Abstracts tagged "Osteoarthritis"

Abstract Number: 1888 • ACR Convergence 2022
Novel Small Molecule Modulator of the gp130 Receptor Shows Dose-dependent Therapeutic Efficacy in a Canine Model of Osteoarthritis
Ben Van Handel¹, Candace Flynn², Emma Lamoure², Nancy Liu³, Jinxiu Lu³, Nancy Lane⁴, Mark Hurtig² and Denis Evseenko³, ¹CarthroniX, Inc., Los Angeles, CA, ²University of Guelph, Guelph, ON, Canada, ³University of Southern California, Los Angeles, CA, ⁴University of California Davis, Hillsborough, CA
Background/Purpose: The pathogenesis of OA often begins from an injury to articular cartilage, which establishes chronic, low-grade inflammation principally mediated by IL-6 family cytokines that…
Abstract Number: 1904 • ACR Convergence 2022
Is Treating Painful Hand Osteoarthritis with Hormone Replacement Therapy Feasible? Primary Results from a Randomised Controlled Trial in Post-menopausal Women
Jennifer Williams¹, Mae Chester-Jones¹, Megan Goff², Anne Francis¹, Gretchen Brewer¹, Ioana Marian¹, Malvika Gulati¹, Charles Mackworth-Young³, Victoria Glover⁴, Sarah Lamb¹, Tonia Vincent⁵, Katy Vincent¹, Susan Dutton¹ and Fiona Watt⁶, ¹University of Oxford, Oxford, United Kingdom, ²University of Oxford, London, United Kingdom, ³Imperial College Healthcare NHS Trust, London, United Kingdom, ⁴White Horse Medical Practice, Faringdon, United Kingdom, ⁵Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁶Imperial College London, London, United Kingdom
Background/Purpose: Hand osteoarthritis (OA) is more common in females and relative risk increases further around the age of menopause, potentially implicating sex hormone deficiency. There…
Abstract Number: 1920 • ACR Convergence 2022
Gait and Physical Activity Predictors of Knee Replacement: A Machine Learning Analysis in the Multicenter Osteoarthritis Study
Kerry Costello¹, David Felson¹, S. Reza Jafarzadeh², Neil Segal³, Cora E. Lewis⁴, Michael Nevitt⁵, Vijaya Kolachalama² and Deepak Kumar¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of Kansas, Kansas City, KS, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵University of California at San Francisco, Orinda, CA
Background/Purpose: Rates of knee replacement (KR) due to knee osteoarthritis (OA) are rising exponentially and currently no interventions prevent KR. Gait and physical activity are…
Abstract Number: 0122 • ACR Convergence 2022
Documentation of Social Determinants of Health Among Individuals with Systemic Rheumatic and Musculoskeletal Diseases
Sciaska Ulysse, Mia Chandler, Leah Santacroce, Tianrun Cai, Katherine Liao and Candace Feldman, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Social determinants of health (SDoH), "the conditions in which people are born, grow, work, live, and age" (World Health Organization, 2022), directly influence health…
Abstract Number: 0845 • ACR Convergence 2022
Predictors of Moderate-Vigorous Physical Activity Following a Physical Therapist Led Physical Activity Intervention for Adults with Total Knee Replacement
Scott Jamieson¹ and Christine Pellegrini², ¹The University of South Carolina, Arnold School of Public Health, Department of Exercise Science, Columbia, SC, ²University of South Carolina, Columbia, SC
Background/Purpose: Following total knee replacement rehabilitation, patients are advised to participate in physical activity. Yet, most individuals at this stage do not increase their physical…
Abstract Number: 1639 • ACR Convergence 2022
A Phase 3, 56-Week, Multicenter, Randomized, Double-Blind, Placebo Controlled Trial (OA-11) to Evaluate the Efficacy and Safety of a Single Injection of Lorecivivint Injected in the Target Knee Joint of Moderate to Severe Osteoarthritis Participants
Yusuf Yazici¹, Christopher Swearingen², Heli Ghandehari³, Jon Britt⁴, ismail simsek⁵, Mark Fineman⁶, Sarah Kennedy², Jeyanesh Tambiah⁷ and Timothy McAlindon⁸, ¹New York University School of Medicine, La Jolla, CA, ²Biosplice Therapeutics, Inc, San Diego, CA, ³Biosplice Therapeutics, Inc., San Diego, CA, ⁴Biosplice Therapeutics, Inc., Los Angeles, CA, ⁵Alpine Immunesciences, San Diego, CA, ⁶Biosplice Therapeutics, San Diego, CA, ⁷Biosplice Ther Inc., San Diego, CA, ⁸Tufts Medical Center, Arlington, MA
Background/Purpose: Knee osteoarthritis (OA) is a common joint disorder associated with pain, disability, and joint damage. There remains a large unmet need for treatments that…
Abstract Number: 1889 • ACR Convergence 2022
Investigating a Possible Bi-Directional Causal Relationship Between Gout and Osteoarthritis for the European Population: Two-Sampled Mendelian Randomization Analysis Study
Yun-Chen Tsai¹, Yu-Jing Chang², Che-Kai Chen², Michael Doherty³, Weiya Zhang³ and Chang-Fu Kuo¹, ¹Chang Gung Memorial Hospital, Taoyuan, Taiwan, ²Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ³University of Nottingham, Nottingham, United Kingdom
Background/Purpose: Gout is the most common inflammatory arthritis, and osteoarthritis is the leading cause of arthritis globally. Gout and osteoarthritis frequently coexist in the same…
Abstract Number: 1905 • ACR Convergence 2022
Does Exercise Before Surgery Predict Trajectories of Physical Activity After Knee Replacement?
