Abstracts tagged "Osteoarthritis"

Abstract Number: 1759 • ACR Convergence 2022
Factors Affecting Success of Behavioral Interventions to Improve Physical Activity in Patients with Knee Osteoarthritis
Lakshmi Jayaram¹, jing song², Pamela Semanik³, Daniel Pinto⁴, Linda Ehrlich-Jones⁵, Lutfiyya Muhammad⁶, Alison Chang⁶ and Rowland Chang⁷, ¹McGaw Medical Center, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Rush University, Chicago, IL, ⁴Marquette University, Wauwatosa, WI, ⁵Shirley Ryan AbilityLab, Aurora, IL, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: Knee osteoarthritis (KOA) is a chronic long-term condition that results in pain, disability and reduced quality of life. Over 13 million US adults 45…
Abstract Number: 1898 • ACR Convergence 2022
Radiographic Osteoarthritis Progression Can Be Predicted via Pyrosequencing Analysis of Baseline Peripheral Blood
Chris Dunn¹, Cassandra Velasco², Leoni Schlupp³, Emmaline Prinz³, Vladislav Izda⁴, Liubov Arbeeva⁵, Yvonne Golightly⁶, Amanda Nelson⁶ and Matlock Jeffries³, ¹University of Oklahoma Health Sciences Center, Edmond, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, New York, NY, ⁵University of North Carolina Chapel Hill, Chapel Hill, NC, ⁶UNC School of Medicine, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (OA) is a heterogeneous disease characterized by a variety of clinical and molecular phenotypes. However, we do not yet have robust biomarkers…
Abstract Number: 1914 • ACR Convergence 2022
Acoustic Classification of Early and Advanced Osteoarthritis of the Knee in Clinical Settings
Dave Ewart¹, Ashley Draisey², Omer Inan³, Chris Nichols³ and Goktug Ozmen³, ¹Minneapolis Veterans Affairs Medical Center, Minneapolis, MN, ²Allina Health, Minneapolis, MN, ³Georgia Institute of Technology, Atlanta, GA
Background/Purpose: Knee osteoarthritis (OA) is a prevalent and debilitating disease. Diagnosis of early knee OA is difficult and insensitive with current technologies. The human knee…
Abstract Number: 0030 • ACR Convergence 2022
Fluidic Shear Stress Reduces TNFα-mediated Cartilage Damage in a 3D Model of Degenerative Joint Disease
Alexandra Damerau¹, Duc Ha Do Nguyen¹, Christina Lubahn¹, Thomas Leeuw², Timo Gaber³ and Frank Buttgereit³, ¹Charité-Universitätsmedizin Berlin, Berlin, Germany, ²Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, ³Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany
Background/Purpose: Degenerative joint diseases such as osteoarthritis (OA) ultimately result in the breakdown of cartilage. The exact underlying mechanisms of cause and progression of OA…
Abstract Number: 0756 • ACR Convergence 2022
Rheumatic Toxicities of Immune Checkpoint Inhibitors in Patients with Advanced Melanoma and the Effect of Pre-existing Autoimmune and Non-immune Mediated Rheumatic Conditions
Alana Bruce¹, Georgina V Long², Alexander M Menzies², Brian Fernandes³ and Fredrick Joshua⁴, ¹Macquarie University, Balaclava, Victoria, Australia, ²Melanoma Institute Australia, The University of Sydney, Royal North Shore and Mater Hospitals, Sydney, Australia, ³Royal Prince Alfred Hospital, Sydney, Australia, ⁴Macquarie University, Integrated Specialist Medical Care, Sydney, Australia
Background/Purpose: To estimate the frequency of rheumatic toxicities of immune checkpoint inhibitors (ICI) presenting as de novo or exacerbations of pre-existing rheumatic disease in patients…
Abstract Number: 1228 • ACR Convergence 2022
Distinctive Alterations in the Functional Anatomy of the Cerebral Cortex in Pain-sensitized Osteoarthritis and Fibromyalgia Patients
Jesús Pujol¹, Fabiola Ojeda¹, Laura Blanco-Hinojo¹, Andrea Doreste¹, Gerard Martinez-Vilavella¹, Víctor Pérez-Solá¹, Joan Deus² and Jordi Monfort¹, ¹Hospital del Mar, Barcelona, Spain, ²Autonomous University of Barcelona, Barcelona, Spain
