Abstracts tagged "Osteoarthritis"

Abstract Number: 0097 • ACR Convergence 2022
Sex and Race/ethnicity Differences in Knee Symptoms, Function, and Radiographic Features: Preliminary Descriptive Data from the Johnston County Health Study
Luis Palomino¹, Carolina Alvarez², Todd Schwartz³, Yvonne Golightly⁴ and Amanda Nelson², ¹University of North Carolina Chapel hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina-Chapel Hill, Chapel Hill, NC, ⁴University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Osteoarthritis (OA) is the most common form of joint disorder worldwide. Differences in pain, function, and radiographic features in ethnic groups, specifically Hispanics, are…
Abstract Number: 0839 • ACR Convergence 2022
Association of Tibial Acceleration During Walking to Knee Pain and Loading in Adults with Knee Osteoarthritis
Khara James¹, Patrick Corrigan², Corey Lanois³, Chun-Hao Huang⁴, Irene Davis⁵ and Joshua Stefanik⁴, ¹Northeastern Unviersity, Boston, MA, ²Saint Louis University, St. Louis, MO, ³Northeastern University, Providence, RI, ⁴Northeastern University, Boston, MA, ⁵University of South Florida, Tampa, FL
Background/Purpose: Pain and abnormal loading are known to be associated with the progression of knee osteoarthritis (OA). Individuals with knee OA have increased vertical loading…
Abstract Number: 1350 • ACR Convergence 2022
A Prospective Study on Pain Associated with Injection of Needles: PAIN Study
Chay Bae¹, Eugenia Chen¹ and Maida Wong², ¹Rheumatology, University of California, Irvine School of Medicine, Irvine, CA, ²Rheumatology, VA Long Beach Healthcare System, Long Beach, CA
Background/Purpose: Joint pain is a common issue amongst patients. In the appropriate clinical setting, joint injections or aspirations may benefit the patient. Pain, however, is…
Abstract Number: 1786 • ACR Convergence 2022
Anterior Knee Pain Is Associated with 2-year Compartment Specific Patellofemoral Cartilage Worsening: The MOST Study
Corey Lanois¹, Natalie Collins², Tuhina Neogi³, Ali Guermazi⁴, Frank Roemer⁵, Michael LaValley⁶, Michael Nevitt⁷, James Torner⁸, Cora E. Lewis⁹ and Joshua Stefanik¹⁰, ¹Northeastern University, Providence, RI, ²University of Queensland, Brisbane, Australia, ³Boston University School of Medicine, Boston, MA, ⁴Boston University, Boston, MA, ⁵Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany, ⁶Boston University School of Public Health, Arlington, MA, ⁷University of California at San Francisco, Orinda, CA, ⁸University of Iowa, Iowa City, IA, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰Northeastern University, Boston, MA
Background/Purpose: Anterior knee pain (AKP) may be a precursor to patellofemoral osteoarthritis (PFOA). Cross-sectionally, frequent AKP has been associated with MRI features of PFOA; however,…
Abstract Number: 1903 • ACR Convergence 2022
Does Pain Sensitization by Pressure Pain Thresholds and Temporal Summation Predict Persistent Pain in Persons with Hand OA?
Pernille Steen Pettersen¹, Tuhina Neogi², Elisabeth Mulrooney¹, Marthe Gløersen¹, Hilde Berner Hammer³ and Ida K. Haugen¹, ¹Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, ²Boston University School of Medicine, Boston, MA, ³Diakonhjemmet hospital, Jar, Norway
Background/Purpose: Pain sensitization is part of the complexity of osteoarthritis (OA) pain. We aimed to examine whether pain sensitization by pressure pain thresholds (PPT) and…
Abstract Number: 1919 • ACR Convergence 2022
Underdiagnosis and Undertreatment of Knee Osteoarthritis in Persons with Type 2 Diabetes: A Cross-sectional Study
Lauren King¹, Esther Waugh¹, Ian Stanaitis², Alanna Weisman¹, Baiju Shah¹, Lorraine Lipscombe¹ and Gillian Hawker¹, ¹University of Toronto, Toronto, ON, Canada, ²Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes commonly co-occur due to shared risk factors. Concomitant knee OA makes type 2 diabetes management, particularly engaging…
Abstract Number: 0220 • ACR Convergence 2021
Relation of Knee Extensor Power to Worsening Cartilage Damage in the Knee: The MOST Study
Joshua Stefanik¹, David Felson², Cara Lewis³, Gabriela Rabasa², Ali Guermazi², Frank Roemer⁴, Michael Nevitt⁵, Cora Lewis⁶ and Neil Segal⁷, ¹Northeastern University, Boston, MA, ²Boston University, Boston, MA, ³Boston University, Brookline, MA, ⁴Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany, ⁵University of California San Francisco, Orinda, CA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of Kansas Medical Center, Iowa City, IA
Background/Purpose: The relation between knee extensor muscle weakness and osteoarthritis (OA) outcomes has been well-studied. Muscle power, another measure of knee extensor function, however, has…
