Abstracts tagged "Osteoarthritis"

Abstract Number: 2092 • ACR Convergence 2025
Associations Among Biomarkers, Cytokines, and Ultrasound Features of Knee Osteoarthritis: A Cross-Sectional Analysis in the Johnston County Health Study
Jasmine Kimber¹, Carolina Alvarez², Virginia Kraus³, Janet Huebner³, Liubov Arbeeva⁴, Todd Schwartz⁵, Yvonne Golightly⁶, Richard Loeser⁷ and Amanda Nelson¹, ¹University of North Carolina at Chapel HIll, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³Duke University, Durham, NC, ⁴University of North Carolina, Chapel Hill, Carrboro, NC, ⁵University of North Carolina-Chapel Hill, Chapel Hill, NC, ⁶University of Nebraska Medical Center, Omaha, NE, ⁷University of North Carolina, Chapel Hill, NC
Background/Purpose: Osteoarthritis (OA) is a leading cause of disability worldwide, characterized by progressive joint degeneration, chronic pain and functional impairment (PMID: 24024017). While imaging modalities…
Abstract Number: 1948 • ACR Convergence 2025
Enhanced Prediction of Knee Osteoarthritis Progression through Deep Learning-Based Multimodal Data Fusion
Daniela Herrera¹, Ahmad Almhdie-Imjabbar², Hechmi Toumi³ and Eric Lespessailles⁴, ¹PRIMMO- University Hospital Center of Orleans, Olreans, France, ²University Hospital Center of Orleans, Orleans, France, ³PRIMMO- University Hospital Center of Orleans, Orleans, France, ⁴CHU Orléans, Orléans, France
Background/Purpose: Effective diagnosis and management of knee osteoarthritis (KOA) increasingly rely on integrating diverse data sources, including imaging and clinical information. The practice of combining…
Abstract Number: 1792 • ACR Convergence 2025
OA protection in African spiny (Acomys) mice is partially mediated by the gut microbiome and is transferrable to wild-type mice via microbiome transplantation
Gabriella Dyson¹, Montana Barrett¹, Nicholas Hanebutt¹, Aleksander Szymczak², Cindy Miranda Brawner¹, Pratibha Dube³, Padmaja Mehta-d'Souza¹, Ashley Siefert⁴ and Matlock Jeffries², ¹Oklahoma Medical Research Foundation, Oklahoma City, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Edmond, OK, ⁴University of Kentucky, Lexington, KY
Background/Purpose: Mounting evidence suggests that gut microbiome shifts may be associated with knee osteoarthritis (OA) development. We have previously shown that gut microbiome transplantation from…
Abstract Number: 1649 • ACR Convergence 2025
Does Physical Activity Differ Among those with Autoimmune vs Non-Autoimmune Rheumatic Diseases?
Sydney Liles¹, Jennifer Copson², Yvonne Lee³ and Daniel K. White¹, ¹University of Delaware, Newark, DE, ²University of Delaware, Wilmington, DE, ³Northwestern University, Chicago, IL
Background/Purpose: Individuals with rheumatic conditions, such as Rheumatoid Arthritis (RA) and Osteoarthritis (OA), often experience low physical activity levels. Physical activity may vary by autoimmune…
Abstract Number: 0765 • ACR Convergence 2025
Rural Access to Physical Therapy for Osteoarthritis Rehabilitation (RAPTOR): A Pilot Feasibility Study
Allyn Bove, Emma Zavacky, Hallie Zeleznik, Christopher Bise, Charity Patterson, Bambang Parmanto and G Kelley Fitzgerald, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Individuals who live in rural areas are more likely to experience knee osteoarthritis-related disability and less likely to be referred to physical therapy for…
Abstract Number: 0322 • ACR Convergence 2025
Metabolites Reflective of the Gut Microbiome Relate to Future Incident Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Shike Xu², Timothy McAlington³, John Haran⁴, Julieann Patarini⁴ and Bing Lu⁵, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²University of Connecticut Health Center, Farmington, CT, ³UMass Chan School of Medicine, Arlington, MA, ⁴UMass Chan Medical School, Worcester, MA, ⁵UConn Health Center, Newton, MA
Background/Purpose: Numerous cross-sectional and animal studies have linked an altered gut microbiome to osteoarthritis (OA). Human studies are needed to explore the association between the…
Abstract Number: 0165 • ACR Convergence 2025
Per-Protocol Analysis of the Effectiveness of GLP1 Agonists Against SGLT2 Inhibitors on Osteoarthritis Outcomes
Nene Ukonu¹, David Felson², Michael LaValley³ and S. Reza Jafarzadeh⁴, ¹Boston University School of Public Health, Boston, MA, ²Boston University, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Boston University Chobanian & Avedisian School of Medicine, Boston, MA
Background/Purpose: Anti-diabetic medications often have effects on other conditions. GLP1 agonists (GLP1a) have shown protective effects on OA outcomes in trials and short-term trial emulations,…
Abstract Number: 2603 • ACR Convergence 2025
Evaluating the Feasibility, Acceptability, and Behavioral Impact of Brief Action Planning (BAP) Coaching for Physical Activity in Adults with Chronic Knee Symptoms: A Qualitative Study
Moath Alshahrani¹, Kristin Haglund², Miranda McIlheran², Rowland Chang³, Pamela Semanik⁴, Sheikh Iqbal Ahamed² and Daniel Pinto⁵, ¹Marquette University/ King Khalid University, Milwaukee, WI, ²Marquette University, Milwaukee, WI, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Rush uUniversity, Chicago, IL, ⁵Marquette University, Wauwatosa, WI
Background/Purpose: Physical activity (PA) improves chronic knee symptoms (CKS) by decreasing pain and improving function, yet many interventions to increase PA are resource-intensive or poorly…
Abstract Number: 2091 • ACR Convergence 2025
Multiplanar MRI Quantification of Effusion-Synovitis: Reliability and Potential Investigative Utility for Inflammation-Mediated Knee Conditions
Greg Gilles¹, Dagoberto Robles², Luke Grawer³, Nathaniel H. Christiansen⁴, Karim Jayyusi³, Ali Shaikh³, Rongrong Tang⁵, Mihra S. Taljanovic³, Jeffrey Duryea⁶, Edward J. Bedrick⁵ and C. Kent Kwoh⁷, ¹University of Arizona Arthritis Center, The University of Arizona College of Medicine, Tucson, AZ, ²University of Arizona, Tucson, AZ, ³University of Arizona, Tucson, ⁴University of Arizona, Stockton, NJ, ⁵The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: Effusion-synovitis (ES) is often seen in knee osteoarthritis (KOA), and MRI-detected ES may serve as a potential imaging biomarker of disease activity, progression, and…
Abstract Number: 1937 • ACR Convergence 2025
Does Combining Standard MRI-Based Scores with Radiographic Trabecular Bone Texture Biomarkers Improve Predictive Performance for Radiographic Knee Osteoarthritis Progression?
