Abstracts tagged "osteoarthritis and radiography"

Abstract Number: 1201 • 2017 ACR/ARHP Annual Meeting
Reducing Heterogeneity in OA Clinical Trials: Data from a Phase 2 Study of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor in Knee Osteoarthritis
Philip G. Conaghan¹, Anita DiFrancesco², Christopher J. Swearingen², Sarah Kennedy², Ismail Simsek², Jeymi Tambiah² and Yusuf Yazici², ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Samumed, LLC, San Diego, CA
Background/Purpose: Kellgren-Lawrence [KL] radiographic grading is used to classify knee osteoarthritis (OA), but may not accurately reflect disease progression. Classifying subjects by baseline medial joint…
Abstract Number: 2353 • 2016 ACR/ARHP Annual Meeting
Radiographic Variations in Hip Morphology Are Associated with Hip Symptoms: A Cross-Sectional Analysis of a Large Community-Based Cohort
Reshmi Raveendran¹, Jamie L. Stiller¹, Xiaoyan A. Shi², Jordan B. Renner³, Todd A. Schwartz⁴, Nigel K Arden⁵, Joanne M. Jordan¹ and Amanda E. Nelson¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²SAS Institute, Inc, Cary, NC, ³Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: Preliminary investigation in this cohort supported an association between hip morphology and symptoms, however, the influence of race, gender, age, BMI and radiographic hip…
Abstract Number: 312 • 2016 ACR/ARHP Annual Meeting
Association Between Grip Strength and Hand and Knee Radiographic Osteoarthritis in Older Adults: Data from the Dong-Gu Study
Dong-Jin Park¹, Lihui Wen², Ji-Hyoun Kang¹, Yi-Rang Yim², Ji-Eun Kim², Jeong-Won Lee², Kyung-Eun Lee¹, Tae-Jong Kim³, Yong-Wook Park¹ and Shin-Seok Lee³, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Chonnam National University Medical School and Hospital, Gwangju, South Korea, ³Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, The Republic of
Background/Purpose: Although some studies have shown a negative relationship between grip strength and hand osteoarthritis (OA), little is known about how grip strength is related…
Abstract Number: 318 • 2016 ACR/ARHP Annual Meeting
Observer Variability of Joint Space with Measurements Is Subject Related in Medial Knee Osteoarthritis
Berna Goker¹, Seminur Haznedaroglu¹, Abdurrahman Tufan¹ and Joel Block², ¹Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, ²Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Assessment of structural progression of knee osteoarthritis (OA) requires quantitative evaluation of the radiographic joint space width (JSW). Significant reduction in the rate…
Abstract Number: 1269 • 2016 ACR/ARHP Annual Meeting
Description of Radiographic Hip Measurements By OA Status in a Large Community-Based Study of African American and White Men and Women
Amanda E. Nelson¹, Reshmi Raveendran¹, Jamie L. Stiller¹, Carolina Alvarez², Jordan B. Renner³, Todd A. Schwartz⁴, Nigel K Arden⁵ and Joanne M. Jordan¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Thurston Arthritis Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: There has been increasing interest in hip morphology as a risk factor for OA. There is a need for frequency estimates in the general…
Abstract Number: 1304 • 2016 ACR/ARHP Annual Meeting
2D and 3D Measurements of Osteoarthritis Joint Space Width Have Good Agreement in Radiographically Normal Knees but Poor Agreement with Advancing Kellgren-Lawrence Grade: Data from the Osteoarthritis Initiative
Aaron Ray¹, Michael A Bowes², Bright Dube¹, Elizabeth M.A. Hensor¹, Andrew J Barr¹ and Philip G. Conaghan¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom
2D and 3D Measurements of Osteoarthritis Joint Space Width have Good Agreement in Radiographically Normal Knees but Poor Agreement with Advancing Kellgren-Lawrence Grade: Data from…
Abstract Number: 2350 • 2016 ACR/ARHP Annual Meeting
Radiographic Outcomes from a Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study of a Novel, Intra-Articular, Injectable, Wnt Inhibitor (SM04690) in the Treatment of Osteoarthritis of the Knee
Christopher J. Swearingen¹, Sharmila Majumdar², Ismail Simsek¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Yusuf Yazici¹, ¹Samumed, LLC, San Diego, CA, ²University of California San Francisco, San Francisco, CA
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional impairment, disability, and joint space narrowing due to degradation of articular cartilage and bone remodeling. The…
Abstract Number: 98 • 2015 ACR/ARHP Annual Meeting
The Mitochondrial DNA (mtDNA) Haplogroups Influence the Risk of Incidence Knee OA. Replication Study Including Data from Check and OAI Cohorts
