Abstracts tagged "Osteoarthritis"

Abstract Number: 1661 • ACR Convergence 2020
Systematic Review and Meta-Analysis of the Prevalence of Neuropathic-Like Pain and Pain Sensitisation in People with Knee and Hip Osteoarthritis
Luigi Zolio¹, Kai Ying Lim², Mabel Yan¹, Mahnuma Estee³, Sultana Monira Hussain⁴, Flavia Cicuttini⁴ and Anita Wluka⁵, ¹Alfred Health, Melbourne, Australia, ²Monash University, Kuala Lumpur, Malaysia, ³Monash University, Melbourne, Australia, ⁴Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ⁵Monash University, Melbourne, Victoria, Australia
Background/Purpose: Pain in osteoarthritis (OA) may be nociceptive or neuropathic-like in nature. In knee OA, pain severity is known to be poorly correlated with joint…
Abstract Number: 0539 • ACR Convergence 2020
Sports with a Bat or Racket Are Not Associated with Thumb-base Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Grace Lo², Mary Roberts³, Matthew Harkey⁴, Lena Schaefer⁵, Ida Kristin Haugen⁶, Stacy Smith⁷, Jeffrey Duryea⁷, Bing Lu⁸, Charles Eaton⁹, Marc Hochberg¹⁰, Rebecca Jackson¹¹, C. Kent Kwoh¹², Michael Nevitt¹³ and Timothy McAlindon¹, ¹Tufts Medical Center, Boston, MA, ²Michael E. Debakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Center for Primary Care & Prevention, Alpert Medical School of Brown University, Pawtucket, RI, ⁴University of Massachusetts, Worcester, MA, ⁵Radiology Department, Klinikum Nürnberg Süd, Nürnberg, Germany, ⁶Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁷Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Brigham and Women's Hospital and Harvard Medical School, Newton, MA, ⁹Brown University, Pawtucket, RI, ¹⁰University of Maryland School of Medicine, Baltimore, MD, ¹¹Ohio State University, Columbus, OH, ¹²University of Arizona of Arizona Arthritis Center and Division of Rheumatology, College of Medicine, University of Arizona, Tucson, AZ, ¹³Department of Epidemiology and Biostatistics, University of California San Francisco, Orinda, CA
Background/Purpose: Sports that require the use of a racket or bat to propel a ball (e.g., baseball, softball, tennis) expose the thumb-base to repetitive high-velocity…
Abstract Number: 0704 • ACR Convergence 2020
The Murine Ear Wound Cartilage Superhealer Trait, Mediated by the Gut Microbiome, Is Transgenerationally Heritable Following Cecal Transplantation
Christopher Dunn¹, Cassandra Garman², Cassandra Velasco², Vladislav Izda², Jake Martin² and Matlock Jeffries², ¹University of Oklahoma Health Sciences Center, Oklahoma City, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 1104 • ACR Convergence 2020
The Disability Associated with Hand Osteoarthritis Is Substantial in a Cohort of Post-menopausal Women : The QUALYOR Study
Maxime Auroux¹, Blandine Merle², Eric Lespessailles³ and Roland Chapurlat¹, ¹Hospices Civils de Lyon, Lyon Cedex 03, Rhone-Alpes, France, ²INSERM UMR 1033, Université de Lyon, Lyon Cedex 03, Rhone-Alpes, France, ³Regional Hospital and University of Orleans, Orléans, France
Background/Purpose: Osteoarthritis (OA) is a highly prevalent disease, affecting more than 400 millions individuals around the world. Hand osteoarthritis (HOA) is the most frequent form…
Abstract Number: 1120 • ACR Convergence 2020
A Comparison of Opioid-Related Outcomes Among Commercially-Insured Osteoarthritis Patients Treated with Tramadol vs. Non-Tramadol Opioids
Stuart Silverman¹, James Rice², Alan White², Catherine Fernan², Michael Somma², Craig Beck³, Rebecca Robinson⁴ and Patricia Schepman⁵, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Analysis Group, Boston, MA, ³Pfizer, London, ⁴Eli Lilly and Company, Indanapolis, IN, ⁵Pfizer, New York City, NY
Background/Purpose: In 2019, the American College of Rheumatology conditionally recommended tramadol for patients with hip and knee osteoarthritis (OA). While tramadol is known to be…
Abstract Number: 1486 • ACR Convergence 2020
Long-term Efficacy and Safety of Intra-articular Sprifermin in Patients with Knee Osteoarthritis: Results from the 5-Year Forward Study