Ahmad Almhdie-Imjabbar¹, Saida Daroussi², Daniela Herrera³, Hechmi Toumi² and Eric Lespessailles⁴, ¹University Hospital Center of Orleans, Orleans, France, ²PRIMMO- University Hospital Center of Orleans, Orleans, France, ³PRIMMO- University Hospital Center of Orleans, Olreans, France, ⁴CHU Orléans, Orléans, France
Background/Purpose: Knee osteoarthritis (KOA) is a major cause of disability worldwide, particularly impacting the elderly and obese population. Radiographic trabecular bone texture (TBT) is demonstrated…
Abstract Number: 1791 • ACR Convergence 2025
Determining the Effect of CD14 Deficiency on Osteoblastogenesis and Subchondral Bone Remodeling In Mice
Kate Sharp¹, Lance Murphy², Vu Nguyen³, Baofeng Hu⁴ and Carla Scanzello⁵, ¹University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³University of Pennsylvania, Phildealphia, ⁴University of Pennsylvania, Wynnewood, PA, ⁵University of Pennsylvania, Philadelphia
Background/Purpose: Osteoarthritis (OA) is a debilitating disease affecting ~54% of US adults 75 and older. Toll-like receptor 4 (TLR4), and its co-receptor CD14, have been…
Abstract Number: 1647 • ACR Convergence 2025
Clinical Phenotypes of Participants with Radiographic Osteoarthritis Attaining Patient Acceptable Symptom State in the Multicenter Osteoarthritis Study
Sarah Tilley¹, Michael LaValley², Brooke McGinley³, Cora Lewis⁴, James Torner⁵, David Felson³ and Tuhina Neogi⁶, ¹Boston University School of Medicine, Somerville, MA, ²Boston University School of Public Health, Arlington, MA, ³Boston University, Boston, MA, ⁴The University of Alabama at Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: Osteoarthritis (OA) is a leading cause of pain and disability in older adults marked by progressive joint degeneration. Symptom trajectories vary: some experience persistent…
Abstract Number: 0439 • ACR Convergence 2025
Osteoarthritis and Other Degenerative Musculoskeletal Disorders Are Common and Often Associated with Active Inflammation in Difficult-to-Treat Rheumatoid Arthritis: A Cross-Sectional Cohort
Blanche QUERE¹, Grégoire CORMIER², LE GOFF Benoit³ and Adrien LE PLUART⁴, ¹CHU de Nantes, Nantes, Pays de la Loire, France, ²Centre Hospitalier département de Vendée, La Roche Sur Yon, France, ³CHU Nantes, Nantes, France, ⁴CHU Nantes, Nantes, Pays de la Loire, France
Background/Purpose: Despite advances in therapeutic strategies, a subset of patients with rheumatoid arthritis (RA) continues to experience persistent symptoms. In 2022, the EULAR proposed a…
Abstract Number: 0321 • ACR Convergence 2025
Per- and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Lisa Rokoff², Bing Lu³, Timothy McAlington⁴, Charles Eaton⁵, Mary Roberts⁶, Diana Mathes⁷, Colleen Lestician⁷, Zhijin Carrie Xu⁷, Zhihua Tina Fan⁷, Shawn O'Leary⁷ and Abby Fleisch⁸, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, ME, ³UConn Health Center, Newton, MA, ⁴UMass Chan School of Medicine, Arlington, MA, ⁵Brown University, Pawtucket, RI, ⁶Center for Primary Care and Prevention, Kent Hospital, Pawtucket, RI, ⁷Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing, NJ, ⁸Maine Medical Center; ². Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, ME
Background/Purpose: The prevalence of hand osteoarthritis (OA) has doubled in the United States over the past half century – a finding that cannot be solely…
Abstract Number: 2562 • ACR Convergence 2025
Enhancing Hand Osteoarthritis Classification with Generative AI: A CycleGAN and EfficientNetB7 Approach
Zhen Cao¹, Juan Shan², Xiaohan Jiang¹, Qiong Wang¹, Timothy McAlington³, Jeffrey Driban⁴ and Ming Zhang⁵, ¹Boston University, Boston, MA, ²Pace University, New York, NY, ³UMass Chan School of Medicine, Arlington, MA, ⁴University of Massachusetts Chan Medical School, Marlborough, NH, ⁵Boston University, Westford, MA
Background/Purpose: Hand osteoarthritis (OA) is a prevalent disease that significantly impacts hand function and quality of life. The Kellgren-Lawrence (KL) grading system is widely used…

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