Abstracts tagged "Osteoarthritis"

Abstract Number: 1193 • ACR Convergence 2024
Ultrasound-Guided Corticosteroid Injection versus Iontophoresis in Rhizarthrosis: A Prospective Comparative Multicentric Study
Olga Rusinovich¹, Andrea Liso Andrino², Maria Concepcion Sanchez³, Pilar Navarro Alonso⁴, Miguel Cantalejo Moreira⁵, ALBERTO DIAZ OCA⁴, Pablo Navarro Palomo⁶, Maria Machattou⁷, Maria Alonso de Francisco³, Carlota Navarro Joven⁸, Alejandro Martinez Rodado³, laura Ramos Ortiz de Zarate⁹, hildegarda Godoy Tundidor¹⁰, Maria Carmen Barbadillo Mateos⁷, Blanca Garcia-Magallon⁷, Jose Campos⁷, Mónica Fernández Castro¹¹, JESUS SANZ SANZ⁶ and Jose Luis Andreu⁶, ¹Hospital Universitario Puerta de Hierro Majadahonda., Boadilla del Monte, Spain, ²Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Majadahonda, Madrid, Spain, ³Puerta de Hierro Majadahonda University Hospital, Majadahonda, Spain, ⁴Fuenlabrada University Hospital, Fuenlabrada, Spain, ⁵Hospital Universitario de Fuenlabrada, Fuenlabrada. Madrid, Spain, ⁶Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda, Spain, ⁷Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Spain, ⁸Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Spain, ⁹Puerta de Hierro Majadahonda University Hospital, Majahonda, Spain, ¹⁰Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Madrid, Spain, ¹¹Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Madrid, Spain
Background/Purpose: Trapeziometacarpal osteoarthritis is a common degenerative disease that causes pain and thumb dysfunction. It affects 16-25% of the population, mainly middle-aged women. Treatment modalities…
Abstract Number: 1209 • ACR Convergence 2024
Time to Knee Replacement by Kellgren-Lawrence Grade and Presence of Frequent Knee Pain in Two Large and Diverse Longitudinal Cohorts: Data from MOST and OAI
Kent Kwoh¹, Rongrong Tang², Edward Bedrick³, Jeffery Duryea⁴, Zong-Ming Li², Jean Liew⁵, Xiaoxiao Sun⁶ and Tuhina Neogi⁵, ¹University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, University of Arizona College of Medicine - Tucson, Tucson, AZ, ³Department of Epidemiology andBiostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, ⁴Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁵Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁶Department of Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ
Background/Purpose: Receipt of knee replacement has been proposed by the FDA as a structural and symptom outcome for clinical trials of Disease Modifying Osteoarthritis Drugs…
Abstract Number: 1665 • ACR Convergence 2024
Multicenter Randomized Controlled Trial of Physical Therapy (PT) or Sham PT in Persons with Knee Pain, Meniscal Tear, and Osteoarthritic Imaging Changes
Jeffrey Katz¹, Jamie Collins², Leslie Bisson³, Faith Selzer⁴, Morgan Jones², Heidi Yang², James Irrgang⁵, Clare Safran-Norton², Kurt Spindler⁶ and Elena Losina², ¹Brigham and Women's Hospital, Brookline, MA, ²Brigham and Women's Hospital, Boston, MA, ³University at Buffalo, Buffalo, NY, ⁴Brigham and Women's Hospital, Amesbury, MA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Cleveland Clinic, Clev, OH
Background/Purpose: The syndrome of knee pain and meniscal tear (MT) is prevalent and disabling. The TeMPO trial (Treatment of Meniscal Problems in Osteoarthritis (OA)) compares…
Abstract Number: 2089 • ACR Convergence 2024
Diagnostic Performance of ACR and NICE Criteria for Hip Osteoarthritis
Jos Runhaar¹, Dieuwke Schiphof¹, Qiuke Wang¹, Margreet Kloppenburg², Maarten Boers³, Hans Bijlsma⁴ and Sebastia Bierma-Zeinstra¹, and the CREDO expert group, ¹Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Amsterdam UMC, Vrije Universiteit, Amersfoort, Netherlands, ⁴UMCU, Utrecht, Utrecht, Netherlands
Background/Purpose: Available criteria for diagnosis or classification of hip osteoarthritis (OA) have been poorly validated. The few validation studies available all used radiographic features of…
Abstract Number: 2105 • ACR Convergence 2024
The Identity, Impact, and Management of OA and OA Pain from the Perspective of People with OA: A Systematic Literature Review of Qualitative Studies
Sylvain Mathieu¹, Alice Courties², Céline Mathy³, Serge Perrot⁴, Françoise Alliot Launois⁵, Stan Moumbe⁶, Nathan Foulquier⁷, Jérémie Sellam⁸ and Rinie Geenen⁹, and GO-PAIN Working group, ¹CHU Gabriel Montpied, Clermont-Ferrand, France, ²AP-HP, Paris, France, ³University of Liège, Liège, Belgium, ⁴Paris Dauphine University, Paris, France, ⁵AFLAR, Paris, France, ⁶Patient, Paris, France, ⁷LBAI. UMR 1227, University of Brest, Brest, France, ⁸Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France, ⁹Department of Psychology, Utrecht, Netherlands