Background/Purpose: Fibromyalgia is a primary pain sensitization disorder showing augmented pain sensitivity with no apparent origin. In contrast, secondary sensitization often occurs in knee osteoarthritis…
Abstract Number: 1775 • ACR Convergence 2022
More Than Half of Patients with Osteoarthritis Have Positive Screening for Fibromyalgia And/or Depression, Feasibly Assessed in Routine Care on Indices Within a Single MDHAQ (multidimensional Health Assessment Questionnaire)
Theodore Pincus¹, Kathryn Gibson², Juan Schmukler¹, Tengfei Li³ and Joel Block¹, ¹Rush University Medical Center, Chicago, IL, ²Liverpool Hospital, Sydney, Australia, ³Georgetown University, Washington, DC
Background/Purpose: Osteoarthritis (OA) patients may have widely divergent scores for pain severity vs X-ray joint damage, indicating that elevated OA pain 0-10 visual numeric scale…
Abstract Number: 1899 • ACR Convergence 2022
A Phase 3, 28-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (OA-10) to Evaluate the Efficacy and Safety of a Single Injection of Lorecivivint Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
Yusuf Yazici¹, Christopher Swearingen², Heli Ghandehari³, Victor Lopez⁴, ismail simsek⁵, Mark Fineman⁶, Sarah Kennedy⁷, Jeyanesh Tambiah⁸ and Timothy McAlindon⁹, ¹New York University School of Medicine, La Jolla, CA, ²Samumed LLC, San Diego, CA, ³Biosplice Therapeutics, Inc., San Diego, CA, ⁴Biosplice Therapeutics, Santa Clarita, CA, ⁵Alpine Immunesciences, San Diego, CA, ⁶Biosplice Therapeutics, San Diego, CA, ⁷Biosplice Therapeutics, Inc, San Diego, CA, ⁸Biosplice Ther Inc., San Diego, CA, ⁹Tufts Medical Center, Arlington, MA
Background/Purpose: Knee osteoarthritis (OA) is a common joint disorder associated with pain, disability, and joint damage. There remains a large unmet need for treatments that…
Abstract Number: 1915 • ACR Convergence 2022
Development of an MRI-based Definition of Knee Osteoarthritis: Data from the Multicenter Osteoarthritis Study
Jean Liew¹, Gabriela Rabasa², Michael LaValley³, Jamie collins⁴, Joshua Stefanik⁵, Ali Guermazi², Cora E. Lewis⁶, Michael Nevitt⁷, James Torner⁸ and David Felson², ¹Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Northeastern University, Boston, MA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of California at San Francisco, Orinda, CA, ⁸University of Iowa, Iowa City, IA
Background/Purpose: MRI is becoming the OA imaging modality of choice. It allows quantification of cartilage damage, the signature pathologic feature of disease. Proposed MRI-based definitions…
Abstract Number: 0216 • ACR Convergence 2021
Distribution of Medial Femur and Tibia Cartilage Volume Change over 48 Months on MRI: Comparison Among Kellgren-Lawrence Grades
Rebecca Amesbury¹, Hedieh Ragati Haghi¹, Todd Laffaye¹, Rebekah Stein¹, Erin Ashbeck², C. Kent Kwoh³, Alexander Mathiessen¹ and Jeffrey Duryea¹, ¹Brigham and Women's Hospital, Boston, MA, ²University of Arizona Arthritis Center, Tucson, AZ, ³University of Arizona College of Medicine, Tuscon, AZ
Background/Purpose: Semi-automated Local Area Cartilage Segmentation (LACS) software uses two robust coordinate systems to measure cartilage change in focused regions in the femur and tibia.…
Abstract Number: 0532 • ACR Convergence 2021
Development of a Predictive Tool for the Rapid Progressive Knee Osteoarthritis Phenotype: Data from the Osteoarthritis Initiative
