Abstracts tagged "Osteoarthritis"

Abstract Number: 2135 • ACR Convergence 2023
Synovial Fluid High-density Lipoprotein (HDL)-miR-1246 Is Enriched in Patients with Inflammatory Arthritis Compared to Osteoarthritis and Increases Synovial Fibroblast IL-6 Expression
Olivia Posey¹, Qiong Wu¹, Anastasiia Phothisane¹, Christine Pham², Deborah Parks², Antonina Akk³, Danielle Michell¹, Kasey Vickers¹ and Michelle Ormseth¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Washington University, St. Louis, MO, ³Washington University in St. Louis, St. Louis, MO
Background/Purpose: High-density lipoprotein (HDL), known for its anti-atherogenic reverse cholesterol transport function, also transports miRNAs between cells, altering cellular function. We found that compared to…
Abstract Number: 0310 • ACR Convergence 2023
Implementing an Osteoarthritis Management Program to Deliver Guideline-Driven Care for Knee and Hip Osteoarthritis in a U.S. Academic Health System
Kathryn Miller¹, Divya Vundamati², Linda Baier¹, Roger Brown¹, Tommy Yue Yu¹ and Christie M. Bartels³, ¹University of Wisconsin, Madison, WI, ²UW Health, Madison, WI, ³University of Wisconsin, School of Medicine and Public Health, Madison, WI
Background/Purpose: To assess patient outcomes from an Osteoarthritis Management Program (OAMP) situated in an academic medical center.Methods: Eligibility for this open cohort study included adults…
Abstract Number: 0749 • ACR Convergence 2023
Impact of Sprifermin on Denuded Areas of Subchondral Bone (dABs): A Post Hoc Analysis of the FORWARD Study
Felix Eckstein¹, Wolfgang Wirth², Philip Conaghan³, Marc Hochberg⁴, Ali Guermazi⁵, Jade Andrade⁶, Luping Zhao⁶ and Niti Goel⁷, ¹Paracelsus Medical University, Institute of Anatomy & Ludwig Boltzmann Institute, and Chondrometrics GmbH, Salzburg, Austria, ²Paracelsus Medical University, Institute of Anatomy & Ludwig Boltzmann Institute, and Chondrometrics GmbH, Freilassing, Germany, ³University of Leeds, Leeds, United Kingdom, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Boston University, Boston, MA, ⁶TrialSpark, New York, NY, ⁷TrialSpark, Duke University, Durham, NC
Background/Purpose: Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF-18), is being investigated as a potential disease-modifying osteoarthritis drug. The Phase 2 FORWARD study demonstrated that…
Abstract Number: 0868 • ACR Convergence 2023
Enhancing Oxidative Phosphorylation Through PDK2 Depletion Alleviates Cartilage Degradation in Surgically Induced Osteoarthritis
Seungwoo Han¹, Jin Han², Yujung kim², Yoonhee Kim² and Donghwi Park³, ¹Kyungpook national university hospital, Daegu, South Korea, ²Kyungpook National University, Daegu, South Korea, ³Daegu Fatima hospital, Daegu, South Korea
Background/Purpose: Although chondrocytes rely primarily on glycolysis to meet their cellular energy needs, they have the metabolic flexibility to shift toward oxidative phosphorylation (OxPhos) in…
Abstract Number: 0884 • ACR Convergence 2023
Identification of a Mast Cell-high Synovial Pathotype of Osteoarthritis
Shady Younis, Audrey Bai, heidi Wong, Zelda Love, Qian Wang and William Robinson, Stanford School of Medicine, Stanford, CA
Background/Purpose: Mast cells in the osteoarthritis (OA) synovium correlate with disease severity. This study aimed to further elucidate the role of mast cells in OA…
Abstract Number: 1194 • ACR Convergence 2023
Extent of Subregional Involvement of Subchondral Bone Marrow Lesions in Incident Knee OA Is Associated with Weight-Bearing Knee Pain
Kent Kwoh¹, Frank Roemer², Erin Ashbeck³ and Ali Guermazi⁴, ¹University of Arizona, Tucson, AZ, ²Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, ³University of Arizona Arthritis Center, Tucson, AZ, ⁴Boston University, Boston, MA
