Abstracts tagged "Osteoarthritis"

Abstract Number: 1883 • ACR Convergence 2023
Thalamocortical Mechanisms of a Remote Mind-body Intervention for Knee Osteoarthritis Pain
Jian Kong¹, Valeria Sacca¹ and Chenchen Wang², ¹Massachusetts General Hospital, Boston, MA, ²Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Studies found that individuals with pain exhibit altered thalamocortical rhythm, abnormal function, and structural connectivity within the network. Effective treatment may relieve pain by…
Abstract Number: 1989 • ACR Convergence 2023
Shared Variation Among Cartilage Thickness Change Maps and Baseline Clinical Features at the Initiation of Structural Knee Osteoarthritis
Thomas Keefe¹, Marc Niethammer¹, Boqi Chen¹, Zhengyang Shen¹, Daniel Nissman¹, Mary Catherine Minnig², Yvonne Golightly³, J.S. Marron¹ and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Durham, NC, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: To identify features of cartilage thickness change and baseline clinical indicators associated with the transition from normal to mildly reduced joint space as an…
Abstract Number: 2499 • ACR Convergence 2023
Influence of Adiposity on Physical Function, Physical Activity, and Self-Reported Symptom Severity for Individuals with Arthritis Prior to Beginning a Physical Activity Promotion Intervention
Scott Jamieson, Sara Wilcox and Christine Pellegrini, The University of South Carolina, Columbia, SC
Background/Purpose: Engagement in moderate-vigorous physical activity (MVPA) is recommended for individuals with obesity to promote weight loss and mitigate severity of chronic diseases associated with…
Abstract Number: 0319 • ACR Convergence 2023
Knee Flexion Contracture Was Associated with Articular Cartilage Loss in the Central Region but Cartilage Preservation in the Posterior Region of the Tibia: Data from the Osteoarthritis Initiative
Mark Campbell¹, Odette Laneuville² and Guy Trudel³, ¹Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²University of Ottawa, Ottawa, ON, Canada, ³Ottawa Hospital Research Institute, Ottawa, ON, Canada
Background/Purpose: A knee flexion contracture (FC), present in ~⅓ of patients with knee OA1, is the inability to fully extend the knee2, 3. Having a…
Abstract Number: 0859 • ACR Convergence 2023
Single Injection AAV2-hFGF18 Demonstrates Superior Safety and Efficacy over Repeat rhFGF18 Protein Injections in a Model of Induced Osteoarthritis
Alex Goraltchouk¹, Judith Hollander², Francesco Luppino³, Li Zeng² and Alexey Seregin³, ¹Remedium Bio, Inc, Needham, MA, ²Tufts University, Boston, MA, ³Remedium Bio, Inc., Needham, MA
Background/Purpose: Osteoarthritis (OA) is the largest unmet need in rheumatology, affecting 1 in 7 adults, with no approved disease modifying treatments. A recent placebo-controlled clinical…
Abstract Number: 0877 • ACR Convergence 2023
Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis
Meike Sambale¹, starlee lively², Osvaldo Espin-Garcia², Pratibha Potla², Chiara Pastrello³, Alexandra Schaefer¹, Jessica Bertrand⁴, Mohit Kapoor⁵, Thomas Pap¹ and Joanna Sherwood¹, ¹University Hospital Münster, Münster, Germany, ²University Health Network, Toronto, ON, Canada, ³Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, ⁴Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, ⁵Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…
Abstract Number: 1187 • ACR Convergence 2023
Post-hoc Analysis of Individual Questions from the Australian/Canadian Osteoarthritis Hand Index from a Randomized, Double-blind, Placebo-controlled Trial of Patients with Hand OA
Karin Nicholson¹, Edwin Sanchez¹, Wendy Wright², Joel Block³ and Richard Petruschke¹, ¹Haleon, Warren, NJ, ²Wright & Associates Family Healthcare, Amherst, NH, ³Rush University Medical Center, Chicago, IL
Background/Purpose: Hand osteoarthritis (OA) is a frequently occurring form of OA characterized by symptoms including joint pain, stiffness, and swelling which affect performance of activities…
Abstract Number: 1592 • ACR Convergence 2023
Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence
Ning Wang¹, Qingmei Cheng¹, Xiaoxiao Li², ke he¹, Junyu Zhu¹, Hui Li³ and Jie Wei⁴, ¹中南大学湘雅医院, Changsha, China, ²Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, ³Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ⁴Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
Abstract Number: 1894 • ACR Convergence 2023
3-Dimensional Regional Variation in Inter-rater Reliability of Bone Marrow Lesion Scoring in the Knee
Stephanie Wichuk¹, Walter P. Maksymowych¹, Joel Paschke², Abhilash Hareendranathan³ and Jacob Jaremko¹, ¹University of Alberta, Edmonton, AB, Canada, ²CARE Arthritis, Edmonton, AB, Canada, ³Radiology and Diagnostic Imaging, Edmonton, AB, Canada