Alejandro Durán-Sotuela¹, Mercedes Fernández-Moreno¹, Maria Vázquez-Mosquera¹, Paula Ramos-Louro¹, Andrea Dalmao-Fernández¹, Sara Relaño¹, Victoria Suárez-Ulloa², Vanesa Balboa-Barreiro³, Natividad Oreiro¹, Jorge Vázquez-García¹, Francisco Blanco-García⁴ and Ignacio Rego-Pérez¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Plataforma de Bioinformática. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006, A Coruña, Spain, ³Unidad de apoyo a la Investigación. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Unidad de Proteómica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). C/ As Xubias de Arriba 84, 15006, A Coruña, España.Universidade da Coruña (UDC), Grupo de Investigación de Reumatología y Salud (GIR-S). Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, Campus de Oza, 15008, A Coruña, España., A Coruña, Spain
Background/Purpose: There is a pressing need of identifying patients suffering the rapid progressive phenotype of Osteoarthritis (RPOA) to implement prevention strategies and to include them…
Abstract Number: 0738 • ACR Convergence 2021
Therapeutic Effects of Oral Chinese Patent Medicine on Knee Osteoarthritis
Weiheng Chen¹, Mengge Song¹, Yan Jia¹, Jigao Sun¹, Yan Zhao², Zhipeng Xue³, Qianglong Chen², xiangrong Zeng² and Chenchen Wang⁴, ¹The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China (People's Republic), ²2Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China (People's Republic), ³1The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China;, Beijing, China (People's Republic), ⁴Tufts Medical Center, Boston, MA
Background/Purpose: Oral Chinese patent medicine (CPM) has been deemed to have analgesic and anti-inflammatory effects and is widely used as the first-line treatment for osteoarthritis…
Abstract Number: 1070 • ACR Convergence 2021
Experiences of Wearable Technology by Persons with Knee Osteoarthritis Participating in a Physical Activity Counselling Intervention Study: A Relational Ethics Lens
Jenny Leese¹, Graham Macdonald¹, Anne Townsend², Catherine L. Backman¹, Laura Nimmon¹ and Linda Li¹, ¹University of British Columbia, Vancouver, BC, Canada, ²Lancaster University, Lancaster, United Kingdom
Background/Purpose: Current evidence indicates wearable physical activity trackers could support persons with knee osteoarthritis (OA) to be more physically active. Recent empirical evidence also identifies,…
Abstract Number: 1133 • ACR Convergence 2021
The Relation of Serum Urate to Radiographic Knee Osteoarthritis in 2 Cohorts: The ELSA-Brasil MSK and the Original Cohort of the Framingham Heart Study
Ana Beatriz Vargas-Santos¹, Tuhina Neogi², Luciana Machado³, Isabela Beseñor⁴, Luciana Costa-Silva⁵, David Felson⁶, Sandhi Barreto⁷ and Rosa Telles⁸, ¹Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ²Boston University School of Medicine, Boston, MA, ³Clinical Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ⁴Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁵Instituto Hermes Pardini. Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ⁶Boston University, Boston, MA, ⁷Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ⁸Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Hyperuricemia may contribute to the development and/or progression of knee osteoarthritis (OA), based on increased inflammation associated with elevated serum urate (SU). Because hyperuricemia…
Abstract Number: 1584 • ACR Convergence 2021
Relation of Depressive Symptoms to Alterations in Conditioned Pain Modulation in Knee Osteoarthritis: The Multicenter Osteoarthritis Study (MOST)
Kosaku Aoyagi¹, Lisa Carlesso², Laura Frey-Law³, Gabriela Rabasa⁴, Cora Lewis⁵, Michael Nevitt⁶ and Tuhina Neogi⁷, ¹Boston University, Quincy, MA, ²McMaster University, Hamilton, ON, Canada, ³University of Iowa, Iowa City, IA, ⁴Boston University, Boston, MA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of California San Francisco, Orinda, CA, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: Inefficiency of descending conditioned pain modulation (CPM) is present in 42-55% of individuals with knee osteoarthritis (OA), which can contribute to more pain and…

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