Background/Purpose: Subchondral bone marrow lesions (BMLs) have been associated with incident and progressive pain and reported to fluctuate along with concurrent fluctuations in symptoms. While…
Abstract Number: 1792 • ACR Convergence 2023
Identifying Synovial Fluid Micro-RNA Signature That Distinguishes Psoriatic Arthritis from Osteoarthritis
Darshini Ganatra¹, Anas Samman¹, David Nasri¹, Sara Rahmati¹, Omar Cruz Correa¹, Rohan Machhar¹, Rajiv Gandhi², Mohit Kapoor³ and Vinod Chandran⁴, ¹Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Orthopaedics, Department of Surgery, University of Toronto, Toronto, ON, Canada, ³Schroeder Arthritis Institute, University Health Network and Department of Surgery, University of Toronto, Toronto, ON, Canada, ⁴Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic Arthritis (PsA) is an inflammatory arthritis and shares several clinical features with Osteoarthritis (OA), the most common form of arthritis. This often leads…
Abstract Number: 1981 • ACR Convergence 2023
The Association Between X-ray Progression and Clinical Outcomes in Patients with Hand Osteoarthritis with 5-year Follow-up
Olga Sleglova¹, Jiri Baloun², Jindriska Gatterova¹, Xiao Svec¹, Olga Ruzickova¹, Karel Pavelka³ and Ladislav Senolt⁴, ¹Rheumatology Institute, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, ³Institut of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Praha, Czech Republic, ⁴Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Praha, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) is a heterogeneous disorder with two main subtypes, non-erosive and erosive. The progression of HOA is assessed by various radiographic scoring…
Abstract Number: 2426 • ACR Convergence 2023
The Role of β-catenin in Synovial Lining Fibroblast Differentiation
Sonia Presti¹, Gerald F.M. Watts¹, Junning Case¹, Zhu Zhu², Teri Bowman¹, Hung Nguyen¹, Gabriel Nigrovic¹, Ce Gao¹, Kartik Bhamidipati¹, Yuhong Li¹, Suppawat Kongthong¹, Fan Zhang³, Anna Helena Jonsson¹, Accelerating Medicines Partnership Program (AMP RA/SLE) Network⁴, STARS BWH¹, Michael Brenner⁵, Shideh Kazerounian¹ and Kevin Wei⁵, ¹Brigham and Women's Hospital, Boston, MA, ²10x Genomics, St. Louis, MO, ³University of Colorado, Aurora, CO, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, Boston, MA, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In healthy synovium, lining fibroblasts promote joint health by secreting proteoglycans that lubricate the joint cavity. In rheumatoid arthritis (RA), sublining fibroblasts undergo marked…
Abstract Number: L05 • ACR Convergence 2022
Effect of Denosumab on Structure Modification in Erosive Hand Osteoarthritis: Results of a 48-Week, Monocentric, Randomized, Placebo-controlled, Double-blind Phase 2 Study and Open Label Extension Phase
Ruth Wittoek¹, August Verbruggen², Tine Vanhaverbeke² and Dirk Elewaut³, ¹Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Oost-Vlaanderen, Belgium, ²Ghent University Hospital, Ghent, Belgium, ³Ghent University and VIB Center for Inflammation Research, Ghent, Belgium
Background/Purpose: Erosive hand osteoarthritis (OA) is a disabling disease with limited therapeutic options. Denosumab, a Receptor Activator of Nuclear Factor kappa-b Ligand inhibitor, affects bone…
Abstract Number: 0101 • ACR Convergence 2022
Twenty-five Years of Mortality Data in Those with Lower Extremity Osteoarthritis: The Role of Socioeconomic Status
Cara Murphy¹, Rebecca Cleveland¹, Amanda Nelson², Yvonne Golightly³ and Leigh Callahan⁴, ¹University of North Carolina, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of Nebraska Medical Center, Omaha, NE, ⁴University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: The purpose of this study is to explore the relationship between socioeconomic status (SES) measures (income, professional employment, block group poverty level, education level,…