Background/Purpose: Knowledge of beliefs, needs, and priorities of people with osteoarthritis (OA) is of utmost important to be able to offer person-centered care. Concepts that…
Abstract Number: 0023 • ACR Convergence 2024
Adenosine and Guanosine-based Oligonucleotide Attenuates Catabolic Phenotypes in Chondrocytes and Slows Progression of Surgically Induced Osteoarthritis
Yoonhee Kim¹, Jin Han² and Seungwoo Han³, ¹Kyungpook National University School of Medicine, Buk-gu, Daegu, Republic of Korea, ²Kyungpook National University, Buk-gu, Daegu, Republic of Korea, ³Kyungpook national university hospital, Daegu, South Korea
Background/Purpose: Adenosine is a potent endogenous modulator of inflammation; however, its clinical application is limited due to its extremely short half-life in blood. In this…
Abstract Number: 0790 • ACR Convergence 2024
CoLchicine for Treatment of OsteoArthritis of the Knee: Clinical Outcomes from a 90-day Double-Blind, Placebo-Controlled Study
Jonathan Samuels¹, Katherine Tse², Wei David², maryfe Coronel², Fernando Bomfim², Renata La Rocca Vieira³, Nicole Leung⁴, Svetlana Krasnokutsky Samuels⁵, Michael Toprover⁶ and Michael Pillinger⁷, ¹NYU Langone, Rye Brook, NY, ²NYU Langone Health, new york, NY, ³NYU., New York, NY, ⁴New York University Langone Medical Center, New York, NY, ⁵Summit Health, Rye Brook, NY, ⁶New York University Langone Health, New York, NY, ⁷New York University Grossman School of Medicine, New York,, NY
Background/Purpose: Knee osteoarthritis (OA) leads to progressive disability, but approved pharmacologic treatments target analgesia without affecting disease course. Colchicine is well-tolerated and inhibits inflammation thought…
Abstract Number: 1172 • ACR Convergence 2024
Participation in Baseball/Softball Associates with Increased Risk for Knee Pain and Osteoarthritis as an Adult: Data from the Osteoarthritis Initiative
Christopher Boldt¹, Jeffrey Driban², Timothy McAlindon², Andrea Kriska³, Bonny Rockette-Wagner³, Charles Eaton⁴, Marc Hochberg⁵, Kent Kwoh⁶, Michael Nevitt⁷ and Grace Lo⁸, ¹Baylor College of Medicine, Houston, TX, ²University of Massachusets, Worchester, MA, ³University of Pittsburgh, Pittsburgh, PA, ⁴Memorial Hospital of Rhode Island, Pawtucket, RI, ⁵University of Maryland School of Medicine, Cambridge, MD, ⁶University of Arizona, Tucson, AZ, ⁷University of California, San Francisco, San Francisco, CA, ⁸Baylor College of Medicine / MEDVAMC, Houston, TX
Background/Purpose: Baseball is often referred to as “America’s Pastime” and youth in the United States commonly participate in baseball and softball. With the increasing popularity…
Abstract Number: 1194 • ACR Convergence 2024
Treatment Effect of Lorecivivint Across Multiple Trials in Patients with Knee OA: A Meta-analysis
Christopher Swearingen¹, Jeyanesh Tambiah² and Yusuf Yazici³, ¹Biosplice Therapeutics, Inc, San Diego, CA, ²Biosplice Therapeutics Inc., San Diego, CA, ³NYU Grossman School of Medicine, La Jolla, CA
Background/Purpose: Lorecivivint (LOR), an intra-articular (IA) CLK/DYRK inhibitor thought to modulate inflammatory and Wnt pathways has previously appeared safe, improved patient-reported outcomes (PROs) compared with…
Abstract Number: 1210 • ACR Convergence 2024
Optimal Definitions of Worsening Cartilage Using Sequential MRI OsteoArthritis Knee Scores (MOAKS)
Kathryn Bacon¹, mike LaValley², Tuhina Neogi³, Ali Guermazi³, Frank Roemer³, Neil Segal⁴, Cora Lewis⁵, Michael Nevitt⁶, David Felson⁷ and John Lynch⁸, ¹Boston University, Webster, NH, ²Boston University School of Public Health, Arlington, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁴University of Kansas, Kansas City, KS, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶University of California, San Francisco, San Francisco, CA, ⁷Boston University, Boston, MA, ⁸UCSF, San Francisco, CA
Background/Purpose: The MRI OsteoArthritis Knee Score (MOAKS) is increasingly used in studies of knee osteoarthritis. Our aim was to evaluate methods using MOAKS scores to…
Abstract Number: 1667 • ACR Convergence 2024
Correlates of Physical Activity (PA) in Persons Undergoing Total Knee Arthroplasty (TKA): Does Pain Matter?
