Abstracts tagged "Osteoarthritis"

Abstract Number: 0707 • ACR Convergence 2020
Contribution of NOTUM and Glypicans to the Development of Osteoarthritis
Arkaitz Mucientes¹, Eva Herranz¹, Pia Lois², Gloria Candelas², Lydia Abasolo¹, Luis Rodriguez-Rodriguez¹, Jose Ramon Lamas¹ and Benjamin Fernandez-Gutierrez³, ¹IdISSC, Madrid, Madrid, Spain, ²Hospital Clínico San Carlos, Madrid, Madrid, Spain, ³Hospital Clínico San Carlos / IdISSC, Madrid, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts,…
Abstract Number: 1107 • ACR Convergence 2020
IL1RN Polymorphism Predicts Weight Loss, Inflammatory Biomarker Changes and Knee Osteoarthritis Pain Relief After Bariatric Surgery
Jonathan Samuels¹, Fernando Bomfim², Mukundan Attur³, Christine Ren-Fielding⁴, Manish Parikh⁵, Renata La Rocca-Vieira⁶ and Steven B. Abramson⁷, ¹NYU Langone, Rye Brook, NY, ²New York University, Department of Medicine, Division of Rheumatology, Millburn, NJ, ³NYU Langone Health, New York, NY, ⁴NYU Langone Health, New YOrk, ⁵Bellevue Hospital, New York, NY, ⁶NYU, New YOrk, ⁷New York University School of Medicine, New York, NY
Background/Purpose: Symptomatic knee osteoarthritis (SKOA) patients with obesity who undergo bariatric surgery experience knee pain relief, though the reduced mechanical load explains only part of…
Abstract Number: 1123 • ACR Convergence 2020
The Patient Journey in Knee OA: Variations in Patient Characteristics and Treatment by Physician Specialty
Angela Bedenbaugh¹, Vinson Lee¹, Gary Oderda², Sarah Kennedy¹, Diana Brixner², Jeyanesh Tambiah³ and Timothy McAlindon⁴, ¹Samumed, LLC, San Diego, CA, ²University of Utah, Salt Lake City, UT, ³Samumed LLC, San Diego, CA, ⁴Tufts Medical Center, Boston, MA
Background/Purpose: Knee osteoarthritis (OA) affects 32.5 million US adults and is typically treated by primary care physicians, rheumatologists (RH), orthopedists (OS), sports medicine (SM) physicians,…
Abstract Number: 1489 • ACR Convergence 2020
Relation of Pain Mechanisms to Development of Knee Pain in Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Na Wang¹, Kosaku Aoyagi¹, Laura Frey Law², Cora Lewis³, Michael Nevitt⁴ and Lisa Carlesso⁵, ¹Boston University School of Medicine, Boston, MA, ²University of Iowa, Iowa City, IA, ³University of Alabama Birmingham, Birmingham, AL, ⁴University of California, San Francisco, San Francisco, CA, ⁵McMaster University, Hamilton, ON, Canada
Background/Purpose: Whether altered nociceptive signaling, such as pain sensitization and abnormal descending pain modulation, impact the risk of developing knee pain, more pain severity, and/or…
Abstract Number: 1649 • ACR Convergence 2020
Effect of Knee Aspiration and Intra-articular Corticosteroid Injection on Gait Biomechanics and Strength Impairment in Patients with Signs of Inflammation Due to Knee Osteoarthritis
Ryan Pinto¹, Trevor Birmingham¹, Holly Philpott², Dominique Arsenault¹, Codie Primeau¹ and Tom Appleton³, ¹Western University, London, Canada, ²Western University, London, ON, Canada, ³The University of Western Ontario, LONDON, ON, Canada
Background/Purpose: Synovial inflammation in knees with OA can be measured with musculoskeletal ultrasound (MSK US), is associated with increased pain and disease progression, and may…
Abstract Number: 1960 • ACR Convergence 2020
Cost-effectiveness of Surgical and Non-Surgical Weight Loss Programs for Morbidly Obese Patients with Knee Osteoarthritis
Valia Leifer¹, Jeffrey Katz², Faith Selzer³, Tuhina Neogi⁴, Jamie Collins⁵ and Elena Losina², ¹The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, ²Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ³The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Amesbury, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA
Background/Purpose: Growing numbers of knee osteoarthritis (KOA) patients are morbidly obese (BMI ≥ 35 kg/m2). Evolving evidence suggests weight reduction may delay the structural progression…
Abstract Number: 0562 • ACR Convergence 2020
The Relationship Between Heart Disease Risk Profile and Osteoarthritis, Overall and by Multi-/Single-Joint Involvement
Anthony Perruccio¹, Shatabdy Zahid², Calvin Yip³, J Denise Power², Mayilee Canizares², George Heckman⁴ and Elizabeth Badley¹, ¹Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, ²Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Osteoarthritis (OA) and heart disease (HD) are among the most common chronic conditions. Several studies have shown that OA increases the risk of HD…
Abstract Number: 0708 • ACR Convergence 2020
Differences in Treating Knee Osteoarthritis by Clinician Specialty
Denise Baldock¹ and Casey Zhang², ¹Ipsos MORI, London, England, United Kingdom, ²Ipsos Insight, New York, NY