Ignacio Rego-Pérez¹, Angel Soto-Hermida¹, Juan Fernandez-Tajes¹, Mercedes Fernandez Moreno¹, Maria Eugenia Vazquez Mosquera¹, Estefanía Cortés-Pereira¹, Sonia Pertega², Sara Relaño-Fernandez¹, Natividad Oreiro¹, Carlos Fernandez-Lopez¹ and Francisco J. Blanco¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose:Previous studies showed a significant influence of the mtDNA haplogroups on prevalence, radiographic progression and cartilage integrity of knee OA patients from different worldwide cohorts.…
Abstract Number: 111 • 2015 ACR/ARHP Annual Meeting
The Mitochondrial DNA (mtDNA) Haplogroups Influence the Risk of Radiographic OA Progression. a Meta-Analysis
Angel Soto-Hermida¹, Ignacio Rego-Pérez¹, Juan Fernandez-Tajes¹, Mercedes Fernandez Moreno¹, Maria Eugenia Vazquez Mosquera¹, Estefanía Cortés-Pereira¹, Sara Relaño-Fernandez¹, Sonia Pertega², Natividad Oreiro¹, Carlos Fernandez-Lopez¹ and Francisco J. Blanco¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain
Background/Purpose: In the last years the role played by the mtDNA haplogroups in the pathogenesis of OA attracted much attention. The aim of this study…
Abstract Number: 317 • 2015 ACR/ARHP Annual Meeting
Relation of Incident Bisphosphonate Use to Trajectory of Joint-Space Width
Tuhina Neogi¹, Na Lu², Jingbo Niu¹, Jeffrey Duryea³ and Yuqing Zhang¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Radiology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Trials regarding bisphosphonate (Bisph) effects in knee osteoarthritis (OA) have been conflicting, and are unable to provide insights into long-term effects. While Bisph may…
Abstract Number: 325 • 2015 ACR/ARHP Annual Meeting
Best Performing Definition of Accelerated Knee Osteoarthritis
Jeffrey Driban¹, Grace H. Lo², Charles B. Eaton³, Lori Lyn Price⁴, Bing Lu⁵ and Timothy E. McAlindon¹, ¹Tufts Medical Center, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁴Clinical Care Research, Tufts Medical Center, Boston, MA, ⁵Brigham & Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) may be a unique subset of knee osteoarthritis (KOA) that is associated with a knee injury and greater age, body…
Abstract Number: 1004 • 2015 ACR/ARHP Annual Meeting
Prevalence and Cross-Sectional Risk Factors of Ankle Osteoarthritis in a Community-Based Cohort
Shahmeer Lateef¹, Yvonne M. Golightly², Jordan B. Renner³, Joanne M. Jordan¹ and Amanda E. Nelson¹, ¹Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Epidemiology, University of North Carolina, Chapel Hill, NC, ³Radiology, University of North Carolina, Chapel Hill, NC
Background/Purpose: Historically, ankle osteoarthritis (OA) has been considered uncommon, and its development has been thought of as a consequence of primarily ankle injury. Other etiologies…
Abstract Number: 1303 • 2015 ACR/ARHP Annual Meeting
Is MRI More Sensitive Than Conventional Radiographs to Detect Hand Osteoarthritis Progression over 5 Years Follow-up?
Ida K. Haugen¹, Barbara Slatkowsky-Christensen², Karwan Faraj³ and Tore K. Kvien⁴, ¹P.O. Box 23, Diakonhjemmet Hospital, Vinderen, Norway, ²Diakonhjemmet Sykehus, Revmatologisk Avd, Oslo, Norway, ³Radiology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose : Conventional radiographs (CR) are currently the imaging modality of choice for evaluation of structural hand osteoarthritis (OA) progression. Lately Magnetic Resonance Imaging (MRI)…
Abstract Number: 2250 • 2015 ACR/ARHP Annual Meeting
The Relationship Between Sex and Incident Knee Osteoarthritis Is Mediated By Shape
Barton L. Wise¹, Jingbo Niu², Yuqing Zhang³, Felix Liu⁴, Joyce H. Pang⁵, John A. Lynch⁶ and Nancy E. Lane⁷, ¹Department of Internal Medicine, UC Davis School of Medicine, Sacramento, CA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³BUSM, Boston, MA, ⁴University of California at San Francisco, San Francisco, CA, ⁵University of Nevada School of Medicine, Reno, NV, ⁶University of California San Francisco, San Francisco, CA, ⁷Center for Musculoskeletal Health, Univ of California at Davis, Sacramento, CA
Background/Purpose: Incidence of knee osteoarthritis (OA) is higher in women than in men. We have previously shown that knee bone shape differs between men and…
Abstract Number: 1801 • 2014 ACR/ARHP Annual Meeting
The Association of Knee Shape with Sex: The Osteoarthritis Initiative
Barton L. Wise¹, Lisa Kritikos², Felix Liu³, Neeta Parimi³, John A. Lynch⁴, Yuqing Zhang⁵ and Nancy E. Lane¹, ¹Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ²Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ³University of California at San Francisco, San Francisco, CA, ⁴Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Incidence of knee osteoarthritis (OA) is much higher in women than in men. Previous studies have shown that bone shape is a risk factor…

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