Background/Purpose: Bone marrow lesions (BML) are an important scoring feature on magnetic resonance imaging (MRI) of knee osteoarthritis (OA), and their presence in certain anatomical…
Abstract Number: 1990 • ACR Convergence 2023
Effects of Exercise on Movement-Evoked Pain in People with Knee Osteoarthritis
Ehyun Kim¹, Tuhina Neogi², Benjamin Senderling¹, Mary Gheller¹, Lee Marinko¹, Michael LaValley³, Lukas Adamowicz⁴, Pirinka Georgiev⁴, Charmaine Demanuele⁴, Paul Wacnik⁴ and Deepak Kumar¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Pfizer Inc., Cambridge, MA
Background/Purpose: Movement-evoked pain (MEP), i.e., pain that appears with or is made worse by movement, is a common complaint in people with knee osteoarthritis (OA).…
Abstract Number: 2503 • ACR Convergence 2023
Cytokines Regulate the Fibrotic Response of Growth Factors in Joint Fibroblast-like Synoviocytes
Sofie Falkenløve Madsen¹, Mikkel Rathsach Andersen², Alexander Scheller Madrid², Signe Holm Nielsen³, Morten Karsdal³, Christian Thudium³ and Anne-Christine Bay-Jensen³, ¹University of Copenhagen, Herlev, Denmark, ²Herlev-Gentofte Hospital, Gentofte, Denmark, ³Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) and osteoarthritis (OA) are characterized by inflammation, joint swelling, stiffness, and pain. A fibroid phenotype has been identified in RA, where…
Abstract Number: 0320 • ACR Convergence 2023
Feasibility and Acceptability of Geniculate Artery Embolization for the Treatment of Painful Knee Osteoarthritis
Amaya Smole¹, Benjamin Swett¹, Alison Zhao¹, Yvonne Shea¹, Sarah Gottesman¹, Dongmei Sun¹, Geoffrey Westrich¹, Michael Alexiades¹, Alejandro Gonzalez Della Valle¹, Sirish Kishore² and Lisa Mandl³, ¹Hospital for Special Surgery, New York, NY, ²Stanford Medicine, Stanford, CA, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: There are limited non-surgical options for patients with severe pain due to knee osteoarthritis (KOA).Using geniculate artery embolization (GAE) to infarct hypervascular synovium, a…
Abstract Number: 0861 • ACR Convergence 2023
The Analgesic Effect of RC-0165, a TRPV1 Antagonist, for Osteoarthritis Pain
Donghui kim, Juil park, Minjung kim and Yongho kim, RudaCure, Seoul, South Korea
Background/Purpose: Osteoarthritis (OA), the most common form of arthritis, arises from the deterioration of cartilage within joint bones, resulting in pain and functional disability with…
Abstract Number: 0878 • ACR Convergence 2023
Synovial Fibroblasts Undergo a Phenotypic Shift from Early- to Late-stage Knee Osteoarthritis
Kabriya Thavaratnam¹, Eric Gracey², Anusha Ratneswaran¹, Jason Rockel¹, Shabana Vohra¹, Chiara Pastrello³, Igor Jurisica⁴, starlee lively⁵, Sam Dupont⁶, Raja Rampersaud¹, Nizar Mahomed⁷, Rajiv Gandhi⁸, Dirk Elewaut⁹ and Mohit Kapoor¹⁰, ¹Schroeder Arthritis Institute, Toronto, ON, Canada, ²Ghent University Hospital, Gent, Belgium, ³Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, ⁴Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵University Health Network, Toronto, ON, Canada, ⁶Ghent University Hospital, Ghent, Belgium, ⁷Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁸Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Orthopaedics, Department of Surgery, University of Toronto, Toronto, ON, Canada, ⁹Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, ¹⁰Schroeder Arthritis Institute, University Health Network and Department of Surgery, University of Toronto, Toronto, ON, Canada
Background/Purpose: The synovium is a connective tissue that lines the joint capsule and is emerging as a key contributor to joint destruction during osteoarthritis (OA).…
Abstract Number: 1188 • ACR Convergence 2023
Development of a Method to Isolate Functional Mitochondria and Assess Their Functionality and Integration in Joint Tissues: In Vitro and in Vivo Models
Mercedes Fernandez-Moreno¹, Tamara Hermida-Gomez², Sara Paniagua-Barro¹, Arianna Rodriguez-Coello¹, Carlos Vaamonde-garcia¹ and Francisco J. Blanco³, ¹Grupo de Investigación en Reumatología (GIR), Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Spain; Universidade de A Coruña (UDC), A Coruña, Spain; Grupo de Investigación en Reumatología y Salud (GIR-S), Departamento de Biologia, Facultad de Ciencias. Centro Interdisciplinar de Química y Biología (CICA), INIBIC-Sergas, Universidade de A Coruña (UDC), A Coruña, Spain, ²2) Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). Centro interdisciplinar de química e bioloxia (CICA). As Xubias, 15006. A Coruña, España. 3) Centro de investigación biomédica en Red, Bioingenieria, Biomatereial y Nanomedicina (CIBER-BBN), A Coruña, Spain, ³Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain
Background/Purpose: There is not cure or an efficient treatment for the osteoarthritis (OA). Mitochondrial damage and dysfunction are described during OA process modulating chondrocyte function…

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