Abstracts tagged "Osteoarthritis"

Abstract Number: 2469 • ACR Convergence 2023
Associations Between Body Composition Measurements of Obesity and the Radiographic Progression of Hand Osteoarthritis: Data from the Dong-gu Study
Sung-Eun Choi¹, Hyemin Jeong¹, Dong-Jin Park¹, Ji-Hyoun Kang², Min-Ho Shin³ and Shin-Seok Lee¹, ¹Chonnam National University Medical School & Hospital, Gwangju, South Korea, ²Chonnam National University Hospital, Gwangju, South Korea, ³Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: Previous studies have found that obesity is a risk factor for hand osteoarthritis (OA), but most have been cross-sectional studies and thus causality is…
Abstract Number: 0314 • ACR Convergence 2023
Lack of Systemic Effects from Intra-articular XT-150 for the Treatment of Moderate to Severe Pain Due to OA of the Knee: Safety Results from a Phase 2 Trial
Leonard Kapural¹, Stephen D. Collins², Eric Grigsby³, Mark McBride⁴, Jayson Rieger⁵, Morgan Stokes⁶, Howard Rutman⁶ and Flavia Cicuttini⁷, ¹Center for Clinical Research, Winston-Salem, NC, ²Xalud Therapeutics, Inc., Chicago, IL, ³Neurovations Clinical Research, Napa, CA, ⁴Instat Clinical Research, Chatham, NJ, ⁵PBM Capital, Charlottesville, VA, ⁶Xalud Therapeutics, Inc., Berkeley, CA, ⁷Monash University, Melbourne, Australia
Background/Purpose: This study (NCT04124042) was designed to assess the safety, tolerability, and efficacy of XT-150, a non-viral gene therapy, in adult participants with moderate to…
Abstract Number: 0819 • ACR Convergence 2023
Regression to the Mean for Physical Function and Quality of Life in Trials for Symptomatic Knee Osteoarthritis
Martin Englund and Aleksandra Turkiewicz, Lund University, Lund, Sweden
Background/Purpose: Improvement in pain reported in clinical trials for osteoarthritis (OA) is typically strongly depending on the regression-to-the-mean phenomenon. Regression to the mean has been…
Abstract Number: 0872 • ACR Convergence 2023
Synovial 5-LOX-Derived Oxylipins Define a B Cell-Enriched Synovium
Jessica Murillo-Saich¹, Roxana Coras², Felipe Julio Ramirez Garcia³, Estefania Quesada-Masachs⁴, Marta Sala Climent⁵, Katharina Eschelbach⁴, Christopher Mahony⁶, Raquel Celis⁷, Aaron Armando⁸, Oswald Quehenberger⁸, Adam Croft⁶, Arthur Kavanaugh⁹, Eric Chang⁵, Juan D Canete¹⁰, Abha Singh¹ and Monica Guma¹¹, ¹Department of Medicine, University of California San Diego, La Jolla, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Hospital Clínic, Barcelona, Spain, ⁴La Jolla Institute for Immunology, La Jolla, CA, ⁵University of California San Diego, San Diego, CA, ⁶University of Birmingham, Birmingham, United Kingdom, ⁷Arthritis Unit, Rheumatology Department, Hospital Clinic and IDIBAPS, Barcelona, Spain, ⁸Department of Pharmacology, University of California San Diego, La Jolla, CA, ⁹University of California San Diego, School of Medicine, Riverside, CA, ¹⁰Hospital Clinic an IDIBAPS, Barcelona, Spain, ¹¹San Diego VA Healthcare Service, La Jolla, CA
Background/Purpose: Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFAs) that modulate inflammation and may remain overexpressed in refractory synovitis. These mediators in plasma…
Abstract Number: 1047 • ACR Convergence 2023
Infrared Thermography Imaging Discriminates Between Inflamed and Non-inflamed Joints
Maria I. ("Maio") Danila¹, Giovanna Rosas², Fenglong Xie², Jeffrey R Curtis³, Kiara Aaron², Stephanie Ford² and Laura Hughes⁴, ¹University of Alabama at Birmingham (UAB), Birmingham VA Medical Center, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, ⁴University of Alabama at Birmingham; East Alabama Medical Center, Birmingham, AL
Background/Purpose: Infrared thermography (IRT) is an emerging technology that has the potential to rapidly assist in identifying joint inflammation in patients with joint symptoms. However,…
Abstract Number: 1198 • ACR Convergence 2023
Bicycling Is Not Associated with New Knee Pain or Disease Progression over 48 Months in Those with Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Colin McLaughlin¹, Grace Lo¹, Jeffrey Driban², Timothy McAlindon³, Andrea Kriska⁴, Bonnie Rockette-Wagner⁴, Marc Hochberg⁵, Michael Nevitt⁶, Kent Kwoh⁷ and Charles Eaton⁸, ¹Baylor College of Medicine, Houston, TX, ²Tufts Medical Center, Westborough, MA, ³Tufts Medical Center, Arlington, MA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶University of California San Francisco, Orinda, CA, ⁷University of Arizona, Tucson, AZ, ⁸Brown University, Pawtucket, RI