Felix Eckstein¹, Marc Hochberg², Hans Guehring³, Flavie Moreau⁴, Victor Ona⁴, Asger Bihlet⁵, Inger Byrjalsen⁵, Jeppe Andersen⁵, Benjamin Daelken³, Oliver Guenther³, Christoph Ladel³, Martin Michaelis³ and Philip G Conaghan⁶, ¹Paracelsus Medical University, Salzburg, Austria, ²University of Maryland School of Medicine, Baltimore, MD, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵Nordic Bioscience, Herlev, Denmark, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: The 5-year Phase II FORWARD study assessed the efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin (recombinant human fibroblast growth factor…
Abstract Number: 1646 • ACR Convergence 2020
Use of Prescription Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Adults with Hip/Knee Osteoarthritis (OA) at Increased Risk for NSAID-related Adverse Events
Jayeshkumar Patel¹, Wenhui Wei², Raveendhara Bannuru³, Ravi Iyer⁴, Nazneen Fatima Shaikh¹, Traci LeMasters¹, Chibuzo Iloabuchi¹, Degang Wang² and Usha Sambamoorthi¹, ¹West Virginia University School of Pharmacy, Morgantown, WV, ²Regeneron Pharmaceuticals, Tarrytown, NY, ³Tufts Medical Center, Boston, MA, ⁴Teva Pharmaceutical Industries, West Chester, PA
Background/Purpose: NSAIDs are commonly used for OA pain, but the benefits of pain relief must be carefully weighed against the potential risk for gastrointestinal (GI),…
Abstract Number: 1662 • ACR Convergence 2020
Do Weight-bearing versus Non-weight-bearing Pain Reflect Different Pain Mechanisms in Knee Osteoarthritis?: The Multicenter Osteoarthritis Study
Jean Liew¹, John Farrar², Na Wang³, Lisa Carlesso⁴, Kosaku Aoyagi³, Laura Frey Law⁵, Cora Lewis⁶, Michael Nevitt⁷ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Pennsylvania, Philadelphia, PA, ³Boston University School of Medicine, Boston, MA, ⁴McMaster University, Hamilton, ON, Canada, ⁵University of Iowa, Iowa City, IA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of California, San Francisco, San Francisco, CA
Background/Purpose: Pain with weightbearing in knee OA is thought to be related to the activation of nociceptors; however, this is not considered the sole mechanism…
Abstract Number: 0543 • ACR Convergence 2020
Exercise Among Older Adults Living with Rheumatic Disease: Physical Activity Habits and Patient Reported Outcomes
Alexis Ogdie¹, Sofia Pedro², Joshua Baker³, Kaleb Michaud⁴ and Patricia Katz⁵, ¹University of Pennsylvania, Philadelphia, PA, ²FORWARD-The National Data Bank for Rheumatic Diseases, Wichita, ³Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁴FORWARD-The National Data Bank for Rheumatic Diseases; University of Nebraska Medical Center, Wichita, ⁵University of California, San Francisco, Novato, CA
Background/Purpose: Among patients with rheumatic disease, physical activity is important for maintaining health and improving outcomes. EULAR recommendations suggest at least 30 min of vigorous…
Abstract Number: 0705 • ACR Convergence 2020
lncRNA H19 and Micro RNA 675-3p Are Altered by Visfatin During Osteogenesis
Dennis Küppers¹, Lali Tsiklauri², Marie-Lisa Hülser¹, Klaus Frommer², Stefan Rehart³, Caroline Ospelt⁴, Ulf Müller-Ladner⁵ and Elena Neumann⁶, ¹Justus-Liebig-University Giessen, Campus Kerckhoff, Dept. of Rheumatology and Clinical Immunology, Giessen, Germany, ²Justus-Liebig-University Giessen, Campus Kerckhoff, Dept. of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, ³Department of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital, Frankfurt, Frankfurt, Germany, ⁴University Hospital Zürich; University Hospital of Zurich; Center of Experimental Rheumatology, Department of Rheumatology, Zurich, Switzerland, ⁵Department of Rheumatology, Immunology, Osteology and Physical Medicine, Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, Bad Nauheim, Germany, ⁶Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus Liebig University Giessen, Bad Nauheim, Germany
