Abstracts tagged "Osteoarthritis"

Abstract Number: 0699 • ACR Convergence 2020
Lumbar Spine Stenosis Treatment : Is Surgery Better Than Medical Treatment in Afro-Descendant Populations ?
Fabienne Louis-sidney¹, Serge Arfi¹, Moustapha Drame¹, Christophe Deligny¹, Philippe Cabre¹ and Michel de Bandt¹, ¹University Hospital Martinique, Fort de France, Martinique
Background/Purpose: Lumbar spinal stenosis (LSS) is a disabling condition, mostly prevalent in the aging population and associated with significant healthcare cost. Clinical presentation involving neurogenic…
Abstract Number: 0964 • ACR Convergence 2020
Is Meniscal Status in the Anterior Cruciate Ligament Injured Knee Associated with Change in Bone Surface Area? An Exploratory Analysis of Data from the KANON Trial
Barbara Snoeker¹, Aleksandra Turkiewicz¹, Mike Bowes², Frank Roemer³, Stefan Lohmander¹, Richard Frobell¹ and Martin Englund¹, ¹Lund University, Lund, Sweden, ²Imorphics Ltd, Manchester, United Kingdom, ³Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Bone shape changes, which may be an important feature of osteoarthritis (OA) development, have been observed to occur early in the knee after anterior…
Abstract Number: 1115 • ACR Convergence 2020
The Relation of MRI-Based Cartilage Lesions to Knee Replacement and Knee Pain Severity in Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, David Felson¹, Kathy Bacon², James Torner³, Cora Lewis⁴, Michael Nevitt⁵ and S. Reza Jafarzadeh¹, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, ³University of Iowa, Iowa City, IA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of California, San Francisco, San Francisco, CA
Background/Purpose: Recently, the FDA has indicated that data supporting imaging biomarkers of relevance to clinically important outcomes, such as knee replacement (KR) may be considered…
Abstract Number: 1470 • ACR Convergence 2020
Machine Learning-Based Prediction of Knee Replacement in Persons with and Without Radiographic Osteoarthritis Using Clinical and Imaging Features of Osteoarthritis: The Multicenter Osteoarthritis Study
S. Reza Jafarzadeh¹, David Felson¹, Michael Nevitt², James Torner³, Cora Lewis⁴, Frank Roemer⁵, Ali Guermazi¹ and Tuhina Neogi¹, ¹Boston University School of Medicine, Boston, MA, ²University of California, San Francisco, San Francisco, CA, ³University of Iowa, Iowa City, IA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Prior studies of predictors of knee replacement (KR) have often included only a limited set of risk factors, been conducted primarily in knees with…
Abstract Number: 1641 • ACR Convergence 2020
Clinically Important Improvements in Patients with Osteoarthritis Treated with Subcutaneous Tanezumab: Results from a 56-Week Randomized NSAID-Controlled Study
David Hunter¹, Tuhina Neogi², Melvin Churchill³, Ivan Shirinsky⁴, Masanari Omata⁵, Alexander White⁶, Ali Guermazi², Robert Fountaine⁷, Glenn Pixton⁸, Lars Viktrup⁹, Mark Brown⁷, Christine West¹⁰ and Kenneth Verburg¹¹, ¹Institute of Bone and Joint Research, University of Sydney, St Leonards, New South Wales, Australia, ²Boston University School of Medicine, Boston, MA, ³Arthritis Center of Nebraska, Lincoln, NE, ⁴Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, ⁵Ohimachi Orthopaedic Clinic, Tokyo, Japan, ⁶Progessive Medical Research, Port Orange, FL, ⁷Pfizer Inc., Groton, CT, ⁸Pfizer Inc., Morrisville, NC, ⁹Eli Lilly and Company, Indianapolis, IN, ¹⁰Pfizer Inc, Groton, CT, ¹¹Pfizer Inc, Groton
Background/Purpose: Subcutaneous (SC) tanezumab, a monoclonal antibody that inhibits nerve growth factor, was investigated for the relief of signs and symptoms of moderate-severe OA in…
Abstract Number: 1657 • ACR Convergence 2020
Do Comorbidities Limit Improvement in Pain and Physical Function After Total Knee Arthroplasty in Patients with Knee Osteoarthritis?