Abstract Number: 0841 • ACR Convergence 2022
Relation of PainDETECT to Unpredictable Pain in People with or at Risk of Knee Osteoarthritis
Kosaku Aoyagi¹, Laura Frey-Law², Gabriela Rabasa³, Cora E. Lewis⁴, Michael Nevitt⁵ and Tuhina Neogi⁶, ¹Boston University, Quincy, MA, ²University of Iowa, Iowa City, IA, ³Boston University, Boston, MA, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of California at San Francisco, Orinda, CA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: PainDETECT has been used in studies of knee OA to identify "neuropathic-like pain", though neuropathic lesions have not been identified in clinical knee OA.…
Abstract Number: 1353 • ACR Convergence 2022
Dietary Practices and Beliefs of Patients with Rheumatic Diseases and Relationship with Symptoms: Results of a Multicenter Cross-sectional Study
Domitille RENARD¹, Sophie Tuffet², Philippe Dieude³, Pascal Claudepierre⁴, Laure Gossec⁵, Bruno Fautrel⁶, Anna Molto⁷, Corinne MIceli⁸, Pascal Richette⁹, Emmanuel Maheu¹⁰, Claire Carette¹¹, Sebastien Czernichow¹¹, Chloe JAMAKORZYAN¹², alexandra Rousseau², Francis Berenbaum¹³, Catherine Beauvais¹⁴ and Jérémie SELLAM¹⁵, ¹Sorbonne University Paris- Sant Antoine Hospital, Paris, France, ²Saint Antoine hospital, Paris, Ile-de-France, France, ³Université Paris Cité, Paris, France, ⁴Paris Est Creteil University, Creteil, France, ⁵Sorbonne Université, Paris, France, ⁶Sorbonne University Paris, France and Pierre Louis Institute of Epidemiology and Public Health, Paris, France, Paris, France, ⁷Rheumatology Department, Cochin Hospital, APHP, Paris, France, ⁸APHP, Paris, France, ⁹Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, ¹⁰Hôpital Paris Saint Antoine, Moirans, Auvergne-Rhône-Alpes, France, ¹¹Hôpital Européen Georges Pompidou, Paris, France, ¹²Hopital Begin, Saint-Mandé, France, ¹³Sorbonne University - Saint-Antoine hospital, Paris, France, ¹⁴Saint Antoine hospital, Paris, France, ¹⁵Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France
Background/Purpose: Diet is a subject of questioning and beliefs among patients with rheumatic diseases. They are inclined to change their eating habits and sometimes follow…
Abstract Number: 1888 • ACR Convergence 2022
Novel Small Molecule Modulator of the gp130 Receptor Shows Dose-dependent Therapeutic Efficacy in a Canine Model of Osteoarthritis
Ben Van Handel¹, Candace Flynn², Emma Lamoure², Nancy Liu³, Jinxiu Lu³, Nancy Lane⁴, Mark Hurtig² and Denis Evseenko³, ¹CarthroniX, Inc., Los Angeles, CA, ²University of Guelph, Guelph, ON, Canada, ³University of Southern California, Los Angeles, CA, ⁴University of California Davis, Hillsborough, CA
Background/Purpose: The pathogenesis of OA often begins from an injury to articular cartilage, which establishes chronic, low-grade inflammation principally mediated by IL-6 family cytokines that…
Abstract Number: 1904 • ACR Convergence 2022
Is Treating Painful Hand Osteoarthritis with Hormone Replacement Therapy Feasible? Primary Results from a Randomised Controlled Trial in Post-menopausal Women
Jennifer Williams¹, Mae Chester-Jones¹, Megan Goff², Anne Francis¹, Gretchen Brewer¹, Ioana Marian¹, Malvika Gulati¹, Charles Mackworth-Young³, Victoria Glover⁴, Sarah Lamb¹, Tonia Vincent⁵, Katy Vincent¹, Susan Dutton¹ and Fiona Watt⁶, ¹University of Oxford, Oxford, United Kingdom, ²University of Oxford, London, United Kingdom, ³Imperial College Healthcare NHS Trust, London, United Kingdom, ⁴White Horse Medical Practice, Faringdon, United Kingdom, ⁵Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁶Imperial College London, London, United Kingdom
Background/Purpose: Hand osteoarthritis (OA) is more common in females and relative risk increases further around the age of menopause, potentially implicating sex hormone deficiency. There…

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