Elena Losina¹, Jamie Collins¹, Clare Safran-Norton¹, Mike Paskewicz¹, Faith Selzer², Sonia Pavlesen³, Kelly Frier¹, Jon Dhani¹, Darya Lee¹, Ella Macdonald³, Alexa Streicher³, Linda Ehrlich-Jones⁴, Neil Segal⁵, Christine Pellegrini⁶, Elizabeth Wellsandt⁷, Rowland Chang⁸ and Jeffrey Katz¹, and KArAT Team, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Amesbury, MA, ³University of Buffalo, Buffalo, NY, ⁴Shirley Ryan Ability Lab, Chicago, IL, ⁵University of Kansas, Kansas City, KS, ⁶University of South Carolina, Columbia, SC, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: Low PA in persons with symptomatic knee osteoarthritis (OA) has often been attributed to pain. Evolving data suggest that TKA recipients do not increase…
Abstract Number: 2090 • ACR Convergence 2024
Prevalence of Steatotic Liver Disease and Liver Fibrosis Among Patients with Osteoarthritis (OA)
Athanasios Vassilopoulos¹, Stephanos Vassilopoulos², Markos Kalligeros², Eleftherios Mylonakis³ and Anthony M. Reginato⁴, ¹Warren Alpert Medical School of Brown University, Providence, RI, ²Division of Internal Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, Providence, RI, ³Department of Medicine, Houston Methodist Hospital, Houston, ⁴Brown University, Providence, RI
Background/Purpose: Steatotic liver disease (SLD) and osteoarthritis (OA) affect a large proportion of the general population and prevalence of both is expected to increase given…
Abstract Number: 2106 • ACR Convergence 2024
EP-104IAR (Long-Acting Intra-Articular Injection of Fluticasone Propionate) Shows Sustained Improvement in Pain for Subjects with Moderate Baseline Pain and BMI Less Than 30 in SPRINGBOARD, a Phase 2, Randomized, 24-Week Study of Osteoarthritis of the Knee
Amanda Malone¹, James Helliwell¹, Mark Kowalski¹, Helene Rovsing², Sidsel Lynggaard Boll³, Asger Reinstrup Bihlet⁴, Claire Prener Miller⁵, Alejandro Castillo Mondragón⁶, Yanqi Li⁶, Christine Dobek¹, Vik Peck¹, Andrew Dye¹, Mike Wilmink⁷, Lee Simon⁸ and Philip G Conaghan⁹, ¹Eupraxia Pharmaceuticals, Victoria, BC, Canada, ²NBCD A/S, Nordjylland, Denmark, ³NBCD A/S, Syddanmark, Denmark, ⁴NBCD A/S, Soeborg, Denmark, ⁵Novo Nordisk A/S, Bagsværd, Denmark, ⁶NBCD A/S, Soborg, Denmark, ⁷OrthoArizona, Phoenix, AZ, ⁸SDG LLC, West Newton, MA, ⁹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Knee osteoarthritis (KOA) is a leading cause of disability associated with risk of cardiovascular disease and reduced self-management of diabetes and hypertension. Recommended treatment…
Abstract Number: 0024 • ACR Convergence 2024
Trans-Signaling by Soluble CD14 Sensitizes Chondrocytes to Lipopolysaccharide Stimuli, Increasing Chondrocyte Inflammatory Responses
Anna E. Rapp, Baofeng Hu and Carla Scanzello, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The understanding of osteoarthritis (OA) has evolved significantly over the past decade. Recently attention is being drawn to the role of pattern-recognition receptor (PRR)…
Abstract Number: 0791 • ACR Convergence 2024
Optimizing Knee Osteoarthritis Treatment with the Precision Medicine Approach in a Clinical Trial Dataset
Caroline Walton¹, Forrest Hurley², Liubov Arbeeva³, Stephen Messier⁴, Shannon Mihalko⁴, Jeffrey Katz⁵, Richard Loeser⁶, David Hunter⁷, Leigh Callahan⁸ and Amanda Nelson², ¹UNC School of Medicine, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina, Chapel Hill, Carrboro, NC, ⁴Wake Forest University, Winston Salem, NC, ⁵Brigham and Women's Hospital, Brookline, MA, ⁶University of North Carolina, Chapel Hill, NC, ⁷Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁸University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Precision medicine has previously identified subgroups of clinical trial participants with knee osteoarthritis (kOA) that benefit more from a specific intervention than others. We…

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