Abstract Number: 0724 • ACR Convergence 2021
Dose (Exposure) Efficacy Response of Tanezumab Following Intravenous and Subcutaneous Administration Across Phase 2 and Phase 3 Studies in Patients with Osteoarthritis of Hip and Knee
Martin Boucher¹, Kenneth Verburg², Puneet Gaitonde² and Scott marshall¹, ¹Pfizer R&D Ltd., Sandwich, United Kingdom, ²Pfizer Inc., Groton, CT
Background/Purpose: Tanezumab is a humanized monoclonal antibody against nerve growth factor that has been evaluated for relief of chronic osteoarthritis pain by subcutaneous (SC) or…
Abstract Number: 0852 • ACR Convergence 2021
Bone Marrow Lesion Segmentation Using Synthetic Data and Deep Learning Models
Barak Michaely¹, Ming Zhang² and Juan Shan¹, ¹Pace University, New York, NY, ²Wentworth Institute of Technology, Boston, MA
Background/Purpose: Bone marrow lesions (BML) are indicators for knee osteoarthritis (OA) and can be detected from magnetic resonance imaging (MRI). Due to the small size,…
Abstract Number: 1121 • ACR Convergence 2021
Association of Healthcare Costs and Utilization with Increasing Severity of Pain in Osteoarthritis Patients: An 18-Year Retrospective Study
Jove Graham¹, Tonia Novosat¹, Haiyan Sun¹, Brian Piper¹, Joseph Boscarino¹, Melissa Kern¹, Vanessa Duboski¹, Eric Wright¹, Craig Beck², Rebecca Robinson³, Edward Casey⁴, Jerry A. Hall³ and Patricia Schepman⁴, ¹Geisinger, Danville, PA, ²Pfizer, Inc., London, ³Eli Lilly and Company, Indianapolis, IN, ⁴Pfizer, Inc., New York, NY
Background/Purpose: Osteoarthritis (OA) is a disease with complex pathogenesis, and it is important to understand a patient's level of severity in order to plan and…
Abstract Number: 1447 • ACR Convergence 2021
Long-Term Effect of Prescription Non-Steroidal Anti-Inflammatory Drug Regular Use on the Risk of a Knee Replacement
S. Reza Jafarzadeh¹, Tuhina Neogi¹ and David Felson², ¹Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are a primary treatment for osteoarthritis (OA). It is uncertain, however, whether regular use of NSAIDs affects the risk of…
Abstract Number: 1903 • ACR Convergence 2021
Does Limited Stair Climbing Lead to Poor Future Health? The Relationship Between Short-term Trajectories of Stair Climbing Frequency and Incident Slow Gait Speed over 1 and 2 Years in Adults with Knee Osteoarthritis
Jason Jakiela¹, Yuqing Zhang², Dana Voinier¹, Thomas Bye¹, Jennifer Copson¹ and Daniel White¹, ¹University of Delaware, Newark, DE, ²Massachusetts General Hospital, Quincy, MA
Background/Purpose: Knee osteoarthritis (OA) is a common cause of functional limitation in older adults, and difficulty with climbing stairs is one of the first limitations…
Abstract Number: 0222 • ACR Convergence 2021
Effects of Multi-Joint Osteoarthritis Phenotypes on Self-Reported Physical Function over 3.5 Years: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Carolina Alvarez¹, Liubov Arbeeva¹, Jordan Renner¹, Virginia Kraus², Duncan Lascelles³ and Yvonne Golightly¹, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Duke University, Durham, NC, ³North Carolina State University, Raleigh, NC
Background/Purpose: To determine the differential effects of several literature-based definitions of multi-joint osteoarthritis (MJOA) on change in self-reported physical function in a community-based cohort.Methods: We…
Abstract Number: 0725 • ACR Convergence 2021
Efficacy of Subcutaneous Tanezumab for the Treatment of Osteoarthritis of the Knee or Hip: A Post Hoc Subgroup Analysis of Patients from a Randomized, NSAID-Controlled Study with a History of Depression, Anxiety, or Insomnia
Philip Mease¹, Theresa Mallick-Searle², Elizabeth Johnston³, Lars Viktrup³, Dominique Menuet⁴, Ruoyong Yang⁵ and Robert Fountaine⁶, ¹Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, ²Stanford Health Care, Redwood City, ³Eli Lilly and Company, Indianapolis, IN, ⁴Pfizer SAS, Paris, France, ⁵Pfizer Inc., New York, NY, ⁶Pfizer Inc., Groton, CT
Background/Purpose: Tanezumab is a monoclonal antibody directed against nerve growth factor that is under study to treat moderate to severe chronic pain associated with osteoarthritis…
Abstract Number: 0940 • ACR Convergence 2021
Overactivation of the Kinase IKK2 Causes a Hand Osteoarthritis-Like Phenotype in Mice
Sergio Ramirez-Perez, kyle Jones, Umesh Gangishetti and Pallavi Bhattaram, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Hand osteoarthritis (OA) presents the highest prevalence among rheumatic diseases. Synovitis is a defining feature in hand OA that has been associated with radiographic…

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