Background/Purpose: Long non-coding (lnc-)RNAs are transcribed from DNA similar to mRNA. lncRNA are able to interact directly with DNA, RNA and proteins. Some lncRNAs contain…
Abstract Number: 1105 • ACR Convergence 2020
RANK-L Activity: Understanding the Pathogenesis of Erosive Osteoarthritis
Kalyna Jakibchuk¹, Javier Rangel-Moreno¹, Bethany Marston², Jennifer Anolik¹ and Allen Anandarajah¹, ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester Medical Center, Rochester
Background/Purpose: Erosive osteoarthritis (EOA) is characterized by osteoarthritic findings with central erosions and collapse of the interphalangeal joint subchondral bone plate. A number of studies…
Abstract Number: 1121 • ACR Convergence 2020
Osteoarthritis in the Million Veterans Program: Integrating the Electronic Medical Record with Precision Medicine
Merry-Lynn McDonald¹, Preeti Lakshman Kumar¹, Vinod Srinivasasainagendra¹, Joshua Richman¹, Sarah Pinson¹, Alison Rocco¹, Dennis Richard², Vivek Jagadale², Cynthia Brown¹, Hemant Tiwari¹, Jasvinder Singh³ and Marcas Bamman¹, ¹University of Alabama at Birmingham, Birmingham, ²Central Arkansas Veterans Healthcare System, Little Rock, ³University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Osteoarthritis (OA) had profound impacts on societal and patient-centered outcomes, including disability. As the first step to leverage the rich resource of the Million…
Abstract Number: 1487 • ACR Convergence 2020
Biclustering Reveals Potential Knee Osteoarthritis Phenotypes in Exploratory Analyses: Data from the Osteoarthritis Initiative
Amanda Nelson¹, Thomas Keefe², Todd Schwartz³, Richard Loeser¹, Yvonne Golightly⁴, Liubov Arbeeva¹ and J Marron², ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Dept of Biostatistics, Chapel Hill, NC, ⁴University of North Carolina at Chapel Hill Dept of Epidemiology, Chapel Hill, NC
Background/Purpose: To utilize novel methodologies to explore subgroups within the OAI clinical data.Methods: From the OAI baseline dataset (n=4796 individuals with or at risk of…
Abstract Number: 1647 • ACR Convergence 2020
An Oleuropein-based Dietary Supplement Improves Joint Function in Older People with High Knee Joint Pain
Marie-Noelle Horcajada¹, Maurice Beaumont², Nicolas Sauvageot², Madleen Saboundjian¹, Laure Poquet¹, Anne-Christine Hick³, Berenice Costes⁴ and Yves Henrotin⁵, ¹Nestle Research, EPFL Innovation Park, Lausanne, Switzerland, ²Nestle Research, Clinical Development Unit, Lausanne, Switzerland, ³Artialis SA, Liège, Belgium, ⁴Artialis SA, Liege, Belgium, ⁵University of Liège, Liège, Belgium
Background/Purpose: The aim of this study was to investigate the effects of a 6-month intervention with an Olive Leaf Extract (OLE) standardized for oleuropein content…
Abstract Number: 1663 • ACR Convergence 2020
Walking for Exercise May Be Symptom and Structure Modifying for Those with Established OA and with Varus Alignment – Data from the Osteoarthritis Initiative
Grace Lo¹, Surabhi Vinod², Matthew Harkey³, Timothy McAlindon⁴, Andrea Kriska⁵, Bonny Rockette-Wagner⁵, Charles Eaton⁶, Marc Hochberg⁷, Rebecca Jackson⁸, C. Kent Kwoh⁹, Michael Nevitt¹⁰ and Jeffrey Driban⁴, ¹Michael E. Debakey VA Medical Center, Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Houston, ³University of Massachusetts, Worcester, MA, ⁴Tufts Medical Center, Boston, MA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Department of Family Medicine and Epidemiology, Warren Alpert Medical School of Brown University,Department of Epidemiology, School of Public Health of Brown University, Providence, RI, ⁷University of Maryland School of Medicine, Baltimore, MD, ⁸Ohio State University, Columbus, OH, ⁹The University of Arizona, Tucson, AZ, ¹⁰University of California, San Francisco, San Francisco, CA
Background/Purpose: Walking for exercise is recommended for knee osteoarthritis (OA) management though benefits have not been demonstrated in epidemiologic studies. We aimed to assess the…

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