Background/Purpose: Bicycling is viewed as a non-weight bearing exercise and is often recommended as a preferred exercise for those with knee osteoarthritis (OA).However, there is…
Abstract Number: 1840 • ACR Convergence 2023
Value of Various Intra-Articular Injections for Knee Osteoarthritis Management
Hanna Mass¹, Jamie Collins¹, david Hunter², Catherine Yang¹, Morgan Jones¹, Stephen Messier³, Tuhina Neogi⁴, A. David Paltiel⁵, Jeffrey Katz¹ and Elena Losina⁶, ¹Brigham and Women's Hospital, Boston, MA, ²Sydney Musculoskeletal Health, University of Sydney, St. Leonards, Australia, ³Wake Forest University, Winston-Salem, NC, ⁴Boston University School of Medicine, Boston, MA, ⁵Yale School of Public health, New Haven, CT, ⁶Brigham and Women's Hospital, Boston, MA
Background/Purpose: Intra-articular injections (IAI) are commonly used to relieve pain and delay total knee replacement (TKR) in persons with knee OA. Despite higher costs and…
Abstract Number: 1985 • ACR Convergence 2023
Preliminary Results for the Total Knee Replacement Coaching Program for Patients Preparing to Undergo Total Knee Arthroplasty, a Pilot Randomized Trial
Noelia Hernandez¹, Yuliana Dominguez Paez², Assem Jabri², Mackenzie Brown², Geyanne Lui³, Wai-Kwong Hui⁴, Michael Parks⁴, Alejandro Gonzalez Della Valle⁴, Fred Cushner⁴, Peter Sculco⁴, Thomas Sculco⁴, Mathias Bostrom⁴, Alejandro Leali⁴, Jason Blevins⁴, Jose Rodriguez⁴, Gwo-Chin Lee⁴, Lisa Mandl⁵, Susan Goodman⁴, Samprit Banerjee², Monika Safford⁶ and Iris Navarro-Millán⁷, ¹Weill Cornell Medicine, The Bronx, NY, ²Weill Cornell Medicine, New York, NY, ³New York Institute of Technology, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁶WCM Department of Medicine, New York, NY, ⁷Weill Cornell Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Up to 30% of patients with primary knee osteoarthritis (KOA) who have undergone Total Knee Replacement (TKR) continue to experience knee pain after surgery.High…
Abstract Number: 2470 • ACR Convergence 2023
Low Serum Adiponectin Levels Were Associated with Radiographic Progression of Hand Osteoarthritis in a 6-year Follow-up of the Dong-gu Study
Sung-Eun Choi¹, Hyemin Jeong¹, Dong-Jin Park¹, Ji-Hyoun Kang², Min-Ho Shin³ and Shin-Seok Lee¹, ¹Chonnam National University Medical School & Hospital, Gwangju, South Korea, ²Chonnam National University Hospital, Gwangju, South Korea, ³Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: The association between serum adiponectin levels and hand osteoarthritis (OA) has been studied cross-sectionally, but longitudinal studies on the radiographic progression of hand OA…
Abstract Number: L05 • ACR Convergence 2022
Effect of Denosumab on Structure Modification in Erosive Hand Osteoarthritis: Results of a 48-Week, Monocentric, Randomized, Placebo-controlled, Double-blind Phase 2 Study and Open Label Extension Phase
Ruth Wittoek¹, August Verbruggen², Tine Vanhaverbeke² and Dirk Elewaut³, ¹Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Oost-Vlaanderen, Belgium, ²Ghent University Hospital, Ghent, Belgium, ³Ghent University and VIB Center for Inflammation Research, Ghent, Belgium
Background/Purpose: Erosive hand osteoarthritis (OA) is a disabling disease with limited therapeutic options. Denosumab, a Receptor Activator of Nuclear Factor kappa-b Ligand inhibitor, affects bone…
Abstract Number: 1892 • ACR Convergence 2022
Genicular Nerve Block for Pain Management in Patients with Knee Osteoarthritis: A Randomised Double-blind Placebo Controlled Trial
Ernst Shanahan¹, Fin Cai², Frank Voyvodic², Suellen Lyne², Richard Woodman¹, Kokum Dissanayake², Kate Paddick², Giovanna Cheung² and Lucinda Robinson², ¹Flinders University, Adelaide, Australia, ²SALHN, Adelaide, Australia
Background/Purpose: To determine whether Genicular Nerve Block (GNB) is an efficacious treatment for patients with knee osteoarthritis (OA)Methods: Adults with symptomatic knee OA for greater than 3…
Abstract Number: 1908 • ACR Convergence 2022
Should Osteoarthritis Patients with Pain Scores More Than 8/10 Be Analyzed Separately or Excluded from Clinical Trial Protocols, as 72% Screen Positive for Fibromyalgia And/or Depression on a Multidimensional Health Assessment Questionnaire (MDHAQ)?
