ACR Meeting Abstracts

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Abstracts tagged "Osteoarthritis"

  • Abstract Number: 1121 • ACR Convergence 2020

    Osteoarthritis in the Million Veterans Program: Integrating the Electronic Medical Record with Precision Medicine

    Merry-Lynn McDonald1, Preeti Lakshman Kumar1, Vinod Srinivasasainagendra1, Joshua Richman1, Sarah Pinson1, Alison Rocco1, Dennis Richard2, Vivek Jagadale2, Cynthia Brown1, Hemant Tiwari1, Jasvinder Singh3 and Marcas Bamman1, 1University of Alabama at Birmingham, Birmingham, 2Central Arkansas Veterans Healthcare System, Little Rock, 3University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Osteoarthritis (OA) had profound impacts on societal and patient-centered outcomes, including disability. As the first step to leverage the rich resource of the Million…
  • Abstract Number: 1487 • ACR Convergence 2020

    Biclustering Reveals Potential Knee Osteoarthritis Phenotypes in Exploratory Analyses: Data from the Osteoarthritis Initiative

    Amanda Nelson1, Thomas Keefe2, Todd Schwartz3, Richard Loeser1, Yvonne Golightly4, Liubov Arbeeva1 and J Marron2, 1University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, 3University of North Carolina at Chapel Hill Dept of Biostatistics, Chapel Hill, NC, 4University of North Carolina at Chapel Hill Dept of Epidemiology, Chapel Hill, NC

    Background/Purpose: To utilize novel methodologies to explore subgroups within the OAI clinical data.Methods: From the OAI baseline dataset (n=4796 individuals with or at risk of…
  • Abstract Number: 1647 • ACR Convergence 2020

    An Oleuropein-based Dietary Supplement Improves Joint Function in Older People with High Knee Joint Pain

    Marie-Noelle Horcajada1, Maurice Beaumont2, Nicolas Sauvageot2, Madleen Saboundjian1, Laure Poquet1, Anne-Christine Hick3, Berenice Costes4 and Yves Henrotin5, 1Nestle Research, EPFL Innovation Park, Lausanne, Switzerland, 2Nestle Research, Clinical Development Unit, Lausanne, Switzerland, 3Artialis SA, Liège, Belgium, 4Artialis SA, Liege, Belgium, 5University of Liège, Liège, Belgium

    Background/Purpose: The aim of this study was to investigate the effects of a 6-month intervention with an Olive Leaf Extract (OLE) standardized for oleuropein content…
  • Abstract Number: 1663 • ACR Convergence 2020

    Walking for Exercise May Be Symptom and Structure Modifying for Those with Established OA and with Varus Alignment – Data from the Osteoarthritis Initiative

    Grace Lo1, Surabhi Vinod2, Matthew Harkey3, Timothy McAlindon4, Andrea Kriska5, Bonny Rockette-Wagner5, Charles Eaton6, Marc Hochberg7, Rebecca Jackson8, C. Kent Kwoh9, Michael Nevitt10 and Jeffrey Driban4, 1Michael E. Debakey VA Medical Center, Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine, Houston, 3University of Massachusetts, Worcester, MA, 4Tufts Medical Center, Boston, MA, 5University of Pittsburgh, Pittsburgh, PA, 6Department of Family Medicine and Epidemiology, Warren Alpert Medical School of Brown University,Department of Epidemiology, School of Public Health of Brown University, Providence, RI, 7University of Maryland School of Medicine, Baltimore, MD, 8Ohio State University, Columbus, OH, 9The University of Arizona, Tucson, AZ, 10University of California, San Francisco, San Francisco, CA

    Background/Purpose: Walking for exercise is recommended for knee osteoarthritis (OA) management though benefits have not been demonstrated in epidemiologic studies. We aimed to assess the…
  • Abstract Number: 0551 • ACR Convergence 2020

    Physical Performance as a Mediator of the Association Between Depression and Pain in Knee Osteoarthritis

    Alan Rathbun1, Elizabeth Stuart2, Michelle Shardell1, Trang Nguyen2, Alice Ryan1, Joseph Gallo2, Michelle Yau3, Megan Schuler4 and Marc Hochberg1, 1University of Maryland School of Medicine, Baltimore, MD, 2Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 3Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, 4RAND Corporation, Boston, MA

    Background/Purpose: Depression is common in knee osteoarthritis (OA), and leads to reduced physical function, which may mediate the effect of depression on pain. However, research…
  • Abstract Number: 0706 • ACR Convergence 2020

    Adenosine A2A Receptor Activation Reduces Markers of Chondrocyte Senescence and Cartilage Inflammation Associated with Osteoarthritis

    Benjamin Friedman1 and Bruce Cronstein2, 1NYU Rheumatology, New York, NY, 2NYU Grossman School of Medicine, New York, NY

    Background/Purpose: Osteoarthritis is an aging-associated disorder linked to dysfunctional metabolism, chronic inflammation, oxidative stress, and cellular senescence. Cellular senescence is associated with stable cell cycle…
  • Abstract Number: 1106 • ACR Convergence 2020

    MMP Mediated Type I Collagen Degradation Is Associated with Erosive Hand Osteoarthritis in a Hospital-based Observational Cohort – the NOR-HAND Study

    Christian Thudium1, Neha Sharma2, Marthe Gløersen3, Peder Frederiksen2, Anne C. Bay-Jensen1 and Ida Haugen3, 1Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Herlev, 3Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Hand osteoarthritis (OA) is a common degenerative joint disease affecting mainly the interphalangeal and first carpometacarpal joints. The disease manifests as inflammation and deterioration…
  • Abstract Number: 1122 • ACR Convergence 2020