Lauren King¹, Esther Waugh¹, Allyson Jones², Deborah Marshall³ and Gillian Hawker⁴, ¹University of Toronto, Toronto, Canada, ²University of Alberta, Edmonton, AB, Canada, ³University of Calgary, Calgary, AB, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: Individuals with knee osteoarthritis (OA) are increasingly living with multiple comorbid conditions. The presence of comorbidities has been associated with having worse OA symptoms…
Abstract Number: 0150 • ACR Convergence 2020
The Preparation Experience for Total Knee Arthroplasty of Patients with Osteoarthritis: A Cross-Sectional Survey
Aretina Leung¹, Geyanne Lui², Susan Goodman³, Lisa Mandl⁴, Peter Sculco⁵, Mark Figgie³ and Iris Navarro-Millan¹, ¹Weill Cornell Medicine, New York, ²Weill Cornell Medicine, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY
Background/Purpose: We previously identified several barriers and facilitators of exercise before total knee arthroplasty (TKA) in a small qualitative study, as well as the existence…
Abstract Number: 0700 • ACR Convergence 2020
Lipoxin A4 Induces Lipid Class Switching and Inflammation Resolution at the Genomic Level in Human Osteoarthritis
Mandar Dave¹, Abul Islam², Akshat Parekh³, Jay Patel⁴, Arushi Chawla⁵ and Ashok Amin⁶, ¹Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, ²Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, Bangladesh, ³Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, ⁴Northeast Ohio Medical University, Rootstown, OH, ⁵Gujarat Forensic Science University, Gujarat, India, ⁶Department of Rheumatology and Pathology, New York University Hospital for Joint Diseases, New York, NY
Background/Purpose: Human OA-affected cartilage does not show the cardinal signs of inflammation (redness and swelling with heat and pain—rubor et tumor cum calore et dolor) because…
Abstract Number: 1100 • ACR Convergence 2020
The Hand Osteoarthritis Registry of New York University: Impacts of Gender and Obesity
Fernando Bomfim¹, Shannon Chen², Stephen Zak³, Taylor Jazrawi², Vivienne Qie³, Benjamin Plotz² and Jonathan Samuels⁴, ¹New York University, Department of Medicine, Division of Rheumatology, Millburn, NJ, ²NYU Langone Health, New York, ³NYU Langone Health, New York, NY, ⁴NYU Langone, Rye Brook, NY
Background/Purpose: Hand osteoarthritis (HOA) data is often obtained from large knee OA cohorts. Targeted HOA cohorts in Europe have shed light on this disease, but…
Abstract Number: 1116 • ACR Convergence 2020
Magnetic Resonance Imaging Structural Changes Correlated with Knee Extension: Data from the Osteoarthritis Initiative
T Mark Campbell¹, Guy Trudel² and Dennis McGonagle³, ¹Elisabeth Bruyère Hospital, Ottawa, ON, Canada, ²The Ottawa Hospital, Ottawa, ON, Canada, ³The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom
Background/Purpose: Knee OA is often accompanied by loss of passive extension, termed a flexion contracture (FC), resulting in worse clinical outcomes. To our knowledge, MRI-based…
Abstract Number: 1482 • ACR Convergence 2020
Joint Safety with Tanezumab: Integrated Analyses from Randomized Controlled Phase 3 Studies in Patients with Osteoarthritis
John Carrino¹, Timothy McAlindon², Eric Vignon³, Mark Brown⁴, Aimee Burr⁴, Robert Fountaine⁴, Glenn Pixton⁵, Lars Viktrup⁶, Christine West⁷ and Kenneth Verburg⁸, ¹Hospital for Special Surgery, Hackensack, NJ, ²Tufts Medical Center, Boston, MA, ³Université Claude Bernard Lyon 1, Pierre Benite, France, ⁴Pfizer Inc., Groton, CT, ⁵Pfizer Inc., Morrisville, NC, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷Pfizer Inc, Groton, CT, ⁸Pfizer Inc, Groton