Background/Purpose: Current treatment of knee osteoarthritis (OA) is focused primarily around pain relief offering sustained mobility and prioritizing symptom relief over disease progression potentially impacts…
Abstract Number: 1108 • ACR Convergence 2020
Cartilage Biomarkers s-Coll2-1 and s-Coll2-1NO2 Are Associated with Knee Osteoarthritis MRI Features and Predict Disease Worsening
Yves Henrotin¹, Anne-Christine Hick², Berenice Costes³, Alain Labasse³, Thierry Conrozier⁴, Michel Malaise⁵, Yves Maugars⁶, Franz Pelousse⁷, Jean-Marc Lemaire⁸, Cedric Tits⁹, Thibault Helleputte⁹ and Damien Loeuille¹⁰, ¹University of Liège, Liège, Belgium, ²Artialis SA, Liège, Belgium, ³Artialis SA, Liege, Belgium, ⁴5. Department of Rheumatology, Hôpital Nord Franche-Comté, Belfort, France, ⁵University of Liège, Liege, Belgium, ⁶Service de rhumatologie, Hôtel-Dieu, CHU de Nantes, Nantes, France, ⁷SODIRAY, Solution Diagnostique Radiologique, Liège, Belgium, ⁸SODIRAY, Solution Diagnostique Radiologique, Liege, Belgium, ⁹Data-Driven Precision Medicine, DNAlytics, Louvain-la-Neuve, Belgium, ¹⁰CHU NANCY Rheumatology, NANCY
Background/Purpose: To identify if biochemical markers s-Coll2-1, a peptide of type collagen and its nitrated from, s-Coll2-1NO2 are associated to knee osteoarthritis (OA), focusing on…
Abstract Number: 1124 • ACR Convergence 2020
Improving Documentation Rates of Non-Pharmacologic Therapies for Knee Osteoarthritis
Megan Milne¹, Travis Welsh¹ and Una Makris², ¹University of Texas Southwestern, Dallas, TX, ²UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Musculoskeletal (MSK) pain is the leading cause of disability in older adults. Specifically, knee osteoarthritis (OA) accounts for a large burden of MSK disability…
Abstract Number: 1490 • ACR Convergence 2020
Pain Rating Variability and Response to Treatment in Osteoarthritis Clinical Trials
Camila Pinto¹, Joana Barroso² and Thomas Schnitzer³, ¹Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Despite the known high inter- and intra-patient variability in analgesic responses in chronic pain, most interventional pain studies rely on single time point pain…
Abstract Number: 1650 • ACR Convergence 2020
A Double-Blind Randomized Trial to Evaluate the Efficacy of Corticosteroid Injections for Osteoarthritis of the Knee Using Mobile Devices
Joshua Baker¹, Mitesh Patel¹, Tuhina Neogi², Keith Robinson³, Alexis Ogdie¹ and Carla Scanzello¹, ¹University of Pennsylvania, Philadelphia, PA, ²Boston University School of Medicine, Boston, MA, ³Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA
Background/Purpose: The value of intra-articular (IA) corticosteroid injections for osteoarthritis of the knee (KOA) has recently been called into question. Variability in clinical trial design…
Abstract Number: 1968 • ACR Convergence 2020
Cathepsin S Gene Expression Measured in the Peripheral Blood of Osteoarthritic Patients Prior to Surgery as a Biomarker of Post-operative Pain Development
Elena Tchetina¹, Kseniya Glemba¹, Galina Markova¹, Maksim Makarov¹ and Aleksandr Lila¹, ¹Nasonova Research Institute of Rheumatology, Moscow, Russia
Background/Purpose: Osteoarthritis (OA) is a chronic rheumatic disease, which involves pain, limited inflammation, and local destruction of the knee joint. OA pain is a major…
Abstract Number: 0036 • ACR Convergence 2020
Molecular Phenotyping of Late-Stage Knee Osteoarthritis Synovium Through Total RNA-Sequencing
Anusha Ratneswaran¹, Chiara Pastrello¹, Pratibha Potla², Osvaldo Espin-Garcia², Starlee Lively², Anthony Perruccio³, Raj Rampersaud², Rajiv Gandhi² and Mohit Kapoor⁴, ¹University Health Network, Toronto, ON, Canada, ²Krembil RI, Toronto, Canada, ³Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, ⁴Krembil RI, Toronto, ON, Canada
Background/Purpose: Knee Osteoarthritis (OA) is a painful, disabling condition and molecular mechanisms underlying this disease are poorly understood. In recent years, OA is increasingly viewed…
Abstract Number: 0564 • ACR Convergence 2020
Incidence and Progression of Foot Osteoarthritis
Rami Eltaraboulsi¹, Amanda Nelson², Carolina Alvarez³, Jordan Renner⁴, Catherine Bowen⁵, Lucy Gates⁵ and Yvonne Golightly⁶, ¹University of North Carolina at Chapel Hill, Apex, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Miami, FL, ⁴University of North Carolina, Chapel Hill, NC, ⁵University of Southampton, Southampton, United Kingdom, ⁶University of North Carolina at Chapel Hill Dept of Epidemiology, Chapel Hill, NC
Background/Purpose: Foot osteoarthritis (OA) is a common cause of disability in older adults yet remains an understudied area. The purpose of this study was to…

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