Session Type: Abstract Session
Session Time: 2:00PM-3:30PM
Background/Purpose: The association between serum adiponectin levels and hand osteoarthritis (OA) has been studied cross-sectionally, but longitudinal studies on the radiographic progression of hand OA are lacking. Thus, we investigated the relationship between serum adiponectin levels and radiographic features of hand OA in a prospective longitudinal cohort.
Methods: A total of 1,356 subjects were enrolled from the Dong-gu study. Baseline serum adiponectin levels were measured by enzyme linked immunosorbent assay, and hand joint radiographs were assessed using a semi-quantitative grading system at the first visit and 6 years later. Multiple linear regression analysis was used to investigate the association between serum adiponectin levels and radiologic changes in hand OA.
Results: Total hand joint scores increased from 16.5 ± 5.74 at baseline to 19.4 ± 8.11 at year 6 (p < 0.001). The baseline adiponectin levels were negatively associated with the changes in total hand joint score (p = 0.019), subchondral cyst score (p = 0.006), and malalignment score (p = 0.026) after adjusting for age, gender, body mass index, smoking, alcohol consumption, education, physical activity, hypertension, diabetes mellitus, dyslipidemia, chronic pulmonary disease, chronic liver disease, cardiovascular disease, cerebrovascular disease, and malignancy. When serum adiponectin levels above and below the median were compared with the total score for hand OA based on the median radiographic scores, subjects with serum adiponectin levels below the median exhibited radiographic progression in hand joints after adjustment (odds ratio = 0.618, 95% confidence interval: 0.477–0.801, p < 0.001).
Conclusion: In this longitudinal population-based study, decreased serum adiponectin levels were associated with progression of radiographic hand OA.
To cite this abstract in AMA style:Choi S, Jeong H, Park D, Kang J, Shin M, Lee S. Low Serum Adiponectin Levels Were Associated with Radiographic Progression of Hand Osteoarthritis in a 6-year Follow-up of the Dong-gu Study [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 9). https://acrabstracts.org/abstract/low-serum-adiponectin-levels-were-associated-with-radiographic-progression-of-hand-osteoarthritis-in-a-6-year-follow-up-of-the-dong-gu-study/. Accessed .
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