in Unilateral Total knee arthroplasty (UTKA).…
Abstract Number: 0099 • ACR Convergence 2020
Interleukin 6 Concentration in Synovial Fluid of Patients with Different Types of Arthritis
Aleksandra Bukina¹ and Anna Mihailova¹, ¹Rigas Stradins university, Riga, Latvia
Background/Purpose: Persistent synovitis without known markers such as rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) as well as without genetic markers as HLAB27 is not…
Abstract Number: 0628 • ACR Convergence 2020
Factors Associated with Knee Osteoarthritis in an Outpatient HIV-1 Clinic over a 26 Year Interval
Benjamin Naovarat¹, Francis Williams¹, Jonathan Dau², Marka Lyons³, Binh Nguyen⁴, Gloria Salazar³ and John Reveille⁵, ¹The University of Texas McGovern Medical School, Houston, TX, ²Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³University of Texas Houston, McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, ⁴The University of Texas-McGovern Medical School, Houston, TX, ⁵Department of Internal Medicine, University of Texas, Houston, TX
Background/Purpose: With the advent of combined antiretroviral therapy (cART), patients with HIV-1 began living longer and started to develop diseases associated with aging such as…
Abstract Number: 0960 • ACR Convergence 2020
The Risk of Venous Thromboembolism After Septic Total Knee Replacement (TKR) Revision Is Double the Risk After Aseptic TKR Revision: An Analysis of Administrative Discharge Data
Anne Bass¹, Bella Mehta¹, Peter Sculco¹, Yi Zhang², Huong Do², Linda Russell¹ and Susan Goodman³, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Infection can trigger coagulation pathways and increase the risk of thrombosis. However, the impact of infection on postoperative venous thromboembolism (VTE) risk is poorly…
Abstract Number: 1112 • ACR Convergence 2020
Relationship of Depth-Specific Subchondral Bone Mineral Density and Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Jean Liew¹, JD Johnston², Na Wang³, John Lynch⁴, Cora Lewis⁵, James Torner⁶ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Saskatchewan, Saskatoon, SK, Canada, ³Boston University School of Medicine, Boston, MA, ⁴UCSF, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA
Background/Purpose: OA has traditionally been considered a disease of cartilage but early OA changes in subchondral bone may precede cartilage abnormalities. Altered subchondral bone mineral…
Abstract Number: 1459 • ACR Convergence 2020
The Association of Frequent Knee Bending with Trajectories of Pain and Physical Function over 8 Years in Knee Osteoarthritis
Jason Jakiela¹, Dana Voinier¹, Thomas Bye¹, Maria Tukis¹, Kiely Konyak¹, Dylan Orloff¹ and Daniel White¹, ¹University of Delaware, Newark, DE
Background/Purpose: Frequent bending increases loading at the knee and is a risk factor for worsening knee pain associated with knee osteoarthritis (OA). Knee bending is…
Abstract Number: 1564 • ACR Convergence 2020
Feasibility of Ultra-low-dose, Short-duration, Total-body Evaluation of Inflammatory Arthritis Using uEXPLORER 18F-FDG PET/CT
Soumajyoti Sarkar¹, Siba Raychaudhuri², Lorenzo Nardo³, Heather Hunt³, Denise Caudle⁴, Mike Nguyen⁴, Simon Cherry⁴, Ramsey Badawi⁴, Abhijit Chaudhari⁵ and Yasser Abdelhafez³, ¹University of California, Davis, Davis, ²Division of Rheumatology, Allergy & Clinical Immunology, University of California School of Medicine, Davis, and VA Medical Center Sacramento, Sacramento, CA, ³University of California Davis, Sacramento, CA, ⁴University of California Davis, Sacramento, ⁵University of California, Davis, Sacramento, CA
Background/Purpose: The uEXPLORER system enables the unique, simultaneous acquisition of PET data over the entire adult human body with a high-sensitivity, alongside concurrent CT data.…
Abstract Number: 1654 • ACR Convergence 2020
The Relationship Between Patient-Reported Readiness for Total Knee Arthroplasty and the Likelihood of a Good Outcome at One Year
Gillian Hawker¹, Barbara Conner-Spady², Eric Bohm³, Michael Dunbar⁴, Allyson Jones⁵, Bheeshma Ravi¹, Tom Noseworthy², Linda Woodhouse⁶, Peter Faris⁷, Donald Dick⁸, James Powell², Paulose Paul⁵ and Deborah Marshall², ¹University of Toronto, Toronto, ON, Canada, ²University of Calgary, Calgary, AB, Canada, ³Concordia Hip & Knee Institute, University of Manitoba, Winnipeg, MB, Canada, ⁴Dalhousie University, Halifax, NS, Canada, ⁵University of Alberta, Edmonton, AB, Canada, ⁶Curtin University, Perth, Western Australia, Australia, ⁷Alberta Health Services, Calgary, ON, Canada, ⁸Alberta Bone and Joint Health Institute, Edmonton, AB, Canada
Background/Purpose: In prior qualitative research, we found that patients with knee osteoarthritis (OA) equated appropriateness for total knee arthroplasty (TKA) with candidacy for the procedure.…

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