Background/Purpose: Tanezumab, a monoclonal antibody that inhibits nerve growth factor, has been shown effective in the management of osteoarthritis (OA) pain.1,2 Due to the potential…
Abstract Number: 1642 • ACR Convergence 2020
Observed Efficacy with Subcutaneous Tanezumab Is Early and Maintained in Patients with Osteoarthritis: Results from a 56-Week Randomized NSAID-Controlled Study
Tuhina Neogi¹, David Hunter², Melvin Churchill³, Ivan Shirinsky⁴, Masanari Omata⁵, Alexander White⁶, Ali Guermazi¹, Robert Fountaine⁷, Glenn Pixton⁸, Lars Viktrup⁹, Mark Brown⁷, Christine West¹⁰ and Kenneth Verburg¹¹, ¹Boston University School of Medicine, Boston, MA, ²Institute of Bone and Joint Research, University of Sydney, St Leonards, New South Wales, Australia, ³Arthritis Center of Nebraska, Lincoln, NE, ⁴Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia, ⁵Ohimachi Orthopaedic Clinic, Tokyo, Japan, ⁶Progessive Medical Research, Port Orange, FL, ⁷Pfizer Inc., Groton, CT, ⁸Pfizer Inc., Morrisville, NC, ⁹Eli Lilly and Company, Indianapolis, IN, ¹⁰Pfizer Inc, Groton, CT, ¹¹Pfizer Inc, Groton
Background/Purpose: Subcutaneous (SC) tanezumab, a monoclonal antibody that inhibits nerve growth factor, was investigated for the relief of signs and symptoms of moderate-severe OA in…
Abstract Number: 1658 • ACR Convergence 2020
Mediation of the Association Between Obesity and Osteoarthritis by Blood Pressure, Arterial Stiffness, and Subclinical Atherosclerosis
Marieke Loef¹, Rob van der Geest¹, Hildo Lamb¹, Renée de Mutsert¹, Frits Rosendaal¹ and Margreet Kloppenburg¹, ¹Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity-related metabolic dysregulation may lead to atherosclerotic vascular changes. It has been hypothesized that a compromised blood flow may cause detrimental changes to the…
Abstract Number: 0153 • ACR Convergence 2020
Counseling on Safe Driving Strategies in Patients with Osteoarthritis and Rheumatoid Arthritis
Anna Falls¹, Peta-Gay Ricketts¹, John Elliott¹ and Kim Jordan¹, ¹OhioHealth Riverside Methodist Hospital, Columbus, OH
Background/Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) cause functional impairments that impact daily life activities, including automobile driving. Radiographic presence of OA on knee and…
Abstract Number: 0701 • ACR Convergence 2020
miRNome Sequencing Identifies a Unique Profile of Circulating MicroRNAs in Early Knee Osteoarthritis
S. Amanda Ali¹, Rajiv Gandhi², Pratibha Potla², Sareh Keshavarzi², Osvaldo Espin-Garcia², Konstantin Shestopaloff², Chiara Pastrello³, Dylan Bethune-Waddell², Starlee Lively², Anthony Perruccio⁴, Raj Rampersaud², Christian Veillette², Jason Rockel², Igor Jurisica², Tom Appleton⁵ and Mohit Kapoor⁶, ¹Henry Ford Health System, Detroit, MI, ²Krembil RI, Toronto, Canada, ³University Health Network, Toronto, ON, Canada, ⁴Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, ⁵The University of Western Ontario, LONDON, ON, Canada, ⁶Krembil RI, Toronto, ON, Canada
Background/Purpose: MicroRNAs have been shown to contribute to osteoarthritis (OA) pathophysiology, yet little is known about the circulating miRNome in OA. The circulating miRNome (e.g.…

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