Juan Schmukler¹, Kathryn Gibson², Tengfei Li³, Joel Block¹ and Theodore Pincus¹, ¹Rush University Medical Center, Chicago, IL, ²Liverpool Hospital, Sydney, Australia, ³Georgetown University, Washington, DC
Background/Purpose: Most osteoarthritis (OA) clinical trial protocols require a 0-10 pain visual numeric scale (VNS) or other quantitative pain score of 4/10 or more for…
Abstract Number: 2208 • ACR Convergence 2022
Diagnostic Performance of Hip Ultrasound in Calcium Pyrophosphate Deposition Disease
Carina Soto-Fajardo¹, Fabian Carranza-Enriquez², Sinthia Solorzano Flores², Abish Angeles², Paola Flores², Raul Pichardo-Bahena², Luis Javier Jara Quezada², Angélica Peña Ayala², Victor-Manuel Ilizaliturri-Sanchez², Georgios Filippou³ and Carlos Pineda², ¹Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra", Ciudad de México, Mexico, ²Instituto Nacional de Rehabilitacion, Ciudad de México, Mexico, ³Rheumatology Department, Luigi Sacco University Hospital, Siena, Italy
Background/Purpose: Calcium Pyrophosphate Deposition Disease (CPPD) is a chronic and potentially incapacitating disease. The reference standard for its diagnosis is the identification of calcium pyrophosphate…
Abstract Number: 0019 • ACR Convergence 2022
Bacterial Peptidoglycan in Synovial Tissue at Time of Total Knee Arthroplasty Is Associated with Inflammatory Synovitis and Younger Patient Age
Meaghan Holub¹, Amanda Wahhab², Joseph Rouse², Brandon Jutras³, Klemen Strle⁴, Adam Edelstein⁵ and Robert Lochhead⁶, ¹Central Michigan University College of Medicine, Mount Pleasant, MI, ²Medical College of Wisconsin, Milwaukee, WI, ³Virginia Tech, Blacksburg, VA, ⁴Wadsworth Center, Albany, NY, ⁵Northwestern Medicine, Chicago, IL, ⁶Medical College of Wisconsin, Germantown, WI
Background/Purpose: Peptidoglycan (PG) is a bacterial cell wall component that is known to induce innate immune responses. PG has been identified as a driver of…
Abstract Number: 0504 • ACR Convergence 2022
Three-dimensional Ground Reaction Force Symmetry Metrics Largely Fail to Explain Cartilage Worsening in the Contralateral Knee in Persons with Unilateral Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Patrick Corrigan¹, Cara Lewis², Kerry Costello², Ali Guermazi², Frank Roemer³, Deepak Kumar², David Felson², Kathryn Bacon², Tuhina Neogi⁴, Michael LaValley⁵, Michael Nevitt⁶, Cora E. Lewis⁷, James Torner⁸ and Joshua Stefanik⁹, ¹Saint Louis University, St. Louis, MO, ²Boston University, Boston, MA, ³Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany, ⁴Boston University School of Medicine, Boston, MA, ⁵Boston University School of Public Health, Arlington, MA, ⁶University of California San Francisco, Orinda, CA, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸University of Iowa, Iowa City, IA, ⁹Northeastern University, Boston, MA
Background/Purpose: Knee osteoarthritis (KOA) often starts as a unilateral disease and commonly progresses to bilateral KOA. There is a need to identify mechanisms that explain…

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