    Osteoarthritis in a Large Integrated Health System Population: 18-Year Retrospective Review

    Jove Graham1, Tonia Novosat1, Haiyan Sun1, Brian Piper2, Joseph Boscarino1, Melissa Kern1, Vanessa Duboski3, Eric Wright3, Patricia Schepman4, Rebecca Robinson5, Edward Casey6, Craig Beck7 and Jerry Hall8, 1Geisinger, Danville, 2Geisinger, Scranton, 3Geisinger, Forty Fort, 4Pfizer, New York City, NY, 5Eli Lilly and Company, Indianapolis, 6Pfizer, New York, 7Pfizer, London, 8Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Osteoarthritis (OA) is a mechanically and immunologically mediated common disease with a complex pathogenesis.  Despite epidemiologic studies proving increasing age, obesity and female gender…
  • Abstract Number: 1488 • ACR Convergence 2020

    Application of the Knee Injury and Osteoarthritis Outcome Score Percentile Curves on Preoperative and up to 2 Years Postoperative Data of Patients Undergoing Total Knee Arthroplasty

    Marieke Loef1, Maaike G. Gademan1, Daisy A. J. Latijnhouwers1, Herman Kroon1, Herman Kaptijn2, Willem Marijnissen3, Rob G. H. Nelissen1, Thea Vliet Vlieland4 and Margreet Kloppenburg1, 1Leiden University Medical Center, Leiden, Netherlands, 2LangeLand Hospital, Zoetermeer, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Leiden University Medical Center, 2300 RC Leiden, Netherlands

    Background/Purpose: The interpretation of patient-reported outcomes, such as the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire, can prove difficult if benchmarks are lacking. Therefore,…
  • Abstract Number: 1648 • ACR Convergence 2020

    Comparison of Methotrexate and Glucosamine in Primary Knee Osteoarthritis with Inflammation

    Biswadip Ghosh1, Subhankar Haldar2 and Meghna Saha2, 1IPGME&R, Kolkata, Kolkata, West Bengal, India, 2IPGME&R, Kolkata, KOLKATA, India

    Background/Purpose: Many patients suffering from knee OA show swelling, warmth along with pain which are features of inflammation. There are no accepted pharmacological therapy for osteoarthritis…
  • Abstract Number: 1664 • ACR Convergence 2020

    Walking Energetics, Fatigue, and Physical Activity in People with Knee Osteoarthritis

    Kharma Foucher1, Burcu Aydemir1 and Chun-Hao Huang1, 1University of Illinois at Chicago, Chicago, IL

    Background/Purpose: Osteoarthritis (OA) is associated with limitations in physical activity (PA) for many reasons which are not fully understood. While pain can be associated with…
  • Abstract Number: 0561 • ACR Convergence 2020

    Risk Factors for Falls Among Individuals with Knee OA: A Longitudinal Community-based Study

    Jessica Wilfong1, Anthony Perruccio2 and Elizabeth Badley2, 1Krembil Research Institute, University Helath Network, Toronto, ON, Canada, 2Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada

    Background/Purpose: Knee osteoarthritis (OA) is a known risk factor for falling, but little is known about what factors contribute to the risk of falling among…
  • Abstract Number: 0707 • ACR Convergence 2020

    Contribution of NOTUM and Glypicans to the Development of Osteoarthritis

    Arkaitz Mucientes1, Eva Herranz1, Pia Lois2, Gloria Candelas2, Lydia Abasolo1, Luis Rodriguez-Rodriguez1, Jose Ramon Lamas1 and Benjamin Fernandez-Gutierrez3, 1IdISSC, Madrid, Madrid, Spain, 2Hospital Clínico San Carlos, Madrid, Madrid, Spain, 3Hospital Clínico San Carlos / IdISSC, Madrid, Madrid, Spain

    Background/Purpose: Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts,…
  • Abstract Number: 1107 • ACR Convergence 2020

    IL1RN Polymorphism Predicts Weight Loss, Inflammatory Biomarker Changes and Knee Osteoarthritis Pain Relief After Bariatric Surgery

    Jonathan Samuels1, Fernando Bomfim2, Mukundan Attur3, Christine Ren-Fielding4, Manish Parikh5, Renata La Rocca-Vieira6 and Steven B. Abramson7, 1NYU Langone, Rye Brook, NY, 2New York University, Department of Medicine, Division of Rheumatology, Millburn, NJ, 3NYU Langone Health, New York, NY, 4NYU Langone Health, New YOrk, 5Bellevue Hospital, New York, NY, 6NYU, New YOrk, 7New York University School of Medicine, New York, NY

    Background/Purpose: Symptomatic knee osteoarthritis (SKOA) patients with obesity who undergo bariatric surgery experience knee pain relief, though the reduced mechanical load explains only part of…
  • Abstract Number: 1123 • ACR Convergence 2020

    The Patient Journey in Knee OA: Variations in Patient Characteristics and Treatment by Physician Specialty

    Angela Bedenbaugh1, Vinson Lee1, Gary Oderda2, Sarah Kennedy1, Diana Brixner2, Jeyanesh Tambiah3 and Timothy McAlindon4, 1Samumed, LLC, San Diego, CA, 2University of Utah, Salt Lake City, UT, 3Samumed LLC, San Diego, CA, 4Tufts Medical Center, Boston, MA

    Background/Purpose: Knee osteoarthritis (OA) affects 32.5 million US adults and is typically treated by primary care physicians, rheumatologists (RH), orthopedists (OS), sports medicine (SM) physicians,…
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