Jéssica Bianca Aily¹, Dana Voinier¹, Jason Jakiela¹, Thomas Bye¹, Hiral Master¹, Louise Thoma² and Daniel White¹, ¹University of Delaware, Newark, DE, ²UNC School of Medicine, Chapel Hill, NC
Background/Purpose: Total knee replacement (TKR) is the definitive treatment for adults with knee osteoarthritis (OA) and is often successful in reducing pain and improving function.…
Abstract Number: 1921 • ACR Convergence 2022
Association Between Knee Osteoarthritis and Health-Related Quality of Life in Persons with Type 2 Diabetes
Lauren King¹, Esther Waugh¹, Ian Stanaitis², Alanna Weisman¹, Baiju Shah¹, Lorraine Lipscombe¹ and Gillian Hawker¹, ¹University of Toronto, Toronto, ON, Canada, ²Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) and type 2 diabetes commonly co-occur due to shared risk factors. Both knee OA and type 2 diabetes negatively impact health-related…
Abstract Number: 0017 • ACR Convergence 2022
Intra-articular Injection of Bacterial DNA Amplified from Human OA Patient Cartilage Worsens OA Outcomes in Mice
Leoni Schlupp¹, Emmaline Prinz¹, Vladislav Izda², Emily Nguyen¹, Christopher Dunn³ and Matlock Jeffries¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, New York, NY, ³University of Oklahoma Health Sciences Center, Edmond, OK
Background/Purpose: We have previous demonstrated a bacterial DNA signature within cartilage of humans and mice and shown shifts in this signature with OA development. However,…
Abstract Number: 0213 • ACR Convergence 2022
“The Best Part Is Feeling Like I Could Go out There and Maybe Really Help Somebody”: Training Peer Coaches to Deliver the Moving Well Total Knee Replacement Telephone-Based Coaching Program
Yuliana Domínguez Páez¹, Mackenzie Brown², Assem Jabri³, Megan Creasman⁴, Shanthini Kasturi⁵, Monika Safford³ and Iris Navarro-Millan³, ¹Weill Cornell Medicine, Bronx, NY, ²Weill Cornell Medicine, Brooklyn, NY, ³Weill Cornell Medicine, New York, NY, ⁴NYP-Weill Cornell, New York, NY, ⁵Tufts Medical Center, Boston, MA
Background/Purpose: Up to 30% of patients with advanced knee osteoarthritis (KOA) experience knee pain after recovering from Total Knee Replacement (TKR). Studies suggest that high…
Abstract Number: 0847 • ACR Convergence 2022
Association of Frontal Plane Trunk Motion During Gait with Abductor Strength, Fatigue, and Physical Activity in Women with Hip Osteoarthritis
Sanghamitra Nayak¹, Burcu Aydemir², Chun-Hao Huang³ and Kharma Foucher¹, ¹University of Illinois at Chicago, Chicago, IL, ²Northwestern University, Chicago, IL, ³Northeastern University, Boston, MA
Background/Purpose: We have previously reported that fatigue and hip abductor weakness are associated with reduced physical activity (PA) in women with hip osteoarthritis (OA). We…
Abstract Number: 1640 • ACR Convergence 2022
Tryptophan Metabolites Are Associated with Erosion and Symptoms in Hand Osteoarthritis: Results from the DIGICOD Cohort
Marie Binvignat¹, Patrick Emond², Brenda Miao³, Alice Courties⁴, Emmanuel Maheu⁵, Margreet Kloppenburg⁶, Pascal Richette⁷, Atul Butte³, Encarnita Mariotti-Ferrandiz¹, Francis Berenbaum⁸, Harry Sokol⁹ and Jérémie SELLAM¹⁰, ¹Sorbonne Universite, Paris, France, ²Tours University, Tours, France, ³UCSF, San Francisco, CA, ⁴Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ⁵Hopital Paris Saint Antoine, Moirans, Auvergne-Rhone-Alpes, France, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, ⁸Sorbonne University - Saint-Antoine hospital, Paris, France, ⁹Sorbonne Universite Saint Antoine Hospital, Paris, France, ¹⁰Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France
Background/Purpose: Tryptophan (Trp) and its metabolites have been linked to inflammatory processes and associated with gut dysbiosis. However, their role in osteoarthritis (OA) is unknown.…
Abstract Number: 1890 • ACR Convergence 2022
The Efficacy of Intra-articular Triamcinolone Acetonide 10 mg vs. 40 mg in Patients with Knee Osteoarthritis: a Non-inferiority, Randomized, Controlled, Double-blind, Multicenter Study
Sumapa Chaiamnuay¹, Komchan Utamawatin², Ong-art Phruetthiphat² and Rit Apinyankul³, ¹Phramongkutklao hospital, Nonthaburi, Thailand, ²Phramongkutklao Hospital, Bangkok, Thailand, ³Konkaen University Hospital, Konkaen, Thailand
Background/Purpose: Intra-articular (IA) corticosteroid injection is recommended in refractory knee osteoarthritis patients. However, 40-mg of triamcinolone IA every 3 months for 2 years reduces cartilage…
Abstract Number: 1906 • ACR Convergence 2022
Bile Acid Profile Is Associated to Synovitis in Knee Osteoarthritis
Roxana Coras¹, Jessica Murillo Saich², Michal Hose Sanchez³, Anne Quan³, Emily Gentry¹, Pieter Dorrestein¹, Nancy Lane⁴ and Monica Guma⁵, ¹University of California San Diego, San Diego, CA, ²University of California San Diego, La Jolla, CA, ³VA San Diego Healthcare System, San Diego, CA, ⁴University of California Davis, Hillsborough, CA, ⁵Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Increasing evidence indicates that low grade systemic and local inflammation contributes to osteoarthritis (OA) progression. Bioactive lipid mediators are signaling molecules involved in inflammatory…

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